iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-002012

Ensembl Protein ID

ENSAMEP00000016167.1

UniProt Accession

D2HX51; D2HX51_AILME

Genbank Protein ID

EFB22086.1

Protein Name

Coronin

Genbank Nucleotide ID

ACTA01132391

Gene Name

CORO1A; PANDA_017160

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000015314.1	ENSAMET00000016840.1	ENSAMEP00000016167.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.90e-19	67.8	79	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v ++a+   +d+ ++s+s D+t++vW++ +g l
   Q: 79   GHTAPVLDIAWcphNDNVIASSSEDCTVMVWEIPDGGL 116
           8***********9877****************998875 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL 60
VLPLGKTGRV DKNVPMVCGH TAPVLDIAWC PHNDNVIASS SEDCTVMVWE IPDGGLTLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGGC AGGTGGTCCG CTCCAGCAAG TTCCGCCACG TGTTTGGACA GCCAGCCAAG 60
GCCGACCAGT GCTATGAGGA TGTGCGCGTC TCACAGACCA CCTGGGATAG TGGCTTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

KEGG

aml:100479115

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011101	Astyanax mexicanus	68.86	0.00e+00	682.00
IUUC-Bta-013168	Bos taurus	97.18	0.00e+00	933.00
IUUC-Cja-019660	Callithrix jacchus	96.96	0.00e+00	927.00
IUUC-Cfa-020938	Canis familiaris	98.05	0.00e+00	936.00
IUUC-Cpo-022056	Cavia porcellus	94.58	0.00e+00	910.00
IUUC-Csa-023193	Chlorocebus sabaeus	96.53	0.00e+00	920.00
IUUC-Cne-026773	Cryptococcus neoformans	39.18	1.00e-87	317.00
IUUC-Dno-029363	Dasypus novemcinctus	96.53	0.00e+00	918.00
IUUC-Dor-030426	Dipodomys ordii	95.23	0.00e+00	910.00
IUUC-Eca-034229	Equus caballus	96.75	0.00e+00	925.00
IUUC-Eeu-034499	Erinaceus europaeus	95.06	0.00e+00	793.00
IUUC-Fca-036472	Felis catus	96.75	0.00e+00	924.00
IUUC-Gmo-039519	Gadus morhua	66.01	0.00e+00	654.00
IUUC-Gac-042545	Gasterosteus aculeatus	69.00	0.00e+00	682.00
IUUC-Ggo-045162	Gorilla gorilla	96.31	0.00e+00	919.00
IUUC-Hsa-046874	Homo sapiens	96.31	0.00e+00	919.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	95.66	0.00e+00	918.00
IUUC-Lch-050582	Latimeria chalumnae	66.74	0.00e+00	688.00
IUUC-Laf-053427	Loxodonta africana	96.75	0.00e+00	914.00
IUUC-Mcc-055750	Macaca mulatta	96.49	0.00e+00	855.00
IUUC-Meu-056083	Macropus eugenii	88.29	0.00e+00	848.00
IUUC-Mla-058883	Melampsora laricipopulina	43.32	7.00e-88	317.00
IUUC-Mvi-060569	Microbotryum violaceum	40.99	1.00e-89	323.00
IUUC-Mmr-060858	Microcebus murinus	96.53	0.00e+00	922.00
IUUC-Mdo-062469	Monodelphis domestica	90.39	0.00e+00	854.00
IUUC-Mmu-063583	Mus musculus	94.36	0.00e+00	907.00
IUUC-Mpu-066451	Mustela putorius furo	98.64	0.00e+00	904.00
IUUC-Mlu-066978	Myotis lucifugus	96.53	0.00e+00	923.00
IUUC-Nle-069815	Nomascus leucogenys	96.53	0.00e+00	920.00
IUUC-Opr-070911	Ochotona princeps	94.14	0.00e+00	895.00
IUUC-Ont-072391	Oreochromis niloticus	68.83	0.00e+00	686.00
IUUC-Ocu-074429	Oryctolagus cuniculus	86.12	0.00e+00	793.00
IUUC-Oga-089072	Otolemur garnettii	95.68	0.00e+00	913.00
IUUC-Oar-089676	Ovis aries	97.18	0.00e+00	933.00
IUUC-Ptr-091647	Pan troglodytes	96.31	0.00e+00	919.00
IUUC-Pan-092672	Papio anubis	96.53	0.00e+00	920.00
IUUC-Pab-098348	Pongo abelii	90.89	0.00e+00	851.00
IUUC-Pva-102668	Pteropus vampyrus	96.96	0.00e+00	929.00
IUUC-Ptt-103735	Puccinia triticina	35.02	2.00e-70	259.00
IUUC-Rno-105604	Rattus norvegicus	93.71	0.00e+00	898.00
IUUC-Sha-107210	Sarcophilus harrisii	90.02	0.00e+00	877.00
IUUC-Sar-113292	Sorex araneus	96.49	0.00e+00	740.00
IUUC-Sre-114911	Sporisorium reilianum	39.61	7.00e-82	298.00
IUUC-Tme-126924	Tuber melanosporum	41.85	7.00e-94	337.00
IUUC-Tbe-128025	Tupaia belangeri	97.03	3.00e-153	533.00
IUUC-Ttr-128689	Tursiops truncatus	96.75	0.00e+00	929.00
IUUC-Uma-129489	Ustilago maydis	39.56	5.00e-86	311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence