iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011023

Ensembl Protein ID

ENSAMXP00000020460.1

UniProt Accession

W5LKU8; W5LKU8_ASTMX

Genbank Protein ID

ENSAMXP00000020460

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01024029

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000019740.1	ENSAMXT00000020460.1	ENSAMXP00000020460.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-65	220.5	721	1044

Active Site

Position(s)	Description	Evidence
1015	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 5    lkkrlevefvg..EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           lk  l+v f++  Ee  d    +r+f+ ++ +el  p+ g+f+y+++++  ++p++ s      ++++F  +G l+g+a +++ +++
   Q: 721  LKGCLQVVFSEqkEEIKDV--HKRDFFINVYQELLMPESGMFMYNDSKTLIWFPSEPSL----PEERYFL-FGCLCGLAFYNNSVVN 800
           6778899998877888888..9************************************8....4788995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelyks..lkeikenaesdieelgldltfsvseeilgetkeee.LkpgGenipVtneNkeeY 173
           lp++ +++k+l++++ sledl e+ p l +   l++ +++ ++d++ +++  t+  s  + g+tk+   +  + ++ + +++N++++
   Q: 801  LPFPLALFKKLVNVQPSLEDLTEFSPVLGQIrsLQSTLDYSDEDLQSAEMPYTV--SVLLSGTTKSSTwIQISLRRSSQAQTNRKKF 885
           ***************************987555999999987777776555555..55556666665557888888889999***** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v+++v++ ++ ++++ +e+fr+Gf++v++ ++++lF +eel+ ++ G+ee+d++ lk++ +y+g +++++p+i+ Fwev+ e+s+ +
   Q: 886  VEAYVDHAMNGSVERVFEEFRRGFYKVCDRDVVKLFLPEELRGVMLGSEEYDWDILKQNVTYEGLFHPRHPTIISFWEVFDELSARD 972
           *************************************************************************************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           +kafL F+Tg +r+P+ G++++k   + +r     ++d+lP++ TC ++L+LP Y++ke+lk+kL+ A ++++gF
   Q: 973  KKAFLLFLTGFDRVPVLGMNQVK---MRVRPllFYTQDHLPEALTCHSLLELPVYNTKETLKDKLTEALQHKRGF 1044
           ***********************...556666788999*********************************9998 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MFCWGDASRG QLLLPAAEGH YLPKPTFISI ITEPVVGVSC GENHSLIVAE NGRVFSCGRN 60
SKGQLGRAKS KDTKQPVIEG LGGVAAVACG QEHSLALCDS GQVFSWGAGG EGQLGLSTPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGCAGTAG GAGGCAGCAG GGCTGAGCTC ATTATTGTGA GTCAGTGGAG CTGCTCCTCT 60
CAGATCAGTC AGTGGAGCTT TCTCTCAGCA GCTTCGGGAT GTTCTGCTGG GGAGACGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gmo-038792	Gadus morhua	41.17	0.00e+00	695.00
IUUC-Gac-041342	Gasterosteus aculeatus	44.81	0.00e+00	793.00
IUUC-Loc-052736	Lepisosteus oculatus	46.84	0.00e+00	891.00
IUUC-Ont-071328	Oreochromis niloticus	45.75	0.00e+00	880.00
IUUC-Pfo-096202	Poecilia formosa	46.47	0.00e+00	822.00
IUUC-Tru-117816	Takifugu rubripes	42.74	0.00e+00	770.00
IUUC-Tni-120770	Tetraodon nigroviridis	40.44	0.00e+00	662.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence