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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046650
UUCD1 version UUC-HoS-00240
Ensembl Protein ID ENSP00000369335.5
UniProt Accession Q8NFZ0; Q5JVB0; Q5JVB1; Q7Z4Q6; Q7Z4R0; Q8N1P5; Q8N586; Q96E82; Q96K67; Q96SW7; Q9UFB2; FBH1_HUMAN
Genbank Protein ID AAM73631.1; AAP97700.1; AAP97705.1; BAB55073.1; BAB55154.1; BAC04535.1; CAI41073.1; CAI41074.1; EAW86426.1; AAH12762.2; AAH32674.2; AAI13378.1; CAB61392.1
Protein Name F-box DNA helicase 1; F-box only protein 18
Genbank Nucleotide ID AF380349; AF454502; AF456237; AK027381; AK027496; AK095343; AL137186; AL137186; CH471072; BC012762; BC032674; BC113377; AL133069
Gene Name FBXO18; FBH1; FBX18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134452.19 ENST00000379999.6 ENSP00000369335.5
ENSG00000134452.19 ENST00000397269.7 ENSP00000380439.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 15117950
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 29.67 5.00e-42 168.00 IUUC-Spo-108147
Organism Homo sapiens
Functional Description
(View)

Functional Description


     3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).
 3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).
Protein Sequence
(Fasta)
MSYEVTSGCH WTCQVPESCD NGLHCAGPLG HLHRRCQRTS AHLLVFTEHA EMRRFKRKHL 60
TAIDCQHLAR SHLAVTQPFG QRWTNRDPNH GLYPKPRTKR GSRGQGSQRC IPEFFLAGKQ 120
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Protein Fasta Sequence


>IUUC-Hsa-046650|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAGCTCGCG GAGGAAGTCG GCGGGCGTCT CGGGCTCCAG GTCCCGGCCA GAGGAGGAGC 60
TCGCTGCCGG GGGACGCTGG GCTGAGCGGC CGGCGGCGCG GGCCCGGCGG CGGCGGCAGC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046650|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF13361--UvrD_C
Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003678--F:DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0000724--P:double-strand break repair via homologous recombination
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
KEGG hsa:84893
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000424 Aegilops tauschii 43.48 1.00e-03 40.00
IUUC-Aml-001396 Ailuropoda melanoleuca 91.13 0.00e+00 1948.00
IUUC-Atr-002826 Amborella trichopoda 41.27 1.00e-03 39.70
IUUC-Apl-003317 Anas platyrhynchos 48.46 0.00e+00 951.00
IUUC-Aca-004498 Anolis carolinensis 54.06 0.00e+00 951.00
IUUC-Ath-007293 Arabidopsis thaliana 35.29 5.00e-03 37.40
IUUC-Ani-009226 Aspergillus nidulans 32.50 2.00e-06 48.50
IUUC-Ate-010526 Aspergillus terreus 38.24 1.00e-03 39.30
IUUC-Ame-011808 Astyanax mexicanus 59.34 1.00e-133 469.00
IUUC-Bta-013250 Bos taurus 88.81 0.00e+00 1891.00
IUUC-Bol-015348 Brassica oleracea 37.68 4.00e-03 37.70
IUUC-Cja-019638 Callithrix jacchus 97.13 0.00e+00 2113.00
IUUC-Cfa-020195 Canis familiaris 92.49 0.00e+00 1865.00
IUUC-Cpo-022269 Cavia porcellus 86.69 0.00e+00 1821.00
IUUC-Cre-022611 Chlamydomonas reinhardtii 40.28 3.00e-08 54.70
IUUC-Csa-024060 Chlorocebus sabaeus 98.04 0.00e+00 1875.00
IUUC-Cho-025003 Choloepus hoffmanni 88.89 0.00e+00 722.00
IUUC-Cin-025694 Ciona intestinalis 28.57 9.00e-32 131.00
IUUC-Cgl-026626 Colletotrichum gloeosporioides 45.71 1.70e-02 35.40
IUUC-Dre-028083 Danio rerio 49.72 0.00e+00 852.00
IUUC-Dno-029203 Dasypus novemcinctus 87.49 0.00e+00 1793.00
IUUC-Dor-030477 Dipodomys ordii 79.07 0.00e+00 794.00
IUUC-Ete-032861 Echinops telfairi 88.53 0.00e+00 1870.00
IUUC-Eca-033205 Equus caballus 92.07 0.00e+00 2002.00
IUUC-Eeu-034784 Erinaceus europaeus 85.78 0.00e+00 1211.00
IUUC-Fca-035797 Felis catus 90.84 0.00e+00 1961.00
IUUC-Gmo-038855 Gadus morhua 46.45 6.00e-125 442.00
IUUC-Gga-040326 Gallus gallus 50.91 0.00e+00 990.00
IUUC-Gac-042240 Gasterosteus aculeatus 42.27 0.00e+00 738.00
IUUC-Ggo-045050 Gorilla gorilla 94.53 0.00e+00 2082.00
IUUC-Itr-047965 Ictidomys tridecemlineatus 97.42 0.00e+00 780.00
IUUC-Lch-050231 Latimeria chalumnae 42.94 2.00e-171 596.00
IUUC-Loc-051884 Lepisosteus oculatus 50.00 0.00e+00 994.00
IUUC-Lma-053267 Leptosphaeria maculans 22.53 2.00e-04 42.00
IUUC-Laf-053843 Loxodonta africana 90.82 0.00e+00 1943.00
IUUC-Mcc-055570 Macaca mulatta 95.89 0.00e+00 2132.00
IUUC-Meu-056798 Macropus eugenii 67.68 6.00e-154 538.00
IUUC-Mtr-057915 Medicago truncatula 38.24 4.00e-05 44.70
IUUC-Mla-058841 Melampsora laricipopulina 34.55 3.00e-02 31.60
IUUC-Mga-059648 Meleagris gallopavo 51.82 0.00e+00 954.00
IUUC-Mmr-060757 Microcebus murinus 90.46 0.00e+00 1930.00
IUUC-Mdo-061913 Monodelphis domestica 69.75 0.00e+00 1387.00
IUUC-Mmu-064337 Mus musculus 89.87 0.00e+00 1943.00
IUUC-Mac-064479 Musa acuminata 36.92 3.00e-03 37.70
IUUC-Mpu-066483 Mustela putorius furo 90.14 0.00e+00 1954.00
IUUC-Mlu-068204 Myotis lucifugus 85.21 0.00e+00 1826.00
IUUC-Ncr-068735 Neurospora crassa 35.94 6.00e-03 37.00
IUUC-Nle-070053 Nomascus leucogenys 97.26 0.00e+00 2125.00
IUUC-Opr-070588 Ochotona princeps 83.96 0.00e+00 1817.00
IUUC-Ont-072655 Oreochromis niloticus 47.13 0.00e+00 762.00
IUUC-Oan-073351 Ornithorhynchus anatinus 63.02 0.00e+00 1338.00
IUUC-Ocu-074465 Oryctolagus cuniculus 90.65 0.00e+00 1864.00
IUUC-Obr-076710 Oryza brachyantha 35.29 4.00e-03 37.70
IUUC-Oin-079176 Oryza indica 23.62 3.00e-05 43.50
IUUC-Opu-083155 Oryza punctata 47.50 4.00e-03 37.40
IUUC-Olu-087831 Ostreococcus lucimarinus 32.14 4.00e-66 247.00
IUUC-Oga-089088 Otolemur garnettii 91.48 0.00e+00 1907.00
IUUC-Oar-089870 Ovis aries 87.95 0.00e+00 1846.00
IUUC-Ptr-090957 Pan troglodytes 98.16 0.00e+00 2164.00
IUUC-Pan-092632 Papio anubis 97.99 0.00e+00 2029.00
IUUC-Psi-093035 Pelodiscus sinensis 55.92 0.00e+00 1158.00
IUUC-Pno-094870 Phaeosphaeria nodorum 25.27 4.00e-05 43.90
IUUC-Ppa-095660 Physcomitrella patens 38.36 1.00e-03 40.00
IUUC-Pfo-096902 Poecilia formosa 44.66 0.00e+00 686.00
IUUC-Pab-098206 Pongo abelii 97.78 0.00e+00 1913.00
IUUC-Pop-098801 Populus trichocarpa 37.68 9.00e-05 43.10
IUUC-Pca-100238 Procavia capensis 83.53 0.00e+00 1842.00
IUUC-Ppe-101748 Prunus persica 33.82 4.00e-03 37.70
IUUC-Pva-103182 Pteropus vampyrus 86.46 0.00e+00 1872.00
IUUC-Pte-104033 Pyrenophora teres 24.29 2.00e-04 41.60
IUUC-Pyt-104599 Pyrenophora triticirepentis 24.29 2.00e-04 42.00
IUUC-Rno-105141 Rattus norvegicus 89.67 0.00e+00 1944.00
IUUC-Sce-106341 Saccharomyces cerevisiae 27.91 5.00e-03 36.60
IUUC-Sha-106827 Sarcophilus harrisii 67.87 0.00e+00 1451.00
IUUC-Sja-107882 Schizosaccharomyces japonicus 29.33 7.00e-43 169.00
IUUC-Spo-108147 Schizosaccharomyces pombe 29.67 2.00e-42 167.00
IUUC-Ssl-108584 Sclerotinia sclerotiorum 24.24 7.00e-04 39.70
IUUC-Sly-111170 Solanum lycopersicum 37.88 6.00e-03 36.20
IUUC-Sre-115025 Sporisorium reilianum 34.39 2.00e-38 154.00
IUUC-Ssc-116188 Sus scrofa 94.14 0.00e+00 1277.00
IUUC-Tgu-116612 Taeniopygia guttata 57.80 2.00e-163 568.00
IUUC-Tsy-119560 Tarsius syrichta 83.06 9.00e-117 415.00
IUUC-Tni-120734 Tetraodon nigroviridis 45.77 0.00e+00 707.00
IUUC-Tca-121338 Theobroma cacao 31.78 2.00e-03 38.50
IUUC-Tre-122089 Trichoderma reesei 35.82 2.00e-04 41.60
IUUC-Tae-125126 Triticum aestivum 36.23 1.00e-03 38.10
IUUC-Tme-127009 Tuber melanosporum 22.86 2.00e-04 42.00
IUUC-Tbe-127431 Tupaia belangeri 88.02 0.00e+00 1693.00
IUUC-Ttr-128744 Tursiops truncatus 85.39 0.00e+00 1852.00
IUUC-Uma-129536 Ustilago maydis 34.78 1.00e-39 159.00
IUUC-Vpa-130123 Vicugna pacos 69.31 2.00e-108 387.00
IUUC-Vvi-131025 Vitis vinifera 36.76 7.00e-04 40.00
IUUC-Xtr-132902 Xenopus tropicalis 58.37 0.00e+00 1017.00
IUUC-Xma-133978 Xiphophorus maculatus 45.94 9.00e-153 534.00
Created Date 25-Jun-2017

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