iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004620

UUCD1 version

UUC-AnC-00938

Ensembl Protein ID

ENSACAP00000005284.2

UniProt Accession

G1KE14; G1KE14_ANOCA

Protein Name

Uncharacterized protein

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000005270.3	ENSACAT00000005401.3	ENSACAP00000005284.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-229	761.3	452	932

Active Site

Position(s)	Description	Evidence
633	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ q+kl+++k++lvGag++GcEllKn++++G+     g++ v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a+ke+
   Q: 452  YDGQIAVFGSDLQAKLGQQKYFLVGAGAIGCELLKNFAMIGLgcrpgGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSDTAAAAVKEM 540
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np++++++h++++ +++e+++   Ff+ +d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+++v+i+ lte+ys+s+dpp+k+
   Q: 541  NPNIHITSHQDRVGPDTERVYdddFFESLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNIQVVIPFLTESYSSSQDPPEKS 629
           ********************9******************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n+++ +++++ e+++kl  ++++e++++v+++l++ +++++++++++a++++++
   Q: 630  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYI-TDPKFMERTQKLPGTQPLEVLEAVFKSLVTDRPKSWADCVTWACNHWHT 717
           ***************************************.89999999999************************************** PP
   S: 248  ttinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........ 286
           +++n+i+qll++f++++ t+s++ fw+                                           + ++ +++q+p        
   Q: 718  QYSNNIRQLLHNFPPNQKTNSGTLFWSgpkrcphpltfdssnslhmdyvmaaanlfaqtygitgtrdraAVAELLRQVQIPeftpksgv 806
           *****************************************************************999966666666665555555555 PP
   S: 287  ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
             +++d+e + a+a+     l+ l+ +l   ++ ++  +  ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 807  RIHISDQELQNANASvddsrLEELKSSLPGPQQLQEFRMFPVDFEKDDDTnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPA 894
           55555555555555566778****************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+a+v Gl+++E++K+++g  + e +kn fl++a+
   Q: 895  IATTTAAVVGLVCLELYKIIQGhkRLESFKNGFLNLAL 932
           **********************888999******9875 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSSSPLSKKR RLSESETKTG SNCSSGKSVQ TDLREAPANG MAKNGNEADI DEGLYSRQLY 60
VLGHEAMKRM QNANILVSGL RGLGVEIAKN IILGGVKSVT IHDQGVAEWS DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCT CGCCGTTGTC CAAGAAGCGT CGCTTGTCTG AATCGGAGAC GAAGACGGGT 60
TCAAACTGCT CCTCTGGCAA ATCCGTACAG ACTGACCTGC GCGAAGCGCC TGCCAACGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus

KEGG

acs:100552704

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	45.47	0.00e+00	850.00
IUUC-Aml-001311	Ailuropoda melanoleuca	79.59	0.00e+00	1787.00
IUUC-Atr-002684	Amborella trichopoda	44.04	0.00e+00	885.00
IUUC-Aly-005515	Arabidopsis lyrata	45.85	0.00e+00	915.00
IUUC-Ath-006891	Arabidopsis thaliana	45.95	0.00e+00	912.00
IUUC-Ago-007873	Ashbya gossypii	53.40	0.00e+00	1058.00
IUUC-Acl-008181	Aspergillus clavatus	55.47	0.00e+00	1080.00
IUUC-Afl-008455	Aspergillus flavus	54.47	0.00e+00	1033.00
IUUC-Afu-009065	Aspergillus fumigatus	55.18	0.00e+00	1098.00
IUUC-Ani-009371	Aspergillus nidulans	54.54	0.00e+00	1053.00
IUUC-Ang-009737	Aspergillus niger	55.05	0.00e+00	1087.00
IUUC-Aor-010007	Aspergillus oryzae	54.47	0.00e+00	1033.00
IUUC-Ate-010466	Aspergillus terreus	54.59	0.00e+00	1099.00
IUUC-Ame-010933	Astyanax mexicanus	79.13	0.00e+00	1677.00
IUUC-Bgr-012281	Blumeria graminis	53.91	0.00e+00	1067.00
IUUC-Bta-012767	Bos taurus	80.17	0.00e+00	1805.00
IUUC-Bci-013721	Botrytis cinerea	55.71	0.00e+00	1040.00
IUUC-Bdi-014335	Brachypodium distachyon	44.48	0.00e+00	888.00
IUUC-Bol-015665	Brassica oleracea	43.96	0.00e+00	892.00
IUUC-Bra-017522	Brassica rapa	45.15	0.00e+00	872.00
IUUC-Cel-018260	Caenorhabditis elegans	48.55	0.00e+00	945.00
IUUC-Cja-019152	Callithrix jacchus	80.55	0.00e+00	1806.00
IUUC-Cfa-020622	Canis familiaris	78.85	0.00e+00	1740.00
IUUC-Cpo-022526	Cavia porcellus	80.17	0.00e+00	1783.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.33	0.00e+00	836.00
IUUC-Csa-023780	Chlorocebus sabaeus	80.83	0.00e+00	1815.00
IUUC-Cin-025790	Ciona intestinalis	63.54	0.00e+00	1369.00
IUUC-Csv-026084	Ciona savignyi	60.48	0.00e+00	1338.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	54.85	0.00e+00	1108.00
IUUC-Cne-026960	Cryptococcus neoformans	56.47	0.00e+00	1116.00
IUUC-Cme-027290	Cyanidioschyzon merolae	43.69	0.00e+00	826.00
IUUC-Dre-028149	Danio rerio	78.94	0.00e+00	1710.00
IUUC-Dno-028884	Dasypus novemcinctus	79.79	0.00e+00	1795.00
IUUC-Dor-030229	Dipodomys ordii	76.96	0.00e+00	1707.00
IUUC-Dse-031524	Dothistroma septosporum	53.09	0.00e+00	1062.00
IUUC-Dme-032045	Drosophila melanogaster	59.11	0.00e+00	1248.00
IUUC-Ete-032544	Echinops telfairi	69.01	0.00e+00	729.00
IUUC-Eca-033330	Equus caballus	80.55	0.00e+00	1818.00
IUUC-Eeu-034717	Erinaceus europaeus	42.74	3.00e-162	565.00
IUUC-Fca-036255	Felis catus	80.64	0.00e+00	1801.00
IUUC-Fox-038007	Fusarium oxysporum	54.10	4.00e-164	571.00
IUUC-Fso-038339	Fusarium solani	55.26	0.00e+00	1066.00
IUUC-Gmo-039338	Gadus morhua	76.46	0.00e+00	1623.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.39	0.00e+00	1122.00
IUUC-Gac-041773	Gasterosteus aculeatus	76.56	0.00e+00	1620.00
IUUC-Gma-043198	Glycine max	44.79	0.00e+00	870.00
IUUC-Ggo-045336	Gorilla gorilla	80.64	0.00e+00	1787.00
IUUC-Hsa-045982	Homo sapiens	80.45	0.00e+00	1783.00
IUUC-Hvu-047418	Hordeum vulgare	44.85	0.00e+00	867.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	80.83	0.00e+00	1808.00
IUUC-Kpa-049112	Komagataella pastoris	50.98	0.00e+00	1005.00
IUUC-Lch-050371	Latimeria chalumnae	80.36	0.00e+00	1773.00
IUUC-Lpe-051299	Leersia perrieri	44.13	0.00e+00	879.00
IUUC-Loc-052936	Lepisosteus oculatus	79.13	0.00e+00	1725.00
IUUC-Lma-053315	Leptosphaeria maculans	52.88	0.00e+00	1102.00
IUUC-Laf-053948	Loxodonta africana	78.66	0.00e+00	1753.00
IUUC-Mcc-055843	Macaca mulatta	80.93	0.00e+00	1815.00
IUUC-Meu-056258	Macropus eugenii	78.66	0.00e+00	1752.00
IUUC-Mor-057269	Magnaporthe oryzae	54.92	0.00e+00	1097.00
IUUC-Mpo-057435	Magnaporthe poae	54.54	0.00e+00	1090.00
IUUC-Mtr-058572	Medicago truncatula	44.05	0.00e+00	844.00
IUUC-Mla-059176	Melampsora laricipopulina	56.34	0.00e+00	1117.00
IUUC-Mvi-060437	Microbotryum violaceum	54.27	0.00e+00	1077.00
IUUC-Mmr-061405	Microcebus murinus	78.09	0.00e+00	1742.00
IUUC-Mdo-062032	Monodelphis domestica	77.53	0.00e+00	1730.00
IUUC-Mmu-063280	Mus musculus	79.79	0.00e+00	1783.00
IUUC-Mac-065505	Musa acuminata	44.83	0.00e+00	885.00
IUUC-Mpu-066409	Mustela putorius furo	80.26	0.00e+00	1807.00
IUUC-Mlu-067217	Myotis lucifugus	79.13	0.00e+00	1773.00
IUUC-Nfi-068407	Neosartorya fischeri	55.47	0.00e+00	1078.00
IUUC-Ncr-068698	Neurospora crassa	55.59	0.00e+00	1113.00
IUUC-Nle-070072	Nomascus leucogenys	76.72	0.00e+00	1673.00
IUUC-Ont-071671	Oreochromis niloticus	78.37	0.00e+00	1686.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.10	0.00e+00	716.00
IUUC-Ocu-074544	Oryctolagus cuniculus	80.93	0.00e+00	1816.00
IUUC-Oba-075120	Oryza barthii	44.56	0.00e+00	872.00
IUUC-Obr-076557	Oryza brachyantha	44.40	0.00e+00	852.00
IUUC-Ogl-077887	Oryza glaberrima	44.66	0.00e+00	874.00
IUUC-Ogu-078305	Oryza glumaepatula	43.64	0.00e+00	872.00
IUUC-Oin-080154	Oryza indica	43.64	0.00e+00	872.00
IUUC-Olo-081089	Oryza longistaminata	43.71	0.00e+00	874.00
IUUC-Ome-081942	Oryza meridionalis	44.56	0.00e+00	871.00
IUUC-Oni-082365	Oryza nivara	44.56	0.00e+00	874.00
IUUC-Opu-083977	Oryza punctata	44.82	0.00e+00	875.00
IUUC-Oru-084469	Oryza rufipogon	43.71	0.00e+00	875.00
IUUC-Osa-085949	Oryza sativa	44.87	0.00e+00	879.00
IUUC-Ola-087002	Oryzias latipes	77.89	0.00e+00	1685.00
IUUC-Olu-087687	Ostreococcus lucimarinus	42.98	0.00e+00	789.00
IUUC-Oga-088594	Otolemur garnettii	80.09	0.00e+00	1775.00
IUUC-Oar-090068	Ovis aries	79.81	0.00e+00	1796.00
IUUC-Pan-092114	Papio anubis	80.93	0.00e+00	1817.00
IUUC-Pma-094214	Petromyzon marinus	59.43	2.00e-54	204.00
IUUC-Pno-095154	Phaeosphaeria nodorum	52.90	0.00e+00	1102.00
IUUC-Ppa-095416	Physcomitrella patens	45.50	0.00e+00	901.00
IUUC-Pfo-097184	Poecilia formosa	77.99	0.00e+00	1680.00
IUUC-Pab-097861	Pongo abelii	80.45	0.00e+00	1772.00
IUUC-Pop-098934	Populus trichocarpa	43.36	0.00e+00	896.00
IUUC-Pca-100347	Procavia capensis	77.42	0.00e+00	1433.00
IUUC-Ppe-102012	Prunus persica	44.36	0.00e+00	889.00
IUUC-Pva-102584	Pteropus vampyrus	80.74	0.00e+00	1834.00
IUUC-Pgr-103336	Puccinia graminis	55.66	0.00e+00	1090.00
IUUC-Ptt-103939	Puccinia triticina	54.65	0.00e+00	1095.00
IUUC-Pte-104200	Pyrenophora teres	53.10	0.00e+00	1108.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	52.88	0.00e+00	1095.00
IUUC-Rno-105462	Rattus norvegicus	80.17	0.00e+00	1781.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.96	0.00e+00	1061.00
IUUC-Sha-107142	Sarcophilus harrisii	78.66	0.00e+00	1764.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	54.96	0.00e+00	1131.00
IUUC-Spo-108034	Schizosaccharomyces pombe	53.07	0.00e+00	1068.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	55.00	0.00e+00	1057.00
IUUC-Smo-109211	Selaginella moellendorffii	44.71	0.00e+00	876.00
IUUC-Sit-110281	Setaria italica	44.57	0.00e+00	890.00
IUUC-Sly-110914	Solanum lycopersicum	44.27	0.00e+00	897.00
IUUC-Stu-112109	Solanum tuberosum	43.88	0.00e+00	894.00
IUUC-Sar-113737	Sorex araneus	79.32	0.00e+00	1778.00
IUUC-Sbi-114089	Sorghum bicolor	44.27	0.00e+00	899.00
IUUC-Sre-115148	Sporisorium reilianum	55.95	0.00e+00	1094.00
IUUC-Ssc-115777	Sus scrofa	80.19	0.00e+00	1801.00
IUUC-Tru-118742	Takifugu rubripes	77.89	0.00e+00	1630.00
IUUC-Tni-120401	Tetraodon nigroviridis	76.94	0.00e+00	1615.00
IUUC-Tca-121436	Theobroma cacao	43.46	0.00e+00	883.00
IUUC-Tre-122009	Trichoderma reesei	54.41	0.00e+00	1044.00
IUUC-Tvi-122259	Trichoderma virens	54.56	0.00e+00	1046.00
IUUC-Tae-125113	Triticum aestivum	45.47	0.00e+00	850.00
IUUC-Tur-126330	Triticum urartu	45.46	0.00e+00	887.00
IUUC-Tme-127055	Tuber melanosporum	52.83	0.00e+00	1003.00
IUUC-Tbe-127487	Tupaia belangeri	78.21	0.00e+00	877.00
IUUC-Ttr-128331	Tursiops truncatus	79.89	0.00e+00	1783.00
IUUC-Uma-129387	Ustilago maydis	55.58	0.00e+00	1086.00
IUUC-Vda-129977	Verticillium dahliae	54.10	0.00e+00	1026.00
IUUC-Vvi-130857	Vitis vinifera	44.79	0.00e+00	889.00
IUUC-Xtr-132026	Xenopus tropicalis	64.50	0.00e+00	1298.00
IUUC-Xma-133805	Xiphophorus maculatus	78.37	0.00e+00	1665.00
IUUC-Yli-134547	Yarrowia lipolytica	53.20	0.00e+00	1105.00
IUUC-Zma-135052	Zea mays	44.52	0.00e+00	899.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence