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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063504
Ensembl Protein ID ENSMUSP00000041915.6
UniProt Accession Q8BYR2; B2RY46; Q9Z0W4; LATS1_MOUSE
Genbank Protein ID AAI58093.1; AAI58124.1; BAC30063.1; AAD16883.1
Protein Name Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase
Genbank Nucleotide ID BC158092; BC158123; AK038612; AF104414
Gene Name Lats1; Warts
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040021.12 ENSMUST00000040043.6 ENSMUSP00000041915.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRNAMapRAID2
Protein-protein Interaction
IIDPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 9988269; 21212414; 21233212; 25350971
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 3.50e-06 28.1 102 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++ + l++ GFd++ ++qaL+ + n ++eaAve++ 
   Q: 102  NPQMFQDLQAAGFDEDMVIQALQKTnNRSIEAAVEFIS 139
           67899*******************99*********975 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.
 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.
Protein Sequence
(Fasta)
MKRGEKPEGY RQMRPKTFPA SNYPGSSRQM LQEIRESLRN LSKPSDASKA EHNLNKMSTE 60
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETSSSRSPSE VNPQMFQDLQ AAGFDEDMVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063504|UBD,UBA|Mus musculus
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Nucleotide Sequence
(Fasta)
GACACGGAGT GGAAGGCAAA ATGGCGGCGG CAGCGATGGC CTGGTGCTGA GGGGAGAGCC 60
AGGTCCTCGC GACCCCGCGT CGGGCCGCGC TGGCCGGCCG CAGCCCCCCG GCGTGTGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063504|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor
Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0030331--F:estrogen receptor binding
GO:0000287--F:magnesium ion binding
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0034613--P:cellular protein localization
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0006468--P:protein phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0046620--P:regulation of organ growth
GO:0043254--P:regulation of protein complex assembly
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation
KEGG mmu:16798
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001895 Ailuropoda melanoleuca 92.57 0.00e+00 1932.00
IUUC-Apl-003278 Anas platyrhynchos 81.81 0.00e+00 1749.00
IUUC-Aca-005319 Anolis carolinensis 80.28 0.00e+00 1691.00
IUUC-Ame-011324 Astyanax mexicanus 84.72 0.00e+00 941.00
IUUC-Bta-013438 Bos taurus 91.86 0.00e+00 1871.00
IUUC-Cel-018517 Caenorhabditis elegans 50.11 2.00e-129 456.00
IUUC-Cja-019072 Callithrix jacchus 93.09 0.00e+00 1968.00
IUUC-Cfa-021267 Canis familiaris 92.03 0.00e+00 1945.00
IUUC-Cpo-021496 Cavia porcellus 88.16 0.00e+00 1627.00
IUUC-Csa-023255 Chlorocebus sabaeus 93.36 0.00e+00 1937.00
IUUC-Cho-024461 Choloepus hoffmanni 97.60 0.00e+00 781.00
IUUC-Cin-025264 Ciona intestinalis 64.49 5.00e-141 494.00
IUUC-Dre-028034 Danio rerio 80.61 0.00e+00 932.00
IUUC-Dno-029888 Dasypus novemcinctus 89.39 0.00e+00 1924.00
IUUC-Dor-030144 Dipodomys ordii 82.40 0.00e+00 1637.00
IUUC-Dme-031656 Drosophila melanogaster 74.82 0.00e+00 657.00
IUUC-Ete-032813 Echinops telfairi 92.37 0.00e+00 1208.00
IUUC-Eca-033781 Equus caballus 91.86 0.00e+00 1894.00
IUUC-Eeu-035007 Erinaceus europaeus 89.47 0.00e+00 1906.00
IUUC-Fca-036142 Felis catus 88.13 0.00e+00 1824.00
IUUC-Fal-036626 Ficedula albicollis 81.90 0.00e+00 1756.00
IUUC-Gmo-038688 Gadus morhua 86.46 0.00e+00 786.00
IUUC-Gga-040553 Gallus gallus 82.41 0.00e+00 1761.00
IUUC-Gac-042031 Gasterosteus aculeatus 63.37 0.00e+00 1241.00
IUUC-Ggo-045242 Gorilla gorilla 93.20 0.00e+00 1942.00
IUUC-Hsa-046081 Homo sapiens 93.10 0.00e+00 1941.00
IUUC-Itr-048668 Ictidomys tridecemlineatus 92.56 0.00e+00 1636.00
IUUC-Lch-049425 Latimeria chalumnae 76.50 0.00e+00 1645.00
IUUC-Loc-052418 Lepisosteus oculatus 66.67 0.00e+00 1342.00
IUUC-Laf-053710 Loxodonta africana 90.81 0.00e+00 1900.00
IUUC-Mcc-055079 Macaca mulatta 93.10 0.00e+00 1932.00
IUUC-Mga-059713 Meleagris gallopavo 81.65 0.00e+00 1756.00
IUUC-Mmr-061728 Microcebus murinus 92.48 0.00e+00 1947.00
IUUC-Mdo-061942 Monodelphis domestica 85.06 0.00e+00 1775.00
IUUC-Mpu-066034 Mustela putorius furo 92.56 0.00e+00 1928.00
IUUC-Mlu-067986 Myotis lucifugus 90.79 0.00e+00 1910.00
IUUC-Nle-069202 Nomascus leucogenys 93.36 0.00e+00 1945.00
IUUC-Opr-070801 Ochotona princeps 93.33 0.00e+00 1268.00
IUUC-Ont-072487 Oreochromis niloticus 60.66 0.00e+00 1214.00
IUUC-Oan-073128 Ornithorhynchus anatinus 85.25 0.00e+00 1571.00
IUUC-Ocu-073998 Oryctolagus cuniculus 92.47 0.00e+00 1394.00
IUUC-Ola-086858 Oryzias latipes 59.47 0.00e+00 1157.00
IUUC-Oga-088874 Otolemur garnettii 90.64 0.00e+00 1860.00
IUUC-Oar-089236 Ovis aries 91.87 0.00e+00 1879.00
IUUC-Ptr-091425 Pan troglodytes 93.27 0.00e+00 1944.00
IUUC-Pan-091851 Papio anubis 93.20 0.00e+00 1935.00
IUUC-Psi-093825 Pelodiscus sinensis 83.11 0.00e+00 1452.00
IUUC-Pfo-096326 Poecilia formosa 61.16 0.00e+00 1160.00
IUUC-Pab-097815 Pongo abelii 93.27 0.00e+00 1945.00
IUUC-Pva-102836 Pteropus vampyrus 90.80 0.00e+00 1821.00
IUUC-Ptt-103762 Puccinia triticina 37.98 4.00e-93 336.00
IUUC-Rno-106053 Rattus norvegicus 96.19 0.00e+00 2000.00
IUUC-Sha-106843 Sarcophilus harrisii 85.99 0.00e+00 1805.00
IUUC-Sar-113649 Sorex araneus 90.71 0.00e+00 1496.00
IUUC-Ssc-115486 Sus scrofa 95.71 0.00e+00 846.00
IUUC-Tgu-116903 Taeniopygia guttata 81.28 0.00e+00 1734.00
IUUC-Tru-118760 Takifugu rubripes 63.76 0.00e+00 1272.00
IUUC-Tsy-119361 Tarsius syrichta 92.02 0.00e+00 1667.00
IUUC-Tni-120058 Tetraodon nigroviridis 60.05 0.00e+00 1143.00
IUUC-Tbe-127681 Tupaia belangeri 92.09 0.00e+00 1525.00
IUUC-Ttr-128652 Tursiops truncatus 91.78 0.00e+00 1590.00
IUUC-Vpa-130538 Vicugna pacos 90.80 0.00e+00 1866.00
IUUC-Xtr-132895 Xenopus tropicalis 70.59 0.00e+00 1252.00
Created Date 25-Jun-2017

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