iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050038

Ensembl Protein ID

ENSLACP00000011007.1

UniProt Accession

H3AMY6; H3AMY6_LATCH

Genbank Protein ID

ENSLACP00000011007

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AFYH01146781

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000009686.1	ENSLACT00000011089.1	ENSLACP00000011007.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-117	392.7	17	527

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQi.rlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv 88
           YDRQ+ rlwG+++qe+l+sa+v+l++a+ +G+E+lKnLvl G+gs+t+vD+++v+ ++++++F+++++++gks+A++a e l+eln+dv
   Q: 17   YDRQLsRLWGDHGQEALESAHVCLINATVTGTEILKNLVLPGIGSFTIVDGNQVTGEDVGNNFFLNRSSIGKSRAQCATELLQELNSDV 105
           9***8799********************************************************************************* PP
   S: 89   nveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPf 173
           ++ + ees+++l ++++ Ff +f+vVv+++ +++  ++++  ++na++pl+ ++t+Gl G++r+ ik++t+++s++d   ++++++ Pf
   Q: 106  SGNFMEESPEKLLDNDPtFFHRFSVVVATQLPESILLRLAANLWNASIPLLVCRTYGLTGYMRIAIKEHTVIESHPDnvlEDLRLDLPF 194
           ***************************************************************************************** PP
   S: 174  ctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafak 247
            +lk ++n         +++++++w+ l+ k+le+++ e++++ +++++eke+++d++++++ +      +deenf+ea++++++a++ 
   Q: 195  LELKRHINsydlehmekKDHSHTPWIILVTKYLEKWRHEHSGQLPKTYKEKEAFRDLIRQGILKnengvpADEENFDEAVKNVNTALNI 283
           ******99999999998***********************************************9************************ PP
   S: 248  ttins.ikqllksfecdivtkskspfwv............................................................. 274
           t i+s i++++++ +c + t + +pfw+                                                             
   Q: 284  TKIPSgIEEIFNDKRCTRTTAQIPPFWIlaravkefvskegqgnlpvrgtipdmiadsdkfialqnvyreresasprahkkkffflllq 372
           ***************************************************************************************** PP
   S: 275  ...........sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avd 334
                       fc n++ l+v            e+++kde+++ +++p     lyl+lra++rf +++gr+pg+ ++++++d+  + +
   Q: 373  ppesipekdirLFCRNSAFLRVVccrslaeeysiETTNKDEIASYMDNPdsemvLYLMLRAIDRFYQQHGRYPGVYNYQVEEDIgkLKA 461
           *********************778888888888899999999999988899999*****************************999999 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +v+ ++    +++g++  ++dd+++e++++++++ +t++a++gG+aa Ev+K+++g+f+p++n+f+++a+
   Q: 462  CVNGVL----QEYGLPVTVKDDYVHEFCRYGAAEPHTVAAFLGGAAAHEVVKIITGQFVPFNNTFIYNAM 527
           999999....*********************************************************997 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MASSAVGQSK VSKEQKYDRQ LSRLWGDHGQ EALESAHVCL INATVTGTEI LKNLVLPGIG 60
SFTIVDGNQV TGEDVGNNFF LNRSSIGKSR AQCATELLQE LNSDVSGNFM EESPEKLLDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCCCCTC ACCCGTGACG AAAGTGGAGC TGCAAATCCA AAGCGGACTT TTACCCAGAA 60
TGGCGAGCAG CGCTGTTGGC CAGAGCAAAG TCAGCAAAGA GCAAAAATAC GACCGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.29	1.00e-120	426.00
IUUC-Aml-002333	Ailuropoda melanoleuca	76.13	0.00e+00	854.00
IUUC-Atr-002644	Amborella trichopoda	39.59	1.00e-107	383.00
IUUC-Apl-003446	Anas platyrhynchos	75.63	0.00e+00	813.00
IUUC-Aca-004450	Anolis carolinensis	73.57	0.00e+00	836.00
IUUC-Aly-006187	Arabidopsis lyrata	40.04	3.00e-121	428.00
IUUC-Ath-007600	Arabidopsis thaliana	40.42	2.00e-120	425.00
IUUC-Ago-007900	Ashbya gossypii	25.97	2.00e-37	149.00
IUUC-Acl-008333	Aspergillus clavatus	34.57	2.00e-75	276.00
IUUC-Afl-008529	Aspergillus flavus	34.89	9.00e-78	284.00
IUUC-Afu-009071	Aspergillus fumigatus	33.75	1.00e-72	266.00
IUUC-Ani-009443	Aspergillus nidulans	33.75	8.00e-73	268.00
IUUC-Ang-009669	Aspergillus niger	32.68	1.00e-74	273.00
IUUC-Aor-009914	Aspergillus oryzae	34.58	2.00e-75	276.00
IUUC-Ate-010450	Aspergillus terreus	34.85	2.00e-76	280.00
IUUC-Ame-011183	Astyanax mexicanus	71.91	0.00e+00	823.00
IUUC-Bgr-012111	Blumeria graminis	31.08	1.00e-60	227.00
IUUC-Bta-012583	Bos taurus	76.60	0.00e+00	857.00
IUUC-Bci-013892	Botrytis cinerea	32.25	4.00e-60	225.00
IUUC-Bdi-014592	Brachypodium distachyon	42.88	9.00e-124	436.00
IUUC-Bol-016399	Brassica oleracea	39.09	2.00e-116	412.00
IUUC-Bra-017506	Brassica rapa	39.16	6.00e-114	404.00
IUUC-Cel-018456	Caenorhabditis elegans	35.28	2.00e-88	319.00
IUUC-Cja-020007	Callithrix jacchus	76.03	0.00e+00	854.00
IUUC-Cfa-020324	Canis familiaris	76.42	0.00e+00	856.00
IUUC-Cpo-022248	Cavia porcellus	69.77	8.00e-137	480.00
IUUC-Csa-023149	Chlorocebus sabaeus	72.19	0.00e+00	714.00
IUUC-Cho-024537	Choloepus hoffmanni	65.73	3.00e-178	617.00
IUUC-Cin-025763	Ciona intestinalis	47.36	4.00e-148	517.00
IUUC-Csv-026113	Ciona savignyi	43.81	9.00e-137	480.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.43	2.00e-62	233.00
IUUC-Cne-026884	Cryptococcus neoformans	30.70	1.00e-68	253.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.87	3.00e-18	86.70
IUUC-Dre-028140	Danio rerio	74.15	0.00e+00	839.00
IUUC-Dno-030033	Dasypus novemcinctus	75.85	0.00e+00	746.00
IUUC-Dor-030513	Dipodomys ordii	49.84	2.00e-80	293.00
IUUC-Dse-031536	Dothistroma septosporum	34.69	8.00e-78	284.00
IUUC-Dme-031683	Drosophila melanogaster	42.91	2.00e-122	432.00
IUUC-Ete-032420	Echinops telfairi	66.47	0.00e+00	711.00
IUUC-Eca-033992	Equus caballus	75.23	0.00e+00	708.00
IUUC-Eeu-034713	Erinaceus europaeus	65.75	2.00e-95	342.00
IUUC-Fca-036548	Felis catus	75.89	0.00e+00	847.00
IUUC-Fal-037600	Ficedula albicollis	74.47	0.00e+00	803.00
IUUC-Fox-038037	Fusarium oxysporum	31.14	4.00e-67	248.00
IUUC-Fso-038387	Fusarium solani	33.33	2.00e-70	259.00
IUUC-Gmo-038562	Gadus morhua	70.75	0.00e+00	806.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.25	9.00e-69	254.00
IUUC-Gga-041129	Gallus gallus	75.90	0.00e+00	820.00
IUUC-Gac-042558	Gasterosteus aculeatus	71.83	0.00e+00	823.00
IUUC-Gma-043610	Glycine max	39.17	2.00e-113	402.00
IUUC-Ggo-045611	Gorilla gorilla	76.17	0.00e+00	852.00
IUUC-Hsa-046563	Homo sapiens	76.42	0.00e+00	856.00
IUUC-Hvu-047790	Hordeum vulgare	38.17	5.00e-76	278.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	76.46	0.00e+00	856.00
IUUC-Kpa-049309	Komagataella pastoris	34.15	2.00e-72	266.00
IUUC-Lpe-051535	Leersia perrieri	40.77	8.00e-107	380.00
IUUC-Loc-051917	Lepisosteus oculatus	69.72	0.00e+00	785.00
IUUC-Lma-053112	Leptosphaeria maculans	34.51	6.00e-81	295.00
IUUC-Laf-053690	Loxodonta africana	76.46	0.00e+00	858.00
IUUC-Mcc-055117	Macaca mulatta	74.58	0.00e+00	836.00
IUUC-Meu-056761	Macropus eugenii	64.02	0.00e+00	685.00
IUUC-Mor-057230	Magnaporthe oryzae	33.70	1.00e-75	277.00
IUUC-Mpo-057514	Magnaporthe poae	33.09	2.00e-68	252.00
IUUC-Mtr-058551	Medicago truncatula	38.31	1.00e-110	393.00
IUUC-Mla-059183	Melampsora laricipopulina	36.40	2.00e-95	342.00
IUUC-Mga-060144	Meleagris gallopavo	75.63	0.00e+00	806.00
IUUC-Mvi-060221	Microbotryum violaceum	34.07	9.00e-75	274.00
IUUC-Mmr-061325	Microcebus murinus	75.05	0.00e+00	838.00
IUUC-Mdo-062532	Monodelphis domestica	76.49	0.00e+00	858.00
IUUC-Mmu-063956	Mus musculus	76.04	0.00e+00	855.00
IUUC-Mac-064521	Musa acuminata	39.63	3.00e-115	408.00
IUUC-Mpu-066716	Mustela putorius furo	75.55	0.00e+00	800.00
IUUC-Mlu-067459	Myotis lucifugus	74.53	0.00e+00	843.00
IUUC-Nfi-068245	Neosartorya fischeri	35.20	7.00e-75	274.00
IUUC-Ncr-068910	Neurospora crassa	32.45	7.00e-71	261.00
IUUC-Nle-070034	Nomascus leucogenys	75.10	0.00e+00	825.00
IUUC-Opr-070552	Ochotona princeps	69.48	0.00e+00	699.00
IUUC-Ont-071426	Oreochromis niloticus	73.78	0.00e+00	848.00
IUUC-Oan-073389	Ornithorhynchus anatinus	71.85	0.00e+00	660.00
IUUC-Ocu-074911	Oryctolagus cuniculus	75.66	0.00e+00	852.00
IUUC-Oba-075437	Oryza barthii	42.13	3.00e-112	398.00
IUUC-Obr-076684	Oryza brachyantha	41.56	2.00e-108	385.00
IUUC-Ogl-077170	Oryza glaberrima	42.13	3.00e-112	398.00
IUUC-Ogu-078844	Oryza glumaepatula	42.43	8.00e-105	374.00
IUUC-Oin-079105	Oryza indica	42.13	1.00e-111	396.00
IUUC-Olo-080943	Oryza longistaminata	39.40	6.00e-99	354.00
IUUC-Oni-082891	Oryza nivara	39.09	8.00e-105	374.00
IUUC-Opu-083457	Oryza punctata	42.13	2.00e-111	396.00
IUUC-Oru-084960	Oryza rufipogon	39.40	4.00e-99	355.00
IUUC-Osa-085358	Oryza sativa	42.13	3.00e-111	395.00
IUUC-Ola-086420	Oryzias latipes	72.12	3.00e-169	587.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.72	2.00e-57	216.00
IUUC-Oga-088810	Otolemur garnettii	75.47	0.00e+00	846.00
IUUC-Oar-089196	Ovis aries	76.17	0.00e+00	852.00
IUUC-Ptr-090617	Pan troglodytes	76.60	0.00e+00	857.00
IUUC-Pan-092761	Papio anubis	76.79	0.00e+00	859.00
IUUC-Psi-093191	Pelodiscus sinensis	76.88	0.00e+00	852.00
IUUC-Pma-094380	Petromyzon marinus	62.15	0.00e+00	657.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.39	2.00e-71	264.00
IUUC-Ppa-095798	Physcomitrella patens	39.96	9.00e-117	413.00
IUUC-Pfo-096467	Poecilia formosa	72.63	0.00e+00	834.00
IUUC-Pab-098255	Pongo abelii	75.45	0.00e+00	703.00
IUUC-Pop-099722	Populus trichocarpa	40.42	6.00e-120	424.00
IUUC-Pca-100807	Procavia capensis	67.55	6.00e-100	357.00
IUUC-Ppe-101280	Prunus persica	39.09	3.00e-115	408.00
IUUC-Pva-102333	Pteropus vampyrus	73.22	0.00e+00	807.00
IUUC-Pgr-103401	Puccinia graminis	30.29	3.00e-75	276.00
IUUC-Ptt-103889	Puccinia triticina	25.43	6.00e-54	205.00
IUUC-Pte-104355	Pyrenophora teres	35.28	3.00e-84	306.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.59	2.00e-85	310.00
IUUC-Rno-105810	Rattus norvegicus	75.75	0.00e+00	850.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.35	4.00e-28	119.00
IUUC-Sha-106770	Sarcophilus harrisii	80.42	3.00e-136	477.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.07	3.00e-71	262.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.09	5.00e-78	285.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.62	1.00e-64	240.00
IUUC-Smo-109296	Selaginella moellendorffii	41.43	3.00e-116	412.00
IUUC-Sit-110157	Setaria italica	43.45	8.00e-127	447.00
IUUC-Sly-111105	Solanum lycopersicum	39.15	3.00e-116	411.00
IUUC-Stu-112469	Solanum tuberosum	38.82	6.00e-118	417.00
IUUC-Sar-113083	Sorex araneus	57.75	5.00e-174	603.00
IUUC-Sbi-113813	Sorghum bicolor	44.21	1.00e-125	443.00
IUUC-Sre-115058	Sporisorium reilianum	35.99	1.00e-72	267.00
IUUC-Tgu-116772	Taeniopygia guttata	74.24	0.00e+00	808.00
IUUC-Tru-118686	Takifugu rubripes	71.72	0.00e+00	828.00
IUUC-Tsy-119111	Tarsius syrichta	73.93	1.00e-119	423.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.85	0.00e+00	755.00
IUUC-Tca-121491	Theobroma cacao	38.90	7.00e-111	394.00
IUUC-Tre-122103	Trichoderma reesei	34.13	3.00e-76	278.00
IUUC-Tvi-122672	Trichoderma virens	34.43	1.00e-73	270.00
IUUC-Tae-125950	Triticum aestivum	43.07	3.00e-123	435.00
IUUC-Tur-126487	Triticum urartu	41.41	3.00e-117	415.00
IUUC-Tme-127097	Tuber melanosporum	39.01	8.00e-94	337.00
IUUC-Ttr-128465	Tursiops truncatus	70.97	0.00e+00	782.00
IUUC-Uma-129645	Ustilago maydis	35.29	2.00e-73	270.00
IUUC-Vda-129989	Verticillium dahliae	29.60	4.00e-53	202.00
IUUC-Vpa-130529	Vicugna pacos	72.10	0.00e+00	803.00
IUUC-Vvi-131059	Vitis vinifera	39.47	2.00e-115	409.00
IUUC-Xtr-132002	Xenopus tropicalis	74.00	0.00e+00	837.00
IUUC-Xma-133930	Xiphophorus maculatus	73.60	0.00e+00	842.00
IUUC-Yli-134505	Yarrowia lipolytica	35.31	1.00e-83	303.00
IUUC-Zma-135895	Zea mays	44.40	1.00e-125	443.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence