iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107630

Ensembl Protein ID

ENSSHAP00000021698.1

UniProt Accession

G3X1Z3; G3X1Z3_SARHA

Genbank Protein ID

ENSSHAP00000021698

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEFK01134607

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018374.1	ENSSHAT00000021872.1	ENSSHAP00000021698.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.86	1.00e-157	552.00	IUUC-Hsa-046179
E3 activity/RING/RING	98.48	2.00e-156	548.00	IUUC-Mmu-063206
E3 activity/RING/RING	98.86	3.00e-157	550.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sarcophilus harrisii

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

GGGGGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGSLTP 60
SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS 120

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Nucleotide Sequence
(Fasta)

GGGGGGGGGG GAGTGGAGAA TGGGAAAGAA AATAGAAAGA TGAAAAAAGA CAAGTTTTGA 60
GACCCAGTGC TTGGGAATAA GGTGGTGCCA TCAACATAAA TAGGGCAGGA GAGATGGGTG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.22	3.00e-154	537.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	9.00e-141	492.00
IUUC-Bta-012750	Bos taurus	98.82	2.00e-152	531.00
IUUC-Cja-019800	Callithrix jacchus	99.22	8.00e-153	532.00
IUUC-Cfa-020505	Canis familiaris	99.61	9.00e-153	532.00
IUUC-Cpo-021394	Cavia porcellus	98.45	8.00e-153	532.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.22	8.00e-153	532.00
IUUC-Cho-024933	Choloepus hoffmanni	99.22	1.00e-152	531.00
IUUC-Dre-027711	Danio rerio	91.30	2.00e-140	491.00
IUUC-Dno-029260	Dasypus novemcinctus	93.56	9.00e-148	515.00
IUUC-Dor-030489	Dipodomys ordii	96.76	1.00e-107	380.00
IUUC-Ete-032946	Echinops telfairi	98.46	8.00e-155	539.00
IUUC-Eca-033546	Equus caballus	97.73	1.00e-156	545.00
IUUC-Eeu-034861	Erinaceus europaeus	95.37	2.00e-148	517.00
IUUC-Fal-037160	Ficedula albicollis	88.45	1.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	90.12	2.00e-139	487.00
IUUC-Gga-040252	Gallus gallus	98.05	1.00e-151	528.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	5.00e-139	486.00
IUUC-Ggo-044618	Gorilla gorilla	99.22	8.00e-153	532.00
IUUC-Hsa-046179	Homo sapiens	99.22	8.00e-153	532.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	1.00e-152	531.00
IUUC-Lch-049496	Latimeria chalumnae	94.66	1.00e-150	525.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	6.00e-141	493.00
IUUC-Laf-054257	Loxodonta africana	98.08	2.00e-153	534.00
IUUC-Mcc-055023	Macaca mulatta	99.22	8.00e-153	532.00
IUUC-Meu-055922	Macropus eugenii	98.04	1.00e-149	521.00
IUUC-Mga-060070	Meleagris gallopavo	94.72	3.00e-149	520.00
IUUC-Mmr-061494	Microcebus murinus	99.22	8.00e-153	532.00
IUUC-Mdo-061971	Monodelphis domestica	99.61	1.00e-152	531.00
IUUC-Mmu-063206	Mus musculus	99.21	4.00e-152	530.00
IUUC-Mpu-066597	Mustela putorius furo	99.22	8.00e-153	532.00
IUUC-Mlu-067199	Myotis lucifugus	98.82	3.00e-152	530.00
IUUC-Nle-069342	Nomascus leucogenys	99.22	8.00e-153	532.00
IUUC-Opr-070341	Ochotona princeps	56.86	6.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	5.00e-140	489.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-49	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	98.84	1.00e-154	538.00
IUUC-Oga-089154	Otolemur garnettii	99.22	8.00e-153	532.00
IUUC-Oar-089446	Ovis aries	97.70	1.00e-154	538.00
IUUC-Ptr-091088	Pan troglodytes	99.22	8.00e-153	532.00
IUUC-Psi-093079	Pelodiscus sinensis	99.62	1.00e-158	551.00
IUUC-Pfo-097007	Poecilia formosa	85.77	4.00e-133	467.00
IUUC-Pab-098092	Pongo abelii	99.22	8.00e-153	532.00
IUUC-Pca-100328	Procavia capensis	96.08	2.00e-147	514.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	1.00e-63	236.00
IUUC-Rno-105477	Rattus norvegicus	99.21	4.00e-152	530.00
IUUC-Ssc-116441	Sus scrofa	98.82	2.00e-152	531.00
IUUC-Tru-118004	Takifugu rubripes	86.96	3.00e-134	470.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	5.00e-67	246.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	9.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	98.84	1.00e-102	364.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence