iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-15	57.5	78	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gHt++v ++++   +d  ++sGs D+t++vW +
   Q: 78   GHTGPVLDIDWcphNDQVIASGSEDCTVMVWQI 110
           8***********977799*************86 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII EASGGGAFLV 60
LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS EDCTVMVWQI PENGLTLSLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCCCTCC CCCGCGCGGC GCTCAGTGCC AGGCGGGAGG CGGCAGCGGT TGGAAGGCTT 60
CGCGGGGCTT TGCAGCTGGG ACTTCGGCGG CGCCTCAGGC ACCCGGGCTC TGGTGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027333--CORO1C
IPR015505--Coronin
IPR015048--DUF1899
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016600--C:flotillin complex
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0016328--C:lateral plasma membrane
GO:0031982--C:vesicle
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0090630--P:activation of GTPase activity
GO:0045184--P:establishment of protein localization
GO:0010633--P:negative regulation of epithelial cell migration
GO:0051895--P:negative regulation of focal adhesion assembly
GO:0044387--P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:1900025--P:negative regulation of substrate adhesion-dependent cell spreading
GO:0001755--P:neural crest cell migration
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0010762--P:regulation of fibroblast migration
GO:1900027--P:regulation of ruffle assembly

KEGG

rno:501841

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002236	Ailuropoda melanoleuca	97.68	0.00e+00	969.00
IUUC-Apl-003861	Anas platyrhynchos	94.29	0.00e+00	945.00
IUUC-Acl-008280	Aspergillus clavatus	44.06	1.00e-98	354.00
IUUC-Afl-008393	Aspergillus flavus	44.31	3.00e-98	352.00
IUUC-Afu-008865	Aspergillus fumigatus	42.31	2.00e-94	339.00
IUUC-Ani-009155	Aspergillus nidulans	44.55	2.00e-99	356.00
IUUC-Ang-009523	Aspergillus niger	41.86	5.00e-89	322.00
IUUC-Aor-010049	Aspergillus oryzae	43.83	6.00e-95	342.00
IUUC-Ate-010368	Aspergillus terreus	43.61	1.00e-94	340.00
IUUC-Ame-011256	Astyanax mexicanus	80.54	0.00e+00	788.00
IUUC-Bta-013225	Bos taurus	97.05	0.00e+00	960.00
IUUC-Bci-013935	Botrytis cinerea	43.28	2.00e-100	360.00
IUUC-Cja-019948	Callithrix jacchus	97.89	0.00e+00	970.00
IUUC-Cfa-020591	Canis familiaris	98.10	0.00e+00	972.00
IUUC-Cpo-021480	Cavia porcellus	98.10	0.00e+00	973.00
IUUC-Csa-024152	Chlorocebus sabaeus	98.31	0.00e+00	975.00
IUUC-Cho-024687	Choloepus hoffmanni	97.47	0.00e+00	893.00
IUUC-Cgl-026456	Colletotrichum gloeosporioides	42.68	6.00e-96	344.00
IUUC-Dre-028541	Danio rerio	83.54	0.00e+00	792.00
IUUC-Dno-029552	Dasypus novemcinctus	98.16	0.00e+00	897.00
IUUC-Dse-031378	Dothistroma septosporum	42.71	3.00e-92	332.00
IUUC-Dme-032091	Drosophila melanogaster	53.67	4.00e-153	534.00
IUUC-Ete-032839	Echinops telfairi	88.82	0.00e+00	869.00
IUUC-Eca-034118	Equus caballus	97.05	0.00e+00	966.00
IUUC-Fca-035549	Felis catus	97.89	0.00e+00	970.00
IUUC-Fal-037065	Ficedula albicollis	93.87	0.00e+00	947.00
IUUC-Fox-037737	Fusarium oxysporum	43.03	9.00e-93	334.00
IUUC-Fso-038184	Fusarium solani	43.17	2.00e-98	353.00
IUUC-Gmo-038678	Gadus morhua	77.38	0.00e+00	780.00
IUUC-Ggr-039956	Gaeumannomyces graminis	42.89	5.00e-97	348.00
IUUC-Gga-040842	Gallus gallus	94.29	0.00e+00	951.00
IUUC-Gac-041543	Gasterosteus aculeatus	78.41	0.00e+00	776.00
IUUC-Ggo-044477	Gorilla gorilla	98.10	0.00e+00	972.00
IUUC-Hsa-046610	Homo sapiens	98.31	0.00e+00	973.00
IUUC-Itr-048583	Ictidomys tridecemlineatus	97.68	0.00e+00	968.00
IUUC-Lch-050453	Latimeria chalumnae	84.21	0.00e+00	830.00
IUUC-Loc-052911	Lepisosteus oculatus	84.14	0.00e+00	834.00
IUUC-Lma-053160	Leptosphaeria maculans	43.52	7.00e-100	358.00
IUUC-Laf-053416	Loxodonta africana	97.47	0.00e+00	968.00
IUUC-Mcc-055113	Macaca mulatta	98.31	0.00e+00	973.00
IUUC-Meu-056732	Macropus eugenii	81.26	0.00e+00	753.00
IUUC-Mor-056978	Magnaporthe oryzae	39.19	2.00e-98	353.00
IUUC-Mla-058883	Melampsora laricipopulina	42.08	9.00e-87	314.00
IUUC-Mga-060143	Meleagris gallopavo	94.29	0.00e+00	948.00
IUUC-Mmr-061130	Microcebus murinus	97.89	0.00e+00	970.00
IUUC-Mdo-062851	Monodelphis domestica	86.29	0.00e+00	805.00
IUUC-Mmu-063663	Mus musculus	98.73	0.00e+00	978.00
IUUC-Mpu-066179	Mustela putorius furo	97.47	0.00e+00	967.00
IUUC-Mlu-068175	Myotis lucifugus	97.68	0.00e+00	967.00
IUUC-Nfi-068476	Neosartorya fischeri	43.07	6.00e-97	348.00
IUUC-Opr-070617	Ochotona princeps	97.05	0.00e+00	931.00
IUUC-Ont-072629	Oreochromis niloticus	82.03	0.00e+00	837.00
IUUC-Oan-073547	Ornithorhynchus anatinus	95.76	0.00e+00	952.00
IUUC-Ocu-074569	Oryctolagus cuniculus	96.20	0.00e+00	960.00
IUUC-Ola-086558	Oryzias latipes	79.88	0.00e+00	827.00
IUUC-Oga-089145	Otolemur garnettii	97.89	0.00e+00	972.00
IUUC-Oar-089654	Ovis aries	96.62	0.00e+00	960.00
IUUC-Ptr-090763	Pan troglodytes	98.31	0.00e+00	974.00
IUUC-Pan-091885	Papio anubis	98.03	0.00e+00	933.00
IUUC-Psi-093011	Pelodiscus sinensis	93.66	0.00e+00	938.00
IUUC-Pno-094994	Phaeosphaeria nodorum	44.53	2.00e-98	353.00
IUUC-Pfo-097309	Poecilia formosa	82.24	0.00e+00	844.00
IUUC-Pab-097542	Pongo abelii	89.66	0.00e+00	868.00
IUUC-Pca-100630	Procavia capensis	82.24	0.00e+00	782.00
IUUC-Ptt-103735	Puccinia triticina	35.03	2.00e-69	256.00
IUUC-Pte-104194	Pyrenophora teres	42.89	6.00e-99	355.00
IUUC-Pyt-104437	Pyrenophora triticirepentis	42.89	6.00e-99	355.00
IUUC-Sha-106695	Sarcophilus harrisii	93.90	0.00e+00	773.00
IUUC-Sja-107992	Schizosaccharomyces japonicus	41.71	1.00e-97	350.00
IUUC-Ssc-115348	Sus scrofa	96.84	0.00e+00	961.00
IUUC-Tgu-116597	Taeniopygia guttata	94.29	0.00e+00	944.00
IUUC-Tru-118425	Takifugu rubripes	81.18	0.00e+00	824.00
IUUC-Tsy-119223	Tarsius syrichta	87.59	0.00e+00	760.00
IUUC-Tni-120610	Tetraodon nigroviridis	80.67	0.00e+00	822.00
IUUC-Tbe-127679	Tupaia belangeri	87.57	0.00e+00	641.00
IUUC-Ttr-129226	Tursiops truncatus	87.74	0.00e+00	835.00
IUUC-Vda-129792	Verticillium dahliae	41.90	1.00e-93	337.00
IUUC-Vpa-130339	Vicugna pacos	98.80	0.00e+00	700.00
IUUC-Xtr-132873	Xenopus tropicalis	74.74	0.00e+00	749.00
IUUC-Xma-134047	Xiphophorus maculatus	82.24	0.00e+00	845.00
IUUC-Yli-134440	Yarrowia lipolytica	40.47	5.00e-93	335.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence