iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037465

Ensembl Protein ID

ENSFALP00000002760.1

UniProt Accession

U3JJ06; U3JJ06_FICAL

Genbank Protein ID

ENSFALP00000002760

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000663

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002652.1	ENSFALT00000002772.1	ENSFALP00000002760.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-33	113.4	238	275
UBD/Beta-Prp	6.10e-52	176.3	337	598

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 238  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 275
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l       +  +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 337  SGSKRYLSSTGADGTICFWLWDAGTLkinprpTKFTERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 425
           67899***********999999999988888544447777777755522778888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs s++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 426  DSIQFSNSSSRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqsfqgvEDKITKLKVTMVAWDRHDNSVITAVNNMTLKVWNSFTGQ 514
           ********************************99***************888888889******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 515  LIHILMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 598
           ******9.*********999999..89******************999998875544444566667777999999999988888886 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MDGWRDGGMD GWRRRAWRGG GGRAGPPPPP PPPPPPPPPP PPPPPPPPPA GRGRPGRAAD 60
RAARWPLRPP SPIFSLFETF SHAPLLLLLQ VLIREVAEKE LLPKRTDWTG KEHPRSYENL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGGAAG AAAGGGAAGC CCGCGGGAAA GGGGCGAGCT CCAGCCCTGA CGGCCTCTCC 60
TCTCCCCGCA GAGCTCTACT TCCTCATCGC TCGCTTTTTG GAGGACGGAC CATGCCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	85.78	0.00e+00	2882.00
IUUC-Atr-002600	Amborella trichopoda	30.67	2.00e-64	241.00
IUUC-Apl-003700	Anas platyrhynchos	96.22	0.00e+00	3182.00
IUUC-Aca-004474	Anolis carolinensis	84.81	0.00e+00	2934.00
IUUC-Bta-013125	Bos taurus	85.96	0.00e+00	2825.00
IUUC-Cja-018868	Callithrix jacchus	83.64	0.00e+00	2919.00
IUUC-Cfa-021179	Canis familiaris	84.03	0.00e+00	2802.00
IUUC-Cpo-022077	Cavia porcellus	81.25	0.00e+00	2768.00
IUUC-Csa-023618	Chlorocebus sabaeus	85.23	0.00e+00	2942.00
IUUC-Cho-024794	Choloepus hoffmanni	86.30	0.00e+00	842.00
IUUC-Dno-030048	Dasypus novemcinctus	85.84	0.00e+00	2876.00
IUUC-Dor-030195	Dipodomys ordii	85.24	0.00e+00	1394.00
IUUC-Eca-034274	Equus caballus	86.08	0.00e+00	2845.00
IUUC-Eeu-034688	Erinaceus europaeus	91.48	0.00e+00	1273.00
IUUC-Fca-035451	Felis catus	85.20	0.00e+00	2746.00
IUUC-Gmo-039451	Gadus morhua	67.86	0.00e+00	715.00
IUUC-Gga-040798	Gallus gallus	95.29	0.00e+00	3236.00
IUUC-Ggo-045347	Gorilla gorilla	84.97	0.00e+00	2910.00
IUUC-Hsa-046757	Homo sapiens	85.39	0.00e+00	2918.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	6.00e-37	147.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	75.59	0.00e+00	943.00
IUUC-Loc-052672	Lepisosteus oculatus	70.72	0.00e+00	2412.00
IUUC-Laf-054140	Loxodonta africana	85.58	0.00e+00	2908.00
IUUC-Mcc-055061	Macaca mulatta	84.95	0.00e+00	2928.00
IUUC-Mmr-060837	Microcebus murinus	85.87	0.00e+00	2884.00
IUUC-Mdo-061903	Monodelphis domestica	86.60	0.00e+00	2994.00
IUUC-Mmu-063772	Mus musculus	84.95	0.00e+00	2918.00
IUUC-Mpu-066359	Mustela putorius furo	85.47	0.00e+00	2630.00
IUUC-Mlu-067928	Myotis lucifugus	85.85	0.00e+00	2888.00
IUUC-Nle-070094	Nomascus leucogenys	86.15	0.00e+00	2923.00
IUUC-Opr-070971	Ochotona princeps	69.63	0.00e+00	896.00
IUUC-Ont-072221	Oreochromis niloticus	73.99	0.00e+00	1281.00
IUUC-Oan-073185	Ornithorhynchus anatinus	84.41	0.00e+00	2833.00
IUUC-Ocu-074033	Oryctolagus cuniculus	85.66	0.00e+00	2626.00
IUUC-Ogl-077493	Oryza glaberrima	24.45	1.00e-30	129.00
IUUC-Oin-079669	Oryza indica	31.22	4.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.86	2.00e-54	208.00
IUUC-Oni-082991	Oryza nivara	27.78	3.00e-39	157.00
IUUC-Oga-088578	Otolemur garnettii	85.69	0.00e+00	2841.00
IUUC-Oar-090247	Ovis aries	86.18	0.00e+00	2823.00
IUUC-Ptr-091266	Pan troglodytes	85.79	0.00e+00	2877.00
IUUC-Pan-092734	Papio anubis	85.34	0.00e+00	2946.00
IUUC-Pfo-096191	Poecilia formosa	72.13	0.00e+00	2050.00
IUUC-Pab-098402	Pongo abelii	85.50	0.00e+00	2926.00
IUUC-Pca-101128	Procavia capensis	78.15	0.00e+00	2583.00
IUUC-Rno-106013	Rattus norvegicus	84.10	0.00e+00	2833.00
IUUC-Sha-107496	Sarcophilus harrisii	87.56	0.00e+00	2987.00
IUUC-Sit-110017	Setaria italica	31.50	9.00e-55	209.00
IUUC-Sar-113520	Sorex araneus	77.63	0.00e+00	1265.00
IUUC-Ssc-115461	Sus scrofa	81.88	0.00e+00	2756.00
IUUC-Tgu-116821	Taeniopygia guttata	96.77	0.00e+00	3281.00
IUUC-Tsy-119132	Tarsius syrichta	74.50	0.00e+00	2292.00
IUUC-Tbe-127479	Tupaia belangeri	80.70	0.00e+00	1261.00
IUUC-Vpa-130160	Vicugna pacos	82.86	0.00e+00	2730.00
IUUC-Xtr-132717	Xenopus tropicalis	74.69	0.00e+00	2551.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence