iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074640

Ensembl Protein ID

ENSOCUP00000026560.1

UniProt Accession

U3KMV1; U3KMV1_RABIT

Genbank Protein ID

ENSOCUP00000026560

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02022573

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000029688.1	ENSOCUT00000033514.1	ENSOCUP00000026560.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.40e-84	283.6	308	627

Active Site

Position(s)	Description	Evidence
597	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           sd+ k+l v fv+E   + gGv +ef++++++e+ +p++g+f+y en++ +++p   +     +  + + ++G+l+g++l + ++ +lp
   Q: 308  SDFCKELVVGFVKEIRPESGGVRSEFFHCIFEEMTKPEYGMFMYPENGSFMWFPVTPQC----D-KNNYLLFGILCGLSLLHCNVANLP 391
           789999***********************************************999886....3.4556678***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ ++yk+ll++k sledl+e+ p l k+l+ei++ + +d e+l++ ++++       +++++ L+p+G +ipV ++Nk++Yv++ v+y
   Q: 392  FPLALYKKLLDQKPSLEDLKELSPLLGKNLQEILNGEADDFEDLSMYFSIH------WDQNNVALIPNGISIPVDQSNKKDYVSQCVDY 474
           **********************************99887888876665554......5668888************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           +++ ++k  +e+f++Gf++v++++++++F++eel + + G++++d+e+++k+ ky +gy+e++++i  Fw+++++++ +e+k+fL F+T
   Q: 475  IFNVSVKAVYEKFQRGFYKVCDKDIIEYFHPEELMTAVVGNSDYDWEQFEKNSKYLEGYHESDRTIVLFWKAFHKLTLDEKKKFLFFLT 563
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+++  ++G++++   lf ++k  s+++ P+s TC   L+LP+Ys+++ ++e L++Ai++++gF 
   Q: 564  GCDKFHARGLQQIG-ILFRCPKTMSEKDSPRSLTCHCILDLPKYSTMKRMEEALQVAIRNNRGFT 627
           **************.99*****9****************************************96 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MEKWIAVKRR SSEQEVAKRE IRMIFSSPAC LTASFLKKSQ RGTGEGISMD VDLQKARDTF 60
KKLTEENWIS SLIQTSLEDN LLKALPCHSP HQEALLIFLL LPECPMMCDS ENSNKLVAPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAAAAT GGATAGCAGT GAAAAGAAGA AGTAGTGAAC AAGAAGTGGC TAAAAGGTGG 60
CTCTGTCTGT TAAATTATAA ACCACTCTTA CCTGTTTCTG AAGCCTTGGT CATTTTATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-018891	Callithrix jacchus	70.42	0.00e+00	866.00
IUUC-Ete-032531	Echinops telfairi	47.45	6.00e-104	372.00
IUUC-Hsa-046396	Homo sapiens	70.53	0.00e+00	899.00
IUUC-Lch-050341	Latimeria chalumnae	41.78	6.00e-114	404.00
IUUC-Mcc-055014	Macaca mulatta	67.72	0.00e+00	891.00
IUUC-Meu-056369	Macropus eugenii	54.60	4.00e-47	182.00
IUUC-Nle-069978	Nomascus leucogenys	70.24	0.00e+00	900.00
IUUC-Opr-070190	Ochotona princeps	71.43	8.00e-130	458.00
IUUC-Pan-091802	Papio anubis	71.18	0.00e+00	910.00
IUUC-Pab-098024	Pongo abelii	70.85	0.00e+00	907.00
IUUC-Pca-100315	Procavia capensis	54.63	0.00e+00	661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence