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Tag Content
iUUCD ID IUUC-Acl-008036
Ensembl Protein ID CADACLAP00008965
UniProt Accession A1CMF8; NACA_ASPCL
Genbank Protein ID EAW08745.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC
Genbank Nucleotide ID DS027058
Gene Name ACLA_096790; egd2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADACLAG00009189 CADACLAT00009189 CADACLAP00008965
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 52.86 1.00e-17 84.00 IUUC-Sce-106371
UBD/Alpha-Helix/UBA 50.00 1.00e-15 77.80 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus clavatus
Functional Description
(View)

Functional Description


     Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity).
 Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity).
Protein Sequence
(Fasta)
MADPRVEELP DEEVPKTNVE DAGSDSESEA GEESSIPSGA AVTIHSRNEK KARKAIGKLG 60
LKHVPGITRV TLRRPKNILF VINQPDVYRS PTSNTWIIFG EAKIEDLNSQ AQASAAQQLA 120
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Protein Fasta Sequence


>IUUC-Acl-008036|UBD,UBA|Aspergillus clavatus
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Nucleotide Sequence
(Fasta)
ATGGCTGATC CCCGTGTTGA AGAGCTCCCC GATGAGGAGG TTCCCAAGAC CAACGTCGAG 60
GACGCTGGCA GCGACTCCGA GTCCGAGGCT GGCGAGGAGA GCAGCATCCC CTCCGGTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Acl-008036|UBD,UBA|Aspergillus clavatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0015031--P:protein transport
KEGG act:ACLA_096790
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001167 Aegilops tauschii 61.54 2.00e-17 80.90
IUUC-Aml-002185 Ailuropoda melanoleuca 48.75 2.00e-27 117.00
IUUC-Atr-002586 Amborella trichopoda 44.12 3.00e-11 60.10
IUUC-Apl-003190 Anas platyrhynchos 62.12 2.00e-21 93.20
IUUC-Aca-005265 Anolis carolinensis 70.31 5.00e-25 105.00
IUUC-Aly-006397 Arabidopsis lyrata 66.67 2.00e-08 50.10
IUUC-Ath-007378 Arabidopsis thaliana 61.54 2.00e-16 77.00
IUUC-Ago-007936 Ashbya gossypii 48.61 5.00e-18 82.00
IUUC-Afl-008462 Aspergillus flavus 89.81 3.00e-47 179.00
IUUC-Afu-008832 Aspergillus fumigatus 97.14 2.00e-42 162.00
IUUC-Ani-009246 Aspergillus nidulans 92.59 6.00e-48 181.00
IUUC-Ang-009808 Aspergillus niger 94.29 2.00e-46 176.00
IUUC-Aor-009972 Aspergillus oryzae 89.81 3.00e-47 179.00
IUUC-Ame-011674 Astyanax mexicanus 70.31 5.00e-25 105.00
IUUC-Bgr-012162 Blumeria graminis 63.64 7.00e-31 125.00
IUUC-Bta-012508 Bos taurus 70.31 4.00e-25 105.00
IUUC-Bci-013643 Botrytis cinerea 65.79 2.00e-33 133.00
IUUC-Bdi-014874 Brachypodium distachyon 61.54 2.00e-17 80.50
IUUC-Bol-015681 Brassica oleracea 59.26 2.00e-17 80.10
IUUC-Bra-017630 Brassica rapa 59.26 2.00e-17 80.10
IUUC-Cel-018111 Caenorhabditis elegans 47.83 2.00e-33 133.00
IUUC-Cja-019846 Callithrix jacchus 48.12 7.00e-30 125.00
IUUC-Cfa-020429 Canis familiaris 70.31 3.00e-25 106.00
IUUC-Cpo-022542 Cavia porcellus 70.31 6.00e-25 105.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 64.29 2.00e-10 57.00
IUUC-Csa-023260 Chlorocebus sabaeus 48.12 4.00e-28 119.00
IUUC-Cho-024869 Choloepus hoffmanni 72.97 1.00e-10 57.40
IUUC-Cin-025166 Ciona intestinalis 49.38 9.00e-32 127.00
IUUC-Csv-026284 Ciona savignyi 69.81 9.00e-20 87.00
IUUC-Cgl-026520 Colletotrichum gloeosporioides 64.86 3.00e-33 133.00
IUUC-Cne-026920 Cryptococcus neoformans 61.64 4.00e-24 102.00
IUUC-Cme-027301 Cyanidioschyzon merolae 58.33 2.00e-19 87.00
IUUC-Dre-028709 Danio rerio 70.31 2.00e-24 106.00
IUUC-Dno-029786 Dasypus novemcinctus 70.31 6.00e-24 105.00
IUUC-Dor-030962 Dipodomys ordii 70.31 6.00e-25 105.00
IUUC-Dme-032061 Drosophila melanogaster 67.19 1.00e-22 97.40
IUUC-Ete-032965 Echinops telfairi 70.27 4.00e-10 56.20
IUUC-Eca-034049 Equus caballus 68.75 2.00e-24 103.00
IUUC-Eeu-034673 Erinaceus europaeus 70.31 4.00e-25 105.00
IUUC-Fca-035429 Felis catus 50.62 5.00e-28 119.00
IUUC-Fal-037006 Ficedula albicollis 70.31 5.00e-25 105.00
IUUC-Fox-037704 Fusarium oxysporum 65.18 2.00e-33 133.00
IUUC-Fso-038247 Fusarium solani 63.96 4.00e-33 132.00
IUUC-Gmo-039002 Gadus morhua 65.62 6.00e-22 95.50
IUUC-Ggr-039888 Gaeumannomyces graminis 62.14 2.00e-46 176.00
IUUC-Gga-040237 Gallus gallus 70.31 5.00e-25 105.00
IUUC-Gac-041800 Gasterosteus aculeatus 70.31 2.00e-24 105.00
IUUC-Gma-043275 Glycine max 65.62 6.00e-23 98.60
IUUC-Ggo-045163 Gorilla gorilla 62.50 1.00e-22 97.80
IUUC-Hsa-045795 Homo sapiens 70.31 7.00e-24 105.00
IUUC-Hvu-047376 Hordeum vulgare 61.54 2.00e-17 80.10
IUUC-Itr-048152 Ictidomys tridecemlineatus 70.31 4.00e-25 105.00
IUUC-Kpa-049166 Komagataella pastoris 56.16 2.00e-19 86.70
IUUC-Lch-050076 Latimeria chalumnae 70.31 3.00e-25 106.00
IUUC-Lpe-051258 Leersia perrieri 62.96 2.00e-19 86.70
IUUC-Loc-052292 Lepisosteus oculatus 70.31 3.00e-24 103.00
IUUC-Lma-053293 Leptosphaeria maculans 71.17 3.00e-38 149.00
IUUC-Laf-054393 Loxodonta africana 62.50 4.00e-23 99.40
IUUC-Mcc-054632 Macaca mulatta 70.31 9.00e-24 104.00
IUUC-Meu-056242 Macropus eugenii 70.31 3.00e-25 106.00
IUUC-Mor-057099 Magnaporthe oryzae 70.00 3.00e-34 135.00
IUUC-Mpo-057543 Magnaporthe poae 62.86 5.00e-27 111.00
IUUC-Mtr-058112 Medicago truncatula 47.80 4.00e-28 115.00
IUUC-Mla-059166 Melampsora laricipopulina 50.77 2.00e-14 70.10
IUUC-Mga-059406 Meleagris gallopavo 70.31 2.00e-24 103.00
IUUC-Mvi-060390 Microbotryum violaceum 38.06 1.00e-21 94.00
IUUC-Mmr-061569 Microcebus murinus 70.31 4.00e-25 106.00
IUUC-Mdo-062077 Monodelphis domestica 70.31 3.00e-24 105.00
IUUC-Mmu-063984 Mus musculus 70.31 4.00e-24 106.00
IUUC-Mac-065175 Musa acuminata 64.81 1.00e-19 87.80
IUUC-Mpu-066751 Mustela putorius furo 51.25 1.00e-27 117.00
IUUC-Mlu-068234 Myotis lucifugus 70.31 4.00e-25 105.00
IUUC-Nfi-068541 Neosartorya fischeri 97.14 2.00e-42 162.00
IUUC-Ncr-068830 Neurospora crassa 72.07 6.00e-37 145.00
IUUC-Nle-069126 Nomascus leucogenys 70.31 6.00e-25 105.00
IUUC-Opr-070742 Ochotona princeps 70.31 5.00e-25 105.00
IUUC-Ont-071828 Oreochromis niloticus 70.31 1.00e-24 104.00
IUUC-Oan-073462 Ornithorhynchus anatinus 70.31 8.00e-24 104.00
IUUC-Ocu-074890 Oryctolagus cuniculus 47.50 1.00e-27 117.00
IUUC-Oba-075995 Oryza barthii 48.32 1.00e-27 114.00
IUUC-Obr-076073 Oryza brachyantha 48.32 5.00e-28 115.00
IUUC-Ogl-077445 Oryza glaberrima 48.32 1.00e-27 114.00
IUUC-Ogu-078606 Oryza glumaepatula 48.32 1.00e-27 114.00
IUUC-Oin-079287 Oryza indica 48.32 1.00e-27 114.00
IUUC-Olo-080686 Oryza longistaminata 45.21 9.00e-15 71.60
IUUC-Ome-081567 Oryza meridionalis 37.66 7.00e-22 94.70
IUUC-Oni-082873 Oryza nivara 48.32 1.00e-27 114.00
IUUC-Opu-083488 Oryza punctata 62.96 3.00e-19 86.30
IUUC-Oru-084592 Oryza rufipogon 48.32 1.00e-27 114.00
IUUC-Osa-086102 Oryza sativa 48.32 1.00e-27 114.00
IUUC-Ola-087531 Oryzias latipes 72.97 1.00e-10 58.20
IUUC-Olu-087895 Ostreococcus lucimarinus 56.00 2.00e-14 69.30
IUUC-Oga-088239 Otolemur garnettii 70.31 4.00e-25 105.00
IUUC-Oar-089723 Ovis aries 70.31 3.00e-24 107.00
IUUC-Ptr-090481 Pan troglodytes 51.25 6.00e-27 115.00
IUUC-Pan-092210 Papio anubis 48.12 9.00e-28 118.00
IUUC-Psi-093588 Pelodiscus sinensis 70.31 4.00e-25 105.00
IUUC-Pma-094702 Petromyzon marinus 70.31 6.00e-25 105.00
IUUC-Pno-094927 Phaeosphaeria nodorum 72.07 6.00e-39 151.00
IUUC-Ppa-095389 Physcomitrella patens 67.74 6.00e-22 95.10
IUUC-Pfo-096744 Poecilia formosa 70.31 6.00e-25 105.00
IUUC-Pab-098044 Pongo abelii 70.31 4.00e-25 105.00
IUUC-Pop-099938 Populus trichocarpa 64.81 5.00e-20 89.00
IUUC-Pca-100355 Procavia capensis 47.20 1.00e-27 117.00
IUUC-Ppe-101786 Prunus persica 48.32 6.00e-28 115.00
IUUC-Pva-102494 Pteropus vampyrus 70.31 4.00e-25 105.00
IUUC-Pgr-103303 Puccinia graminis 60.00 2.00e-19 86.70
IUUC-Ptt-103748 Puccinia triticina 59.09 3.00e-11 59.70
IUUC-Pte-104368 Pyrenophora teres 71.17 4.00e-38 149.00
IUUC-Pyt-104542 Pyrenophora triticirepentis 70.27 1.00e-37 147.00
IUUC-Rno-105387 Rattus norvegicus 70.31 4.00e-24 106.00
IUUC-Sce-106371 Saccharomyces cerevisiae 51.39 8.00e-19 84.70
IUUC-Sha-107189 Sarcophilus harrisii 70.31 4.00e-25 105.00
IUUC-Sja-107942 Schizosaccharomyces japonicus 47.22 9.00e-16 74.30
IUUC-Spo-108121 Schizosaccharomyces pombe 46.15 2.00e-29 119.00
IUUC-Ssl-108595 Sclerotinia sclerotiorum 62.28 2.00e-35 139.00
IUUC-Smo-108783 Selaginella moellendorffii 47.65 2.00e-26 110.00
IUUC-Sit-109728 Setaria italica 61.11 4.00e-18 82.40
IUUC-Sly-110957 Solanum lycopersicum 63.46 6.00e-18 82.00
IUUC-Stu-112873 Solanum tuberosum 61.54 4.00e-17 79.30
IUUC-Sar-113668 Sorex araneus 72.97 2.00e-10 57.40
IUUC-Sbi-114223 Sorghum bicolor 61.54 9.00e-18 81.60
IUUC-Sre-115220 Sporisorium reilianum 56.72 5.00e-19 85.50
IUUC-Ssc-116119 Sus scrofa 70.31 4.00e-25 105.00
IUUC-Tgu-116528 Taeniopygia guttata 70.31 4.00e-25 105.00
IUUC-Tru-117538 Takifugu rubripes 70.31 4.00e-25 105.00
IUUC-Tsy-118855 Tarsius syrichta 72.97 2.00e-10 57.00
IUUC-Tni-120134 Tetraodon nigroviridis 70.31 6.00e-25 105.00
IUUC-Tca-121524 Theobroma cacao 47.65 6.00e-28 115.00
IUUC-Tre-121915 Trichoderma reesei 61.40 1.00e-30 124.00
IUUC-Tvi-122411 Trichoderma virens 60.91 5.00e-27 112.00
IUUC-Tae-124851 Triticum aestivum 61.54 2.00e-17 80.50
IUUC-Tur-126821 Triticum urartu 61.54 3.00e-17 79.70
IUUC-Tme-126875 Tuber melanosporum 70.00 8.00e-34 134.00
IUUC-Tbe-127759 Tupaia belangeri 67.57 5.00e-09 52.40
IUUC-Ttr-129124 Tursiops truncatus 53.21 5.00e-28 118.00
IUUC-Uma-129551 Ustilago maydis 43.93 1.00e-19 87.40
IUUC-Vda-129992 Verticillium dahliae 66.34 5.00e-48 181.00
IUUC-Vpa-130096 Vicugna pacos 67.19 5.00e-22 95.50
IUUC-Vvi-130940 Vitis vinifera 63.46 2.00e-16 77.40
IUUC-Xtr-132454 Xenopus tropicalis 70.31 1.00e-24 104.00
IUUC-Xma-133842 Xiphophorus maculatus 70.31 8.00e-25 105.00
IUUC-Yli-134485 Yarrowia lipolytica 35.85 5.00e-16 75.50
IUUC-Zma-135748 Zea mays 61.11 5.00e-18 82.40
Created Date 25-Jun-2017

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