iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017939

Ensembl Protein ID

Bra035762.1-P

UniProt Accession

M4F3W2; M4F3W2_BRARP

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra035762	Bra035762.1	Bra035762.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-53	182.5	308	794
UBD/Alpha-Helix/UBA	8.80e-18	64.8	613	653

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
757	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklnee.npkepkgellkslqklfeel...............w.kskkkavsprellkalkk 79
           tGl NlgN+CY+ +++Q L++++++ + ++++++ kl+ e +p +p+ +l ++l+kl + l               + + +++ + pr++++++++
   Q: 308  TGLVNLGNSCYLAATMQILFSTHSFISRYFSHQSLKLAFEmAPADPTLDLNMQLTKLGHGLlsgkysipvtekdaaTaEARQEGIPPRMFKSVVAA 403
           7*************************9999977777765515689999*************7888777777666552588888************* PP
   S: 80   eaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlsl 174
            + efs+++qqDa +f+ +lld++e+                             ++k +   s+ F++ ++++i c + + ++ +r++  l+l++
   Q: 404  GHGEFSSMRQQDALDFFLHLLDKVERGN---------------------------NTKPDLDPSRSFKFGVEEKILCSSGKVSYnKRDDCILSLNI 472
           *************************988...........................5677778899************7765555444455555555 PP
   S: 175  pvpgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
           p+++ +  +k                               l+ cL+ f+++e++++   yy++  k+k++a k+++l+++P++L+lh+ +f +  
   Q: 473  PLQEAT--NKDeleafnnqkagkgleennmstddivrprvPLEACLATFASPEQIHD---YYSTALKGKTTAIKTTGLTSFPDYLVLHMRKFVM-D 562
           555555..444569*****************************************97...********************************65.5 PP
   S: 242  eqksrekinkkvefpleLdlspfcts...................................................................... 267
           ++++++k++ ++++p+ +d+s++ ++                                                                      
   Q: 563  AGWVPKKLDVYIDVPDVIDISHMRSKglqpgeellpdavpeevmetaqpvaneeivaqlvsmgfnqlhcqkaaintsnvgveeatnwlfshmddpd 658
           67*******************999999999999999999888888888888888888888888887777777777777777777777777777766 PP
   S: 268  ..........................peekqke..................................................kkkYeLiavvvHs 287
                                     +     e                                                    +Y+L+++v+H+
   Q: 659  idapishqasdvdqssvdtlisfgfaE-----EvarkalkasggdiekatdwifnnpnasvsdmdvsssssaqtpaqtglpdgGGRYKLFGIVSHM 749
           666666666655555555555555550.....0555555555555555666666666666666777777777788889999999************ PP
   S: 288  G.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           G s+++GHYva++ + +g+W+ f+DskV  +  ++  +   + +Y++f++r
   Q: 750  GtSTHCGHYVAHILK-EGRWVIFNDSKVGIS--TDPPK---DMGYLYFFQR 794
           ***************.9***********998..78888...999**99997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++e++++qlv+MGF++ ++++a  ++ n  +e+A+++L+++
   Q: 613  ANEEIVAQLVSMGFNQLHCQKAAINTsNVGVEEATNWLFSH 653
           589************************************97 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MELLRSNLSR VQIPEPTHRI YKHECCLSFD TPRSEGGLFV DMNSFLAFGK DYVAWNHEKT 60
GNPVYLHIKE TPKSVPEDRP LKKPTLLAIG VDGGFDNNET EYEESYSIVI LPDFVSLPFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTTC TCCGATCCAA CTTGTCTAGG GTTCAGATCC CCGAACCCAC CCACCGCATC 60
TACAAGCACG AGTGTTGCCT CTCCTTCGAC ACCCCGGTAA ACCTCTCGAT AACCCCTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	47.54	0.00e+00	744.00
IUUC-Aca-005368	Anolis carolinensis	48.92	0.00e+00	782.00
IUUC-Aly-005727	Arabidopsis lyrata	90.97	0.00e+00	1474.00
IUUC-Ath-006974	Arabidopsis thaliana	90.84	0.00e+00	1471.00
IUUC-Ago-007890	Ashbya gossypii	27.50	6.00e-70	258.00
IUUC-Ang-009720	Aspergillus niger	35.29	8.00e-113	400.00
IUUC-Aor-010111	Aspergillus oryzae	35.48	1.00e-124	440.00
IUUC-Ate-010531	Aspergillus terreus	32.55	1.00e-100	360.00
IUUC-Ame-011470	Astyanax mexicanus	42.49	0.00e+00	674.00
IUUC-Bgr-012183	Blumeria graminis	32.47	2.00e-109	390.00
IUUC-Bta-013179	Bos taurus	47.65	0.00e+00	749.00
IUUC-Bci-013858	Botrytis cinerea	33.66	5.00e-124	438.00
IUUC-Bdi-014904	Brachypodium distachyon	69.95	0.00e+00	1113.00
IUUC-Bol-015536	Brassica oleracea	98.12	0.00e+00	1580.00
IUUC-Cel-018625	Caenorhabditis elegans	33.82	1.00e-118	420.00
IUUC-Cja-019063	Callithrix jacchus	47.42	0.00e+00	746.00
IUUC-Cfa-020976	Canis familiaris	49.22	0.00e+00	764.00
IUUC-Cpo-022265	Cavia porcellus	48.98	0.00e+00	764.00
IUUC-Csa-024177	Chlorocebus sabaeus	49.52	0.00e+00	678.00
IUUC-Cin-025411	Ciona intestinalis	43.02	3.00e-179	621.00
IUUC-Csv-026347	Ciona savignyi	42.05	2.00e-177	615.00
IUUC-Dre-027651	Danio rerio	42.69	0.00e+00	704.00
IUUC-Dno-029034	Dasypus novemcinctus	48.00	0.00e+00	754.00
IUUC-Dor-030130	Dipodomys ordii	38.80	3.00e-108	385.00
IUUC-Dse-031467	Dothistroma septosporum	36.00	3.00e-120	426.00
IUUC-Dme-032075	Drosophila melanogaster	44.86	0.00e+00	666.00
IUUC-Ete-032865	Echinops telfairi	44.33	0.00e+00	668.00
IUUC-Eca-034059	Equus caballus	47.67	0.00e+00	749.00
IUUC-Fca-035515	Felis catus	47.77	0.00e+00	752.00
IUUC-Fox-037745	Fusarium oxysporum	35.83	3.00e-125	442.00
IUUC-Gmo-039071	Gadus morhua	45.03	0.00e+00	669.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.66	3.00e-117	416.00
IUUC-Gga-040635	Gallus gallus	47.43	0.00e+00	771.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.27	0.00e+00	678.00
IUUC-Gma-043614	Glycine max	76.46	0.00e+00	1214.00
IUUC-Ggo-044602	Gorilla gorilla	48.00	0.00e+00	756.00
IUUC-Hsa-045959	Homo sapiens	48.00	0.00e+00	756.00
IUUC-Hvu-047563	Hordeum vulgare	68.23	0.00e+00	870.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.42	0.00e+00	752.00
IUUC-Kpa-049156	Komagataella pastoris	32.57	3.00e-109	389.00
IUUC-Lch-049648	Latimeria chalumnae	48.86	0.00e+00	771.00
IUUC-Lpe-051523	Leersia perrieri	67.85	0.00e+00	1093.00
IUUC-Loc-052072	Lepisosteus oculatus	43.93	0.00e+00	686.00
IUUC-Lma-053216	Leptosphaeria maculans	34.49	4.00e-109	390.00
IUUC-Laf-054327	Loxodonta africana	47.77	0.00e+00	753.00
IUUC-Mcc-055443	Macaca mulatta	48.00	0.00e+00	756.00
IUUC-Meu-056298	Macropus eugenii	50.52	7.00e-156	544.00
IUUC-Mla-058903	Melampsora laricipopulina	35.56	7.00e-116	411.00
IUUC-Mvi-060476	Microbotryum violaceum	34.40	9.00e-107	380.00
IUUC-Mmr-060575	Microcebus murinus	47.77	0.00e+00	752.00
IUUC-Mdo-062183	Monodelphis domestica	48.15	0.00e+00	753.00
IUUC-Mmu-063592	Mus musculus	47.77	0.00e+00	753.00
IUUC-Mpu-066082	Mustela putorius furo	49.10	0.00e+00	761.00
IUUC-Mlu-067345	Myotis lucifugus	47.54	0.00e+00	746.00
IUUC-Nle-070173	Nomascus leucogenys	49.46	0.00e+00	767.00
IUUC-Opr-070556	Ochotona princeps	47.89	0.00e+00	763.00
IUUC-Ont-071502	Oreochromis niloticus	46.47	0.00e+00	687.00
IUUC-Ocu-074861	Oryctolagus cuniculus	49.34	0.00e+00	774.00
IUUC-Oba-075109	Oryza barthii	67.75	0.00e+00	1095.00
IUUC-Obr-076292	Oryza brachyantha	68.12	0.00e+00	1092.00
IUUC-Ogl-077065	Oryza glaberrima	69.36	0.00e+00	1140.00
IUUC-Ogu-078776	Oryza glumaepatula	67.62	0.00e+00	1114.00
IUUC-Oin-080048	Oryza indica	69.24	0.00e+00	1134.00
IUUC-Olo-080711	Oryza longistaminata	66.11	0.00e+00	1018.00
IUUC-Ome-081506	Oryza meridionalis	67.59	0.00e+00	1031.00
IUUC-Oni-082320	Oryza nivara	65.86	0.00e+00	1086.00
IUUC-Opu-083801	Oryza punctata	68.00	0.00e+00	1082.00
IUUC-Oru-085139	Oryza rufipogon	65.86	0.00e+00	1084.00
IUUC-Osa-085713	Oryza sativa	69.49	0.00e+00	1144.00
IUUC-Ola-086951	Oryzias latipes	42.91	0.00e+00	652.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.73	1.00e-162	566.00
IUUC-Oga-088625	Otolemur garnettii	47.36	0.00e+00	751.00
IUUC-Oar-089995	Ovis aries	47.13	0.00e+00	742.00
IUUC-Ptr-090640	Pan troglodytes	47.18	0.00e+00	755.00
IUUC-Pan-091974	Papio anubis	47.54	0.00e+00	750.00
IUUC-Psi-093957	Pelodiscus sinensis	47.79	0.00e+00	782.00
IUUC-Ppa-095901	Physcomitrella patens	64.09	0.00e+00	1088.00
IUUC-Pfo-097148	Poecilia formosa	46.00	0.00e+00	684.00
IUUC-Pab-098068	Pongo abelii	43.74	0.00e+00	632.00
IUUC-Pop-098855	Populus trichocarpa	76.95	0.00e+00	1224.00
IUUC-Ppe-101315	Prunus persica	77.71	0.00e+00	1245.00
IUUC-Pva-102154	Pteropus vampyrus	47.42	0.00e+00	745.00
IUUC-Pgr-103343	Puccinia graminis	34.65	2.00e-102	366.00
IUUC-Ptt-103928	Puccinia triticina	29.63	2.00e-91	330.00
IUUC-Pte-104306	Pyrenophora teres	33.66	2.00e-101	363.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.61	4.00e-108	385.00
IUUC-Rno-105801	Rattus norvegicus	47.89	0.00e+00	754.00
IUUC-Sha-107635	Sarcophilus harrisii	49.03	0.00e+00	758.00
IUUC-Smo-108848	Selaginella moellendorffii	62.72	0.00e+00	981.00
IUUC-Sit-110728	Setaria italica	71.29	0.00e+00	1174.00
IUUC-Sly-111523	Solanum lycopersicum	71.82	0.00e+00	1221.00
IUUC-Sbi-114419	Sorghum bicolor	71.64	0.00e+00	1167.00
IUUC-Ssc-115686	Sus scrofa	47.07	0.00e+00	748.00
IUUC-Tgu-117346	Taeniopygia guttata	47.61	0.00e+00	756.00
IUUC-Tru-118350	Takifugu rubripes	43.92	0.00e+00	676.00
IUUC-Tsy-119278	Tarsius syrichta	39.80	6.00e-160	557.00
IUUC-Tni-120658	Tetraodon nigroviridis	44.06	0.00e+00	656.00
IUUC-Tca-121585	Theobroma cacao	79.25	0.00e+00	1267.00
IUUC-Tre-122043	Trichoderma reesei	35.99	3.00e-116	412.00
IUUC-Tvi-122303	Trichoderma virens	36.24	2.00e-123	436.00
IUUC-Tae-123798	Triticum aestivum	68.70	0.00e+00	1120.00
IUUC-Tur-126732	Triticum urartu	63.97	0.00e+00	1035.00
IUUC-Tme-126909	Tuber melanosporum	34.66	2.00e-107	382.00
IUUC-Ttr-128295	Tursiops truncatus	38.15	3.00e-164	572.00
IUUC-Vda-129688	Verticillium dahliae	34.04	2.00e-114	406.00
IUUC-Vvi-131116	Vitis vinifera	76.70	0.00e+00	1224.00
IUUC-Xtr-131953	Xenopus tropicalis	46.67	0.00e+00	726.00
IUUC-Xma-133837	Xiphophorus maculatus	46.00	0.00e+00	685.00
IUUC-Yli-134510	Yarrowia lipolytica	34.24	1.00e-107	384.00
IUUC-Zma-135786	Zea mays	69.28	0.00e+00	1123.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence