iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000009989.1	ENSONIT00000012573.1	ENSONIP00000012563.1
ENSONIG00000009989.1	ENSONIT00000012574.1	ENSONIP00000012564.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-78	263.3	445	938

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl NlgNtCYmNS++Q+L++ +++r+ +l+    +ln +      ++l+k+lq lf+ l ++++ a++pr++l+a +   + f+  +q
   Q: 445  TGLVNLGNTCYMNSIIQTLFMATDFRRHVLS---LHLNGS------NTLMKKLQLLFAFLAHTQRAAYAPRNFLEASR--PPWFNMGSQ 522
           7******************************...666665......59***************************998..777****** PP
   S: 90   qDaqEflaflldqleeelkk..................eknkpkeeeeeedkselsde...............aeekkkkknkslisdl 145
           qD++E+l+flld+l+ee k                   +k++                               ae k+   +++li+++
   Q: 523  QDCSEYLRFLLDRLHEEEKTlqaldsakpkavspadtsSKDS---------------AttsaqedneqtilplAEAKPGDDTRTLIEKM 596
           ******************778887777666544433222222...............1233333456667777999************* PP
   S: 146  Fqgqlksqikclecdnvssreepfldlslpvpgkeetkke................................................s 186
           F+g+l ++i c  c+ +s++eepf+dlsl++   ++ +                                                  s
   Q: 597  FGGKLITSICCTLCNCISEKEEPFTDLSLAFCPGTTLQDGpqtqrqseepkalcqgsvnggseapepgsakapasnahfvpvtnepplS 685
           ******************************996664433367788888999************************************** PP
   S: 187  lqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls......pfcts.. 267
           + d+ + f ++e l+g+n+y+cekc ++q+aek++k+ + Pe+Lil L Rfs++ + ++r+ki ++v++p  + l       p   +  
   Q: 686  VPDLVNYFLAPEILDGDNAYFCEKCSSLQRAEKTIKVVSAPEYLILTLLRFSYDAKCHVRRKILDNVTIPPLIRLPvhdpsiP---Tqc 771
           **********************************************************************7766663354332...133 PP
   S: 268  .......peekqke.......................................kkkYeLiavvvHsG.slssGHYvayvkn........ 301
                        +                                       ++ Y L++vv+HsG s++sGHY++y +n        
   Q: 772  ssstsspL-----QvdspessenlakklkssqhdeeeekaridgaeemsraiqSVPYVLSSVVIHSGiSSESGHYYSYGRNingtdgaq 855
           34555550.....1555555555556666666666777788888888889998************************************ PP
   S: 302  ..........................................ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                                                     e ++Wllf+Ds+Vt ++ ++v++ t+    +taYvl+Y+++
   Q: 856  hpdnqygikedlgnaqaesslytcsapslpreqsetlpnssqEAKDWLLFNDSRVTFTSFQSVQNITNrfpkDTAYVLMYRKQ 938
           ******************************9999999988755666*******************999************986 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MDKILEGLVS SNHSVPVKKA IVKKVVEAAE RAVTEDQCQA LFTLTTRLIL LGEDAFQKQI 60
GSQVLDAYAR YHRPEFERFF SKDFVLSLLQ QGYGQLDRKD PAIVEYIHCC LRLLISCPSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAACGCAAC ACACGAAGTT TGCAATAAAA GGATAAAGGT TCTCGAAAAT GCTCGTGAAA 60
ACGCAGCTTC GTTTAATTGG AAGCGTGTCA AACGCCCAGC AGCGCCATCC GTGGAAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002174	Ailuropoda melanoleuca	62.38	0.00e+00	1173.00
IUUC-Apl-003435	Anas platyrhynchos	61.55	0.00e+00	1004.00
IUUC-Aca-004556	Anolis carolinensis	58.76	0.00e+00	1061.00
IUUC-Ame-010616	Astyanax mexicanus	69.03	0.00e+00	1369.00
IUUC-Bta-013544	Bos taurus	62.30	0.00e+00	1181.00
IUUC-Cja-018745	Callithrix jacchus	61.80	0.00e+00	1207.00
IUUC-Cfa-020434	Canis familiaris	61.60	0.00e+00	1159.00
IUUC-Cpo-021666	Cavia porcellus	61.81	0.00e+00	1142.00
IUUC-Csa-023965	Chlorocebus sabaeus	63.56	0.00e+00	1257.00
IUUC-Cho-024809	Choloepus hoffmanni	54.89	0.00e+00	771.00
IUUC-Cin-025604	Ciona intestinalis	31.40	7.00e-41	161.00
IUUC-Csv-026333	Ciona savignyi	43.09	1.00e-31	129.00
IUUC-Dre-028338	Danio rerio	69.66	0.00e+00	1392.00
IUUC-Dno-029372	Dasypus novemcinctus	63.93	0.00e+00	1224.00
IUUC-Dor-030752	Dipodomys ordii	59.12	0.00e+00	759.00
IUUC-Dme-031871	Drosophila melanogaster	26.94	3.00e-64	240.00
IUUC-Ete-032588	Echinops telfairi	53.68	0.00e+00	721.00
IUUC-Eca-034416	Equus caballus	62.90	0.00e+00	1233.00
IUUC-Eeu-035132	Erinaceus europaeus	50.43	0.00e+00	881.00
IUUC-Fca-036137	Felis catus	63.53	0.00e+00	1243.00
IUUC-Fal-037297	Ficedula albicollis	60.82	0.00e+00	1145.00
IUUC-Gmo-038727	Gadus morhua	79.48	0.00e+00	1224.00
IUUC-Gga-041091	Gallus gallus	60.52	0.00e+00	1105.00
IUUC-Gac-042082	Gasterosteus aculeatus	84.33	0.00e+00	1593.00
IUUC-Ggo-045376	Gorilla gorilla	59.28	0.00e+00	1124.00
IUUC-Hsa-046444	Homo sapiens	63.41	0.00e+00	1242.00
IUUC-Itr-047976	Ictidomys tridecemlineatus	62.85	0.00e+00	1233.00
IUUC-Lch-050500	Latimeria chalumnae	61.67	0.00e+00	1244.00
IUUC-Loc-052625	Lepisosteus oculatus	69.13	0.00e+00	1393.00
IUUC-Laf-053689	Loxodonta africana	62.80	0.00e+00	1217.00
IUUC-Mcc-055286	Macaca mulatta	63.06	0.00e+00	1238.00
IUUC-Meu-056906	Macropus eugenii	48.97	1.00e-175	610.00
IUUC-Mga-059905	Meleagris gallopavo	60.40	0.00e+00	974.00
IUUC-Mmr-061397	Microcebus murinus	63.37	0.00e+00	1187.00
IUUC-Mdo-062833	Monodelphis domestica	63.57	0.00e+00	1275.00
IUUC-Mmu-063157	Mus musculus	62.35	0.00e+00	1188.00
IUUC-Mpu-066434	Mustela putorius furo	63.29	0.00e+00	1238.00
IUUC-Mlu-068178	Myotis lucifugus	63.15	0.00e+00	1167.00
IUUC-Nle-070153	Nomascus leucogenys	62.72	0.00e+00	1168.00
IUUC-Opr-070454	Ochotona princeps	44.29	2.00e-65	244.00
IUUC-Oan-072709	Ornithorhynchus anatinus	61.79	0.00e+00	952.00
IUUC-Ocu-074832	Oryctolagus cuniculus	63.09	0.00e+00	1181.00
IUUC-Ola-087003	Oryzias latipes	70.73	4.00e-69	253.00
IUUC-Oga-088517	Otolemur garnettii	60.61	0.00e+00	1155.00
IUUC-Oar-089472	Ovis aries	60.17	0.00e+00	1102.00
IUUC-Ptr-090996	Pan troglodytes	63.59	0.00e+00	1242.00
IUUC-Pan-091837	Papio anubis	62.04	0.00e+00	1209.00
IUUC-Psi-093236	Pelodiscus sinensis	61.35	0.00e+00	886.00
IUUC-Pma-094349	Petromyzon marinus	52.45	0.00e+00	944.00
IUUC-Pfo-097193	Poecilia formosa	80.02	0.00e+00	1518.00
IUUC-Pab-098710	Pongo abelii	63.90	0.00e+00	1262.00
IUUC-Pca-100794	Procavia capensis	55.63	0.00e+00	1030.00
IUUC-Pva-102722	Pteropus vampyrus	62.70	0.00e+00	1222.00
IUUC-Rno-105743	Rattus norvegicus	61.56	0.00e+00	1174.00
IUUC-Sha-106563	Sarcophilus harrisii	62.93	0.00e+00	1034.00
IUUC-Sar-113533	Sorex araneus	57.05	0.00e+00	1048.00
IUUC-Ssc-116259	Sus scrofa	77.84	0.00e+00	793.00
IUUC-Tgu-117475	Taeniopygia guttata	60.78	0.00e+00	1039.00
IUUC-Tru-118623	Takifugu rubripes	78.05	0.00e+00	1486.00
IUUC-Tsy-119250	Tarsius syrichta	60.95	0.00e+00	929.00
IUUC-Tni-120441	Tetraodon nigroviridis	74.95	0.00e+00	1418.00
IUUC-Tbe-127936	Tupaia belangeri	52.98	0.00e+00	900.00
IUUC-Ttr-128483	Tursiops truncatus	53.41	0.00e+00	842.00
IUUC-Vpa-130303	Vicugna pacos	76.97	0.00e+00	852.00
IUUC-Xtr-132773	Xenopus tropicalis	61.58	0.00e+00	1184.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence