iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000007431.1	ENSCJAT00000014687.1	ENSCJAP00000013942.1
ENSCJAG00000007431.1	ENSCJAT00000014674.1	ENSCJAP00000013931.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-60	206.4	328	858
UBD/Alpha-Helix/UBA	2.00e-22	79.6	728	765

Active Site

Position(s)	Description	Evidence
337	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
821	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+ + +   +kl + l                    +k+ +  ++
   Q: 328  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTPRTSAPRAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 415
           7******************************.999999999******999999999999966666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 416  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 475
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaek 219
            ++v+ ++   + ++lpvp++   +k                              +++cLe++ ++e++++   ++++  ++k+ a+k
   Q: 476  TEKVKYTQRVDYIMQLPVPMDAALNKVeelleyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVK 561
           ********************998877699*****************************************97...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                         
   Q: 562  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsph 649
           ********************997.*******************9888878888888888888888888888888888888877777777 PP
   S: 268  ..................................................................................peekqke 274
                                                                                             +     +
   Q: 650  fssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----T 733
           77777777777777777777777777777777777666666666666666666666666666666665555555555555550.....0 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kY+L+a ++H+G s+ +GHY
   Q: 734  ivsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHY 822
           5555555555555566666666667777777777777777777777777778888888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 823  VCHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 858
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 728  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 765
           889999******************************97 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDPTTGTGD PPRKKPTRLA IGVEGGFDLN EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGGAGGGG ACTGGGAACG GTGCGAGCCG CGGTGTGTGG AGAAGCTGCT GCCGGTGTCA 60
TGGCGGAGCT GAGTGAGGAG GCGCTGCTGT CAGTATTACC GACGATCCGG GTTCCTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.08	0.00e+00	640.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.29	0.00e+00	1637.00
IUUC-Atr-002580	Amborella trichopoda	45.77	0.00e+00	731.00
IUUC-Apl-003774	Anas platyrhynchos	90.37	0.00e+00	1507.00
IUUC-Aca-005368	Anolis carolinensis	85.02	0.00e+00	1482.00
IUUC-Aly-005727	Arabidopsis lyrata	46.94	0.00e+00	725.00
IUUC-Ath-006974	Arabidopsis thaliana	47.04	0.00e+00	725.00
IUUC-Ago-007890	Ashbya gossypii	29.13	3.00e-81	296.00
IUUC-Acl-008057	Aspergillus clavatus	33.61	4.00e-121	428.00
IUUC-Afl-008547	Aspergillus flavus	36.03	2.00e-114	406.00
IUUC-Afu-008805	Aspergillus fumigatus	33.82	5.00e-111	395.00
IUUC-Ani-009441	Aspergillus nidulans	31.69	1.00e-94	341.00
IUUC-Ang-009720	Aspergillus niger	33.68	3.00e-116	412.00
IUUC-Aor-010111	Aspergillus oryzae	33.76	2.00e-123	436.00
IUUC-Ate-010531	Aspergillus terreus	31.54	6.00e-100	358.00
IUUC-Ame-011893	Astyanax mexicanus	64.35	0.00e+00	974.00
IUUC-Bgr-012183	Blumeria graminis	32.72	3.00e-118	419.00
IUUC-Bta-013179	Bos taurus	97.06	0.00e+00	1624.00
IUUC-Bci-013858	Botrytis cinerea	34.38	4.00e-127	448.00
IUUC-Bdi-014904	Brachypodium distachyon	46.40	0.00e+00	702.00
IUUC-Bol-015296	Brassica oleracea	47.67	0.00e+00	739.00
IUUC-Bra-017939	Brassica rapa	47.67	0.00e+00	744.00
IUUC-Cel-018625	Caenorhabditis elegans	34.58	3.00e-132	466.00
IUUC-Cfa-020976	Canis familiaris	94.47	0.00e+00	1567.00
IUUC-Cpo-022265	Cavia porcellus	94.48	0.00e+00	1561.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.24	1.00e-109	390.00
IUUC-Csa-024177	Chlorocebus sabaeus	94.82	0.00e+00	1444.00
IUUC-Cho-024702	Choloepus hoffmanni	87.57	0.00e+00	972.00
IUUC-Cin-025411	Ciona intestinalis	49.65	0.00e+00	825.00
IUUC-Csv-026347	Ciona savignyi	45.84	0.00e+00	787.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.32	3.00e-112	399.00
IUUC-Cne-026831	Cryptococcus neoformans	35.48	2.00e-127	449.00
IUUC-Dre-027982	Danio rerio	66.67	0.00e+00	1086.00
IUUC-Dno-029034	Dasypus novemcinctus	97.29	0.00e+00	1645.00
IUUC-Dor-030479	Dipodomys ordii	91.39	0.00e+00	694.00
IUUC-Dse-031467	Dothistroma septosporum	36.17	6.00e-132	464.00
IUUC-Dme-032075	Drosophila melanogaster	48.51	0.00e+00	786.00
IUUC-Ete-032865	Echinops telfairi	86.06	0.00e+00	1445.00
IUUC-Eca-034059	Equus caballus	96.97	0.00e+00	1633.00
IUUC-Eeu-035304	Erinaceus europaeus	91.06	0.00e+00	1472.00
IUUC-Fca-035515	Felis catus	97.18	0.00e+00	1627.00
IUUC-Fal-037271	Ficedula albicollis	86.63	0.00e+00	1402.00
IUUC-Fox-037745	Fusarium oxysporum	34.69	5.00e-127	448.00
IUUC-Fso-038158	Fusarium solani	35.19	4.00e-125	442.00
IUUC-Gmo-039071	Gadus morhua	63.92	0.00e+00	1062.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.99	1.00e-115	410.00
IUUC-Gga-040635	Gallus gallus	89.90	0.00e+00	1572.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.50	0.00e+00	1076.00
IUUC-Gma-043614	Glycine max	46.28	0.00e+00	698.00
IUUC-Ggo-044602	Gorilla gorilla	98.00	0.00e+00	1638.00
IUUC-Hsa-045959	Homo sapiens	98.00	0.00e+00	1638.00
IUUC-Hvu-047563	Hordeum vulgare	46.80	1.00e-167	583.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	97.88	0.00e+00	1630.00
IUUC-Kpa-049156	Komagataella pastoris	33.18	2.00e-114	406.00
IUUC-Lch-049648	Latimeria chalumnae	80.78	0.00e+00	1351.00
IUUC-Lpe-051523	Leersia perrieri	46.09	0.00e+00	707.00
IUUC-Loc-052520	Lepisosteus oculatus	62.08	0.00e+00	1027.00
IUUC-Lma-053216	Leptosphaeria maculans	34.28	1.00e-110	395.00
IUUC-Laf-054327	Loxodonta africana	96.24	0.00e+00	1612.00
IUUC-Mcc-055443	Macaca mulatta	97.88	0.00e+00	1635.00
IUUC-Meu-056298	Macropus eugenii	89.98	0.00e+00	1036.00
IUUC-Mor-057106	Magnaporthe oryzae	34.86	3.00e-128	452.00
IUUC-Mpo-057589	Magnaporthe poae	34.53	9.00e-120	424.00
IUUC-Mtr-058680	Medicago truncatula	47.97	0.00e+00	729.00
IUUC-Mla-058903	Melampsora laricipopulina	32.73	2.00e-120	426.00
IUUC-Mga-059669	Meleagris gallopavo	89.01	0.00e+00	1491.00
IUUC-Mvi-060476	Microbotryum violaceum	34.24	4.00e-118	419.00
IUUC-Mmr-060575	Microcebus murinus	97.29	0.00e+00	1628.00
IUUC-Mdo-062183	Monodelphis domestica	90.71	0.00e+00	1510.00
IUUC-Mmu-063592	Mus musculus	97.06	0.00e+00	1623.00
IUUC-Mac-065634	Musa acuminata	42.70	0.00e+00	683.00
IUUC-Mpu-066082	Mustela putorius furo	93.65	0.00e+00	1552.00
IUUC-Mlu-067345	Myotis lucifugus	96.47	0.00e+00	1617.00
IUUC-Nfi-068558	Neosartorya fischeri	34.68	4.00e-119	422.00
IUUC-Ncr-068960	Neurospora crassa	34.57	1.00e-113	404.00
IUUC-Nle-070173	Nomascus leucogenys	95.29	0.00e+00	1576.00
IUUC-Opr-070556	Ochotona princeps	96.24	0.00e+00	1619.00
IUUC-Ont-071502	Oreochromis niloticus	64.16	0.00e+00	1071.00
IUUC-Ocu-074861	Oryctolagus cuniculus	94.47	0.00e+00	1568.00
IUUC-Oba-075109	Oryza barthii	45.79	0.00e+00	709.00
IUUC-Obr-076292	Oryza brachyantha	47.20	0.00e+00	706.00
IUUC-Ogl-077065	Oryza glaberrima	47.09	0.00e+00	739.00
IUUC-Ogu-078776	Oryza glumaepatula	45.79	0.00e+00	721.00
IUUC-Oin-080048	Oryza indica	46.62	0.00e+00	733.00
IUUC-Olo-080711	Oryza longistaminata	43.95	0.00e+00	652.00
IUUC-Ome-081506	Oryza meridionalis	44.99	0.00e+00	664.00
IUUC-Oni-082320	Oryza nivara	45.26	0.00e+00	709.00
IUUC-Opu-083801	Oryza punctata	45.97	0.00e+00	702.00
IUUC-Oru-085139	Oryza rufipogon	45.26	0.00e+00	709.00
IUUC-Osa-085713	Oryza sativa	47.20	0.00e+00	742.00
IUUC-Ola-086951	Oryzias latipes	64.73	0.00e+00	1064.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.78	5.00e-179	621.00
IUUC-Oga-088625	Otolemur garnettii	97.65	0.00e+00	1621.00
IUUC-Oar-089995	Ovis aries	96.71	0.00e+00	1627.00
IUUC-Ptr-090640	Pan troglodytes	95.65	0.00e+00	1624.00
IUUC-Pan-091974	Papio anubis	98.59	0.00e+00	1647.00
IUUC-Psi-093957	Pelodiscus sinensis	88.76	0.00e+00	1573.00
IUUC-Pma-094242	Petromyzon marinus	70.16	7.00e-161	559.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.72	7.00e-105	375.00
IUUC-Ppa-095901	Physcomitrella patens	48.34	0.00e+00	774.00
IUUC-Pfo-097148	Poecilia formosa	65.62	0.00e+00	1082.00
IUUC-Pab-098068	Pongo abelii	90.35	0.00e+00	1466.00
IUUC-Pop-098943	Populus trichocarpa	46.86	0.00e+00	713.00
IUUC-Pca-100738	Procavia capensis	96.84	0.00e+00	1124.00
IUUC-Ppe-101315	Prunus persica	47.10	0.00e+00	721.00
IUUC-Pva-102154	Pteropus vampyrus	95.41	0.00e+00	1594.00
IUUC-Pgr-103343	Puccinia graminis	33.24	2.00e-106	380.00
IUUC-Ptt-103928	Puccinia triticina	30.15	6.00e-103	368.00
IUUC-Pte-104306	Pyrenophora teres	31.43	1.00e-101	363.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.45	3.00e-104	372.00
IUUC-Rno-105801	Rattus norvegicus	96.71	0.00e+00	1619.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.24	4.00e-72	266.00
IUUC-Sha-107635	Sarcophilus harrisii	89.65	0.00e+00	1516.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.25	3.00e-108	385.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.99	7.00e-111	394.00
IUUC-Smo-108848	Selaginella moellendorffii	47.37	0.00e+00	726.00
IUUC-Sit-110728	Setaria italica	47.56	0.00e+00	762.00
IUUC-Sly-111523	Solanum lycopersicum	47.05	0.00e+00	753.00
IUUC-Sbi-114419	Sorghum bicolor	46.57	0.00e+00	742.00
IUUC-Sre-115225	Sporisorium reilianum	34.87	3.00e-123	436.00
IUUC-Ssc-115686	Sus scrofa	96.82	0.00e+00	1619.00
IUUC-Tgu-117346	Taeniopygia guttata	89.44	0.00e+00	1541.00
IUUC-Tru-118350	Takifugu rubripes	64.28	0.00e+00	1093.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.36	0.00e+00	1080.00
IUUC-Tca-121585	Theobroma cacao	47.28	0.00e+00	716.00
IUUC-Tre-122043	Trichoderma reesei	33.56	8.00e-117	414.00
IUUC-Tvi-122303	Trichoderma virens	33.87	2.00e-122	433.00
IUUC-Tae-125686	Triticum aestivum	46.96	0.00e+00	722.00
IUUC-Tur-126732	Triticum urartu	44.50	0.00e+00	677.00
IUUC-Tme-126909	Tuber melanosporum	34.55	1.00e-116	414.00
IUUC-Tbe-127261	Tupaia belangeri	89.70	0.00e+00	1019.00
IUUC-Uma-129599	Ustilago maydis	33.99	1.00e-125	444.00
IUUC-Vda-129688	Verticillium dahliae	32.91	8.00e-117	414.00
IUUC-Vvi-131116	Vitis vinifera	47.33	0.00e+00	696.00
IUUC-Xtr-131953	Xenopus tropicalis	78.18	0.00e+00	1329.00
IUUC-Xma-133837	Xiphophorus maculatus	65.85	0.00e+00	1087.00
IUUC-Yli-134510	Yarrowia lipolytica	35.37	1.00e-128	453.00
IUUC-Zma-135786	Zea mays	46.69	0.00e+00	709.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence