iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093071

Ensembl Protein ID

ENSPSIP00000014716.1

UniProt Accession

K7G355; K7G355_PELSI

Genbank Protein ID

ENSPSIP00000014716

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGCU01077812

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000013186.1	ENSPSIT00000014786.1	ENSPSIP00000014716.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-14	51.7	85	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++  ++++++W+ + + ++g+ G +P+n+v+ 
   Q: 85   TFVALYDYESRTETDLSFKKGERLQIV--NNTEGDWWLAHSLTTGQTGYIPSNYVAP 139
           5789***********************..8999*********************975 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MGSSKSKPKD PNQRRRSLES AENAHHAGYP SSQTPSKTPV PDAHRTPNRS FGSMAAEPKL 60
FGGFNTSDTV TSPQRSGALA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTEGDWWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCCTGAAG AGCTGAGGTG ACTTTTTGTG CGGCCCTGCT GCCCCATAGA AAGGCTGTGG 60
CTGGACAGAT CTAGGTAAGA CCTCCTTTTT TCTTCTTCTT CTTTTTGAGC AGTGGGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0030900--P:forebrain development
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0060491--P:regulation of cell projection assembly
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	92.80	0.00e+00	1040.00
IUUC-Aca-004237	Anolis carolinensis	94.75	0.00e+00	1052.00
IUUC-Aly-005712	Arabidopsis lyrata	35.63	3.00e-19	90.50
IUUC-Ath-007146	Arabidopsis thaliana	31.91	3.00e-22	100.00
IUUC-Ame-011887	Astyanax mexicanus	79.52	0.00e+00	889.00
IUUC-Bta-012982	Bos taurus	92.99	0.00e+00	1050.00
IUUC-Bdi-014324	Brachypodium distachyon	35.11	4.00e-23	103.00
IUUC-Bol-016049	Brassica oleracea	34.68	3.00e-17	84.00
IUUC-Cja-019995	Callithrix jacchus	92.99	0.00e+00	1038.00
IUUC-Cfa-020060	Canis familiaris	94.03	0.00e+00	1051.00
IUUC-Cpo-021557	Cavia porcellus	92.35	0.00e+00	1019.00
IUUC-Csa-023711	Chlorocebus sabaeus	93.17	0.00e+00	1038.00
IUUC-Dre-028491	Danio rerio	83.30	0.00e+00	897.00
IUUC-Dno-029651	Dasypus novemcinctus	89.27	0.00e+00	1003.00
IUUC-Ete-033170	Echinops telfairi	95.20	0.00e+00	903.00
IUUC-Eca-033970	Equus caballus	89.72	0.00e+00	974.00
IUUC-Fca-036113	Felis catus	94.03	0.00e+00	1051.00
IUUC-Fal-036785	Ficedula albicollis	95.18	0.00e+00	1073.00
IUUC-Gga-040899	Gallus gallus	95.50	0.00e+00	1074.00
IUUC-Gac-042332	Gasterosteus aculeatus	80.93	0.00e+00	896.00
IUUC-Gma-043938	Glycine max	34.34	1.00e-22	101.00
IUUC-Ggo-044829	Gorilla gorilla	79.15	0.00e+00	846.00
IUUC-Hsa-046192	Homo sapiens	92.99	0.00e+00	1038.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	92.79	0.00e+00	1030.00
IUUC-Lch-049892	Latimeria chalumnae	87.59	0.00e+00	975.00
IUUC-Loc-052812	Lepisosteus oculatus	82.69	0.00e+00	909.00
IUUC-Laf-053977	Loxodonta africana	92.80	0.00e+00	1042.00
IUUC-Mcc-055159	Macaca mulatta	91.32	0.00e+00	1033.00
IUUC-Mtr-058733	Medicago truncatula	32.05	5.00e-23	102.00
IUUC-Mga-060135	Meleagris gallopavo	94.99	0.00e+00	1071.00
IUUC-Mmr-061168	Microcebus murinus	90.78	0.00e+00	1032.00
IUUC-Mdo-063030	Monodelphis domestica	92.55	0.00e+00	1054.00
IUUC-Mmu-063893	Mus musculus	92.61	0.00e+00	1039.00
IUUC-Mpu-066411	Mustela putorius furo	94.03	0.00e+00	1051.00
IUUC-Mlu-068139	Myotis lucifugus	91.90	0.00e+00	1036.00
IUUC-Nle-070178	Nomascus leucogenys	90.59	0.00e+00	984.00
IUUC-Ont-072666	Oreochromis niloticus	82.59	0.00e+00	892.00
IUUC-Ocu-074403	Oryctolagus cuniculus	91.54	0.00e+00	1019.00
IUUC-Ogu-078962	Oryza glumaepatula	34.25	1.00e-23	105.00
IUUC-Ola-086527	Oryzias latipes	80.04	0.00e+00	901.00
IUUC-Oga-088493	Otolemur garnettii	92.99	0.00e+00	1035.00
IUUC-Oar-090279	Ovis aries	92.98	0.00e+00	1047.00
IUUC-Ptr-091050	Pan troglodytes	92.99	0.00e+00	1038.00
IUUC-Pan-091862	Papio anubis	94.22	0.00e+00	1044.00
IUUC-Pfo-096578	Poecilia formosa	81.34	0.00e+00	914.00
IUUC-Pab-097902	Pongo abelii	90.96	0.00e+00	1030.00
IUUC-Pop-099554	Populus trichocarpa	32.42	5.00e-23	102.00
IUUC-Ppe-102072	Prunus persica	34.89	2.00e-26	114.00
IUUC-Pva-103176	Pteropus vampyrus	78.78	0.00e+00	851.00
IUUC-Rno-105847	Rattus norvegicus	92.80	0.00e+00	1039.00
IUUC-Sha-107539	Sarcophilus harrisii	96.06	0.00e+00	1072.00
IUUC-Stu-112331	Solanum tuberosum	32.40	5.00e-23	102.00
IUUC-Sbi-114480	Sorghum bicolor	35.78	9.00e-24	105.00
IUUC-Ssc-115762	Sus scrofa	91.61	0.00e+00	1039.00
IUUC-Tru-117849	Takifugu rubripes	81.14	0.00e+00	878.00
IUUC-Tni-120843	Tetraodon nigroviridis	81.28	0.00e+00	908.00
IUUC-Ttr-128702	Tursiops truncatus	87.08	0.00e+00	962.00
IUUC-Vvi-131181	Vitis vinifera	33.21	8.00e-22	99.00
IUUC-Xtr-132291	Xenopus tropicalis	87.71	0.00e+00	952.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence