iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049801

Ensembl Protein ID

ENSLACP00000016112.1

UniProt Accession

H3B2J1; H3B2J1_LATCH

Genbank Protein ID

ENSLACP00000016112

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01039339

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000014191.1	ENSLACT00000016224.1	ENSLACP00000016112.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-127	424.5	299	631

Active Site

Position(s)	Description	Evidence
600	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 299  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNVYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 386
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 387  GFTLPFYKQLLGKPIQLSDLELVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYVN 471
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G  +id++d+k++t+ k+ + +ds+ ++wFw+++e+f++e r ++LqFv
   Q: 472  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLGKIDLNDWKANTRLKH-CVADSNIVRWFWQAVEAFTEERRGRLLQFV 559
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+++e+l+ekLl+A+eet gF +
   Q: 560  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYETYEKLYEKLLTAVEETCGFAV 631
           ***************************99999**************************************76 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

RVLVSLQTRD RIGTGGGPVV DCRGLVENEG PPPPHPRPPS CAVKCKLYRN AETSKTPFER 60
FERPVYDETG PGRPLSCYME EPAPYTDNTG AAGGGNCRLV ESPNGEQRVQ LQRVRNQEVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGTTTTAG TAAGTTTACA GACCCGGGAC AGGATTGGTA CAGGAGGCGG CCCTGTTGTG 60
GACTGCAGAG GGCTAGTAGA AAATGAAGGG TAGGTAATGG TCAGGTGTAG TAGAATTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eeu-034705	Erinaceus europaeus	93.13	0.00e+00	885.00
IUUC-Gmo-039486	Gadus morhua	80.49	0.00e+00	865.00
IUUC-Mcc-055479	Macaca mulatta	85.85	0.00e+00	1108.00
IUUC-Psi-094074	Pelodiscus sinensis	93.00	0.00e+00	1067.00
IUUC-Pca-100379	Procavia capensis	68.32	3.00e-169	588.00
IUUC-Tni-120829	Tetraodon nigroviridis	76.58	0.00e+00	967.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence