iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108056

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Meiotic fizzy-related protein 1

Genbank Nucleotide ID

CU329671

Gene Name

mfr1; SPBC1198.12; SPBC660.02

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC1198.12	SPBC1198.12.1	SPBC1198.12.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	11493649; 21389117

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-24	80.9	248	285
E3 adaptor/Cullin RING/APC_C/CDC20	1.60e-143	475.6	113	415

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+ ++++l++  + + l+sG++D+++ vWD+r+ ++l+
   Q: 248  HEQEICGLQWdRSlGQLASGGNDNNLFVWDYRSSRPLH 285
           999*******977899****************999876 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl 92
           p+k+ldap+l++dfylnLldW+++nvlav+L+ss+ylwsa++g+v++l+d+  +++vtsv w+ +gt+lavGt++g++ i+D+e++k+vr+l
   Q: 113  PYKILDAPYLKNDFYLNLLDWGQSNVLAVGLASSIYLWSAASGKVVQLHDFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSL 204
           79****************************************************************************************** PP
   S: 93   tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavka 184
           +ghs+rv+aL+Wn+++l+sG++d+ ilh+d+r++++++++++ h+qe+CGl+w+++  +LasGGnDn++ vwd++ss+Pl+kf+eh+aavka
   Q: 205  KGHSERVAALAWNDNTLTSGGKDEVILHHDLRAPGCCAEMMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKA 296
           ******************************************************************************************** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslals 276
           i+wsP+q+++LasGGGt Drc++++ntltg+l +++dtgsqvc+++wsk+s+e+v+thGfa+n+++lwkypsl+++a+l++h++Rvl+l++s
   Q: 297  IGWSPHQRGILASGGGTIDRCLTIHNTLTGRLQNKLDTGSQVCNMAWSKTSNEIVTTHGFAKNQVSLWKYPSLKNIANLTAHTNRVLYLSMS 388
           ******************************************************************************************** PP
   S: 277  pdgeaivtaagDetlrfwklfdkkkak 303
           pdg++ivt+agDetlrfwklf+kk+++
   Q: 389  PDGQSIVTGAGDETLRFWKLFNKKPKE 415
           ***********************9876 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Involved in cdc13 degradation.

Protein Sequence
(Fasta)

MGDRFIPIRN VSNEFNFSFQ SFKECVLSHG SNLRRKTSGT IQRQFMELLS MELFGSQASR 60
SRAFYYGEDK RKIEKKMLDT PDRKSYSLSP ISPQSQDMLR QPQKPKRAFP KTPYKILDAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGACC GATTCATTCC CATTCGCAAC GTTAGCAATG AGTTCAACTT TAGTTTCCAG 60
TCATTCAAAG AATGTGTGTT AAGCCATGGA TCAAATCTTA GGCGCAAAAC CTCTGGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0469--Meiosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0010997--F:anaphase-promoting complex binding
GO:1990757--F:ubiquitin ligase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051321--P:meiotic cell cycle
GO:1905190--P:negative regulation of metaphase/anaphase transition of meiosis II
GO:0075296--P:positive regulation of ascospore formation
GO:0051446--P:positive regulation of meiotic cell cycle
GO:0030435--P:sporulation resulting in formation of a cellular spore

KEGG

spo:SPBC1198.12

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002003	Ailuropoda melanoleuca	47.86	6.00e-112	395.00
IUUC-Atr-003035	Amborella trichopoda	47.16	9.00e-109	385.00
IUUC-Apl-003212	Anas platyrhynchos	48.96	1.00e-114	404.00
IUUC-Ame-011773	Astyanax mexicanus	48.26	6.00e-115	405.00
IUUC-Bta-012586	Bos taurus	48.50	2.00e-114	403.00
IUUC-Cel-018472	Caenorhabditis elegans	55.52	1.00e-108	385.00
IUUC-Cja-019929	Callithrix jacchus	48.73	1.00e-114	404.00
IUUC-Cfa-020977	Canis familiaris	48.73	1.00e-114	404.00
IUUC-Cpo-021537	Cavia porcellus	48.73	1.00e-114	404.00
IUUC-Csa-023389	Chlorocebus sabaeus	48.73	2.00e-114	404.00
IUUC-Cin-025327	Ciona intestinalis	44.32	3.00e-108	383.00
IUUC-Csv-025921	Ciona savignyi	52.00	2.00e-112	397.00
IUUC-Dre-027470	Danio rerio	46.45	4.00e-109	385.00
IUUC-Dor-030187	Dipodomys ordii	52.59	7.00e-108	382.00
IUUC-Dme-031858	Drosophila melanogaster	48.02	1.00e-112	397.00
IUUC-Eca-034210	Equus caballus	48.96	4.00e-115	406.00
IUUC-Fca-035839	Felis catus	49.05	6.00e-112	395.00
IUUC-Fal-036895	Ficedula albicollis	48.96	1.00e-114	404.00
IUUC-Gmo-039544	Gadus morhua	47.62	8.00e-111	392.00
IUUC-Gga-041025	Gallus gallus	49.19	3.00e-115	406.00
IUUC-Gac-041596	Gasterosteus aculeatus	48.62	5.00e-111	392.00
IUUC-Gma-043563	Glycine max	46.26	9.00e-104	368.00
IUUC-Ggo-045599	Gorilla gorilla	46.35	4.00e-109	386.00
IUUC-Hsa-046695	Homo sapiens	48.73	2.00e-114	404.00
IUUC-Itr-048192	Ictidomys tridecemlineatus	48.96	6.00e-115	405.00
IUUC-Lch-049827	Latimeria chalumnae	46.80	9.00e-110	388.00
IUUC-Loc-052856	Lepisosteus oculatus	46.70	2.00e-110	390.00
IUUC-Mcc-055601	Macaca mulatta	48.73	2.00e-114	404.00
IUUC-Mla-059048	Melampsora laricipopulina	45.34	8.00e-110	389.00
IUUC-Mga-060097	Meleagris gallopavo	47.15	2.00e-105	374.00
IUUC-Mmr-061151	Microcebus murinus	43.75	1.00e-92	331.00
IUUC-Mdo-063062	Monodelphis domestica	48.96	2.00e-114	404.00
IUUC-Mmu-063731	Mus musculus	48.50	5.00e-114	402.00
IUUC-Mpu-066173	Mustela putorius furo	48.96	4.00e-115	405.00
IUUC-Mlu-068030	Myotis lucifugus	48.73	1.00e-114	404.00
IUUC-Nle-070163	Nomascus leucogenys	48.73	1.00e-114	404.00
IUUC-Opr-070974	Ochotona princeps	52.40	1.00e-84	304.00
IUUC-Ont-072272	Oreochromis niloticus	48.62	5.00e-111	392.00
IUUC-Ola-087094	Oryzias latipes	46.90	9.00e-110	388.00
IUUC-Oga-088911	Otolemur garnettii	48.73	1.00e-114	404.00
IUUC-Oar-089508	Ovis aries	48.50	2.00e-114	403.00
IUUC-Pan-092147	Papio anubis	48.73	2.00e-114	404.00
IUUC-Psi-093702	Pelodiscus sinensis	48.74	5.00e-113	399.00
IUUC-Pma-094581	Petromyzon marinus	46.47	2.00e-108	384.00
IUUC-Pfo-096309	Poecilia formosa	48.62	4.00e-111	392.00
IUUC-Pca-100565	Procavia capensis	46.00	2.00e-108	384.00
IUUC-Pva-102602	Pteropus vampyrus	47.69	6.00e-109	385.00
IUUC-Pgr-103466	Puccinia graminis	45.49	8.00e-111	392.00
IUUC-Ptt-103888	Puccinia triticina	50.00	1.00e-96	345.00
IUUC-Rno-105028	Rattus norvegicus	48.50	2.00e-114	403.00
IUUC-Sha-106538	Sarcophilus harrisii	44.24	3.00e-105	373.00
IUUC-Sja-107900	Schizosaccharomyces japonicus	67.61	1.00e-173	600.00
IUUC-Sit-110550	Setaria italica	47.34	6.00e-110	389.00
IUUC-Sbi-114386	Sorghum bicolor	55.52	6.00e-107	379.00
IUUC-Ssc-116171	Sus scrofa	48.50	2.00e-114	403.00
IUUC-Tgu-116878	Taeniopygia guttata	43.40	1.00e-92	331.00
IUUC-Tru-118222	Takifugu rubripes	48.22	3.00e-111	393.00
IUUC-Tni-119863	Tetraodon nigroviridis	48.97	1.00e-111	394.00
IUUC-Tca-121599	Theobroma cacao	47.61	3.00e-103	366.00
IUUC-Ttr-129055	Tursiops truncatus	48.49	9.00e-114	401.00
IUUC-Uma-129555	Ustilago maydis	53.01	6.00e-120	422.00
IUUC-Xtr-132808	Xenopus tropicalis	49.19	2.00e-115	407.00
IUUC-Xma-133183	Xiphophorus maculatus	48.62	4.00e-111	392.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence