iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ppa-095798

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

DS544973

Gene Name

PHYPADRAFT_185649

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PP1S84_287V6	PP1S84_287V6.6	PP1S84_287V6.6
PP1S84_287V6	PP1S84_287V6.5	PP1S84_287V6.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.60e-90	302.7	8	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahee 95
           YDRQ+r+wGe++q +l++a+v+++++g++G+E lKnLvl+G+gs+t+vD + v+vs+l++++L++ e+ g+sKA+++++ l+eln +v ++++ee
   Q: 8    YDRQLRIWGEHGQTALERARVCVLNCGPTGSEALKNLVLGGIGSFTIVDASEVSVSDLGNNYLVDWESMGQSKAKSVCALLQELNESVVAKFVEE 102
           *********************************************************************************************** PP
   S: 96   siteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn..... 181
           s+++l ++++ Ff +f++V+++++ +   +k+ ++c++++v l++++++Gl G vr++++++ +++s++d   +++++ iP+++l++++      
   Q: 103  SPEALLKSNPtFFAQFTLVIATQMTETHLLKLEEICRQHNVMLVIARSYGLAGLVRISVREHVIIESKPDnrvEDLRLHIPWPELQSYVDefdid 197
           ****************************************************************************************5555555 PP
   S: 182  ....aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtksksp 271
               +++++i+ a l+ k++e++++++ ++ + +   ++e+ ++ ++    e+e+n+ ea + a   + +  i+s  + +l++ + ++v  s+s+
   Q: 198  tpdnNIHKHIPFAILLIKIAEDWKKAHGGKLPANVRLFKEAITARRRV--VEEEDNYTEALKSAYIMLFPPGISSqLRAVLED-KAAEVEASSSD 289
           6666***************************99877777766666555..45589******9999999999999988888888.77799****** PP
   S: 272  fwv...........................................................................sfcsnaealqvp..... 286
           fw+                                                                            fc+n++ l+v      
   Q: 290  FWImvaalkqfmanegqgeppldgaipdmhsftdyyiklqkiyqaraeadvtavegyvarilkrigrdsspiprstikLFCKNSRNLRVLrckml 384
           ****************************************************************************************5544444 PP
   S: 287  ......ekvekdeevvkasap.............lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikei 361
                  ++ + ++ ++a+++             ly+llra++ f+++++r pg ++ e ++d + +l+  +a+    ++g  +  l++d+++e+
   Q: 385  sdeyssRSGSELQRLLAAEESrfffeqflcshpaLYILLRAVDHFAATYNRFPGAFDGEIEED-VSRLKS-LAVGLLNDMGGGGaSLPEDVVSEV 477
           5555554444444444444445555555555556*******************9999999999.555555.44445599999999********** PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +++++++i+ ++++vgG+a+qE iK+++ +f+p++ +++++a+
   Q: 478  CRFGASEIHCVASIVGGIASQECIKLLTRQFTPIQGTLIYNAM 520
           ****************************************997 PP

Organism

Physcomitrella patens

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAQRNNKYDR QLRIWGEHGQ TALERARVCV LNCGPTGSEA LKNLVLGGIG SFTIVDASEV 60
SVSDLGNNYL VDWESMGQSK AKSVCALLQE LNESVVAKFV EESPEALLKS NPTFFAQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCGTGCCC TGCTCTTCCC TGTTTCATGA ACGGAGACTC AGTACTGGCG TTAAATTTCG 60
CCAGTTTCTG ACAATTTTAA GGTATGGCAC CACATCGCAT TTTCGCTCCC TAGAGAACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

ppp:PHYPADRAFT_185649

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	54.99	5.00e-172	596.00
IUUC-Atr-002644	Amborella trichopoda	55.39	2.00e-177	614.00
IUUC-Aca-004450	Anolis carolinensis	39.06	7.00e-120	423.00
IUUC-Aly-005466	Arabidopsis lyrata	55.53	8.00e-180	622.00
IUUC-Ath-006692	Arabidopsis thaliana	55.91	0.00e+00	627.00
IUUC-Afl-008529	Aspergillus flavus	32.19	6.00e-74	270.00
IUUC-Ang-009669	Aspergillus niger	29.98	2.00e-64	239.00
IUUC-Aor-009914	Aspergillus oryzae	31.91	4.00e-72	265.00
IUUC-Ate-010450	Aspergillus terreus	31.28	1.00e-70	259.00
IUUC-Bgr-012111	Blumeria graminis	29.57	3.00e-55	208.00
IUUC-Bci-013892	Botrytis cinerea	30.49	8.00e-56	210.00
IUUC-Bdi-014592	Brachypodium distachyon	55.81	2.00e-170	591.00
IUUC-Bol-016401	Brassica oleracea	56.65	0.00e+00	633.00
IUUC-Bra-017506	Brassica rapa	54.84	3.00e-177	613.00
IUUC-Cin-025763	Ciona intestinalis	39.26	2.00e-115	408.00
IUUC-Csv-026113	Ciona savignyi	38.80	7.00e-106	377.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.13	1.00e-55	209.00
IUUC-Cne-026884	Cryptococcus neoformans	30.62	2.00e-70	259.00
IUUC-Dse-031536	Dothistroma septosporum	30.86	6.00e-65	241.00
IUUC-Dme-031683	Drosophila melanogaster	38.50	4.00e-99	354.00
IUUC-Fox-038037	Fusarium oxysporum	29.78	9.00e-62	230.00
IUUC-Gma-043221	Glycine max	54.99	7.00e-179	619.00
IUUC-Hvu-047790	Hordeum vulgare	52.53	2.00e-116	411.00
IUUC-Lch-050038	Latimeria chalumnae	39.96	6.00e-117	413.00
IUUC-Lpe-051535	Leersia perrieri	54.49	1.00e-152	531.00
IUUC-Loc-051917	Lepisosteus oculatus	38.24	6.00e-108	383.00
IUUC-Mtr-058551	Medicago truncatula	54.55	3.00e-176	610.00
IUUC-Mla-059183	Melampsora laricipopulina	33.33	3.00e-81	295.00
IUUC-Mvi-060221	Microbotryum violaceum	32.46	1.00e-67	250.00
IUUC-Mac-064521	Musa acuminata	55.03	3.00e-175	607.00
IUUC-Ncr-068910	Neurospora crassa	29.58	2.00e-63	235.00
IUUC-Oba-075437	Oryza barthii	55.53	1.00e-163	568.00
IUUC-Obr-076684	Oryza brachyantha	55.43	2.00e-154	538.00
IUUC-Ogl-077170	Oryza glaberrima	55.53	1.00e-163	568.00
IUUC-Ogu-078844	Oryza glumaepatula	55.29	5.00e-154	536.00
IUUC-Oin-079105	Oryza indica	55.34	1.00e-162	565.00
IUUC-Olo-080943	Oryza longistaminata	53.68	4.00e-148	517.00
IUUC-Oni-082891	Oryza nivara	53.63	6.00e-155	540.00
IUUC-Opu-083457	Oryza punctata	55.15	4.00e-162	563.00
IUUC-Oru-084960	Oryza rufipogon	53.35	2.00e-148	518.00
IUUC-Osa-085358	Oryza sativa	55.34	1.00e-161	561.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.91	6.00e-58	217.00
IUUC-Pma-094380	Petromyzon marinus	39.41	1.00e-104	372.00
IUUC-Pop-099722	Populus trichocarpa	55.09	0.00e+00	630.00
IUUC-Ppe-101280	Prunus persica	56.20	0.00e+00	641.00
IUUC-Pgr-103401	Puccinia graminis	30.49	2.00e-67	249.00
IUUC-Ptt-103889	Puccinia triticina	26.64	1.00e-53	203.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	28.84	7.00e-64	237.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.09	5.00e-59	221.00
IUUC-Smo-109296	Selaginella moellendorffii	56.87	1.00e-174	605.00
IUUC-Sit-110157	Setaria italica	55.26	2.00e-180	624.00
IUUC-Sly-111105	Solanum lycopersicum	53.73	5.00e-178	616.00
IUUC-Stu-112469	Solanum tuberosum	54.66	0.00e+00	626.00
IUUC-Sar-113083	Sorex araneus	48.34	3.00e-42	165.00
IUUC-Sbi-113813	Sorghum bicolor	55.28	2.00e-179	621.00
IUUC-Sre-115058	Sporisorium reilianum	30.55	1.00e-68	253.00
IUUC-Tru-118686	Takifugu rubripes	40.64	8.00e-123	433.00
IUUC-Tni-120231	Tetraodon nigroviridis	37.62	1.00e-102	365.00
IUUC-Tca-121491	Theobroma cacao	55.93	0.00e+00	626.00
IUUC-Tae-125316	Triticum aestivum	55.70	2.00e-174	604.00
IUUC-Tur-126487	Triticum urartu	54.58	5.00e-168	583.00
IUUC-Tme-127097	Tuber melanosporum	35.71	1.00e-77	283.00
IUUC-Vda-129989	Verticillium dahliae	26.92	9.00e-46	177.00
IUUC-Vvi-131059	Vitis vinifera	54.70	4.00e-177	613.00
IUUC-Xtr-132002	Xenopus tropicalis	41.93	5.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence