iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012357

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase BRE1A; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A

Genbank Nucleotide ID

BC133334

Gene Name

RNF20; BRE1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009516.5	ENSBTAT00000012521.5	ENSBTAP00000012521.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	36.13	4.00e-37	153.00	IUUC-Cel-018659
E3 activity/RING/RING	98.05	0.00e+00	1615.00	IUUC-Hsa-046462
E3 activity/RING/RING	43.08	3.00e-14	75.90	IUUC-Spo-108304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation.

Protein Sequence
(Fasta)

MSGIGSKRAA GEPGTSVPPE KKTAVEDSGT TVETIKLGGV SSTEELDIRT LQTKNRKLAE 60
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLEQGLGDL 120

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Nucleotide Sequence
(Fasta)

CCTTGGTGAA TAACTGCCCC GAGTTCCACT CCCGGGCGGC GCAAGTTGGA AGAACTCAGG 60
TCAGATCTCG GCCAAGGGCG GGACGGGACT CAGCGGGCAA CGGGAATCCC CACCCTCTTC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015422--PyrdxlP-dep_Trfase_sub2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0033503--C:HULC complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0002039--F:p53 binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0030336--P:negative regulation of cell migration
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:0031062--P:positive regulation of histone methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:513326

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001976	Ailuropoda melanoleuca	97.95	0.00e+00	1670.00
IUUC-Apl-003407	Anas platyrhynchos	86.65	0.00e+00	945.00
IUUC-Aca-004246	Anolis carolinensis	86.30	0.00e+00	929.00
IUUC-Ago-007988	Ashbya gossypii	31.69	5.00e-15	76.30
IUUC-Acl-008319	Aspergillus clavatus	25.85	4.00e-14	73.60
IUUC-Aor-010142	Aspergillus oryzae	28.00	4.00e-15	77.00
IUUC-Ate-010547	Aspergillus terreus	26.15	3.00e-14	73.90
IUUC-Bgr-012245	Blumeria graminis	41.51	5.00e-10	59.70
IUUC-Bra-017335	Brassica rapa	30.69	1.00e-24	108.00
IUUC-Cel-018659	Caenorhabditis elegans	34.41	6.00e-40	159.00
IUUC-Cja-019244	Callithrix jacchus	97.58	0.00e+00	1008.00
IUUC-Cfa-020320	Canis familiaris	98.15	0.00e+00	1653.00
IUUC-Cpo-021617	Cavia porcellus	94.77	0.00e+00	1675.00
IUUC-Csa-023509	Chlorocebus sabaeus	98.05	0.00e+00	1593.00
IUUC-Cho-024616	Choloepus hoffmanni	80.57	0.00e+00	981.00
IUUC-Cme-027134	Cyanidioschyzon merolae	39.06	1.00e-13	72.00
IUUC-Dno-029537	Dasypus novemcinctus	96.32	0.00e+00	1600.00
IUUC-Dor-030250	Dipodomys ordii	95.38	0.00e+00	1558.00
IUUC-Dse-031300	Dothistroma septosporum	38.46	2.00e-15	77.80
IUUC-Ete-033164	Echinops telfairi	94.39	0.00e+00	1239.00
IUUC-Eca-033347	Equus caballus	98.06	0.00e+00	1633.00
IUUC-Eeu-034801	Erinaceus europaeus	94.05	0.00e+00	644.00
IUUC-Fca-036024	Felis catus	98.15	0.00e+00	1680.00
IUUC-Fal-037622	Ficedula albicollis	87.72	0.00e+00	955.00
IUUC-Gmo-039446	Gadus morhua	77.55	1.00e-132	467.00
IUUC-Ggr-040117	Gaeumannomyces graminis	45.28	2.00e-11	64.30
IUUC-Gga-040412	Gallus gallus	88.64	0.00e+00	902.00
IUUC-Gac-042205	Gasterosteus aculeatus	60.88	4.00e-142	498.00
IUUC-Ggo-044703	Gorilla gorilla	98.15	0.00e+00	1595.00
IUUC-Hsa-046462	Homo sapiens	98.05	0.00e+00	1593.00
IUUC-Itr-048298	Ictidomys tridecemlineatus	98.23	0.00e+00	1616.00
IUUC-Lch-049505	Latimeria chalumnae	75.14	0.00e+00	712.00
IUUC-Loc-051951	Lepisosteus oculatus	63.38	1.00e-112	400.00
IUUC-Lma-053312	Leptosphaeria maculans	28.71	5.00e-15	76.30
IUUC-Laf-054122	Loxodonta africana	96.72	0.00e+00	1609.00
IUUC-Mcc-054647	Macaca mulatta	98.05	0.00e+00	1593.00
IUUC-Meu-056559	Macropus eugenii	92.02	0.00e+00	1471.00
IUUC-Mpo-057568	Magnaporthe poae	45.28	2.00e-11	64.30
IUUC-Mga-059731	Meleagris gallopavo	66.19	6.00e-176	611.00
IUUC-Mmr-061495	Microcebus murinus	97.85	0.00e+00	1669.00
IUUC-Mdo-062599	Monodelphis domestica	93.95	0.00e+00	990.00
IUUC-Mmu-063278	Mus musculus	96.92	0.00e+00	1615.00
IUUC-Mpu-065910	Mustela putorius furo	97.74	0.00e+00	1667.00
IUUC-Mlu-067040	Myotis lucifugus	97.03	0.00e+00	1593.00
IUUC-Ncr-068695	Neurospora crassa	27.31	2.00e-12	67.40
IUUC-Nle-069058	Nomascus leucogenys	97.77	0.00e+00	1008.00
IUUC-Opr-071149	Ochotona princeps	97.24	0.00e+00	1008.00
IUUC-Ocu-074773	Oryctolagus cuniculus	98.36	0.00e+00	1598.00
IUUC-Ola-087287	Oryzias latipes	62.58	0.00e+00	892.00
IUUC-Olu-087683	Ostreococcus lucimarinus	36.36	1.00e-13	68.60
IUUC-Oga-088961	Otolemur garnettii	97.74	0.00e+00	1642.00
IUUC-Oar-089755	Ovis aries	99.38	0.00e+00	1636.00
IUUC-Ptr-091602	Pan troglodytes	98.05	0.00e+00	1593.00
IUUC-Pan-092263	Papio anubis	98.05	0.00e+00	1593.00
IUUC-Psi-093554	Pelodiscus sinensis	88.35	0.00e+00	949.00
IUUC-Pab-098598	Pongo abelii	97.95	0.00e+00	1592.00
IUUC-Pca-100157	Procavia capensis	93.13	0.00e+00	1087.00
IUUC-Pva-102720	Pteropus vampyrus	97.44	0.00e+00	1596.00
IUUC-Rno-104996	Rattus norvegicus	96.93	0.00e+00	1037.00
IUUC-Sha-107000	Sarcophilus harrisii	94.83	0.00e+00	964.00
IUUC-Sja-107993	Schizosaccharomyces japonicus	45.00	1.00e-12	68.20
IUUC-Spo-108304	Schizosaccharomyces pombe	43.08	7.00e-15	75.90
IUUC-Sar-113349	Sorex araneus	96.48	0.00e+00	939.00
IUUC-Ssc-115723	Sus scrofa	98.46	0.00e+00	1636.00
IUUC-Tgu-116549	Taeniopygia guttata	87.69	0.00e+00	886.00
IUUC-Tsy-118808	Tarsius syrichta	95.29	0.00e+00	1180.00
IUUC-Tni-120790	Tetraodon nigroviridis	61.24	0.00e+00	940.00
IUUC-Ttr-128266	Tursiops truncatus	97.95	0.00e+00	1628.00
IUUC-Vpa-130237	Vicugna pacos	98.06	0.00e+00	1668.00
IUUC-Zma-135805	Zea mays	27.42	5.00e-27	116.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence