iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007876

Ensembl Protein ID

AAS50414

UniProt Accession

Q75EN0; RAD18_ASHGO

Genbank Protein ID

AAS50414.1

Protein Name

Postreplication repair E3 ubiquitin-protein ligase RAD18; RING-type E3 ubiquitin transferase RAD18

Genbank Nucleotide ID

AE016814

Gene Name

RAD18; AAR049C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AAR049C	AAS50414	AAS50414

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.70e-09	34.4	32	69
E3 activity/RING/U-box	3.90e-07	28.1	30	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC++++++ p++++CgH+f+  C+  +       +ke rCPlC
   Q: 32   CHICKDMLQT-PVLTQCGHTFCSLCIREY------LNKESRCPLC 69
           99********.999***************......********** PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlv 56
           ++C I +++ + Pv +++G+t+   +I+++l++  + cP++ ++l++++l 
   Q: 30   LRCHICKDMLQTPVLTQCGHTFCSLCIREYLNKESR-CPLCLAELRQNMLQ 79
           79*********************************9.********998875 PP

Organism

Ashbya gossypii

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.

Protein Sequence
(Fasta)

MSIQPGQVVT DPSDFAGTTI PELADLDSLL RCHICKDMLQ TPVLTQCGHT FCSLCIREYL 60
NKESRCPLCL AELRQNMLQK EFLVGELAAC YMELRARLLE TVRIPPKKVA EVVQNNSPIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCATAC AGCCGGGACA AGTGGTCACC GATCCAAGTG ACTTTGCAGG AACAACTATC 60
CCGGAGTTGG CAGACCTTGA CAGCCTGCTG CGATGCCATA TTTGTAAAGA CATGTTACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02037--SAP

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0006301--P:postreplication repair
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

ago:AGOS_AAR049C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	22.67	2.00e-12	65.10
IUUC-Apl-004178	Anas platyrhynchos	33.33	5.00e-09	53.90
IUUC-Aca-004288	Anolis carolinensis	33.93	2.00e-09	55.50
IUUC-Acl-008246	Aspergillus clavatus	27.32	6.00e-29	119.00
IUUC-Afl-008666	Aspergillus flavus	26.75	9.00e-31	125.00
IUUC-Afu-009052	Aspergillus fumigatus	28.04	1.00e-33	135.00
IUUC-Ani-009488	Aspergillus nidulans	27.48	1.00e-32	132.00
IUUC-Ang-009681	Aspergillus niger	29.58	1.00e-36	145.00
IUUC-Aor-010037	Aspergillus oryzae	27.96	4.00e-33	133.00
IUUC-Ate-010516	Aspergillus terreus	36.63	4.00e-18	82.40
IUUC-Ame-010630	Astyanax mexicanus	24.94	3.00e-22	97.40
IUUC-Bgr-012178	Blumeria graminis	29.79	2.00e-35	140.00
IUUC-Bta-012872	Bos taurus	37.84	1.00e-09	56.20
IUUC-Bci-013680	Botrytis cinerea	28.46	8.00e-39	152.00
IUUC-Cel-018356	Caenorhabditis elegans	42.50	1.00e-08	50.10
IUUC-Cja-019453	Callithrix jacchus	31.11	3.00e-10	57.40
IUUC-Cfa-020856	Canis familiaris	22.77	3.00e-13	67.80
IUUC-Cpo-021950	Cavia porcellus	24.88	5.00e-14	70.10
IUUC-Cre-022592	Chlamydomonas reinhardtii	41.86	2.00e-08	51.20
IUUC-Csa-023997	Chlorocebus sabaeus	32.91	3.00e-10	57.80
IUUC-Cho-024771	Choloepus hoffmanni	34.21	5.00e-10	56.60
IUUC-Cgl-026668	Colletotrichum gloeosporioides	27.95	4.00e-33	133.00
IUUC-Cme-027202	Cyanidioschyzon merolae	33.33	5.00e-13	66.60
IUUC-Dre-028479	Danio rerio	22.99	4.00e-13	67.00
IUUC-Dno-028943	Dasypus novemcinctus	32.91	4.00e-10	57.40
IUUC-Dor-030305	Dipodomys ordii	35.29	1.00e-08	52.40
IUUC-Dse-031235	Dothistroma septosporum	34.11	2.00e-13	67.80
IUUC-Dme-031681	Drosophila melanogaster	40.48	4.00e-09	54.70
IUUC-Eca-033725	Equus caballus	32.91	4.00e-10	57.40
IUUC-Eeu-034573	Erinaceus europaeus	36.36	5.00e-10	56.60
IUUC-Fca-036495	Felis catus	34.18	5.00e-10	57.00
IUUC-Fal-036791	Ficedula albicollis	24.08	2.00e-13	68.20
IUUC-Fox-037868	Fusarium oxysporum	42.11	1.00e-19	88.60
IUUC-Fso-038144	Fusarium solani	37.61	2.00e-18	84.70
IUUC-Gmo-039152	Gadus morhua	21.19	3.00e-13	67.00
IUUC-Ggr-039737	Gaeumannomyces graminis	40.22	6.00e-20	89.70
IUUC-Gga-040788	Gallus gallus	35.80	5.00e-12	63.50
IUUC-Gac-041993	Gasterosteus aculeatus	23.60	2.00e-20	90.90
IUUC-Ggo-044889	Gorilla gorilla	32.91	2.00e-10	57.80
IUUC-Hsa-045957	Homo sapiens	32.91	3.00e-10	57.80
IUUC-Hvu-047067	Hordeum vulgare	31.58	1.00e-09	54.70
IUUC-Itr-048998	Ictidomys tridecemlineatus	34.21	4.00e-10	57.40
IUUC-Kpa-049300	Komagataella pastoris	33.01	2.00e-48	184.00
IUUC-Lch-050224	Latimeria chalumnae	39.06	6.00e-10	57.00
IUUC-Loc-052609	Lepisosteus oculatus	26.26	3.00e-15	73.90
IUUC-Lma-053037	Leptosphaeria maculans	23.85	1.00e-22	99.00
IUUC-Laf-053889	Loxodonta africana	34.52	3.00e-11	60.80
IUUC-Mcc-055853	Macaca mulatta	32.91	4.00e-10	57.40
IUUC-Mor-057071	Magnaporthe oryzae	26.29	1.00e-32	131.00
IUUC-Mpo-057628	Magnaporthe poae	39.08	4.00e-18	83.60
IUUC-Mla-058953	Melampsora laricipopulina	31.90	3.00e-11	61.20
IUUC-Mga-059687	Meleagris gallopavo	24.41	2.00e-12	64.70
IUUC-Mvi-060412	Microbotryum violaceum	40.86	4.00e-16	77.40
IUUC-Mmr-061563	Microcebus murinus	34.33	7.00e-10	56.60
IUUC-Mdo-062655	Monodelphis domestica	23.54	8.00e-17	79.70
IUUC-Mmu-063647	Mus musculus	32.63	7.00e-11	59.70
IUUC-Mpu-065778	Mustela putorius furo	32.91	4.00e-10	57.00
IUUC-Mlu-067864	Myotis lucifugus	31.91	4.00e-10	57.40
IUUC-Nfi-068501	Neosartorya fischeri	28.31	3.00e-33	133.00
IUUC-Ncr-068917	Neurospora crassa	28.29	3.00e-34	137.00
IUUC-Nle-068990	Nomascus leucogenys	32.91	3.00e-10	57.80
IUUC-Opr-071146	Ochotona princeps	35.44	1.00e-10	59.30
IUUC-Ont-071835	Oreochromis niloticus	24.31	1.00e-21	95.10
IUUC-Oan-072827	Ornithorhynchus anatinus	30.70	4.00e-14	69.30
IUUC-Ocu-073986	Oryctolagus cuniculus	32.56	1.00e-10	58.50
IUUC-Obr-076675	Oryza brachyantha	35.09	8.00e-10	54.70
IUUC-Ogl-077553	Oryza glaberrima	31.76	8.00e-10	55.10
IUUC-Ogu-078936	Oryza glumaepatula	34.55	9.00e-10	55.10
IUUC-Oin-080177	Oryza indica	31.76	1.00e-09	54.30
IUUC-Ome-081605	Oryza meridionalis	31.76	2.00e-09	53.50
IUUC-Oru-084757	Oryza rufipogon	31.76	1.00e-09	54.70
IUUC-Osa-086198	Oryza sativa	31.76	1.00e-09	54.70
IUUC-Ola-086997	Oryzias latipes	38.16	1.00e-12	65.10
IUUC-Olu-087771	Ostreococcus lucimarinus	32.56	3.00e-08	50.80
IUUC-Oga-088092	Otolemur garnettii	23.32	3.00e-14	70.90
IUUC-Oar-089651	Ovis aries	34.18	1.00e-10	58.90
IUUC-Ptr-091103	Pan troglodytes	32.91	2.00e-10	57.80
IUUC-Pan-092478	Papio anubis	32.91	3.00e-10	57.40
IUUC-Psi-093356	Pelodiscus sinensis	25.57	2.00e-15	75.10
IUUC-Pfo-096663	Poecilia formosa	47.06	2.00e-11	62.00
IUUC-Pab-098034	Pongo abelii	27.75	3.00e-10	57.40
IUUC-Ppe-101428	Prunus persica	40.00	2.00e-10	57.80
IUUC-Pva-102377	Pteropus vampyrus	32.84	4.00e-09	53.90
IUUC-Pgr-103556	Puccinia graminis	24.87	8.00e-14	69.70
IUUC-Pte-104362	Pyrenophora teres	34.74	3.00e-17	80.90
IUUC-Pyt-104823	Pyrenophora triticirepentis	34.07	3.00e-16	77.40
IUUC-Rno-105866	Rattus norvegicus	36.71	1.00e-11	62.00
IUUC-Sce-106454	Saccharomyces cerevisiae	39.81	3.00e-79	286.00
IUUC-Sha-107515	Sarcophilus harrisii	23.58	2.00e-16	78.20
IUUC-Sja-107689	Schizosaccharomyces japonicus	30.81	2.00e-22	97.80
IUUC-Spo-108248	Schizosaccharomyces pombe	40.57	4.00e-21	93.20
IUUC-Ssl-108430	Sclerotinia sclerotiorum	28.00	2.00e-36	144.00
IUUC-Sit-110376	Setaria italica	34.12	1.00e-10	57.40
IUUC-Sar-113333	Sorex araneus	45.45	2.00e-08	52.00
IUUC-Sre-115123	Sporisorium reilianum	45.45	6.00e-11	59.70
IUUC-Ssc-115705	Sus scrofa	39.34	3.00e-08	52.00
IUUC-Tgu-117286	Taeniopygia guttata	26.79	9.00e-16	75.90
IUUC-Tru-117959	Takifugu rubripes	44.00	4.00e-11	60.10
IUUC-Tsy-119286	Tarsius syrichta	38.71	3.00e-09	54.30
IUUC-Tni-120570	Tetraodon nigroviridis	25.26	8.00e-22	95.50
IUUC-Tre-121893	Trichoderma reesei	26.59	2.00e-30	124.00
IUUC-Tvi-122405	Trichoderma virens	26.85	2.00e-30	124.00
IUUC-Tur-126400	Triticum urartu	43.48	4.00e-09	53.90
IUUC-Tbe-127758	Tupaia belangeri	35.94	1.00e-09	55.50
IUUC-Ttr-128841	Tursiops truncatus	32.91	6.00e-10	56.60
IUUC-Uma-129563	Ustilago maydis	46.97	1.00e-10	58.90
IUUC-Vda-130021	Verticillium dahliae	34.62	1.00e-15	74.70
IUUC-Vpa-130169	Vicugna pacos	34.21	1.00e-09	55.80
IUUC-Xtr-132308	Xenopus tropicalis	31.36	3.00e-13	67.00
IUUC-Xma-133868	Xiphophorus maculatus	25.06	1.00e-19	89.00
IUUC-Yli-134474	Yarrowia lipolytica	44.83	2.00e-18	84.30
IUUC-Zma-135032	Zea mays	34.12	4.00e-10	56.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence