iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000005877.2	ENSSTOT00000005887.2	ENSSTOP00000005266.2
ENSSTOG00000005877.2	ENSSTOT00000023587.1	ENSSTOP00000015588.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-135	451.9	354	683

Active Site

Position(s)	Description	Evidence
653	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 354  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 442
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 443  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWR 526
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d+k++tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 527  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWKEHTKYKNGYNVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 615
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+++gF+
   Q: 616  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENAQGFD 683
           *******************************************************************8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MTYLPKTSGS EEDNAEQAEE LEPGWVVLDQ PDAACHLQQQ QEPSPLPPGW EERQDVLGRT 60
YYVNHESRRT QWKRPTPQDD LTDAENGNIQ LQAQRAFTTR RQISEETESV DNRDSSENWE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGAGATG ATTTCCTAGG TCAAGTGGAT GTTCCTCTTT ATCCATTGCC GGTTAGTATA 60
GGTGTCCATG ATTTGGGGTT TTGTGTTTAT TATTTTTAAT TTAATAAATA CTTATAATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0003197--P:endocardial cushion development
GO:0010766--P:negative regulation of sodium ion transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0003151--P:outflow tract morphogenesis
GO:0045732--P:positive regulation of protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048814--P:regulation of dendrite morphogenesis
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	82.47	0.00e+00	1219.00
IUUC-Apl-003886	Anas platyrhynchos	66.54	0.00e+00	1011.00
IUUC-Aca-004744	Anolis carolinensis	54.84	0.00e+00	802.00
IUUC-Ame-011138	Astyanax mexicanus	80.29	0.00e+00	816.00
IUUC-Bta-012453	Bos taurus	79.58	0.00e+00	1178.00
IUUC-Cel-018564	Caenorhabditis elegans	50.08	4.00e-175	607.00
IUUC-Cja-019034	Callithrix jacchus	81.71	0.00e+00	1196.00
IUUC-Cfa-020258	Canis familiaris	82.87	0.00e+00	1166.00
IUUC-Cpo-021648	Cavia porcellus	79.26	0.00e+00	1156.00
IUUC-Csa-023334	Chlorocebus sabaeus	83.80	0.00e+00	1186.00
IUUC-Cho-024832	Choloepus hoffmanni	83.52	1.00e-180	626.00
IUUC-Cin-025157	Ciona intestinalis	71.63	0.00e+00	747.00
IUUC-Csv-026098	Ciona savignyi	66.44	2.00e-178	618.00
IUUC-Dre-027770	Danio rerio	79.22	0.00e+00	797.00
IUUC-Dno-029159	Dasypus novemcinctus	77.59	0.00e+00	1114.00
IUUC-Dor-030729	Dipodomys ordii	82.36	0.00e+00	832.00
IUUC-Dme-032166	Drosophila melanogaster	63.15	0.00e+00	696.00
IUUC-Ete-032409	Echinops telfairi	74.77	0.00e+00	1007.00
IUUC-Eca-033441	Equus caballus	83.16	0.00e+00	1158.00
IUUC-Eeu-034546	Erinaceus europaeus	70.20	0.00e+00	1041.00
IUUC-Fca-036384	Felis catus	82.65	0.00e+00	1197.00
IUUC-Fal-037547	Ficedula albicollis	72.58	0.00e+00	1064.00
IUUC-Gmo-039679	Gadus morhua	63.45	0.00e+00	916.00
IUUC-Gga-040524	Gallus gallus	73.68	0.00e+00	1056.00
IUUC-Gac-042607	Gasterosteus aculeatus	59.80	0.00e+00	903.00
IUUC-Ggo-045332	Gorilla gorilla	57.20	0.00e+00	845.00
IUUC-Hsa-046479	Homo sapiens	83.80	0.00e+00	1216.00
IUUC-Lch-050445	Latimeria chalumnae	66.14	0.00e+00	987.00
IUUC-Loc-052645	Lepisosteus oculatus	65.93	0.00e+00	985.00
IUUC-Laf-053638	Loxodonta africana	92.15	0.00e+00	944.00
IUUC-Mcc-055585	Macaca mulatta	83.93	0.00e+00	1204.00
IUUC-Meu-056897	Macropus eugenii	95.47	3.00e-170	592.00
IUUC-Mga-059362	Meleagris gallopavo	67.44	0.00e+00	1025.00
IUUC-Mmr-061061	Microcebus murinus	81.43	0.00e+00	1205.00
IUUC-Mdo-062178	Monodelphis domestica	61.66	0.00e+00	1001.00
IUUC-Mmu-063318	Mus musculus	87.76	0.00e+00	1223.00
IUUC-Mpu-066567	Mustela putorius furo	82.50	0.00e+00	1211.00
IUUC-Mlu-068148	Myotis lucifugus	81.70	0.00e+00	1172.00
IUUC-Nle-069225	Nomascus leucogenys	83.67	0.00e+00	1236.00
IUUC-Opr-070443	Ochotona princeps	98.19	0.00e+00	816.00
IUUC-Ont-071664	Oreochromis niloticus	60.30	0.00e+00	871.00
IUUC-Oan-073019	Ornithorhynchus anatinus	76.39	0.00e+00	1126.00
IUUC-Ocu-074409	Oryctolagus cuniculus	81.70	0.00e+00	1203.00
IUUC-Ola-087467	Oryzias latipes	75.49	0.00e+00	785.00
IUUC-Oga-088241	Otolemur garnettii	74.07	0.00e+00	1025.00
IUUC-Oar-089797	Ovis aries	81.83	0.00e+00	1220.00
IUUC-Ptr-091629	Pan troglodytes	82.66	0.00e+00	1165.00
IUUC-Pan-092284	Papio anubis	55.93	0.00e+00	840.00
IUUC-Psi-093618	Pelodiscus sinensis	72.50	0.00e+00	1066.00
IUUC-Pma-094364	Petromyzon marinus	78.21	0.00e+00	792.00
IUUC-Pfo-097145	Poecilia formosa	61.58	0.00e+00	868.00
IUUC-Pab-098394	Pongo abelii	83.53	0.00e+00	1187.00
IUUC-Pca-100568	Procavia capensis	70.67	0.00e+00	1023.00
IUUC-Pva-102303	Pteropus vampyrus	75.90	0.00e+00	857.00
IUUC-Rno-106095	Rattus norvegicus	87.61	0.00e+00	1224.00
IUUC-Sha-107370	Sarcophilus harrisii	70.16	0.00e+00	1075.00
IUUC-Ssc-115950	Sus scrofa	70.39	0.00e+00	768.00
IUUC-Tgu-117474	Taeniopygia guttata	72.58	0.00e+00	1074.00
IUUC-Tru-117675	Takifugu rubripes	59.64	0.00e+00	895.00
IUUC-Tsy-118806	Tarsius syrichta	97.59	0.00e+00	956.00
IUUC-Tni-119993	Tetraodon nigroviridis	57.74	0.00e+00	872.00
IUUC-Tbe-127408	Tupaia belangeri	77.25	0.00e+00	1020.00
IUUC-Ttr-128437	Tursiops truncatus	78.05	0.00e+00	1053.00
IUUC-Vpa-130503	Vicugna pacos	76.66	0.00e+00	1130.00
IUUC-Xtr-132431	Xenopus tropicalis	63.28	0.00e+00	951.00
IUUC-Xma-133797	Xiphophorus maculatus	78.19	0.00e+00	793.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence