iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	8.80e-50	169.0	9	156

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........e 88
           l+k+lk+l k+p++g+sa++vde++++ew+v+i+Gp+dt Yegg+F++ ++fp++YP +PP+v+f++ ++hPnvy++G+vC+sil+            
   Q: 9    LQKQLKDLCKHPVDGFSAGLVDEKNIFEWSVTIIGPPDTLYEGGFFNAIMTFPQNYPNSPPTVRFTSDMWHPNVYSDGRVCISILHppgddpsgyelA 106
           799**********************************************************************************999999999*999 PP
   S: 89   eekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +e+W+p+++ves++lsi+s+l+ pn esp+n+eaa++++++r e+kkkv+
   Q: 107  SERWTPVHTVESIMLSIISMLSGPNDESPANVEAAKEWRDKRDEFKKKVS 156
           ***********************************************996 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.

Protein Sequence
(Fasta)

MASQASLLLQ KQLKDLCKHP VDGFSAGLVD EKNIFEWSVT IIGPPDTLYE GGFFNAIMTF 60
PQNYPNSPPT VRFTSDMWHP NVYSDGRVCI SILHPPGDDP SGYELASERW TPVHTVESIM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCGC AAGCTAGCCT TCTCCTTCAG AAACAACTCA AAGGCAAGCC CTTGGAATCT 60
CTCTCCTTAC CAAAATCAAT CTTGTGATTG TTATGTTCTT CTCTAAATCC GATTTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000209--P:protein polyubiquitination

KEGG

ath:AT5G59300

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001379	Ailuropoda melanoleuca	64.19	5.00e-57	212.00
IUUC-Atr-003150	Amborella trichopoda	82.55	1.00e-60	224.00
IUUC-Apl-003579	Anas platyrhynchos	64.19	3.00e-57	213.00
IUUC-Aca-005146	Anolis carolinensis	64.19	6.00e-57	212.00
IUUC-Aly-005452	Arabidopsis lyrata	98.00	1.00e-79	287.00
IUUC-Ago-007853	Ashbya gossypii	56.74	2.00e-44	171.00
IUUC-Bta-013324	Bos taurus	64.19	7.00e-57	212.00
IUUC-Bdi-014838	Brachypodium distachyon	85.98	4.00e-72	262.00
IUUC-Bol-016503	Brassica oleracea	96.39	4.00e-80	289.00
IUUC-Bra-017969	Brassica rapa	97.33	2.00e-79	286.00
IUUC-Cja-018734	Callithrix jacchus	64.19	4.00e-57	213.00
IUUC-Cfa-020846	Canis familiaris	64.19	3.00e-57	213.00
IUUC-Cre-022895	Chlamydomonas reinhardtii	79.87	2.00e-66	243.00
IUUC-Csa-024193	Chlorocebus sabaeus	64.19	7.00e-57	212.00
IUUC-Cin-025131	Ciona intestinalis	62.20	5.00e-55	206.00
IUUC-Csv-026074	Ciona savignyi	67.79	6.00e-60	221.00
IUUC-Cne-026796	Cryptococcus neoformans	56.21	5.00e-41	159.00
IUUC-Cme-027321	Cyanidioschyzon merolae	62.80	3.00e-51	193.00
IUUC-Dre-028653	Danio rerio	64.19	4.00e-57	213.00
IUUC-Dno-029479	Dasypus novemcinctus	64.19	7.00e-57	212.00
IUUC-Dor-030686	Dipodomys ordii	53.74	7.00e-45	172.00
IUUC-Eca-034057	Equus caballus	64.19	6.00e-57	212.00
IUUC-Fca-035835	Felis catus	64.19	7.00e-57	212.00
IUUC-Fal-036778	Ficedula albicollis	64.19	7.00e-57	212.00
IUUC-Gmo-039029	Gadus morhua	65.77	8.00e-57	211.00
IUUC-Gga-040950	Gallus gallus	64.19	7.00e-57	212.00
IUUC-Gac-042210	Gasterosteus aculeatus	63.25	7.00e-58	215.00
IUUC-Gma-044131	Glycine max	89.33	2.00e-65	240.00
IUUC-Ggo-044826	Gorilla gorilla	64.19	7.00e-57	212.00
IUUC-Hsa-046638	Homo sapiens	64.19	7.00e-57	212.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	54.94	3.00e-49	186.00
IUUC-Kpa-049317	Komagataella pastoris	53.90	7.00e-42	162.00
IUUC-Lch-050446	Latimeria chalumnae	64.19	3.00e-57	213.00
IUUC-Lpe-050981	Leersia perrieri	87.84	9.00e-72	261.00
IUUC-Loc-052277	Lepisosteus oculatus	64.19	7.00e-57	212.00
IUUC-Lma-053320	Leptosphaeria maculans	58.90	3.00e-47	179.00
IUUC-Laf-053491	Loxodonta africana	64.19	7.00e-57	212.00
IUUC-Mcc-055624	Macaca mulatta	64.19	6.00e-57	212.00
IUUC-Meu-056870	Macropus eugenii	63.51	4.00e-52	196.00
IUUC-Mtr-058646	Medicago truncatula	91.33	4.00e-74	269.00
IUUC-Mla-059165	Melampsora laricipopulina	63.09	5.00e-55	206.00
IUUC-Mga-060005	Meleagris gallopavo	64.19	6.00e-57	212.00
IUUC-Mvi-060318	Microbotryum violaceum	60.24	5.00e-49	186.00
IUUC-Mmr-061442	Microcebus murinus	64.19	7.00e-57	212.00
IUUC-Mdo-062364	Monodelphis domestica	63.51	2.00e-56	211.00
IUUC-Mmu-064163	Mus musculus	64.19	7.00e-57	212.00
IUUC-Mac-065294	Musa acuminata	87.92	4.00e-71	259.00
IUUC-Mlu-067444	Myotis lucifugus	64.19	4.00e-57	213.00
IUUC-Nle-070007	Nomascus leucogenys	55.56	1.00e-49	187.00
IUUC-Ont-072627	Oreochromis niloticus	65.45	4.00e-59	219.00
IUUC-Oan-073475	Ornithorhynchus anatinus	58.33	5.00e-49	186.00
IUUC-Ocu-074321	Oryctolagus cuniculus	64.19	6.00e-57	212.00
IUUC-Obr-076863	Oryza brachyantha	87.84	6.00e-72	261.00
IUUC-Opu-083784	Oryza punctata	85.81	1.00e-69	254.00
IUUC-Ola-087228	Oryzias latipes	63.86	5.00e-58	216.00
IUUC-Olu-087887	Ostreococcus lucimarinus	72.56	3.00e-67	246.00
IUUC-Oga-088473	Otolemur garnettii	64.19	5.00e-57	212.00
IUUC-Oar-090047	Ovis aries	64.19	6.00e-57	212.00
IUUC-Pan-092230	Papio anubis	64.19	7.00e-57	212.00
IUUC-Psi-093996	Pelodiscus sinensis	64.19	6.00e-57	212.00
IUUC-Pno-094979	Phaeosphaeria nodorum	55.56	9.00e-50	188.00
IUUC-Ppa-095611	Physcomitrella patens	79.14	2.00e-72	263.00
IUUC-Pfo-096425	Poecilia formosa	63.86	3.00e-58	217.00
IUUC-Pab-098727	Pongo abelii	64.19	7.00e-57	212.00
IUUC-Pca-100369	Procavia capensis	64.38	1.00e-54	205.00
IUUC-Ppe-101778	Prunus persica	90.67	3.00e-74	269.00
IUUC-Pva-103074	Pteropus vampyrus	64.19	7.00e-57	212.00
IUUC-Ptt-103840	Puccinia triticina	53.52	1.00e-43	167.00
IUUC-Pte-104389	Pyrenophora teres	55.56	2.00e-49	187.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	56.17	7.00e-50	188.00
IUUC-Rno-104929	Rattus norvegicus	64.19	7.00e-57	212.00
IUUC-Sce-106233	Saccharomyces cerevisiae	56.43	2.00e-43	167.00
IUUC-Sha-106753	Sarcophilus harrisii	63.51	2.00e-56	211.00
IUUC-Sja-107917	Schizosaccharomyces japonicus	67.92	5.00e-42	162.00
IUUC-Smo-109401	Selaginella moellendorffii	81.82	2.00e-60	224.00
IUUC-Sit-110784	Setaria italica	86.49	3.00e-70	256.00
IUUC-Sly-111843	Solanum lycopersicum	88.34	2.00e-75	273.00
IUUC-Stu-112654	Solanum tuberosum	91.10	3.00e-72	263.00
IUUC-Sar-112992	Sorex araneus	52.78	6.00e-40	156.00
IUUC-Sbi-113787	Sorghum bicolor	86.06	4.00e-73	266.00
IUUC-Sre-114933	Sporisorium reilianum	63.09	6.00e-47	179.00
IUUC-Ssc-115912	Sus scrofa	64.19	7.00e-57	212.00
IUUC-Tgu-116635	Taeniopygia guttata	64.19	6.00e-57	212.00
IUUC-Tru-118696	Takifugu rubripes	64.86	1.00e-57	214.00
IUUC-Tsy-119168	Tarsius syrichta	64.19	8.00e-57	212.00
IUUC-Tni-120869	Tetraodon nigroviridis	64.86	2.00e-57	214.00
IUUC-Tca-121649	Theobroma cacao	77.71	5.00e-64	235.00
IUUC-Tae-125278	Triticum aestivum	86.00	2.00e-71	260.00
IUUC-Tur-126873	Triticum urartu	85.53	9.00e-66	243.00
IUUC-Tme-127052	Tuber melanosporum	54.36	2.00e-49	187.00
IUUC-Uma-129506	Ustilago maydis	63.76	1.00e-47	181.00
IUUC-Vpa-130208	Vicugna pacos	64.19	5.00e-57	213.00
IUUC-Vvi-131387	Vitis vinifera	88.67	4.00e-73	266.00
IUUC-Xma-134052	Xiphophorus maculatus	63.86	7.00e-58	215.00
IUUC-Yli-134379	Yarrowia lipolytica	57.34	2.00e-47	180.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence