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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018416
Ensembl Protein ID F15A2.6a
UniProt Accession Q19469; A3FPL0; Q9BMN6; SAD1_CAEEL
Genbank Protein ID AAG50270.1; CAA94127.2; CAM33501.1
Protein Name Serine/threonine kinase SAD-1; Synapses of Amphids Defective
Genbank Nucleotide ID AF316542; Z70207; Z70207
Gene Name sad-1; F15A2.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004719 F15A2.6a F15A2.6a
WBGene00004719 F15A2.6b F15A2.6b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 67.22 5.00e-155 546.00 IUUC-Hsa-046912
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.
 Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.
Protein Sequence
(Fasta)
MFEALKEVLG EINSKLAAVN NELSSKIMSE NIVSTRPVAQ AQYCGPYKLE KTLGKGQTGL 60
VKTGTHCITG RKVAIKIVNK EKLSESVLQK VEREIAIMKL IEHPHVLHLY DVYENKKYLY 120
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Protein Fasta Sequence


>IUUC-Cel-018416|UBD,UBA|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
TGCTCAGGAG CAGAATCAAA AAAAATCCCC GTTTGGAATC CAAGGAAGCT TAAAACTTAG 60
CCGCATGACT GCGCTCGTCA ATCGGGCAAA GTCTGCACAT GTTTGAAGCT CTCAAGGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018416|UBD,UBA|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0770--Synapse
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0030424--C:axon
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0008088--P:axo-dendritic transport
GO:0007411--P:axon guidance
GO:0034613--P:cellular protein localization
GO:0007163--P:establishment or maintenance of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0018105--P:peptidyl-serine phosphorylation
GO:0030516--P:regulation of axon extension
GO:0007416--P:synapse assembly
GO:0050808--P:synapse organization
GO:0048489--P:synaptic vesicle transport
KEGG cel:CELE_F15A2.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003374 Anas platyrhynchos 65.37 1.00e-136 479.00
IUUC-Bta-012608 Bos taurus 66.93 2.00e-149 521.00
IUUC-Cja-019882 Callithrix jacchus 67.71 3.00e-151 527.00
IUUC-Cpo-021604 Cavia porcellus 66.50 2.00e-151 528.00
IUUC-Csv-025996 Ciona savignyi 67.41 1.00e-149 521.00
IUUC-Dre-028706 Danio rerio 66.57 2.00e-136 478.00
IUUC-Dme-031685 Drosophila melanogaster 75.13 2.00e-175 608.00
IUUC-Eca-033483 Equus caballus 66.01 4.00e-134 470.00
IUUC-Fal-037499 Ficedula albicollis 66.57 6.00e-137 479.00
IUUC-Gmo-039305 Gadus morhua 67.09 3.00e-152 531.00
IUUC-Gac-042120 Gasterosteus aculeatus 67.53 9.00e-144 502.00
IUUC-Hsa-046912 Homo sapiens 68.49 1.00e-161 562.00
IUUC-Itr-048825 Ictidomys tridecemlineatus 67.27 1.00e-150 525.00
IUUC-Mcc-055306 Macaca mulatta 67.53 3.00e-151 527.00
IUUC-Mga-059357 Meleagris gallopavo 66.29 1.00e-135 475.00
IUUC-Mmr-061711 Microcebus murinus 60.11 1.00e-113 402.00
IUUC-Mmu-063511 Mus musculus 68.49 3.00e-161 560.00
IUUC-Ont-072425 Oreochromis niloticus 67.74 3.00e-154 537.00
IUUC-Ola-086969 Oryzias latipes 71.63 7.00e-150 523.00
IUUC-Pan-092910 Papio anubis 68.49 9.00e-162 562.00
IUUC-Psi-093857 Pelodiscus sinensis 70.42 1.00e-89 322.00
IUUC-Pfo-097195 Poecilia formosa 68.24 1.00e-155 541.00
IUUC-Rno-105039 Rattus norvegicus 71.95 6.00e-151 526.00
IUUC-Sha-107449 Sarcophilus harrisii 64.18 5.00e-125 440.00
IUUC-Tgu-117372 Taeniopygia guttata 66.29 2.00e-135 474.00
IUUC-Tru-118645 Takifugu rubripes 67.45 1.00e-144 505.00
IUUC-Tni-120483 Tetraodon nigroviridis 70.49 1.00e-152 532.00
IUUC-Tme-126887 Tuber melanosporum 48.77 1.00e-88 318.00
IUUC-Xtr-132457 Xenopus tropicalis 71.35 5.00e-150 523.00
IUUC-Xma-134021 Xiphophorus maculatus 67.70 3.00e-146 510.00
Created Date 25-Jun-2017

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