iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036309

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

AANG02025528

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000010698.2	ENSFCAT00000010701.2	ENSFCAP00000009936.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-44	147.3	176	206
UBD/Beta-Prp	8.00e-50	169.7	142	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 176  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 206
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 18   fspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvw.....dls............tgkcv 87
           ++p+++lla++s+d+t+k+++ ++ +    ++l+ghe++v+++ f+p+g+ l+++s+Drt+++w     + +            + kc+
   Q: 142  WHPSQELLASASYDDTVKLYREEEDDWvcYATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpN-NeqggvacsgsdpSWKCI 229
           599*****************9876544349**********************************876652.1579999999999999** PP
   S: 88   htlkg.hedsvlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl 166
            tl+g h+++++++++++ +  l+++  d+ irv++ +  +  ++        + + h++ vncv+++p++  ll+s+s+D+ v +W+ 
   Q: 230  CTLSGfHSRTIYDVAWCQLTGALATACGDDAIRVFEEDPSSDPQQptfsltahLPQAHSQDVNCVAWNPKEqGLLASCSDDGEVAFWKY 318
           ***976****************************97766666666899999************************************86 PP

Organism

Felis catus

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLAR VPAHPDSRCW FLAWNPAGTL LASCGGDRRV RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGACT CGCTGGTGCT GCTGGCCCGC GTCCCGGCAC ACCCGGACTC CCGCTGCTGG 60
TTCTTGGCCT GGAACCCCGC GGGAACCTTG CTGGCGTCGT GCGGTGGTGA CCGTAGAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	38.72	1.00e-57	217.00
IUUC-Aml-001317	Ailuropoda melanoleuca	90.88	1.00e-175	608.00
IUUC-Atr-003029	Amborella trichopoda	48.26	4.00e-83	301.00
IUUC-Apl-004042	Anas platyrhynchos	76.69	3.00e-54	203.00
IUUC-Aly-006458	Arabidopsis lyrata	45.09	3.00e-75	275.00
IUUC-Ath-006671	Arabidopsis thaliana	44.93	2.00e-75	275.00
IUUC-Ago-007820	Ashbya gossypii	37.24	1.00e-50	193.00
IUUC-Acl-008042	Aspergillus clavatus	30.65	1.00e-44	174.00
IUUC-Afl-008639	Aspergillus flavus	32.14	1.00e-48	187.00
IUUC-Afu-008899	Aspergillus fumigatus	30.59	3.00e-43	169.00
IUUC-Ani-009453	Aspergillus nidulans	31.43	9.00e-45	174.00
IUUC-Ang-009758	Aspergillus niger	33.83	2.00e-47	182.00
IUUC-Aor-010212	Aspergillus oryzae	32.14	1.00e-48	187.00
IUUC-Ate-010314	Aspergillus terreus	31.89	1.00e-47	183.00
IUUC-Ame-010676	Astyanax mexicanus	72.84	6.00e-146	509.00
IUUC-Bgr-012095	Blumeria graminis	28.47	4.00e-32	132.00
IUUC-Bta-012884	Bos taurus	87.06	5.00e-168	583.00
IUUC-Bci-013622	Botrytis cinerea	30.36	9.00e-33	134.00
IUUC-Bdi-014614	Brachypodium distachyon	45.13	1.00e-74	273.00
IUUC-Bol-016439	Brassica oleracea	43.99	7.00e-73	267.00
IUUC-Bra-016830	Brassica rapa	42.94	2.00e-71	262.00
IUUC-Cel-018709	Caenorhabditis elegans	38.11	4.00e-55	208.00
IUUC-Cja-019822	Callithrix jacchus	88.82	4.00e-172	597.00
IUUC-Cfa-020823	Canis familiaris	91.47	1.00e-176	611.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	46.43	7.00e-71	260.00
IUUC-Csa-023754	Chlorocebus sabaeus	89.71	5.00e-174	603.00
IUUC-Cin-025395	Ciona intestinalis	53.57	2.00e-105	375.00
IUUC-Csv-025943	Ciona savignyi	51.80	2.00e-101	362.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	28.76	1.00e-30	127.00
IUUC-Cne-026939	Cryptococcus neoformans	30.13	5.00e-39	155.00
IUUC-Cme-027239	Cyanidioschyzon merolae	36.71	4.00e-35	142.00
IUUC-Dre-028172	Danio rerio	71.64	1.00e-143	502.00
IUUC-Dno-029472	Dasypus novemcinctus	87.33	1.00e-142	498.00
IUUC-Dor-031134	Dipodomys ordii	77.35	3.00e-142	497.00
IUUC-Dse-031535	Dothistroma septosporum	28.84	7.00e-39	154.00
IUUC-Dme-032020	Drosophila melanogaster	54.98	5.00e-105	374.00
IUUC-Eca-033700	Equus caballus	90.59	2.00e-174	604.00
IUUC-Eeu-035010	Erinaceus europaeus	88.79	6.00e-171	593.00
IUUC-Fal-037243	Ficedula albicollis	66.67	3.00e-77	280.00
IUUC-Fox-038058	Fusarium oxysporum	30.75	2.00e-37	150.00
IUUC-Fso-038459	Fusarium solani	31.19	8.00e-32	131.00
IUUC-Gmo-039375	Gadus morhua	68.96	7.00e-134	469.00
IUUC-Ggr-040002	Gaeumannomyces graminis	33.71	7.00e-34	138.00
IUUC-Gga-040294	Gallus gallus	71.84	4.00e-119	420.00
IUUC-Gac-042499	Gasterosteus aculeatus	68.34	7.00e-132	463.00
IUUC-Gma-043543	Glycine max	45.88	5.00e-77	280.00
IUUC-Ggo-045181	Gorilla gorilla	89.71	5.00e-174	603.00
IUUC-Hsa-046528	Homo sapiens	89.71	5.00e-174	603.00
IUUC-Hvu-047341	Hordeum vulgare	51.60	1.00e-45	175.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	90.29	7.00e-174	602.00
IUUC-Kpa-049353	Komagataella pastoris	33.90	4.00e-48	184.00
IUUC-Lch-049763	Latimeria chalumnae	72.54	2.00e-148	518.00
IUUC-Lpe-051500	Leersia perrieri	41.76	2.00e-70	259.00
IUUC-Loc-052021	Lepisosteus oculatus	73.43	1.00e-144	505.00
IUUC-Lma-053331	Leptosphaeria maculans	33.75	7.00e-49	189.00
IUUC-Laf-054558	Loxodonta africana	87.65	2.00e-170	590.00
IUUC-Mcc-055374	Macaca mulatta	89.71	4.00e-174	603.00
IUUC-Meu-056042	Macropus eugenii	69.07	1.00e-103	369.00
IUUC-Mor-057187	Magnaporthe oryzae	32.69	4.00e-32	132.00
IUUC-Mtr-058072	Medicago truncatula	44.84	2.00e-76	279.00
IUUC-Mla-059108	Melampsora laricipopulina	29.25	6.00e-44	171.00
IUUC-Mga-059370	Meleagris gallopavo	57.14	1.00e-90	325.00
IUUC-Mvi-060495	Microbotryum violaceum	35.75	6.00e-49	188.00
IUUC-Mmr-060902	Microcebus murinus	90.00	6.00e-174	602.00
IUUC-Mdo-062510	Monodelphis domestica	86.18	2.00e-162	564.00
IUUC-Mmu-063575	Mus musculus	87.06	3.00e-169	587.00
IUUC-Mac-065322	Musa acuminata	47.04	5.00e-80	290.00
IUUC-Mpu-065925	Mustela putorius furo	92.06	3.00e-178	617.00
IUUC-Mlu-067755	Myotis lucifugus	88.82	1.00e-172	598.00
IUUC-Nfi-068327	Neosartorya fischeri	30.77	4.00e-43	168.00
IUUC-Ncr-068845	Neurospora crassa	31.06	1.00e-27	117.00
IUUC-Nle-069406	Nomascus leucogenys	87.35	6.00e-168	582.00
IUUC-Opr-070416	Ochotona princeps	68.53	6.00e-124	436.00
IUUC-Ont-071936	Oreochromis niloticus	68.93	1.00e-135	475.00
IUUC-Oan-073452	Ornithorhynchus anatinus	77.11	3.00e-65	240.00
IUUC-Ocu-074791	Oryctolagus cuniculus	87.65	5.00e-171	593.00
IUUC-Oba-075636	Oryza barthii	45.86	8.00e-78	283.00
IUUC-Obr-076742	Oryza brachyantha	43.90	1.00e-65	242.00
IUUC-Ogl-077766	Oryza glaberrima	45.86	8.00e-78	283.00
IUUC-Ogu-079039	Oryza glumaepatula	45.86	4.00e-78	284.00
IUUC-Oin-079315	Oryza indica	44.71	6.00e-67	247.00
IUUC-Olo-080669	Oryza longistaminata	40.78	7.00e-70	257.00
IUUC-Ome-081490	Oryza meridionalis	45.86	6.00e-78	284.00
IUUC-Oni-082572	Oryza nivara	45.86	8.00e-78	283.00
IUUC-Opu-083732	Oryza punctata	45.99	6.00e-78	284.00
IUUC-Oru-084763	Oryza rufipogon	45.86	8.00e-78	283.00
IUUC-Osa-085372	Oryza sativa	45.86	8.00e-78	283.00
IUUC-Ola-087379	Oryzias latipes	66.18	2.00e-131	461.00
IUUC-Olu-087801	Ostreococcus lucimarinus	34.72	4.00e-36	145.00
IUUC-Oga-089076	Otolemur garnettii	89.41	2.00e-174	604.00
IUUC-Oar-090022	Ovis aries	87.35	6.00e-169	586.00
IUUC-Ptr-090809	Pan troglodytes	89.71	5.00e-174	603.00
IUUC-Pan-091685	Papio anubis	89.71	3.00e-175	608.00
IUUC-Psi-093046	Pelodiscus sinensis	81.36	4.00e-159	553.00
IUUC-Pma-094181	Petromyzon marinus	59.76	7.00e-119	419.00
IUUC-Pno-094882	Phaeosphaeria nodorum	33.01	6.00e-48	184.00
IUUC-Ppa-095172	Physcomitrella patens	43.77	2.00e-73	269.00
IUUC-Pfo-096396	Poecilia formosa	65.68	1.00e-131	462.00
IUUC-Pab-098427	Pongo abelii	89.12	3.00e-171	594.00
IUUC-Pop-100016	Populus trichocarpa	47.35	7.00e-80	290.00
IUUC-Pca-101048	Procavia capensis	88.53	7.00e-171	592.00
IUUC-Ppe-102050	Prunus persica	44.73	2.00e-76	279.00
IUUC-Pva-103117	Pteropus vampyrus	89.12	1.00e-172	598.00
IUUC-Pgr-103307	Puccinia graminis	32.73	2.00e-49	189.00
IUUC-Ptt-103938	Puccinia triticina	36.73	9.00e-42	163.00
IUUC-Pte-104315	Pyrenophora teres	31.89	5.00e-49	188.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	31.41	1.00e-48	187.00
IUUC-Rno-105523	Rattus norvegicus	86.47	1.00e-168	585.00
IUUC-Sce-106297	Saccharomyces cerevisiae	38.05	5.00e-54	204.00
IUUC-Sha-106981	Sarcophilus harrisii	84.93	4.00e-134	470.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	35.84	1.00e-46	181.00
IUUC-Spo-108214	Schizosaccharomyces pombe	37.50	7.00e-48	185.00
IUUC-Smo-109034	Selaginella moellendorffii	43.94	1.00e-73	269.00
IUUC-Sit-110663	Setaria italica	46.76	1.00e-78	286.00
IUUC-Sly-110898	Solanum lycopersicum	44.35	4.00e-73	268.00
IUUC-Stu-112647	Solanum tuberosum	46.82	3.00e-60	224.00
IUUC-Sbi-114288	Sorghum bicolor	44.74	6.00e-75	274.00
IUUC-Sre-115065	Sporisorium reilianum	41.77	7.00e-68	251.00
IUUC-Ssc-115960	Sus scrofa	89.05	1.00e-174	605.00
IUUC-Tru-118382	Takifugu rubripes	66.86	4.00e-134	470.00
IUUC-Tsy-119585	Tarsius syrichta	80.88	1.00e-151	529.00
IUUC-Tni-120133	Tetraodon nigroviridis	68.58	2.00e-131	461.00
IUUC-Tca-121167	Theobroma cacao	46.18	4.00e-72	264.00
IUUC-Tre-122119	Trichoderma reesei	27.63	2.00e-33	136.00
IUUC-Tvi-122407	Trichoderma virens	27.08	2.00e-33	136.00
IUUC-Tae-125748	Triticum aestivum	44.74	1.00e-71	263.00
IUUC-Tur-126682	Triticum urartu	44.28	7.00e-58	217.00
IUUC-Tme-127095	Tuber melanosporum	33.25	4.00e-52	198.00
IUUC-Tbe-128004	Tupaia belangeri	89.71	1.00e-173	602.00
IUUC-Ttr-129284	Tursiops truncatus	84.55	2.00e-162	565.00
IUUC-Uma-129527	Ustilago maydis	41.82	3.00e-67	248.00
IUUC-Vda-129854	Verticillium dahliae	29.31	1.00e-31	130.00
IUUC-Vpa-130681	Vicugna pacos	76.72	1.00e-41	163.00
IUUC-Vvi-131004	Vitis vinifera	49.70	4.00e-77	281.00
IUUC-Xtr-131928	Xenopus tropicalis	74.26	9.00e-147	512.00
IUUC-Xma-134290	Xiphophorus maculatus	65.38	1.00e-128	452.00
IUUC-Yli-134364	Yarrowia lipolytica	39.94	4.00e-56	211.00
IUUC-Zma-135658	Zea mays	45.88	4.00e-75	275.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence