iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000023256.3	ENSGALT00000038176.3	ENSGALP00000037382.3
ENSGALG00000023256.3	ENSGALT00000059649.1	ENSGALP00000055529.1
ENSGALG00000023256.3	ENSGALT00000068244.1	ENSGALP00000045533.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-06	29.5	398	436

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+f +  ++l+C H f+  C+  w      ++++  CP+Cr
   Q: 398  CTICSEHFIE-AVTLNCAHSFCSYCIDEW------TKRKVECPICR 436
           ********99.899***************......**********8 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.

Protein Sequence
(Fasta)

MAACGASRPA WCLRRVGAGG GWLLLEAGTQ VTVGRGLDLT YQLVSKTCPL MISRKHCVFQ 60
QNAEGQWTVK DNKSLNGVWL NKQRLDPSKT YPIAEGDRIQ LGVPLENKET AEYEYEVIKE 120

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Nucleotide Sequence
(Fasta)

ATGACAGAGT GCAGCACTGG TATCACAGTA CAGCCACGAT GCTCTAAGAA AAGGCCTGCA 60
CGTCCCCCCG CTGAGGACTT GCTCTTGCCA CCTCACCTTG AAGTAATCCC CGAAGGACCA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	58.69	3.00e-106	378.00
IUUC-Apl-003664	Anas platyrhynchos	94.12	3.00e-54	202.00
IUUC-Aca-005036	Anolis carolinensis	62.32	7.00e-129	453.00
IUUC-Ago-007705	Ashbya gossypii	43.86	3.00e-08	53.10
IUUC-Ame-011537	Astyanax mexicanus	43.25	2.00e-87	316.00
IUUC-Bta-013297	Bos taurus	59.03	5.00e-111	394.00
IUUC-Cja-019201	Callithrix jacchus	57.75	5.00e-115	407.00
IUUC-Cfa-021041	Canis familiaris	60.81	3.00e-122	431.00
IUUC-Csa-024133	Chlorocebus sabaeus	58.39	2.00e-124	439.00
IUUC-Cho-024624	Choloepus hoffmanni	51.97	2.00e-66	245.00
IUUC-Cgl-026486	Colletotrichum gloeosporioides	43.86	1.00e-08	54.70
IUUC-Dre-027918	Danio rerio	42.68	3.00e-83	301.00
IUUC-Dno-029774	Dasypus novemcinctus	60.72	2.00e-123	435.00
IUUC-Dor-030190	Dipodomys ordii	48.48	3.00e-81	295.00
IUUC-Dse-031157	Dothistroma septosporum	36.59	4.00e-08	53.10
IUUC-Ete-032301	Echinops telfairi	53.68	6.00e-83	301.00
IUUC-Eca-033607	Equus caballus	60.49	2.00e-103	369.00
IUUC-Eeu-034888	Erinaceus europaeus	59.04	1.00e-72	266.00
IUUC-Fca-036075	Felis catus	58.99	3.00e-121	428.00
IUUC-Fal-037569	Ficedula albicollis	77.68	6.00e-173	600.00
IUUC-Fox-037681	Fusarium oxysporum	41.27	1.00e-08	54.70
IUUC-Fso-038129	Fusarium solani	41.27	1.00e-08	54.70
IUUC-Gmo-038588	Gadus morhua	41.01	2.00e-71	263.00
IUUC-Ggr-039871	Gaeumannomyces graminis	42.86	7.00e-09	55.80
IUUC-Gac-042463	Gasterosteus aculeatus	42.24	5.00e-63	234.00
IUUC-Ggo-045269	Gorilla gorilla	58.35	1.00e-123	436.00
IUUC-Hsa-046249	Homo sapiens	58.69	1.00e-120	426.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	59.12	2.00e-123	435.00
IUUC-Kpa-049298	Komagataella pastoris	40.38	2.00e-06	46.60
IUUC-Lch-049805	Latimeria chalumnae	53.19	1.00e-111	396.00
IUUC-Lpe-050699	Leersia perrieri	33.70	2.00e-08	52.80
IUUC-Loc-052377	Lepisosteus oculatus	46.37	6.00e-88	317.00
IUUC-Mcc-055344	Macaca mulatta	58.14	1.00e-123	436.00
IUUC-Meu-055950	Macropus eugenii	59.62	2.00e-114	405.00
IUUC-Mor-057012	Magnaporthe oryzae	38.96	3.00e-09	57.00
IUUC-Mla-059052	Melampsora laricipopulina	32.58	8.00e-11	60.10
IUUC-Mga-060049	Meleagris gallopavo	91.63	0.00e+00	700.00
IUUC-Mmr-061431	Microcebus murinus	58.94	2.00e-113	402.00
IUUC-Mdo-062016	Monodelphis domestica	67.87	1.00e-115	411.00
IUUC-Mmu-063235	Mus musculus	55.71	2.00e-124	439.00
IUUC-Mpu-066449	Mustela putorius furo	60.47	3.00e-127	448.00
IUUC-Mlu-067588	Myotis lucifugus	58.32	1.00e-109	390.00
IUUC-Ncr-068692	Neurospora crassa	41.27	2.00e-08	54.70
IUUC-Nle-069192	Nomascus leucogenys	58.56	7.00e-124	437.00
IUUC-Opr-070300	Ochotona princeps	49.69	8.00e-95	340.00
IUUC-Ont-071998	Oreochromis niloticus	44.44	1.00e-67	250.00
IUUC-Oan-073610	Ornithorhynchus anatinus	62.50	2.00e-65	241.00
IUUC-Ocu-074603	Oryctolagus cuniculus	59.58	3.00e-120	424.00
IUUC-Ogl-077895	Oryza glaberrima	27.16	4.00e-08	51.20
IUUC-Ogu-078576	Oryza glumaepatula	33.70	3.00e-08	51.60
IUUC-Oni-082120	Oryza nivara	33.70	3.00e-08	52.00
IUUC-Oru-084679	Oryza rufipogon	33.70	3.00e-08	51.60
IUUC-Osa-085728	Oryza sativa	27.16	5.00e-08	50.80
IUUC-Ola-086681	Oryzias latipes	53.97	3.00e-39	155.00
IUUC-Oga-088183	Otolemur garnettii	59.12	2.00e-121	429.00
IUUC-Oar-090255	Ovis aries	58.68	1.00e-103	369.00
IUUC-Ptr-091029	Pan troglodytes	57.95	5.00e-117	414.00
IUUC-Pan-092241	Papio anubis	58.39	2.00e-123	435.00
IUUC-Psi-093506	Pelodiscus sinensis	73.97	1.00e-150	526.00
IUUC-Pma-094579	Petromyzon marinus	57.78	4.00e-26	112.00
IUUC-Pfo-097014	Poecilia formosa	44.04	2.00e-66	246.00
IUUC-Pab-098530	Pongo abelii	57.92	1.00e-116	413.00
IUUC-Pca-100939	Procavia capensis	44.47	2.00e-73	269.00
IUUC-Pva-103148	Pteropus vampyrus	55.32	4.00e-108	384.00
IUUC-Rno-105338	Rattus norvegicus	56.18	2.00e-124	439.00
IUUC-Sce-106402	Saccharomyces cerevisiae	35.96	2.00e-09	56.60
IUUC-Sha-107187	Sarcophilus harrisii	63.95	5.00e-92	330.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	25.56	1.00e-09	57.40
IUUC-Sar-113356	Sorex araneus	49.51	1.00e-84	306.00
IUUC-Ssc-116290	Sus scrofa	60.93	4.00e-134	471.00
IUUC-Tru-117910	Takifugu rubripes	42.71	4.00e-65	241.00
IUUC-Tsy-119329	Tarsius syrichta	55.26	2.00e-96	346.00
IUUC-Tni-120521	Tetraodon nigroviridis	42.41	2.00e-66	245.00
IUUC-Tre-121954	Trichoderma reesei	41.27	9.00e-09	55.10
IUUC-Tvi-122295	Trichoderma virens	41.27	1.00e-08	54.30
IUUC-Ttr-128997	Tursiops truncatus	54.20	5.00e-106	377.00
IUUC-Vda-130024	Verticillium dahliae	33.05	2.00e-09	57.00
IUUC-Vpa-130154	Vicugna pacos	58.09	6.00e-123	434.00
IUUC-Xtr-132805	Xenopus tropicalis	52.95	7.00e-100	357.00
IUUC-Xma-133620	Xiphophorus maculatus	44.78	2.00e-65	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence