iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.10e-51	174.6	8	155

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........eee 90
           Rl+ e+kel++ ppegi a p de++++ewe+li+Gpe+t++++gvF ++i+fp+dYP++PPk++f+  ifhPn+y++G+vC+sil+           ++e
   Q: 8    RLMTEYKELTTRPPEGIIAAPIDEDNFFEWECLITGPEETCFANGVFPARITFPQDYPLSPPKMRFTCGIFHPNIYADGRVCISILHapgddptgyelSNE 108
           99************************************************************************************99999999******* PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           +Wsp++s+e++lls++s+laepn esp+n++aa++++++r++++k++
   Q: 109  RWSPVQSIEKILLSVVSMLAEPNDESPANVSAAKMWREDRAQFEKIA 155
           ********************************************987 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MAGYALKRLM TEYKELTTRP PEGIIAAPID EDNFFEWECL ITGPEETCFA NGVFPARITF 60
PQDYPLSPPK MRFTCGIFHP NIYADGRVCI SILHAPGDDP TGYELSNERW SPVQSIEKIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCTCTCGA TAATGGCTGG TTACGCTTTG AAGCGGTTGA TGACAGAGTA TAAAGGTAAT 60
TATTGATGGT TGAGGCTCAG CGACTACAAA CTACACATTT CCTAGCCTCA CCCATTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_Y87G2A.9

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002172	Ailuropoda melanoleuca	71.34	4.00e-68	248.00
IUUC-Apl-003761	Anas platyrhynchos	74.53	2.00e-70	256.00
IUUC-Aca-005062	Anolis carolinensis	76.97	1.00e-73	266.00
IUUC-Ago-007853	Ashbya gossypii	58.18	3.00e-56	209.00
IUUC-Acl-008080	Aspergillus clavatus	62.65	1.00e-60	223.00
IUUC-Afl-008478	Aspergillus flavus	62.05	1.00e-59	220.00
IUUC-Afu-009051	Aspergillus fumigatus	62.65	9.00e-61	224.00
IUUC-Ani-009271	Aspergillus nidulans	63.45	6.00e-54	201.00
IUUC-Ang-009748	Aspergillus niger	63.25	7.00e-61	224.00
IUUC-Aor-010228	Aspergillus oryzae	62.65	7.00e-60	221.00
IUUC-Ate-010293	Aspergillus terreus	62.65	2.00e-60	223.00
IUUC-Ame-011698	Astyanax mexicanus	76.36	6.00e-76	275.00
IUUC-Bgr-012226	Blumeria graminis	59.01	4.00e-55	205.00
IUUC-Bta-013277	Bos taurus	78.05	2.00e-55	205.00
IUUC-Bci-013676	Botrytis cinerea	60.25	4.00e-56	209.00
IUUC-Cja-019767	Callithrix jacchus	76.97	1.00e-74	270.00
IUUC-Cfa-020047	Canis familiaris	75.76	1.00e-73	266.00
IUUC-Cpo-021507	Cavia porcellus	76.97	1.00e-74	270.00
IUUC-Csa-023745	Chlorocebus sabaeus	74.21	5.00e-69	251.00
IUUC-Cho-024667	Choloepus hoffmanni	46.50	6.00e-37	145.00
IUUC-Cin-025310	Ciona intestinalis	72.12	2.00e-69	253.00
IUUC-Csv-025961	Ciona savignyi	69.88	3.00e-68	249.00
IUUC-Cgl-026553	Colletotrichum gloeosporioides	62.11	6.00e-60	221.00
IUUC-Cne-026903	Cryptococcus neoformans	52.47	2.00e-42	163.00
IUUC-Dre-027900	Danio rerio	76.36	7.00e-76	274.00
IUUC-Dno-029688	Dasypus novemcinctus	72.73	1.00e-69	253.00
IUUC-Dse-031253	Dothistroma septosporum	61.82	5.00e-61	224.00
IUUC-Dme-031849	Drosophila melanogaster	79.04	6.00e-77	278.00
IUUC-Ete-033010	Echinops telfairi	76.97	3.00e-73	265.00
IUUC-Eca-033294	Equus caballus	74.52	7.00e-69	251.00
IUUC-Eeu-034947	Erinaceus europaeus	59.84	1.00e-36	143.00
IUUC-Fca-036442	Felis catus	75.91	2.00e-60	223.00
IUUC-Fal-037188	Ficedula albicollis	76.47	7.00e-69	251.00
IUUC-Fox-037762	Fusarium oxysporum	62.42	5.00e-61	225.00
IUUC-Fso-038181	Fusarium solani	61.82	2.00e-60	223.00
IUUC-Gmo-038663	Gadus morhua	75.76	7.00e-75	271.00
IUUC-Ggr-039808	Gaeumannomyces graminis	61.49	3.00e-59	219.00
IUUC-Gga-040355	Gallus gallus	77.58	1.00e-75	273.00
IUUC-Gac-041847	Gasterosteus aculeatus	76.36	3.00e-75	272.00
IUUC-Ggo-045202	Gorilla gorilla	76.97	8.00e-75	271.00
IUUC-Hsa-046369	Homo sapiens	76.97	8.00e-75	271.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	76.36	3.00e-74	269.00
IUUC-Kpa-049317	Komagataella pastoris	62.11	5.00e-58	215.00
IUUC-Lch-049596	Latimeria chalumnae	75.46	2.00e-71	259.00
IUUC-Loc-052346	Lepisosteus oculatus	79.67	4.00e-56	208.00
IUUC-Lma-053126	Leptosphaeria maculans	66.67	5.00e-52	194.00
IUUC-Laf-054560	Loxodonta africana	73.58	4.00e-68	248.00
IUUC-Mcc-055172	Macaca mulatta	76.97	8.00e-75	271.00
IUUC-Meu-056891	Macropus eugenii	73.89	2.00e-68	249.00
IUUC-Mor-057260	Magnaporthe oryzae	61.49	2.00e-59	219.00
IUUC-Mpo-057468	Magnaporthe poae	61.49	2.00e-59	219.00
IUUC-Mla-059084	Melampsora laricipopulina	55.88	1.00e-53	200.00
IUUC-Mga-059939	Meleagris gallopavo	74.05	3.00e-69	252.00
IUUC-Mvi-060514	Microbotryum violaceum	62.58	3.00e-56	209.00
IUUC-Mmr-061029	Microcebus murinus	73.21	2.00e-68	249.00
IUUC-Mdo-061820	Monodelphis domestica	76.36	4.00e-74	268.00
IUUC-Mmu-063123	Mus musculus	76.97	8.00e-75	271.00
IUUC-Mpu-065866	Mustela putorius furo	70.30	1.00e-67	246.00
IUUC-Mlu-067220	Myotis lucifugus	74.52	2.00e-68	249.00
IUUC-Nfi-068395	Neosartorya fischeri	62.65	9.00e-61	224.00
IUUC-Ncr-068623	Neurospora crassa	63.98	2.00e-60	223.00
IUUC-Nle-070007	Nomascus leucogenys	76.97	8.00e-75	271.00
IUUC-Opr-071095	Ochotona princeps	79.65	5.00e-52	194.00
IUUC-Ont-071736	Oreochromis niloticus	76.97	2.00e-76	276.00
IUUC-Oan-073475	Ornithorhynchus anatinus	73.89	9.00e-68	247.00
IUUC-Ocu-074820	Oryctolagus cuniculus	76.97	2.00e-68	249.00
IUUC-Ola-087571	Oryzias latipes	76.97	7.00e-76	274.00
IUUC-Oar-089706	Ovis aries	76.36	1.00e-74	270.00
IUUC-Ptr-090798	Pan troglodytes	76.97	8.00e-75	271.00
IUUC-Pan-091967	Papio anubis	76.97	8.00e-75	271.00
IUUC-Psi-093524	Pelodiscus sinensis	77.48	1.00e-68	250.00
IUUC-Pma-094602	Petromyzon marinus	79.14	1.00e-63	233.00
IUUC-Pno-094979	Phaeosphaeria nodorum	65.45	3.00e-64	236.00
IUUC-Pfo-097330	Poecilia formosa	77.58	5.00e-76	275.00
IUUC-Pab-098225	Pongo abelii	76.36	3.00e-74	269.00
IUUC-Pca-101040	Procavia capensis	75.82	5.00e-68	248.00
IUUC-Pva-102507	Pteropus vampyrus	64.33	7.00e-56	207.00
IUUC-Pgr-103674	Puccinia graminis	54.97	3.00e-52	196.00
IUUC-Ptt-103840	Puccinia triticina	54.39	7.00e-52	194.00
IUUC-Pte-104389	Pyrenophora teres	63.03	2.00e-62	229.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	63.03	3.00e-62	229.00
IUUC-Rno-105228	Rattus norvegicus	76.97	8.00e-75	271.00
IUUC-Sce-106233	Saccharomyces cerevisiae	57.67	3.00e-54	202.00
IUUC-Sha-107274	Sarcophilus harrisii	71.69	1.00e-68	250.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	65.84	3.00e-63	232.00
IUUC-Spo-108269	Schizosaccharomyces pombe	65.22	3.00e-62	229.00
IUUC-Ssl-108636	Sclerotinia sclerotiorum	60.25	4.00e-57	212.00
IUUC-Sre-114952	Sporisorium reilianum	63.58	2.00e-55	206.00
IUUC-Ssc-115365	Sus scrofa	75.82	4.00e-68	248.00
IUUC-Tgu-116816	Taeniopygia guttata	77.58	1.00e-75	273.00
IUUC-Tni-120278	Tetraodon nigroviridis	75.90	2.00e-73	266.00
IUUC-Tre-122131	Trichoderma reesei	62.73	2.00e-60	223.00
IUUC-Tvi-122669	Trichoderma virens	62.73	2.00e-60	223.00
IUUC-Tme-127052	Tuber melanosporum	65.84	5.00e-64	234.00
IUUC-Tbe-127792	Tupaia belangeri	76.97	8.00e-75	271.00
IUUC-Ttr-128619	Tursiops truncatus	76.67	6.00e-53	197.00
IUUC-Uma-129587	Ustilago maydis	62.96	5.00e-55	205.00
IUUC-Vda-129914	Verticillium dahliae	61.49	2.00e-59	219.00
IUUC-Xtr-132450	Xenopus tropicalis	78.18	4.00e-75	271.00
IUUC-Xma-133016	Xiphophorus maculatus	77.58	8.00e-76	274.00
IUUC-Yli-134379	Yarrowia lipolytica	66.46	2.00e-64	236.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence