iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032253.13	ENSMUST00000034787.11	ENSMUSP00000034787.5
ENSMUSG00000032253.13	ENSMUST00000186089.6	ENSMUSP00000139678.1
ENSMUSG00000032253.13	ENSMUST00000190822.1	ENSMUSP00000139866.1
ENSMUSG00000032253.13	ENSMUST00000189985.1	ENSMUSP00000140445.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Post-translational Modifications (PTMs)
CPLM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-34	117.1	181	218
UBD/Beta-Prp	7.00e-52	177.6	280	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 181  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 218
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l       +  +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 280  SGSKRYLSSTGADGTICFWLWDAGTLkinprpTKFTERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 368
           67899***********999999999988888544447777777755522778888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 369  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 457
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  vr++ +         v + + sp++++++++ s+g + i+
   Q: 458  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKVRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 541
           ******9.*********999999..89******************999998875544445666667777999999999999988887 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSRERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVLIREVA EKELLPRRTD WTGKEHPRTY 60
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTGCGGC GGAGGGATCC CGGCGGAGGC GGCCGCAGCC GGGGCCGCTG CCTGAGAGTT 60
GTTGTTTCCT CCTCCTCCTC CGCCTCCGCC GCCGTTGCTT GAATGGTGGA GCCGAGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

KEGG

mmu:83946

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	31.71	3.00e-63	238.00
IUUC-Aml-002299	Ailuropoda melanoleuca	94.00	0.00e+00	3160.00
IUUC-Atr-002600	Amborella trichopoda	31.50	2.00e-71	265.00
IUUC-Apl-003700	Anas platyrhynchos	86.32	0.00e+00	2862.00
IUUC-Aca-004474	Anolis carolinensis	82.20	0.00e+00	2826.00
IUUC-Bta-013125	Bos taurus	93.97	0.00e+00	3078.00
IUUC-Bdi-014797	Brachypodium distachyon	31.58	5.00e-57	217.00
IUUC-Cja-018868	Callithrix jacchus	92.81	0.00e+00	3284.00
IUUC-Cfa-021179	Canis familiaris	93.52	0.00e+00	3126.00
IUUC-Cpo-022077	Cavia porcellus	90.20	0.00e+00	3053.00
IUUC-Csa-023618	Chlorocebus sabaeus	94.84	0.00e+00	3301.00
IUUC-Cho-024794	Choloepus hoffmanni	88.82	0.00e+00	860.00
IUUC-Dre-028029	Danio rerio	80.25	0.00e+00	1355.00
IUUC-Dno-030048	Dasypus novemcinctus	93.55	0.00e+00	3170.00
IUUC-Dor-030195	Dipodomys ordii	85.12	0.00e+00	1479.00
IUUC-Ete-032748	Echinops telfairi	80.00	0.00e+00	1111.00
IUUC-Eca-034274	Equus caballus	94.99	0.00e+00	3135.00
IUUC-Eeu-034688	Erinaceus europaeus	83.27	0.00e+00	1391.00
IUUC-Fca-035451	Felis catus	93.64	0.00e+00	3014.00
IUUC-Fal-037465	Ficedula albicollis	85.40	0.00e+00	2881.00
IUUC-Gmo-039451	Gadus morhua	68.77	0.00e+00	724.00
IUUC-Gga-040798	Gallus gallus	86.22	0.00e+00	2962.00
IUUC-Ggo-045347	Gorilla gorilla	93.04	0.00e+00	3203.00
IUUC-Hsa-046757	Homo sapiens	94.89	0.00e+00	3272.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	1.00e-37	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	90.34	0.00e+00	1144.00
IUUC-Lch-050646	Latimeria chalumnae	77.78	0.00e+00	2740.00
IUUC-Loc-052672	Lepisosteus oculatus	71.27	0.00e+00	2440.00
IUUC-Laf-054140	Loxodonta africana	94.60	0.00e+00	3189.00
IUUC-Mcc-055061	Macaca mulatta	94.51	0.00e+00	3288.00
IUUC-Mtr-058094	Medicago truncatula	32.51	9.00e-73	269.00
IUUC-Mmr-060837	Microcebus murinus	94.57	0.00e+00	3229.00
IUUC-Mdo-061903	Monodelphis domestica	90.47	0.00e+00	3158.00
IUUC-Mpu-066359	Mustela putorius furo	94.12	0.00e+00	2907.00
IUUC-Mlu-067928	Myotis lucifugus	93.00	0.00e+00	3161.00
IUUC-Nle-070094	Nomascus leucogenys	94.01	0.00e+00	3228.00
IUUC-Opr-070971	Ochotona princeps	73.28	0.00e+00	939.00
IUUC-Ont-072221	Oreochromis niloticus	75.14	0.00e+00	1323.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.35	0.00e+00	2912.00
IUUC-Ocu-074033	Oryctolagus cuniculus	93.23	0.00e+00	2840.00
IUUC-Obr-076619	Oryza brachyantha	30.32	3.00e-71	264.00
IUUC-Ogl-077493	Oryza glaberrima	25.37	4.00e-35	144.00
IUUC-Ogu-078641	Oryza glumaepatula	24.47	8.00e-30	126.00
IUUC-Oin-079669	Oryza indica	31.43	8.00e-53	202.00
IUUC-Olo-080755	Oryza longistaminata	32.07	6.00e-55	210.00
IUUC-Opu-083233	Oryza punctata	29.89	6.00e-66	246.00
IUUC-Oga-088578	Otolemur garnettii	94.71	0.00e+00	3133.00
IUUC-Oar-090247	Ovis aries	94.03	0.00e+00	3078.00
IUUC-Ptr-091266	Pan troglodytes	94.60	0.00e+00	3175.00
IUUC-Pan-092734	Papio anubis	94.78	0.00e+00	3299.00
IUUC-Pfo-096191	Poecilia formosa	72.75	0.00e+00	2089.00
IUUC-Pab-098402	Pongo abelii	94.89	0.00e+00	3274.00
IUUC-Pop-099185	Populus trichocarpa	35.21	1.00e-70	262.00
IUUC-Pca-101128	Procavia capensis	85.19	0.00e+00	2830.00
IUUC-Pva-103058	Pteropus vampyrus	92.05	0.00e+00	1538.00
IUUC-Rno-106013	Rattus norvegicus	96.76	0.00e+00	3258.00
IUUC-Sha-107496	Sarcophilus harrisii	90.77	0.00e+00	3098.00
IUUC-Sar-113520	Sorex araneus	88.52	0.00e+00	1494.00
IUUC-Sbi-114195	Sorghum bicolor	30.25	4.00e-60	226.00
IUUC-Ssc-115461	Sus scrofa	90.72	0.00e+00	3098.00
IUUC-Tgu-116821	Taeniopygia guttata	85.75	0.00e+00	2916.00
IUUC-Tsy-119132	Tarsius syrichta	82.96	0.00e+00	2546.00
IUUC-Tae-125478	Triticum aestivum	31.76	2.00e-72	268.00
IUUC-Tur-126809	Triticum urartu	31.38	2.00e-70	261.00
IUUC-Tbe-127479	Tupaia belangeri	89.79	0.00e+00	1422.00
IUUC-Ttr-128427	Tursiops truncatus	89.46	0.00e+00	3027.00
IUUC-Vpa-130160	Vicugna pacos	90.93	0.00e+00	2997.00
IUUC-Vvi-131332	Vitis vinifera	31.82	5.00e-78	286.00
IUUC-Xtr-132717	Xenopus tropicalis	78.80	0.00e+00	2482.00
IUUC-Xma-134120	Xiphophorus maculatus	78.04	0.00e+00	1286.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence