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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046220
Ensembl Protein ID ENSP00000335083.5
UniProt Accession Q9Y2T4; A8MSY7; B7Z3Y1; Q7Z4V7; Q8NEC4; Q9H3G7; 2ABG_HUMAN
Genbank Protein ID AAD20987.1; AAG39636.1; AAP97279.1; BAG52658.1; BAH12367.1; BAH14374.1; EAW82393.1; EAW82394.1; EAW82395.1; AAH32954.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; IMYPNO1; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B isoform gamma
Genbank Nucleotide ID AH007514; AF086924; AF145027; AK093115; AK296474; AK316003; AC093323; CH471131; CH471131; BC032954
Gene Name PPP2R2C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000074211.13 ENST00000335585.9 ENSP00000335083.5
ENSG00000074211.13 ENST00000506140.5 ENSP00000423649.1
ENSG00000074211.13 ENST00000515571.5 ENSP00000422374.1
ENSG00000074211.13 ENST00000382599.8 ENSP00000372042.4
ENSG00000074211.13 ENST00000509917.1 ENSP00000423650.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.80e-09 38.1 344 366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 9    laf..sdtllvsGsdDgtikvWD 29
           +a+  sd  + +G++++  +++D
   Q: 344  CAWngSDSVIMTGAYNNFFRMFD 366
           789988899***********999 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with IER5 (PubMed:25816751).
 PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with IER5 (PubMed:25816751).
Protein Sequence
(Fasta)
MGLSFFSKHL PIQEGQPWAL KTPADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 60
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046220|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTGCCAGCTC AATGGGGCCG CCGACCTCGA AGTTTCCGAA GGTAAGCGCG GGCTGCAGGG 60
CGCCCGGCCC CGCCGCTCCG GAGCCGCCTC GCGCCCACCC CGCCTCACCC CCAGCCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046220|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0032502--P:developmental process
GO:0000278--P:mitotic cell cycle
GO:0070262--P:peptidyl-serine dephosphorylation
KEGG hsa:5522
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001952 Ailuropoda melanoleuca 99.53 0.00e+00 861.00
IUUC-Apl-003518 Anas platyrhynchos 95.54 0.00e+00 858.00
IUUC-Aca-004784 Anolis carolinensis 94.37 0.00e+00 849.00
IUUC-Bta-012526 Bos taurus 99.76 0.00e+00 862.00
IUUC-Cja-019220 Callithrix jacchus 98.88 0.00e+00 901.00
IUUC-Cfa-020411 Canis familiaris 99.30 0.00e+00 862.00
IUUC-Cpo-021405 Cavia porcellus 98.34 0.00e+00 795.00
IUUC-Csa-024031 Chlorocebus sabaeus 99.77 0.00e+00 864.00
IUUC-Dno-029554 Dasypus novemcinctus 94.67 0.00e+00 820.00
IUUC-Dor-030927 Dipodomys ordii 96.57 0.00e+00 711.00
IUUC-Eca-033640 Equus caballus 99.53 0.00e+00 862.00
IUUC-Fca-035956 Felis catus 98.60 0.00e+00 861.00
IUUC-Fal-037093 Ficedula albicollis 96.24 0.00e+00 867.00
IUUC-Gmo-039583 Gadus morhua 90.59 0.00e+00 791.00
IUUC-Gga-040834 Gallus gallus 96.70 0.00e+00 868.00
IUUC-Gac-042030 Gasterosteus aculeatus 92.24 0.00e+00 827.00
IUUC-Ggo-045066 Gorilla gorilla 99.55 0.00e+00 908.00
IUUC-Lch-050296 Latimeria chalumnae 93.66 0.00e+00 799.00
IUUC-Loc-052052 Lepisosteus oculatus 91.16 0.00e+00 801.00
IUUC-Mcc-055825 Macaca mulatta 99.78 0.00e+00 909.00
IUUC-Mga-059692 Meleagris gallopavo 96.48 0.00e+00 868.00
IUUC-Mmr-060722 Microcebus murinus 99.30 0.00e+00 860.00
IUUC-Mdo-062050 Monodelphis domestica 97.64 0.00e+00 849.00
IUUC-Mmu-063242 Mus musculus 99.06 0.00e+00 860.00
IUUC-Mpu-066882 Mustela putorius furo 98.83 0.00e+00 859.00
IUUC-Nle-069955 Nomascus leucogenys 99.78 0.00e+00 911.00
IUUC-Ont-071241 Oreochromis niloticus 92.27 0.00e+00 807.00
IUUC-Ola-086428 Oryzias latipes 92.04 0.00e+00 828.00
IUUC-Oga-088934 Otolemur garnettii 98.21 0.00e+00 894.00
IUUC-Oar-090059 Ovis aries 99.53 0.00e+00 864.00
IUUC-Ptr-091614 Pan troglodytes 99.78 0.00e+00 910.00
IUUC-Psi-093342 Pelodiscus sinensis 97.17 0.00e+00 868.00
IUUC-Pfo-096689 Poecilia formosa 91.49 0.00e+00 813.00
IUUC-Pab-097639 Pongo abelii 100.00 0.00e+00 849.00
IUUC-Pva-102818 Pteropus vampyrus 97.87 0.00e+00 844.00
IUUC-Rno-104944 Rattus norvegicus 92.72 0.00e+00 780.00
IUUC-Sha-106645 Sarcophilus harrisii 93.74 0.00e+00 858.00
IUUC-Tgu-116485 Taeniopygia guttata 96.47 0.00e+00 868.00
IUUC-Tru-117923 Takifugu rubripes 91.80 0.00e+00 827.00
IUUC-Tni-119977 Tetraodon nigroviridis 90.63 0.00e+00 806.00
IUUC-Ttr-128547 Tursiops truncatus 99.76 0.00e+00 860.00
IUUC-Xtr-132255 Xenopus tropicalis 93.50 0.00e+00 851.00
Created Date 25-Jun-2017

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