iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117784

Ensembl Protein ID

ENSTRUP00000024646.1

UniProt Accession

H2TIZ2; H2TIZ2_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

LOC101069639

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000009803.1	ENSTRUT00000024746.1	ENSTRUP00000024646.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.10e-15	55.8	100	155

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea + d+L++kkGd  ++i  ++++++W+++ +  +g++G +P+n+v+ ++
   Q: 100  FVALYDYEARTADDLSFKKGDRFQII--NNTEGDWWEARSINTGQKGYIPSNYVAPAD 155
           679***********************..8999**********************9875 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCVRSKEDK GPAPKHQSDN PNATTVNAHL GHYGPDPTLM VHSPAMKTHN NSYNSHSAAL 60
APFGGVSSVM TPFGGASTSY TSVAVSSPFP SVITGGVTFF VALYDYEART ADDLSFKKGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCGTGAGG ACAAAAGATC ACAAGACGCA TGTAGTCGAG AACAACGCCT CTAAGGTCAC 60
TATTAAGGTA ATTATCCTGA GAAAAAGTCC CAAATTGTCT TGGAAGTGAG CGGGAAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034334--P:adherens junction maintenance
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0060027--P:convergent extension involved in gastrulation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

tru:101069639

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004032	Anas platyrhynchos	86.11	0.00e+00	962.00
IUUC-Ame-010954	Astyanax mexicanus	90.13	0.00e+00	1041.00
IUUC-Cin-025390	Ciona intestinalis	72.45	0.00e+00	666.00
IUUC-Csv-026029	Ciona savignyi	63.81	0.00e+00	643.00
IUUC-Dre-027978	Danio rerio	89.40	0.00e+00	994.00
IUUC-Dor-030202	Dipodomys ordii	92.48	0.00e+00	886.00
IUUC-Eeu-034950	Erinaceus europaeus	70.34	2.00e-153	535.00
IUUC-Gmo-038929	Gadus morhua	89.25	0.00e+00	967.00
IUUC-Gga-041107	Gallus gallus	85.74	0.00e+00	961.00
IUUC-Gac-042321	Gasterosteus aculeatus	92.34	0.00e+00	1027.00
IUUC-Lpe-051166	Leersia perrieri	35.47	1.00e-22	102.00
IUUC-Loc-052314	Lepisosteus oculatus	88.52	0.00e+00	956.00
IUUC-Mga-059310	Meleagris gallopavo	85.74	0.00e+00	961.00
IUUC-Ont-072337	Oreochromis niloticus	93.60	0.00e+00	1053.00
IUUC-Psi-093310	Pelodiscus sinensis	86.11	0.00e+00	986.00
IUUC-Pma-094232	Petromyzon marinus	85.84	0.00e+00	867.00
IUUC-Pfo-097076	Poecilia formosa	89.23	0.00e+00	1028.00
IUUC-Ppe-102072	Prunus persica	34.17	2.00e-26	114.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence