iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047918

Ensembl Protein ID

ENSSTOP00000023328.1

UniProt Accession

I3NG31; I3NG31_ICTTR

Genbank Protein ID

ENSSTOP00000023328

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01109003

Gene Name

Usp18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000020847.1	ENSSTOT00000019783.1	ENSSTOP00000023328.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-56	191.5	53	365

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+ ++ +++++ l++    k+++e+  e+  ++  +l  l+e++++s++kav p e+  +l+k+++    + q
   Q: 53   VGLHNIGQTCCLNSLIQVFIMNSDFTKILKR---IKVPREA-GEQRRSVPFQLLLLLEKMQDSRQKAVRPMEFAYCLQKYNVP--LFVQ 135
           6******************************...6666554.67788**********************************99..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          +++   + ++ l+ +++k++++cl+c+++ssr++++l+l+l + +
   Q: 136  HDAAQLYLTVWNLIKDQI--------------------------TDMDLVDRLQALYMIRMKESLICLDCAKESSRNSSMLTLPLCLFD 198
           ******************..........................67788999************************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f+++  l +  k++ce c k++ +++ lkl++lP++L++hL+Rfs   ++++ eki  +++fp++Ld ++++++
   Q: 199  MDSKPLQTLEDALRCFFQPRVLSS--KCFCEDCGKRTHSKQDLKLTHLPQTLTIHLMRFSI--KNSRTEKICHSLYFPQSLDFNQVLSN 283
           99999*****************95..9********************************66..667999***************99998 PP
   S: 268  .....peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
                +  k++++ ++eL+av+ H G ++ GHY+ay++n  +g+W++f+Ds+V+ v++e+++ + g       +taY+l+Y++
   Q: 284  eqvlgD-AKEQSEGQFELFAVIAHVGIADLGHYCAYIRNsVDGRWFCFNDSHVSWVSWEDIQCTYGnrnyrwqETAYLLVYMK 365
           555532.3344499*************************44566*******************888***************98 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MDNVFGFLRE TCQLILAESQ QYPGESTWKK EENNSMKRER EHFNSWDNPH GLVGLHNIGQ 60
TCCLNSLIQV FIMNSDFTKI LKRIKVPREA GEQRRSVPFQ LLLLLEKMQD SRQKAVRPME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAATG TGTTCGGGTT CCTGAGAGAA ACTTGCCAGT TAATCCTGGC TGAGTCTCAG 60
CAGTACCCGG GAGAATCCAC CTGGAAGAAG GAAGAGAACA ACAGCATGAA GAGGGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	76.55	5.00e-155	540.00
IUUC-Apl-004006	Anas platyrhynchos	55.94	2.00e-103	368.00
IUUC-Aca-005088	Anolis carolinensis	54.18	1.00e-89	323.00
IUUC-Ame-010606	Astyanax mexicanus	33.96	7.00e-42	164.00
IUUC-Bta-013036	Bos taurus	75.00	2.00e-143	501.00
IUUC-Cja-019052	Callithrix jacchus	76.09	3.00e-142	497.00
IUUC-Cfa-020554	Canis familiaris	80.53	5.00e-162	563.00
IUUC-Cpo-022421	Cavia porcellus	74.47	5.00e-164	570.00
IUUC-Csa-023737	Chlorocebus sabaeus	76.85	5.00e-92	329.00
IUUC-Cho-024807	Choloepus hoffmanni	65.48	3.00e-64	238.00
IUUC-Dre-027408	Danio rerio	33.13	5.00e-45	174.00
IUUC-Dno-029813	Dasypus novemcinctus	65.14	3.00e-122	431.00
IUUC-Dor-030532	Dipodomys ordii	70.78	2.00e-155	541.00
IUUC-Ete-032254	Echinops telfairi	68.72	2.00e-151	527.00
IUUC-Eca-033482	Equus caballus	82.19	4.00e-155	540.00
IUUC-Eeu-034451	Erinaceus europaeus	74.06	2.00e-91	327.00
IUUC-Fca-036313	Felis catus	74.73	1.00e-159	555.00
IUUC-Fal-037216	Ficedula albicollis	51.39	7.00e-102	363.00
IUUC-Gmo-038649	Gadus morhua	33.33	1.00e-41	163.00
IUUC-Gga-041082	Gallus gallus	52.85	5.00e-93	334.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.76	2.00e-49	189.00
IUUC-Ggo-044957	Gorilla gorilla	80.88	2.00e-130	457.00
IUUC-Hsa-046381	Homo sapiens	77.63	1.00e-171	595.00
IUUC-Loc-052688	Lepisosteus oculatus	32.92	2.00e-45	176.00
IUUC-Laf-054109	Loxodonta africana	75.13	8.00e-169	585.00
IUUC-Mcc-054814	Macaca mulatta	76.14	2.00e-170	591.00
IUUC-Meu-056253	Macropus eugenii	66.90	2.00e-103	368.00
IUUC-Mmr-061613	Microcebus murinus	77.88	5.00e-157	546.00
IUUC-Mdo-061890	Monodelphis domestica	63.24	1.00e-118	419.00
IUUC-Mmu-064329	Mus musculus	70.78	5.00e-149	520.00
IUUC-Mpu-066342	Mustela putorius furo	77.72	1.00e-165	575.00
IUUC-Mlu-067010	Myotis lucifugus	75.89	1.00e-165	575.00
IUUC-Nle-069148	Nomascus leucogenys	77.36	6.00e-170	589.00
IUUC-Opr-070988	Ochotona princeps	68.15	2.00e-61	228.00
IUUC-Ont-072039	Oreochromis niloticus	35.02	2.00e-50	192.00
IUUC-Oan-073740	Ornithorhynchus anatinus	54.87	9.00e-73	266.00
IUUC-Ocu-074498	Oryctolagus cuniculus	74.46	3.00e-152	530.00
IUUC-Ola-086753	Oryzias latipes	35.67	5.00e-48	184.00
IUUC-Oga-088497	Otolemur garnettii	76.54	4.00e-163	566.00
IUUC-Oar-089505	Ovis aries	74.69	3.00e-142	497.00
IUUC-Ptr-091656	Pan troglodytes	77.36	7.00e-172	595.00
IUUC-Pan-092498	Papio anubis	76.14	6.00e-170	589.00
IUUC-Psi-093409	Pelodiscus sinensis	53.95	1.00e-107	382.00
IUUC-Pfo-096507	Poecilia formosa	34.39	3.00e-48	185.00
IUUC-Pab-097828	Pongo abelii	81.99	4.00e-157	546.00
IUUC-Pca-100299	Procavia capensis	74.06	7.00e-103	367.00
IUUC-Pva-102972	Pteropus vampyrus	74.05	8.00e-156	542.00
IUUC-Rno-105738	Rattus norvegicus	68.55	2.00e-149	521.00
IUUC-Sha-107309	Sarcophilus harrisii	62.75	1.00e-108	385.00
IUUC-Sar-112983	Sorex araneus	74.22	3.00e-119	421.00
IUUC-Ssc-116049	Sus scrofa	76.25	1.00e-147	514.00
IUUC-Tgu-117115	Taeniopygia guttata	53.80	5.00e-99	353.00
IUUC-Tru-118022	Takifugu rubripes	32.20	2.00e-39	155.00
IUUC-Tsy-118986	Tarsius syrichta	59.72	2.00e-61	229.00
IUUC-Tni-120306	Tetraodon nigroviridis	32.91	5.00e-40	157.00
IUUC-Tbe-127768	Tupaia belangeri	57.22	2.00e-109	389.00
IUUC-Ttr-128686	Tursiops truncatus	73.98	8.00e-148	516.00
IUUC-Xtr-132032	Xenopus tropicalis	42.95	7.00e-69	253.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence