iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049674

Ensembl Protein ID

ENSLACP00000000536.1

UniProt Accession

H2ZT15; H2ZT15_LATCH

Genbank Protein ID

ENSLACP00000000536

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AFYH01181905

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000000475.1	ENSLACT00000000538.1	ENSLACP00000000536.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-43	144.3	145	177
UBD/Beta-Prp	2.80e-62	210.8	15	290

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gHt  v+cl+f +d + l+s++dD+++k+WDl+
   Q: 145  GHTQAVRCLRFsPDgKWLASAGDDNSVKLWDLS 177
           8***********999****************86 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v   ++++l+atg++d ++ +w+v +++++ sl gh+ +v +++fs  +++ v gs+ + ++vwdl++ k+++tl g
   Q: 15   EIVAHTSNVSCLVLGRNSSQLMATGGEDCRVNLWSVNKPNCIMSLTGHTTPVESIRFSAAEELVVAGSQSGSLRVWDLEAAKIFRTLMG 103
           667788888888888************************************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++l+sGs d  +++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D+ v+lWdl+ gk++ ++ + ht+
   Q: 104  HKANICSLDFHPYGEYLASGSMDTNVKLWDIRRKGCVF-RYKGHTQAVRCLRFSPDGKWLASAGDDNSVKLWDLSGGKMMAEFME-HTG 190
           *************************************9.9*******************************************99.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
           +v+ ++f++n   l+sgs+d+tv++wdl++ ++v  ++g t+ v+s++f p++  l sg++D s+r++  +   +  ++  +  +v   
   Q: 191  PVNIIEFHPNEYLLASGSCDRTVRFWDLEKFQMVSCVEGETSAVRSIAFNPDGCCLFSGAQD-SLRVYGWEPECCFDVVPVSWGKVAD- 277
           ***********************************************************977.5666655555555555553333333. PP
   S: 271  avlsfgdnvlvlgse 285
             l + +n l+++s+
   Q: 278  --LAIRNNQLIAASF 290
           ..3336666666665 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MAASGATKTS WKLQEIVAHT SNVSCLVLGR NSSQLMATGG EDCRVNLWSV NKPNCIMSLT 60
GHTTPVESIR FSAAEELVVA GSQSGSLRVW DLEAAKIFRT LMGHKANICS LDFHPYGEYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTTCTGA TCCGCTGTTG TATATTTTTT CCCTTTAGGC CACACTGAGT TACACCAGGA 60
GGGACTGATT CTGACCTTTC TGCTCTGATT ATTAGCTCCA CCACTACAAA CCCATTTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0030901--P:midbrain development
GO:0007067--P:mitotic nuclear division

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.62	1.00e-87	318.00
IUUC-Aml-002187	Ailuropoda melanoleuca	65.21	0.00e+00	829.00
IUUC-Atr-002899	Amborella trichopoda	54.79	4.00e-105	375.00
IUUC-Apl-003305	Anas platyrhynchos	66.09	0.00e+00	860.00
IUUC-Aca-004635	Anolis carolinensis	67.81	0.00e+00	827.00
IUUC-Aly-005711	Arabidopsis lyrata	52.33	6.00e-105	375.00
IUUC-Ath-007606	Arabidopsis thaliana	52.33	8.00e-105	374.00
IUUC-Ame-010870	Astyanax mexicanus	57.95	2.00e-98	352.00
IUUC-Bta-012527	Bos taurus	68.87	0.00e+00	875.00
IUUC-Bdi-014652	Brachypodium distachyon	53.00	2.00e-105	376.00
IUUC-Bol-016374	Brassica oleracea	51.50	9.00e-103	367.00
IUUC-Bra-017390	Brassica rapa	52.35	6.00e-103	368.00
IUUC-Cja-019706	Callithrix jacchus	67.55	0.00e+00	840.00
IUUC-Cfa-020139	Canis familiaris	61.85	5.00e-157	547.00
IUUC-Cpo-021710	Cavia porcellus	68.28	0.00e+00	851.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	43.00	3.00e-70	259.00
IUUC-Csa-023546	Chlorocebus sabaeus	67.40	0.00e+00	808.00
IUUC-Cin-025156	Ciona intestinalis	39.19	1.00e-141	496.00
IUUC-Csv-025962	Ciona savignyi	49.31	2.00e-87	315.00
IUUC-Dre-028215	Danio rerio	64.51	0.00e+00	857.00
IUUC-Dno-029314	Dasypus novemcinctus	66.96	0.00e+00	837.00
IUUC-Dor-030482	Dipodomys ordii	68.14	0.00e+00	879.00
IUUC-Dme-032188	Drosophila melanogaster	40.86	3.00e-60	226.00
IUUC-Eca-034143	Equus caballus	66.81	0.00e+00	841.00
IUUC-Fca-035924	Felis catus	67.55	0.00e+00	862.00
IUUC-Fal-037387	Ficedula albicollis	65.93	0.00e+00	863.00
IUUC-Gmo-038692	Gadus morhua	63.29	2.00e-156	545.00
IUUC-Gga-040597	Gallus gallus	66.32	0.00e+00	898.00
IUUC-Gac-042004	Gasterosteus aculeatus	64.75	5.00e-164	570.00
IUUC-Gma-044134	Glycine max	53.33	4.00e-103	369.00
IUUC-Ggo-044761	Gorilla gorilla	67.40	0.00e+00	826.00
IUUC-Hsa-045698	Homo sapiens	67.55	0.00e+00	843.00
IUUC-Hvu-047649	Hordeum vulgare	52.67	3.00e-105	376.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	68.28	0.00e+00	841.00
IUUC-Lpe-051554	Leersia perrieri	47.62	2.00e-109	390.00
IUUC-Loc-052623	Lepisosteus oculatus	69.13	0.00e+00	905.00
IUUC-Laf-054587	Loxodonta africana	67.69	0.00e+00	890.00
IUUC-Mcc-055851	Macaca mulatta	67.40	0.00e+00	826.00
IUUC-Meu-056704	Macropus eugenii	68.53	0.00e+00	922.00
IUUC-Mtr-058053	Medicago truncatula	53.00	5.00e-107	382.00
IUUC-Mga-059608	Meleagris gallopavo	66.02	0.00e+00	879.00
IUUC-Mmr-061154	Microcebus murinus	66.81	0.00e+00	840.00
IUUC-Mdo-062365	Monodelphis domestica	66.96	0.00e+00	878.00
IUUC-Mmu-063754	Mus musculus	67.30	0.00e+00	850.00
IUUC-Mac-064667	Musa acuminata	54.42	7.00e-105	374.00
IUUC-Mpu-066245	Mustela putorius furo	67.84	0.00e+00	844.00
IUUC-Mlu-067692	Myotis lucifugus	68.24	0.00e+00	866.00
IUUC-Nle-070051	Nomascus leucogenys	65.99	0.00e+00	822.00
IUUC-Opr-070855	Ochotona princeps	68.28	0.00e+00	855.00
IUUC-Ont-071883	Oreochromis niloticus	63.92	2.00e-162	565.00
IUUC-Oan-073293	Ornithorhynchus anatinus	69.86	0.00e+00	816.00
IUUC-Ocu-074644	Oryctolagus cuniculus	68.72	0.00e+00	862.00
IUUC-Oba-075448	Oryza barthii	51.07	7.00e-108	385.00
IUUC-Obr-076385	Oryza brachyantha	47.09	6.00e-108	385.00
IUUC-Ogl-077427	Oryza glaberrima	53.67	1.00e-107	384.00
IUUC-Ogu-079022	Oryza glumaepatula	49.51	1.00e-100	360.00
IUUC-Oin-079811	Oryza indica	53.24	1.00e-104	374.00
IUUC-Olo-080245	Oryza longistaminata	53.24	1.00e-104	374.00
IUUC-Ome-081239	Oryza meridionalis	53.40	2.00e-104	373.00
IUUC-Oni-082640	Oryza nivara	51.07	7.00e-108	385.00
IUUC-Opu-083748	Oryza punctata	54.00	7.00e-108	384.00
IUUC-Oru-084609	Oryza rufipogon	51.07	7.00e-108	385.00
IUUC-Osa-086267	Oryza sativa	49.84	9.00e-101	361.00
IUUC-Ola-087483	Oryzias latipes	65.31	4.00e-161	561.00
IUUC-Oga-087964	Otolemur garnettii	68.28	0.00e+00	879.00
IUUC-Oar-089483	Ovis aries	67.40	0.00e+00	829.00
IUUC-Ptr-091387	Pan troglodytes	67.55	0.00e+00	843.00
IUUC-Pan-092623	Papio anubis	67.40	0.00e+00	826.00
IUUC-Psi-093830	Pelodiscus sinensis	68.38	0.00e+00	899.00
IUUC-Pma-094135	Petromyzon marinus	51.04	1.00e-28	119.00
IUUC-Ppa-095379	Physcomitrella patens	54.11	4.00e-99	355.00
IUUC-Pfo-096755	Poecilia formosa	59.48	0.00e+00	816.00
IUUC-Pab-097564	Pongo abelii	65.52	0.00e+00	715.00
IUUC-Pop-099149	Populus trichocarpa	53.33	4.00e-107	382.00
IUUC-Pca-100357	Procavia capensis	80.95	1.00e-107	383.00
IUUC-Ppe-101237	Prunus persica	53.33	1.00e-106	380.00
IUUC-Pva-102397	Pteropus vampyrus	64.32	0.00e+00	800.00
IUUC-Rno-105349	Rattus norvegicus	68.43	0.00e+00	879.00
IUUC-Smo-109379	Selaginella moellendorffii	54.83	3.00e-104	372.00
IUUC-Sit-110360	Setaria italica	48.39	2.00e-108	387.00
IUUC-Sly-111307	Solanum lycopersicum	53.33	8.00e-102	364.00
IUUC-Stu-112053	Solanum tuberosum	52.86	6.00e-103	368.00
IUUC-Sar-112953	Sorex araneus	69.30	5.00e-92	331.00
IUUC-Sbi-114389	Sorghum bicolor	46.98	1.00e-93	337.00
IUUC-Ssc-115949	Sus scrofa	64.01	1.00e-176	612.00
IUUC-Tgu-117461	Taeniopygia guttata	66.47	0.00e+00	899.00
IUUC-Tru-117865	Takifugu rubripes	58.65	0.00e+00	796.00
IUUC-Tsy-119036	Tarsius syrichta	78.74	3.00e-57	216.00
IUUC-Tni-120903	Tetraodon nigroviridis	61.41	8.00e-149	520.00
IUUC-Tca-121185	Theobroma cacao	52.33	3.00e-104	373.00
IUUC-Tae-125307	Triticum aestivum	51.44	8.00e-106	378.00
IUUC-Tur-126181	Triticum urartu	47.80	5.00e-94	338.00
IUUC-Tbe-127518	Tupaia belangeri	53.35	6.00e-121	427.00
IUUC-Ttr-128172	Tursiops truncatus	67.40	0.00e+00	844.00
IUUC-Vvi-131489	Vitis vinifera	54.00	3.00e-107	382.00
IUUC-Xtr-132915	Xenopus tropicalis	66.86	0.00e+00	888.00
IUUC-Xma-134133	Xiphophorus maculatus	58.62	0.00e+00	806.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence