iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026347

UUCD1 version

UUC-CiS-00485

Ensembl Protein ID

ENSCSAVP00000018670.1

UniProt Accession

H2ZM54; H2ZM54_CIOSA

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000010969.1	ENSCSAVT00000018873.1	ENSCSAVP00000018670.1
ENSCSAVG00000010969.1	ENSCSAVT00000018874.1	ENSCSAVP00000018671.1
ENSCSAVG00000010969.1	ENSCSAVT00000018875.1	ENSCSAVP00000018672.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.30e-59	200.1	316	808
UBD/Alpha-Helix/UBA	9.70e-19	66.9	680	716

Active Site

Position(s)	Description	Evidence
325	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
771	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenpkepkgellkslqklfeelw...........kskkk.. 66
           +Gl N+gNtCYmNSv+Q+L+ ipe+++ + +              l++   ++ + +++ +l kl  +++           +   +  
   Q: 316  VGLDNMGNTCYMNSVMQVLYTIPEFQDRFVNfifhpcflfL----LKRV--SDASSDFTIQLCKLGLAMYspeiiqtgnsaH---Enk 394
           6******************************9987755421....2222..4556667777777777774333333332321...134 PP
   S: 67   .....avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgq 149
                +v+pr+++++++k ++efs+++qqDa+Efl ++l+ +e+                             +k +     ++F++ 
   Q: 395  emtscSVTPRTMKRIVGKGHVEFSTNRQQDAHEFLLHVLSVIERGE---------------------------HKNGGISPGEIFRFM 455
           56667***************************************99...........................3445556789***** PP
   S: 150  lksqikclecdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyyce 209
           ++++i c++ ++v  ++ + + l lp+p +  t+k                              ++ c++sf++ e +++   ++++
   Q: 456  VEDRIECQASKQVRYTKRSDYALALPIPLEAATNKAaveeyqavveankkdvnvkigqivrpvvPFTACIDSFAQDELIQD---FWSS 540
           ****************************99988887999****************************************97...**** PP
   S: 210  kckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.............................. 267
             k+k ea+k++++ ++P+ L++++k+f+     + ++k++ +ve+p++L+l++  +s                              
   Q: 541  AVKEKAEAKKRTRFVTFPDHLVVQMKKFTIGD-DWTPKKLDVSVEMPDNLNLNELRASglqkdetllpdiepppappseplidideea 627
           ****************************8866.5********************9999888888888888888888888888888888 PP
   S: 268  ....................................................................peekqke............. 274
                                                                               +     +             
   Q: 628  vvaisqmgfplsrcraalvatgnmgvepavmwlmennsdaneastecnhatddnissivamgftqeqaK-----Kalkatnnnleraa 710
           888888888888888888888888888888888877777666666666666666666666666555550.....05555555566666 PP
   S: 275  ........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeee 321
                                                   + +YeL+a ++H+G s+ +GHYv+++k+ +g+W+ f+D+kV e+  e+
   Q: 711  dwifshideldsievdsseptnqdaagdvpmdttnnlkdgSGNYELYAFISHMGsSTICGHYVCHIKK-DGRWVIFNDEKVAES--EQ 795
           6666666666666666666666777777788888888888****************************.9************99..78 PP
   S: 322  vleetgstaYvlfYkr 337
             +   + +Y++fYkr
   Q: 796  PPK---DLGYMYFYKR 808
           899...99******98 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d +  +v+MGF++e+a++aL a+nnnle+A+++++++
   Q: 680  DNISSIVAMGFTQEQAKKALKATNNNLERAADWIFSH 716
           678899*****************************97 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

MSITDSLVPL LPKVRIPGIG DNVYKEEGCF SFDTPKCEDG LYVCMTTFLG FNRKFAQLYH 60
EVTGNKLFLH MKQIKKEVRN LNFIFYLSIE GGFTPDNDNK VEYDDVNELV ILPEYTVINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCATAA CTGATTCACT GGTGCCATTA TTACCAAAGG TTCGAATACC AGGAATTGGG 60
GACAATGTCT ATAAAGAGGA AGGATGCTTT TCATTTGATA CTCCGGTGAG TTTATTGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	39.34	6.00e-155	539.00
IUUC-Aml-002104	Ailuropoda melanoleuca	46.34	0.00e+00	793.00
IUUC-Atr-002580	Amborella trichopoda	39.45	6.00e-168	583.00
IUUC-Apl-003774	Anas platyrhynchos	46.31	0.00e+00	768.00
IUUC-Aca-005368	Anolis carolinensis	47.80	0.00e+00	818.00
IUUC-Aly-005727	Arabidopsis lyrata	40.88	2.00e-173	600.00
IUUC-Ath-006974	Arabidopsis thaliana	40.64	6.00e-174	602.00
IUUC-Ago-007890	Ashbya gossypii	26.07	1.00e-62	232.00
IUUC-Acl-008057	Aspergillus clavatus	30.97	3.00e-102	364.00
IUUC-Afl-008547	Aspergillus flavus	32.76	5.00e-98	350.00
IUUC-Afu-008805	Aspergillus fumigatus	32.27	1.00e-88	319.00
IUUC-Ani-009441	Aspergillus nidulans	30.65	1.00e-82	298.00
IUUC-Ang-009720	Aspergillus niger	31.20	4.00e-97	347.00
IUUC-Aor-010111	Aspergillus oryzae	31.32	2.00e-104	372.00
IUUC-Ate-010531	Aspergillus terreus	30.34	7.00e-86	310.00
IUUC-Ame-011470	Astyanax mexicanus	42.40	0.00e+00	700.00
IUUC-Bgr-012183	Blumeria graminis	30.41	5.00e-99	353.00
IUUC-Bta-013179	Bos taurus	46.79	0.00e+00	803.00
IUUC-Bci-013858	Botrytis cinerea	33.01	3.00e-112	397.00
IUUC-Bdi-014904	Brachypodium distachyon	41.99	6.00e-175	606.00
IUUC-Bol-015296	Brassica oleracea	42.36	3.00e-177	613.00
IUUC-Bra-017939	Brassica rapa	42.61	2.00e-179	621.00
IUUC-Cel-018625	Caenorhabditis elegans	34.09	9.00e-117	412.00
IUUC-Cja-019063	Callithrix jacchus	45.88	0.00e+00	791.00
IUUC-Cfa-020976	Canis familiaris	48.09	0.00e+00	810.00
IUUC-Cpo-022265	Cavia porcellus	48.03	0.00e+00	811.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.14	1.00e-109	388.00
IUUC-Csa-024078	Chlorocebus sabaeus	43.25	0.00e+00	709.00
IUUC-Cho-024702	Choloepus hoffmanni	41.72	2.00e-127	447.00
IUUC-Cin-025411	Ciona intestinalis	76.08	0.00e+00	1204.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.38	3.00e-94	337.00
IUUC-Cne-026831	Cryptococcus neoformans	33.05	3.00e-103	368.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.20	9.00e-38	150.00
IUUC-Dre-027982	Danio rerio	45.60	0.00e+00	729.00
IUUC-Dno-029034	Dasypus novemcinctus	46.80	0.00e+00	805.00
IUUC-Dor-030130	Dipodomys ordii	39.50	2.00e-95	342.00
IUUC-Dse-031467	Dothistroma septosporum	31.98	2.00e-107	381.00
IUUC-Dme-032075	Drosophila melanogaster	43.53	0.00e+00	649.00
IUUC-Ete-032865	Echinops telfairi	44.10	0.00e+00	735.00
IUUC-Eca-034059	Equus caballus	46.18	0.00e+00	798.00
IUUC-Eeu-035304	Erinaceus europaeus	47.99	0.00e+00	717.00
IUUC-Fca-035515	Felis catus	46.45	0.00e+00	800.00
IUUC-Fal-037271	Ficedula albicollis	47.12	0.00e+00	756.00
IUUC-Fox-037745	Fusarium oxysporum	33.06	1.00e-103	369.00
IUUC-Fso-038158	Fusarium solani	31.87	5.00e-99	353.00
IUUC-Gmo-039071	Gadus morhua	46.11	0.00e+00	757.00
IUUC-Ggr-040098	Gaeumannomyces graminis	31.30	6.00e-98	350.00
IUUC-Gga-040635	Gallus gallus	45.89	0.00e+00	807.00
IUUC-Gac-042528	Gasterosteus aculeatus	46.88	0.00e+00	761.00
IUUC-Gma-043614	Glycine max	41.18	4.00e-169	586.00
IUUC-Ggo-044602	Gorilla gorilla	46.33	0.00e+00	798.00
IUUC-Hsa-045959	Homo sapiens	46.33	0.00e+00	798.00
IUUC-Hvu-047563	Hordeum vulgare	43.85	1.00e-148	518.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	46.45	0.00e+00	801.00
IUUC-Kpa-049156	Komagataella pastoris	29.74	1.00e-92	332.00
IUUC-Lch-049648	Latimeria chalumnae	49.28	0.00e+00	795.00
IUUC-Lpe-051523	Leersia perrieri	41.44	3.00e-173	600.00
IUUC-Loc-052072	Lepisosteus oculatus	43.02	0.00e+00	706.00
IUUC-Lma-053216	Leptosphaeria maculans	32.84	1.00e-97	350.00
IUUC-Laf-054327	Loxodonta africana	46.45	0.00e+00	796.00
IUUC-Mcc-055443	Macaca mulatta	46.33	0.00e+00	799.00
IUUC-Meu-056298	Macropus eugenii	47.45	2.00e-159	554.00
IUUC-Mor-057106	Magnaporthe oryzae	32.81	5.00e-106	377.00
IUUC-Mpo-057589	Magnaporthe poae	30.93	1.00e-99	355.00
IUUC-Mtr-058680	Medicago truncatula	41.46	7.00e-170	589.00
IUUC-Mla-058903	Melampsora laricipopulina	29.92	8.00e-93	333.00
IUUC-Mga-059669	Meleagris gallopavo	45.90	0.00e+00	760.00
IUUC-Mvi-060476	Microbotryum violaceum	32.10	2.00e-94	338.00
IUUC-Mmr-060575	Microcebus murinus	46.22	0.00e+00	796.00
IUUC-Mdo-062183	Monodelphis domestica	46.64	0.00e+00	801.00
IUUC-Mmu-063592	Mus musculus	46.57	0.00e+00	803.00
IUUC-Mac-065634	Musa acuminata	38.20	6.00e-166	576.00
IUUC-Mpu-066082	Mustela putorius furo	47.85	0.00e+00	806.00
IUUC-Mlu-067345	Myotis lucifugus	47.04	0.00e+00	803.00
IUUC-Nfi-068558	Neosartorya fischeri	31.94	2.00e-100	358.00
IUUC-Ncr-068960	Neurospora crassa	30.68	8.00e-93	333.00
IUUC-Nle-070173	Nomascus leucogenys	47.85	0.00e+00	808.00
IUUC-Opr-070556	Ochotona princeps	46.45	0.00e+00	802.00
IUUC-Ont-071502	Oreochromis niloticus	46.04	0.00e+00	736.00
IUUC-Oan-072959	Ornithorhynchus anatinus	51.09	2.00e-66	243.00
IUUC-Ocu-074861	Oryctolagus cuniculus	48.09	0.00e+00	813.00
IUUC-Oba-075109	Oryza barthii	42.55	1.00e-179	622.00
IUUC-Obr-076292	Oryza brachyantha	42.43	4.00e-178	616.00
IUUC-Ogl-077065	Oryza glaberrima	43.88	0.00e+00	648.00
IUUC-Ogu-078776	Oryza glumaepatula	42.55	5.00e-180	622.00
IUUC-Oin-080048	Oryza indica	44.00	0.00e+00	637.00
IUUC-Olo-080711	Oryza longistaminata	40.90	1.00e-161	561.00
IUUC-Ome-081506	Oryza meridionalis	42.04	6.00e-166	575.00
IUUC-Oni-082320	Oryza nivara	41.92	3.00e-180	623.00
IUUC-Opu-083801	Oryza punctata	42.18	1.00e-173	601.00
IUUC-Oru-085139	Oryza rufipogon	41.92	1.00e-180	625.00
IUUC-Osa-085713	Oryza sativa	43.88	0.00e+00	647.00
IUUC-Ola-086951	Oryzias latipes	46.81	0.00e+00	739.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.12	7.00e-161	559.00
IUUC-Oga-088625	Otolemur garnettii	46.15	0.00e+00	797.00
IUUC-Oar-089995	Ovis aries	46.45	0.00e+00	802.00
IUUC-Ptr-090640	Pan troglodytes	46.10	0.00e+00	798.00
IUUC-Pan-091974	Papio anubis	46.23	0.00e+00	796.00
IUUC-Psi-093957	Pelodiscus sinensis	46.00	0.00e+00	811.00
IUUC-Pma-094242	Petromyzon marinus	49.61	4.00e-112	395.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.09	1.00e-89	322.00
IUUC-Ppa-095901	Physcomitrella patens	41.85	0.00e+00	634.00
IUUC-Pfo-097148	Poecilia formosa	47.05	0.00e+00	747.00
IUUC-Pab-098068	Pongo abelii	41.40	0.00e+00	659.00
IUUC-Pop-098943	Populus trichocarpa	41.48	1.00e-170	591.00
IUUC-Pca-100738	Procavia capensis	41.09	0.00e+00	671.00
IUUC-Ppe-101315	Prunus persica	42.23	3.00e-171	593.00
IUUC-Pva-102154	Pteropus vampyrus	45.75	0.00e+00	780.00
IUUC-Pgr-103343	Puccinia graminis	29.40	7.00e-78	283.00
IUUC-Ptt-103928	Puccinia triticina	27.56	6.00e-81	293.00
IUUC-Pte-104306	Pyrenophora teres	33.97	1.00e-85	309.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.81	1.00e-88	319.00
IUUC-Rno-105801	Rattus norvegicus	46.68	0.00e+00	803.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.53	2.00e-61	228.00
IUUC-Sha-107635	Sarcophilus harrisii	47.73	0.00e+00	802.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	30.99	2.00e-89	322.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.14	2.00e-91	328.00
IUUC-Smo-108848	Selaginella moellendorffii	42.01	2.00e-180	624.00
IUUC-Sit-110728	Setaria italica	42.53	0.00e+00	637.00
IUUC-Sly-111523	Solanum lycopersicum	41.17	4.00e-180	623.00
IUUC-Sar-113733	Sorex araneus	40.05	4.00e-89	321.00
IUUC-Sbi-114419	Sorghum bicolor	42.23	0.00e+00	629.00
IUUC-Sre-115225	Sporisorium reilianum	30.80	2.00e-100	358.00
IUUC-Ssc-115686	Sus scrofa	46.56	0.00e+00	800.00
IUUC-Tgu-117346	Taeniopygia guttata	45.60	0.00e+00	791.00
IUUC-Tru-118350	Takifugu rubripes	44.88	0.00e+00	747.00
IUUC-Tsy-119278	Tarsius syrichta	40.07	3.00e-170	590.00
IUUC-Tni-120658	Tetraodon nigroviridis	44.68	0.00e+00	717.00
IUUC-Tca-121585	Theobroma cacao	41.15	2.00e-167	581.00
IUUC-Tre-122043	Trichoderma reesei	30.86	1.00e-99	355.00
IUUC-Tvi-122303	Trichoderma virens	30.18	1.00e-93	336.00
IUUC-Tae-125686	Triticum aestivum	42.30	6.00e-176	609.00
IUUC-Tur-126732	Triticum urartu	39.85	4.00e-164	570.00
IUUC-Tme-126909	Tuber melanosporum	32.22	2.00e-94	338.00
IUUC-Tbe-127261	Tupaia belangeri	41.28	2.00e-135	474.00
IUUC-Ttr-129119	Tursiops truncatus	50.53	3.00e-114	404.00
IUUC-Uma-129599	Ustilago maydis	30.40	8.00e-102	363.00
IUUC-Vda-129688	Verticillium dahliae	32.61	3.00e-104	370.00
IUUC-Vpa-130170	Vicugna pacos	37.83	4.00e-157	546.00
IUUC-Vvi-131116	Vitis vinifera	41.43	5.00e-169	586.00
IUUC-Xtr-131953	Xenopus tropicalis	46.06	0.00e+00	756.00
IUUC-Xma-133837	Xiphophorus maculatus	46.82	0.00e+00	745.00
IUUC-Yli-134510	Yarrowia lipolytica	32.76	6.00e-102	363.00
IUUC-Zma-135786	Zea mays	41.99	3.00e-172	597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence