iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033915

UUCD1 version

UUC-EqC-00301

Ensembl Protein ID

ENSECAP00000020205.1

UniProt Accession

F6UR14; F6UR14_HORSE

Protein Name

Uncharacterized protein

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021385.1	ENSECAT00000024109.1	ENSECAP00000020012.1
ENSECAG00000021385.1	ENSECAT00000024329.1	ENSECAP00000020205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-122	407.4	4025	4359
UBD/Alpha-Helix/UBA	5.90e-08	32.8	1303	1340

Active Site

Position(s)	Description	Evidence
4327	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4025 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4110
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4111 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4194
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4195 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4280
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 4281 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 4359
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1303 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1340
           89**********************.7***********98 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

PADCRALIDK LKVCNDEQLL LELQQIKTWN IGKCELYHWV DLLDRFDGIL ADAGQTVENM 60
SWMLVCDRPE REQLKMLLLA VLNFTALLIE YSFSRHLYSS IEHLTTLLAS SDMQVVLAVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTCCTCCA GTAGTCTGAC CTGAGTGTGT TAGTGCTCCA GAAGAACCAG CAGACCAACT 60
TGGTCAGGAA GGTTCAGGAA GCTATTGGAG CAGTGTTGGG ATTTCCCACC AGGATGAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.55	6.00e-104	374.00
IUUC-Aml-001684	Ailuropoda melanoleuca	98.79	0.00e+00	4399.00
IUUC-Atr-003044	Amborella trichopoda	51.88	1.00e-123	439.00
IUUC-Apl-003729	Anas platyrhynchos	90.73	0.00e+00	662.00
IUUC-Aca-005263	Anolis carolinensis	92.24	0.00e+00	3117.00
IUUC-Aly-006083	Arabidopsis lyrata	51.22	6.00e-125	444.00
IUUC-Ath-007472	Arabidopsis thaliana	51.22	4.00e-125	444.00
IUUC-Ago-008005	Ashbya gossypii	45.51	2.00e-129	458.00
IUUC-Acl-008254	Aspergillus clavatus	45.61	3.00e-131	465.00
IUUC-Afl-008712	Aspergillus flavus	44.93	1.00e-133	471.00
IUUC-Afu-009022	Aspergillus fumigatus	45.42	6.00e-131	464.00
IUUC-Ani-009412	Aspergillus nidulans	45.98	7.00e-133	470.00
IUUC-Ang-009771	Aspergillus niger	45.98	9.00e-132	466.00
IUUC-Aor-010186	Aspergillus oryzae	44.07	3.00e-124	439.00
IUUC-Ate-010253	Aspergillus terreus	46.14	8.00e-132	466.00
IUUC-Ame-011067	Astyanax mexicanus	80.69	0.00e+00	3627.00
IUUC-Bgr-012043	Blumeria graminis	45.95	4.00e-137	484.00
IUUC-Bta-012813	Bos taurus	98.83	0.00e+00	4429.00
IUUC-Bci-013995	Botrytis cinerea	45.49	1.00e-136	483.00
IUUC-Bdi-014884	Brachypodium distachyon	51.41	9.00e-125	443.00
IUUC-Bol-016533	Brassica oleracea	58.33	5.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	44.09	4.00e-122	434.00
IUUC-Cel-018179	Caenorhabditis elegans	60.55	0.00e+00	630.00
IUUC-Cja-018741	Callithrix jacchus	99.08	0.00e+00	4409.00
IUUC-Cfa-020083	Canis familiaris	97.42	0.00e+00	4390.00
IUUC-Cpo-021923	Cavia porcellus	98.12	0.00e+00	4357.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.24	2.00e-117	415.00
IUUC-Csa-023853	Chlorocebus sabaeus	99.29	0.00e+00	4420.00
IUUC-Cho-024718	Choloepus hoffmanni	100.00	0.00e+00	814.00
IUUC-Cin-025627	Ciona intestinalis	42.54	0.00e+00	1910.00
IUUC-Csv-025824	Ciona savignyi	48.00	0.00e+00	1428.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	51.45	2.00e-134	475.00
IUUC-Cne-027095	Cryptococcus neoformans	41.21	9.00e-104	373.00
IUUC-Cme-027267	Cyanidioschyzon merolae	49.64	2.00e-113	404.00
IUUC-Dre-028525	Danio rerio	81.70	0.00e+00	3606.00
IUUC-Dno-029680	Dasypus novemcinctus	97.66	0.00e+00	4331.00
IUUC-Dor-030902	Dipodomys ordii	96.35	0.00e+00	1217.00
IUUC-Dse-031197	Dothistroma septosporum	46.84	4.00e-137	484.00
IUUC-Dme-032122	Drosophila melanogaster	66.78	0.00e+00	765.00
IUUC-Ete-032690	Echinops telfairi	89.24	0.00e+00	1224.00
IUUC-Eeu-034963	Erinaceus europaeus	93.95	0.00e+00	2936.00
IUUC-Fca-035824	Felis catus	99.33	0.00e+00	4411.00
IUUC-Fox-037756	Fusarium oxysporum	52.51	1.00e-134	476.00
IUUC-Fso-038464	Fusarium solani	53.66	7.00e-135	476.00
IUUC-Gmo-039073	Gadus morhua	82.75	0.00e+00	3620.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.18	1.00e-132	469.00
IUUC-Gga-040309	Gallus gallus	98.38	0.00e+00	654.00
IUUC-Gac-042430	Gasterosteus aculeatus	83.04	0.00e+00	3705.00
IUUC-Gma-044247	Glycine max	51.41	1.00e-123	439.00
IUUC-Ggo-044785	Gorilla gorilla	99.16	0.00e+00	4370.00
IUUC-Hsa-046879	Homo sapiens	99.21	0.00e+00	4372.00
IUUC-Hvu-047697	Hordeum vulgare	44.53	2.00e-125	445.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	97.67	0.00e+00	1450.00
IUUC-Kpa-049228	Komagataella pastoris	48.30	6.00e-140	493.00
IUUC-Lch-050252	Latimeria chalumnae	88.72	0.00e+00	3371.00
IUUC-Lpe-051550	Leersia perrieri	51.41	1.00e-124	442.00
IUUC-Loc-052472	Lepisosteus oculatus	83.59	0.00e+00	3721.00
IUUC-Lma-053159	Leptosphaeria maculans	44.84	1.00e-133	473.00
IUUC-Laf-054154	Loxodonta africana	98.16	0.00e+00	4363.00
IUUC-Mcc-055085	Macaca mulatta	97.58	0.00e+00	4395.00
IUUC-Meu-056727	Macropus eugenii	94.53	0.00e+00	1910.00
IUUC-Mor-057201	Magnaporthe oryzae	45.82	6.00e-133	470.00
IUUC-Mpo-057597	Magnaporthe poae	45.44	2.00e-131	465.00
IUUC-Mtr-058088	Medicago truncatula	52.11	1.00e-124	442.00
IUUC-Mla-058888	Melampsora laricipopulina	47.78	4.00e-114	404.00
IUUC-Mvi-060320	Microbotryum violaceum	43.07	8.00e-121	430.00
IUUC-Mmr-060820	Microcebus murinus	96.90	0.00e+00	4333.00
IUUC-Mdo-062930	Monodelphis domestica	91.93	0.00e+00	4113.00
IUUC-Mmu-063601	Mus musculus	98.29	0.00e+00	4253.00
IUUC-Mac-065557	Musa acuminata	51.52	2.00e-117	418.00
IUUC-Mpu-066653	Mustela putorius furo	97.33	0.00e+00	4279.00
IUUC-Mlu-067418	Myotis lucifugus	98.54	0.00e+00	4458.00
IUUC-Nfi-068278	Neosartorya fischeri	45.23	2.00e-131	466.00
IUUC-Ncr-068813	Neurospora crassa	46.20	2.00e-135	478.00
IUUC-Nle-069418	Nomascus leucogenys	98.79	0.00e+00	4339.00
IUUC-Opr-070187	Ochotona princeps	83.30	0.00e+00	860.00
IUUC-Ont-071300	Oreochromis niloticus	83.34	0.00e+00	3672.00
IUUC-Oan-073046	Ornithorhynchus anatinus	88.23	0.00e+00	5254.00
IUUC-Ocu-074178	Oryctolagus cuniculus	98.58	0.00e+00	4432.00
IUUC-Oba-075757	Oryza barthii	51.17	1.00e-124	442.00
IUUC-Obr-076553	Oryza brachyantha	44.69	2.00e-123	439.00
IUUC-Ogl-077520	Oryza glaberrima	51.17	2.00e-124	442.00
IUUC-Ogu-078278	Oryza glumaepatula	51.17	2.00e-124	442.00
IUUC-Oin-079767	Oryza indica	51.17	1.00e-124	442.00
IUUC-Olo-080380	Oryza longistaminata	50.70	1.00e-122	436.00
IUUC-Ome-081925	Oryza meridionalis	50.70	1.00e-122	436.00
IUUC-Oni-082619	Oryza nivara	51.17	2.00e-124	442.00
IUUC-Opu-083684	Oryza punctata	50.70	7.00e-123	437.00
IUUC-Oru-084501	Oryza rufipogon	51.17	1.00e-124	442.00
IUUC-Osa-086251	Oryza sativa	51.17	5.00e-123	435.00
IUUC-Ola-087437	Oryzias latipes	85.17	0.00e+00	2129.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.00	2.00e-111	395.00
IUUC-Oga-088903	Otolemur garnettii	98.66	0.00e+00	4360.00
IUUC-Oar-090210	Ovis aries	97.33	0.00e+00	4382.00
IUUC-Ptr-090502	Pan troglodytes	99.06	0.00e+00	3395.00
IUUC-Pan-092368	Papio anubis	99.06	0.00e+00	3433.00
IUUC-Pma-094246	Petromyzon marinus	74.30	0.00e+00	1290.00
IUUC-Pno-094871	Phaeosphaeria nodorum	51.73	4.00e-132	468.00
IUUC-Ppa-095657	Physcomitrella patens	50.79	3.00e-124	441.00
IUUC-Pfo-096232	Poecilia formosa	80.82	0.00e+00	3640.00
IUUC-Pab-098583	Pongo abelii	99.25	0.00e+00	4379.00
IUUC-Pop-099613	Populus trichocarpa	52.58	2.00e-126	448.00
IUUC-Pca-100310	Procavia capensis	84.12	0.00e+00	1660.00
IUUC-Ppe-102109	Prunus persica	51.88	3.00e-124	441.00
IUUC-Pva-102116	Pteropus vampyrus	98.75	0.00e+00	4435.00
IUUC-Pgr-103465	Puccinia graminis	42.61	2.00e-125	445.00
IUUC-Ptt-103813	Puccinia triticina	40.53	8.00e-113	403.00
IUUC-Pte-104018	Pyrenophora teres	51.50	8.00e-131	463.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	51.38	1.00e-130	462.00
IUUC-Rno-105889	Rattus norvegicus	90.62	0.00e+00	3856.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.23	1.00e-124	442.00
IUUC-Sha-106961	Sarcophilus harrisii	90.20	0.00e+00	4050.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	44.87	2.00e-126	448.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.54	8.00e-129	456.00
IUUC-Smo-109428	Selaginella moellendorffii	50.33	4.00e-128	454.00
IUUC-Sit-110598	Setaria italica	51.88	3.00e-125	444.00
IUUC-Sly-111285	Solanum lycopersicum	51.12	5.00e-126	447.00
IUUC-Stu-112582	Solanum tuberosum	32.48	6.00e-57	216.00
IUUC-Sar-113291	Sorex araneus	92.93	0.00e+00	2741.00
IUUC-Sbi-114042	Sorghum bicolor	51.88	2.00e-125	445.00
IUUC-Sre-114958	Sporisorium reilianum	55.69	1.00e-136	480.00
IUUC-Ssc-115754	Sus scrofa	99.42	0.00e+00	4410.00
IUUC-Tru-118570	Takifugu rubripes	82.72	0.00e+00	3731.00
IUUC-Tsy-119159	Tarsius syrichta	93.40	0.00e+00	2080.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.31	0.00e+00	1998.00
IUUC-Tca-121479	Theobroma cacao	50.70	4.00e-122	434.00
IUUC-Tre-121909	Trichoderma reesei	52.83	6.00e-132	467.00
IUUC-Tvi-122370	Trichoderma virens	52.59	4.00e-132	467.00
IUUC-Tae-125214	Triticum aestivum	50.47	7.00e-123	436.00
IUUC-Tme-127172	Tuber melanosporum	46.33	6.00e-137	483.00
IUUC-Tbe-127506	Tupaia belangeri	95.58	0.00e+00	1494.00
IUUC-Ttr-129253	Tursiops truncatus	91.35	0.00e+00	2202.00
IUUC-Uma-129355	Ustilago maydis	48.41	6.00e-139	487.00
IUUC-Vda-129886	Verticillium dahliae	46.77	1.00e-136	483.00
IUUC-Vpa-130708	Vicugna pacos	97.54	0.00e+00	3855.00
IUUC-Vvi-131170	Vitis vinifera	50.45	6.00e-125	442.00
IUUC-Xtr-132123	Xenopus tropicalis	85.30	0.00e+00	5067.00
IUUC-Xma-133869	Xiphophorus maculatus	80.88	0.00e+00	3649.00
IUUC-Yli-134657	Yarrowia lipolytica	44.76	2.00e-128	455.00
IUUC-Zma-135570	Zea mays	44.12	8.00e-126	446.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence