iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-070094

Ensembl Protein ID

ENSNLEP00000015026.1

UniProt Accession

G1RP62; G1RP62_NOMLE

Genbank Protein ID

ENSNLEP00000015026

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01180050

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000012332.1	ENSNLET00000015776.1	ENSNLEP00000015026.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.60e-35	117.1	181	218
UBD/Beta-Prp	3.10e-52	177.6	280	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 181  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 218
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 280  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 368
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 369  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 457
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 458  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 541
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSCERKGLSE LRSGKSGXXX XXXGSALPAL LLQVLIREVA EKELLPRRTD WTGKEHPRTY 60
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGTG AGAGGAAAGG CCTCTCGGAG CTGCGATCGG GTAAGTCGGG GGNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	96.41	0.00e+00	3209.00
IUUC-Apl-003700	Anas platyrhynchos	86.77	0.00e+00	2875.00
IUUC-Aca-004474	Anolis carolinensis	82.68	0.00e+00	2792.00
IUUC-Bta-013125	Bos taurus	95.74	0.00e+00	3112.00
IUUC-Cja-018868	Callithrix jacchus	95.33	0.00e+00	3327.00
IUUC-Cfa-021179	Canis familiaris	94.73	0.00e+00	3127.00
IUUC-Cpo-022077	Cavia porcellus	91.61	0.00e+00	3083.00
IUUC-Csa-023618	Chlorocebus sabaeus	97.91	0.00e+00	3372.00
IUUC-Cho-024794	Choloepus hoffmanni	90.75	0.00e+00	876.00
IUUC-Dre-028029	Danio rerio	78.15	0.00e+00	1306.00
IUUC-Dno-030048	Dasypus novemcinctus	94.14	0.00e+00	3194.00
IUUC-Dor-030195	Dipodomys ordii	90.09	0.00e+00	1459.00
IUUC-Ete-032748	Echinops telfairi	83.58	0.00e+00	1159.00
IUUC-Eca-034274	Equus caballus	97.33	0.00e+00	3181.00
IUUC-Eeu-034688	Erinaceus europaeus	84.99	0.00e+00	1414.00
IUUC-Fca-035451	Felis catus	95.91	0.00e+00	3060.00
IUUC-Fal-037465	Ficedula albicollis	86.38	0.00e+00	2891.00
IUUC-Gmo-039451	Gadus morhua	68.58	0.00e+00	723.00
IUUC-Gga-040798	Gallus gallus	86.59	0.00e+00	2927.00
IUUC-Hsa-046757	Homo sapiens	98.68	0.00e+00	3355.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	1.00e-37	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	94.18	0.00e+00	1186.00
IUUC-Lch-050646	Latimeria chalumnae	77.42	0.00e+00	2709.00
IUUC-Laf-054140	Loxodonta africana	96.14	0.00e+00	3211.00
IUUC-Mcc-055061	Macaca mulatta	97.69	0.00e+00	3360.00
IUUC-Mmr-060837	Microcebus murinus	96.48	0.00e+00	1635.00
IUUC-Mdo-061903	Monodelphis domestica	93.52	0.00e+00	1680.00
IUUC-Mmu-063772	Mus musculus	94.01	0.00e+00	3226.00
IUUC-Mpu-066359	Mustela putorius furo	96.54	0.00e+00	2954.00
IUUC-Mlu-067928	Myotis lucifugus	94.90	0.00e+00	3220.00
IUUC-Opr-070971	Ochotona princeps	74.84	0.00e+00	959.00
IUUC-Ont-072221	Oreochromis niloticus	76.69	0.00e+00	1288.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.58	0.00e+00	2895.00
IUUC-Ocu-074033	Oryctolagus cuniculus	95.32	0.00e+00	2880.00
IUUC-Ogl-077493	Oryza glaberrima	24.66	2.00e-29	125.00
IUUC-Ogu-078641	Oryza glumaepatula	24.28	1.00e-29	126.00
IUUC-Oin-079669	Oryza indica	31.13	3.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	3.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.78	1.00e-39	159.00
IUUC-Oga-088578	Otolemur garnettii	96.70	0.00e+00	3163.00
IUUC-Oar-090247	Ovis aries	96.19	0.00e+00	3118.00
IUUC-Ptr-091266	Pan troglodytes	99.38	0.00e+00	3298.00
IUUC-Pan-092734	Papio anubis	98.02	0.00e+00	3373.00
IUUC-Pfo-096191	Poecilia formosa	72.70	0.00e+00	2019.00
IUUC-Pab-098402	Pongo abelii	98.68	0.00e+00	3357.00
IUUC-Pca-101128	Procavia capensis	84.53	0.00e+00	2866.00
IUUC-Pva-103058	Pteropus vampyrus	95.23	0.00e+00	1577.00
IUUC-Rno-106013	Rattus norvegicus	93.52	0.00e+00	3135.00
IUUC-Sha-107496	Sarcophilus harrisii	91.32	0.00e+00	3100.00
IUUC-Sar-113520	Sorex araneus	91.14	0.00e+00	1539.00
IUUC-Ssc-115461	Sus scrofa	91.77	0.00e+00	3098.00
IUUC-Tgu-116821	Taeniopygia guttata	86.16	0.00e+00	2891.00
IUUC-Tsy-119132	Tarsius syrichta	85.28	0.00e+00	2590.00
IUUC-Tae-122854	Triticum aestivum	29.99	3.00e-67	251.00
IUUC-Tbe-127479	Tupaia belangeri	93.31	0.00e+00	1464.00
IUUC-Ttr-128427	Tursiops truncatus	91.11	0.00e+00	3049.00
IUUC-Vpa-130160	Vicugna pacos	93.42	0.00e+00	3046.00
IUUC-Xtr-132717	Xenopus tropicalis	74.73	0.00e+00	2529.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence