iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066597

Ensembl Protein ID

ENSMPUP00000002588.1

UniProt Accession

M3XU38; M3XU38_MUSPF

Genbank Protein ID

ENSMPUP00000002588

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEYP01039213

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002618.1	ENSMPUT00000002642.1	ENSMPUP00000002588.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.38	1.00e-156	550.00	IUUC-Hsa-046179
E3 activity/RING/RING	97.53	3.00e-154	541.00	IUUC-Mmu-063206
E3 activity/RING/RING	97.84	2.00e-154	541.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKPCSKQPP PQPQPAPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG 60
GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGCC CGTCCTCCAC CGGCCCCAGC GCTAACAAAC CCTGCAGCAA GCAGCCGCCG 60
CCGCAGCCCC AGCCCGCTCC GTCCCCGGCT GCGCCCCCGG CCGCCGCCAC CATCTCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	100.00	1.00e-156	545.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	7.00e-142	496.00
IUUC-Bta-012750	Bos taurus	99.61	5.00e-154	536.00
IUUC-Cja-019800	Callithrix jacchus	99.38	2.00e-158	551.00
IUUC-Cfa-020505	Canis familiaris	99.61	1.00e-154	538.00
IUUC-Cpo-021394	Cavia porcellus	88.69	2.00e-157	548.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.38	2.00e-158	551.00
IUUC-Cho-024933	Choloepus hoffmanni	100.00	4.00e-155	540.00
IUUC-Dre-027711	Danio rerio	91.70	2.00e-141	495.00
IUUC-Dno-029260	Dasypus novemcinctus	100.00	3.00e-148	517.00
IUUC-Dor-030489	Dipodomys ordii	96.22	5.00e-108	382.00
IUUC-Ete-032946	Echinops telfairi	91.05	6.00e-160	556.00
IUUC-Eca-033546	Equus caballus	99.61	3.00e-156	543.00
IUUC-Eeu-034861	Erinaceus europaeus	96.12	7.00e-149	519.00
IUUC-Fal-037160	Ficedula albicollis	88.05	6.00e-133	466.00
IUUC-Gmo-039091	Gadus morhua	89.72	1.00e-139	488.00
IUUC-Gga-040252	Gallus gallus	86.73	2.00e-153	534.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	7.00e-140	489.00
IUUC-Ggo-044618	Gorilla gorilla	99.38	2.00e-158	551.00
IUUC-Hsa-046179	Homo sapiens	99.38	2.00e-158	551.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.45	2.00e-154	537.00
IUUC-Lch-049496	Latimeria chalumnae	82.04	5.00e-153	533.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	7.00e-142	496.00
IUUC-Laf-054257	Loxodonta africana	99.61	4.00e-154	536.00
IUUC-Mcc-055023	Macaca mulatta	99.38	2.00e-158	551.00
IUUC-Meu-055922	Macropus eugenii	97.25	1.00e-149	522.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	2.00e-148	518.00
IUUC-Mmr-061494	Microcebus murinus	99.69	2.00e-158	551.00
IUUC-Mdo-061971	Monodelphis domestica	98.82	1.00e-153	535.00
IUUC-Mmu-063206	Mus musculus	88.89	1.00e-156	545.00
IUUC-Mlu-067199	Myotis lucifugus	99.61	2.00e-154	538.00
IUUC-Nle-069342	Nomascus leucogenys	99.38	2.00e-158	551.00
IUUC-Opr-070341	Ochotona princeps	56.86	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	90.12	6.00e-141	493.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	4.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.61	6.00e-157	546.00
IUUC-Oga-089154	Otolemur garnettii	99.38	2.00e-158	551.00
IUUC-Oar-089446	Ovis aries	98.85	4.00e-157	546.00
IUUC-Ptr-091088	Pan troglodytes	99.38	2.00e-158	551.00
IUUC-Psi-093079	Pelodiscus sinensis	99.24	2.00e-159	553.00
IUUC-Pfo-097007	Poecilia formosa	85.38	2.00e-133	468.00
IUUC-Pab-098092	Pongo abelii	99.38	2.00e-158	551.00
IUUC-Pca-100328	Procavia capensis	97.22	5.00e-153	533.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	2.00e-64	239.00
IUUC-Rno-105477	Rattus norvegicus	88.89	1.00e-156	545.00
IUUC-Sha-107630	Sarcophilus harrisii	98.86	5.00e-159	552.00
IUUC-Ssc-116441	Sus scrofa	99.07	1.00e-157	548.00
IUUC-Tru-118004	Takifugu rubripes	87.35	3.00e-135	474.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	8.00e-68	249.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	9.00e-138	482.00
IUUC-Vpa-130799	Vicugna pacos	99.42	3.00e-104	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence