iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074603

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AAGW02017857

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000029655.1	ENSOCUT00000034104.1	ENSOCUP00000027153.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.20e-07	32.2	403	441

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 403  CIICSEYFIE-AVTLNCAHSFCSYCIKEW------MKRKIECPICR 441
           ********99.899***************......**********8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MEKPGSLATG LRCQSWCLRR VGMNVEWLLL EDGREVSLGR GFSVTYQLVS KVCPLMISRK 60
HCVLKQNPEG QWTIMDNKSL NGVWLNRVRL EPLKFYAIHQ GDHIQLGVPL DNKENAEYEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTCGGGCG TCCGCGCCCC ACCCTGCCAA GCCTTCCTGT TGCGCAGGCG CAACGCTCCC 60
TCTTCCTACC GGATCAGGCG GGGCTCGCAG CCCGATCTCG CAGCATCGAT CGCGGTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100343659

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	79.92	4.00e-179	620.00
IUUC-Apl-003664	Anas platyrhynchos	77.78	7.00e-39	152.00
IUUC-Aca-005036	Anolis carolinensis	56.63	4.00e-114	404.00
IUUC-Ame-011537	Astyanax mexicanus	42.32	3.00e-88	318.00
IUUC-Bta-013297	Bos taurus	79.63	5.00e-173	600.00
IUUC-Cel-018658	Caenorhabditis elegans	41.07	1.00e-07	52.00
IUUC-Cja-019201	Callithrix jacchus	76.54	1.00e-173	602.00
IUUC-Cfa-021041	Canis familiaris	81.52	0.00e+00	670.00
IUUC-Csa-024133	Chlorocebus sabaeus	79.01	0.00e+00	654.00
IUUC-Cho-024624	Choloepus hoffmanni	72.39	1.00e-125	442.00
IUUC-Dre-027918	Danio rerio	42.71	2.00e-83	303.00
IUUC-Dno-029774	Dasypus novemcinctus	79.47	0.00e+00	655.00
IUUC-Dor-030190	Dipodomys ordii	71.27	4.00e-142	498.00
IUUC-Ete-032301	Echinops telfairi	65.91	2.00e-140	492.00
IUUC-Eca-033607	Equus caballus	80.71	8.00e-164	569.00
IUUC-Eeu-034888	Erinaceus europaeus	79.80	6.00e-124	437.00
IUUC-Fca-036075	Felis catus	78.44	0.00e+00	660.00
IUUC-Fal-037569	Ficedula albicollis	61.45	4.00e-116	411.00
IUUC-Gmo-038588	Gadus morhua	41.83	7.00e-78	284.00
IUUC-Gga-040777	Gallus gallus	59.79	5.00e-122	431.00
IUUC-Gac-042463	Gasterosteus aculeatus	41.56	7.00e-64	238.00
IUUC-Ggo-045269	Gorilla gorilla	79.01	0.00e+00	660.00
IUUC-Hsa-046249	Homo sapiens	78.81	0.00e+00	642.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	81.11	0.00e+00	679.00
IUUC-Lch-049805	Latimeria chalumnae	51.89	8.00e-116	410.00
IUUC-Loc-052377	Lepisosteus oculatus	48.09	1.00e-94	340.00
IUUC-Mcc-055344	Macaca mulatta	79.01	0.00e+00	660.00
IUUC-Meu-055950	Macropus eugenii	61.88	2.00e-123	436.00
IUUC-Mor-057012	Magnaporthe oryzae	40.35	4.00e-07	50.10
IUUC-Mla-059052	Melampsora laricipopulina	36.92	4.00e-10	57.80
IUUC-Mga-060049	Meleagris gallopavo	60.98	4.00e-121	428.00
IUUC-Mmr-061431	Microcebus murinus	80.95	6.00e-179	620.00
IUUC-Mdo-062016	Monodelphis domestica	64.73	5.00e-116	413.00
IUUC-Mmu-063235	Mus musculus	70.82	4.00e-175	607.00
IUUC-Mpu-066449	Mustela putorius furo	82.44	0.00e+00	695.00
IUUC-Mlu-067588	Myotis lucifugus	77.23	1.00e-174	605.00
IUUC-Nle-069192	Nomascus leucogenys	79.01	0.00e+00	657.00
IUUC-Opr-070300	Ochotona princeps	69.75	3.00e-160	557.00
IUUC-Ont-071998	Oreochromis niloticus	42.89	3.00e-68	252.00
IUUC-Oan-073610	Ornithorhynchus anatinus	64.78	2.00e-65	241.00
IUUC-Ola-086681	Oryzias latipes	41.04	8.00e-74	271.00
IUUC-Oga-088183	Otolemur garnettii	80.45	0.00e+00	663.00
IUUC-Oar-090255	Ovis aries	81.03	2.00e-161	561.00
IUUC-Ptr-091029	Pan troglodytes	79.04	6.00e-176	610.00
IUUC-Pan-092241	Papio anubis	79.01	0.00e+00	661.00
IUUC-Psi-093506	Pelodiscus sinensis	60.12	2.00e-126	445.00
IUUC-Pma-094579	Petromyzon marinus	56.67	1.00e-26	114.00
IUUC-Pfo-097014	Poecilia formosa	42.58	4.00e-67	248.00
IUUC-Pab-098530	Pongo abelii	79.65	0.00e+00	629.00
IUUC-Pca-100939	Procavia capensis	60.08	5.00e-133	467.00
IUUC-Pva-103148	Pteropus vampyrus	75.36	3.00e-178	617.00
IUUC-Rno-105338	Rattus norvegicus	72.22	0.00e+00	632.00
IUUC-Sce-106282	Saccharomyces cerevisiae	42.11	9.00e-06	44.70
IUUC-Sha-107187	Sarcophilus harrisii	65.43	4.00e-101	361.00
IUUC-Sar-113356	Sorex araneus	65.11	4.00e-130	457.00
IUUC-Ssc-116290	Sus scrofa	81.78	0.00e+00	730.00
IUUC-Tru-117910	Takifugu rubripes	41.28	9.00e-63	234.00
IUUC-Tsy-119329	Tarsius syrichta	76.00	4.00e-162	563.00
IUUC-Tni-120521	Tetraodon nigroviridis	39.58	1.00e-63	237.00
IUUC-Tvi-122295	Trichoderma virens	34.34	2.00e-07	50.80
IUUC-Tme-126989	Tuber melanosporum	33.90	8.00e-08	52.00
IUUC-Ttr-128997	Tursiops truncatus	75.56	3.00e-176	611.00
IUUC-Vda-130024	Verticillium dahliae	40.35	6.00e-07	49.30
IUUC-Vpa-130154	Vicugna pacos	78.03	0.00e+00	662.00
IUUC-Xtr-132805	Xenopus tropicalis	49.90	9.00e-104	370.00
IUUC-Xma-133620	Xiphophorus maculatus	42.43	1.00e-65	243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence