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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063802
UUCD1 version UUC-MuM-00511
Ensembl Protein ID ENSMUSP00000124863.1
UniProt Accession Q6P1E1; Q6PDK9; Q6PF85; Q8BW47; ZMIZ1_MOUSE
Genbank Protein ID AAH57691.1; AAH58646.1; AAH65120.1; BAC35753.1
Protein Name Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17
Genbank Nucleotide ID BC057691; BC058646; BC065120; AK054366
Gene Name Zmiz1; Rai17; Zimp10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000007817.14 ENSMUST00000162645.7 ENSMUSP00000124863.1
ENSMUSG00000007817.14 ENSMUST00000007961.14 ENSMUSP00000007961.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 58.28 2.00e-105 381.00 IUUC-Dme-032001
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984).
 Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984).
Protein Sequence
(Fasta)
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 60
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQNDPP 120
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Protein Fasta Sequence


>IUUC-Mmu-063802|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TTTGGAAATA GAATAGCCAA TGTAATCTGA CACTTCAACT TGCTCGGCTC CGGGCGAGTT 60
GATTCACTTA CTCACCCCCT AACGCCGAGT TCCTTTTCAC TGTCTGTGGA CATTAAAAAA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063802|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51044--ZF_SP_RING
Pfam

PF02891--zf-MIZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0048844--P:artery morphogenesis
GO:0007569--P:cell aging
GO:0048589--P:developmental growth
GO:0003007--P:heart morphogenesis
GO:0001701--P:in utero embryonic development
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0001570--P:vasculogenesis
GO:0007296--P:vitellogenesis
KEGG mmu:328365
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001794 Ailuropoda melanoleuca 93.40 0.00e+00 1672.00
IUUC-Apl-003273 Anas platyrhynchos 86.25 0.00e+00 1384.00
IUUC-Aca-004401 Anolis carolinensis 87.27 0.00e+00 1587.00
IUUC-Aly-005490 Arabidopsis lyrata 26.97 5.00e-20 93.20
IUUC-Ame-010808 Astyanax mexicanus 80.55 0.00e+00 1276.00
IUUC-Bta-012614 Bos taurus 95.02 0.00e+00 1672.00
IUUC-Cja-018964 Callithrix jacchus 94.83 0.00e+00 1585.00
IUUC-Cfa-020641 Canis familiaris 96.08 0.00e+00 1699.00
IUUC-Cpo-022418 Cavia porcellus 96.08 0.00e+00 1674.00
IUUC-Cre-022902 Chlamydomonas reinhardtii 23.23 1.00e-04 40.80
IUUC-Csa-023718 Chlorocebus sabaeus 94.93 0.00e+00 1595.00
IUUC-Cin-025758 Ciona intestinalis 60.86 6.00e-110 392.00
IUUC-Csv-026050 Ciona savignyi 60.07 2.00e-104 373.00
IUUC-Dre-028668 Danio rerio 80.53 0.00e+00 1259.00
IUUC-Dno-029204 Dasypus novemcinctus 96.99 0.00e+00 843.00
IUUC-Dor-030159 Dipodomys ordii 95.08 0.00e+00 989.00
IUUC-Dme-032001 Drosophila melanogaster 59.26 4.00e-106 379.00
IUUC-Ete-032521 Echinops telfairi 92.22 0.00e+00 1602.00
IUUC-Eca-034269 Equus caballus 95.31 0.00e+00 1675.00
IUUC-Eeu-034484 Erinaceus europaeus 94.26 0.00e+00 1167.00
IUUC-Fca-036463 Felis catus 95.27 0.00e+00 757.00
IUUC-Fal-036827 Ficedula albicollis 86.82 0.00e+00 1382.00
IUUC-Gmo-039165 Gadus morhua 76.03 0.00e+00 691.00
IUUC-Gga-040680 Gallus gallus 87.50 0.00e+00 1494.00
IUUC-Gac-041570 Gasterosteus aculeatus 79.72 0.00e+00 1374.00
IUUC-Ggo-045289 Gorilla gorilla 94.84 0.00e+00 1630.00
IUUC-Hsa-046661 Homo sapiens 94.93 0.00e+00 1631.00
IUUC-Itr-049077 Ictidomys tridecemlineatus 95.06 0.00e+00 917.00
IUUC-Lch-050080 Latimeria chalumnae 83.65 0.00e+00 1343.00
IUUC-Lpe-050926 Leersia perrieri 44.34 5.00e-20 93.60
IUUC-Loc-052797 Lepisosteus oculatus 84.88 0.00e+00 1358.00
IUUC-Laf-054407 Loxodonta africana 90.68 0.00e+00 1462.00
IUUC-Mcc-055011 Macaca mulatta 95.60 0.00e+00 1614.00
IUUC-Meu-056748 Macropus eugenii 86.24 0.00e+00 1372.00
IUUC-Mga-059480 Meleagris gallopavo 88.40 0.00e+00 1335.00
IUUC-Mmr-061745 Microcebus murinus 95.51 0.00e+00 1690.00
IUUC-Mdo-062087 Monodelphis domestica 94.98 0.00e+00 1339.00
IUUC-Mpu-065779 Mustela putorius furo 84.97 0.00e+00 1282.00
IUUC-Mlu-067227 Myotis lucifugus 87.79 0.00e+00 1440.00
IUUC-Nle-069784 Nomascus leucogenys 95.32 0.00e+00 1648.00
IUUC-Opr-070817 Ochotona princeps 94.46 0.00e+00 981.00
IUUC-Ont-072059 Oreochromis niloticus 76.94 0.00e+00 1268.00
IUUC-Oan-073685 Ornithorhynchus anatinus 89.58 0.00e+00 746.00
IUUC-Ocu-073807 Oryctolagus cuniculus 94.84 0.00e+00 1655.00
IUUC-Opu-083841 Oryza punctata 44.34 2.00e-20 94.70
IUUC-Ola-087350 Oryzias latipes 74.10 0.00e+00 979.00
IUUC-Oga-088062 Otolemur garnettii 93.31 0.00e+00 1446.00
IUUC-Oar-089253 Ovis aries 89.86 0.00e+00 1390.00
IUUC-Ptr-090863 Pan troglodytes 94.84 0.00e+00 1632.00
IUUC-Pan-092229 Papio anubis 95.51 0.00e+00 1612.00
IUUC-Psi-094030 Pelodiscus sinensis 86.04 0.00e+00 1500.00
IUUC-Pfo-096851 Poecilia formosa 80.32 0.00e+00 1318.00
IUUC-Pab-097748 Pongo abelii 95.80 0.00e+00 1532.00
IUUC-Ppe-101666 Prunus persica 25.56 1.00e-18 89.00
IUUC-Pva-103063 Pteropus vampyrus 92.82 0.00e+00 1611.00
IUUC-Rno-105875 Rattus norvegicus 99.23 0.00e+00 1730.00
IUUC-Sha-107172 Sarcophilus harrisii 89.49 0.00e+00 1482.00
IUUC-Ssl-108401 Sclerotinia sclerotiorum 22.07 1.00e-15 79.00
IUUC-Smo-109072 Selaginella moellendorffii 33.33 3.00e-13 71.20
IUUC-Sly-111180 Solanum lycopersicum 37.14 3.00e-21 97.40
IUUC-Ssc-116368 Sus scrofa 96.17 0.00e+00 1681.00
IUUC-Tgu-117017 Taeniopygia guttata 85.96 0.00e+00 1315.00
IUUC-Tru-118190 Takifugu rubripes 78.30 0.00e+00 1055.00
IUUC-Tsy-119246 Tarsius syrichta 69.81 1.00e-73 271.00
IUUC-Tni-120276 Tetraodon nigroviridis 73.54 0.00e+00 1057.00
IUUC-Tbe-127370 Tupaia belangeri 83.54 0.00e+00 870.00
IUUC-Ttr-128851 Tursiops truncatus 92.62 0.00e+00 1619.00
IUUC-Uma-129549 Ustilago maydis 31.08 7.00e-27 115.00
IUUC-Xtr-132102 Xenopus tropicalis 79.80 0.00e+00 1353.00
Created Date 25-Jun-2017

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