iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062639

UUCD1 version

UUC-MoD-01099

Ensembl Protein ID

ENSMODP00000001183.3

UniProt Accession

F7EA91; F7EA91_MONDO

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000000990.3	ENSMODT00000001207.3	ENSMODP00000001183.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-69	234.4	4	267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           ++wl+Le++P++ +++++++g++ ++q+ ++y+++pe l+++++pv+++lllF+i+ek+e +r ++   +++++ ++d++++++f+kq+
   Q: 4    HRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRIEE--EEKIKSEGQDVTESVYFMKQT 90
           79*************************************************************554..5689***************** PP
   S: 95   igNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf.... 178
           i+N+C+t++l+++++n++dk+ ++ G+tl++++e + ++spe++a+ l++ ++++++h+s a++++++  e    ++ +y + +f    
   Q: 91   ISNACGTIGLIHAIANNKDKMnFESGSTLKKFLEDSLSMSPEERARYLEKYEAIRVTHESSAHEGQTEGAELG-PKSGSYWEANFssle 178
           ******************************************************************9998765.7888999999***** PP
   S: 179  ............................hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnll 239
                                       hf+++v+++g+lyeldg+kpfP+++gk+++++ l+d+++v+++f+er    + +e+rfn++
   Q: 179  nvlqqlkpteshmdchveapsidekvdlHFIALVHVDGHLYELDGRKPFPINHGKTSDDTLLEDAIEVCKKFMER----DPEELRFNAI 263
           ***************************************************************************....9********* PP
   S: 240  aiva 243
           a++a
   Q: 264  ALSA 267
           9875 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MESHRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMEPE LLSMVPRPVC AVLLLFPITE 60
KYEVFRIEEE EKIKSEGQDV TESVYFMKQT ISNACGTIGL IHAIANNKDK MNFESGSTLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCGCCG GGCAGGAGCG TGCGTAGAGG CGGTTCACTC GGCAGGCGGG ATTAGGGAGA 60
GCCCAAGTAC CAAATGCAGG AGGGGAGTGA CCTGCGAATG CAGAGTCATT TTTCCTCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	37.13	3.00e-45	174.00
IUUC-Aml-001344	Ailuropoda melanoleuca	79.85	1.00e-117	415.00
IUUC-Atr-002931	Amborella trichopoda	40.55	4.00e-42	164.00
IUUC-Apl-003949	Anas platyrhynchos	76.00	2.00e-98	351.00
IUUC-Aca-004924	Anolis carolinensis	71.64	2.00e-105	374.00
IUUC-Aly-005721	Arabidopsis lyrata	41.89	1.00e-50	192.00
IUUC-Ath-006827	Arabidopsis thaliana	43.02	3.00e-51	194.00
IUUC-Ago-007950	Ashbya gossypii	28.24	4.00e-20	91.30
IUUC-Acl-008305	Aspergillus clavatus	33.59	1.00e-32	133.00
IUUC-Afl-008611	Aspergillus flavus	35.90	3.00e-38	151.00
IUUC-Afu-008945	Aspergillus fumigatus	34.69	7.00e-36	143.00
IUUC-Ani-009339	Aspergillus nidulans	34.80	1.00e-36	146.00
IUUC-Ang-009691	Aspergillus niger	32.97	2.00e-35	142.00
IUUC-Aor-009961	Aspergillus oryzae	36.26	3.00e-38	151.00
IUUC-Ate-010316	Aspergillus terreus	34.80	2.00e-37	149.00
IUUC-Ame-011157	Astyanax mexicanus	63.16	8.00e-91	326.00
IUUC-Bgr-012125	Blumeria graminis	32.47	3.00e-33	134.00
IUUC-Bta-012673	Bos taurus	79.48	5.00e-117	413.00
IUUC-Bdi-014330	Brachypodium distachyon	38.02	9.00e-49	186.00
IUUC-Bol-015214	Brassica oleracea	44.53	9.00e-54	202.00
IUUC-Bra-017491	Brassica rapa	44.91	4.00e-54	204.00
IUUC-Cfa-020371	Canis familiaris	75.44	1.00e-89	322.00
IUUC-Cpo-022036	Cavia porcellus	77.90	2.00e-112	397.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	35.08	1.00e-31	129.00
IUUC-Csa-023854	Chlorocebus sabaeus	79.10	9.00e-116	409.00
IUUC-Cin-025545	Ciona intestinalis	42.59	3.00e-60	224.00
IUUC-Cne-026914	Cryptococcus neoformans	31.50	3.00e-24	105.00
IUUC-Dre-028356	Danio rerio	64.66	3.00e-93	333.00
IUUC-Dme-032146	Drosophila melanogaster	44.11	1.00e-55	209.00
IUUC-Eca-033220	Equus caballus	79.48	1.00e-116	411.00
IUUC-Fca-036421	Felis catus	79.85	1.00e-117	415.00
IUUC-Fal-036773	Ficedula albicollis	75.98	3.00e-100	357.00
IUUC-Gmo-039468	Gadus morhua	59.77	5.00e-75	273.00
IUUC-Ggr-039832	Gaeumannomyces graminis	32.96	1.00e-31	130.00
IUUC-Gga-041205	Gallus gallus	75.37	1.00e-106	378.00
IUUC-Gac-041629	Gasterosteus aculeatus	60.15	1.00e-83	302.00
IUUC-Gma-043057	Glycine max	41.13	3.00e-45	174.00
IUUC-Ggo-044533	Gorilla gorilla	79.55	2.00e-116	410.00
IUUC-Hsa-046754	Homo sapiens	79.85	1.00e-117	415.00
IUUC-Hvu-047176	Hordeum vulgare	34.72	3.00e-36	145.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	89.87	1.00e-78	284.00
IUUC-Kpa-049123	Komagataella pastoris	29.69	7.00e-25	107.00
IUUC-Lch-049685	Latimeria chalumnae	66.54	3.00e-98	350.00
IUUC-Lpe-051377	Leersia perrieri	38.49	1.00e-40	159.00
IUUC-Loc-051988	Lepisosteus oculatus	66.17	1.00e-95	342.00
IUUC-Lma-053316	Leptosphaeria maculans	35.21	3.00e-36	145.00
IUUC-Laf-053985	Loxodonta africana	79.18	7.00e-116	409.00
IUUC-Mcc-055888	Macaca mulatta	77.99	1.00e-112	398.00
IUUC-Mor-057271	Magnaporthe oryzae	32.58	6.00e-35	140.00
IUUC-Mtr-057713	Medicago truncatula	38.49	7.00e-46	176.00
IUUC-Mla-058942	Melampsora laricipopulina	38.87	6.00e-39	153.00
IUUC-Mga-059702	Meleagris gallopavo	75.60	3.00e-98	350.00
IUUC-Mvi-060249	Microbotryum violaceum	37.59	6.00e-35	140.00
IUUC-Mmr-061284	Microcebus murinus	74.74	3.00e-116	410.00
IUUC-Mmu-063299	Mus musculus	80.15	1.00e-117	415.00
IUUC-Mac-065075	Musa acuminata	39.70	4.00e-47	181.00
IUUC-Mpu-066769	Mustela putorius furo	79.85	1.00e-117	415.00
IUUC-Mlu-066937	Myotis lucifugus	78.36	4.00e-115	407.00
IUUC-Nfi-068320	Neosartorya fischeri	35.06	6.00e-37	147.00
IUUC-Ncr-068673	Neurospora crassa	34.33	1.00e-38	152.00
IUUC-Nle-069175	Nomascus leucogenys	79.20	4.00e-106	377.00
IUUC-Opr-070652	Ochotona princeps	71.60	3.00e-91	327.00
IUUC-Ont-072170	Oreochromis niloticus	62.03	1.00e-84	305.00
IUUC-Oan-073247	Ornithorhynchus anatinus	92.04	6.00e-53	198.00
IUUC-Ocu-074422	Oryctolagus cuniculus	79.10	4.00e-117	413.00
IUUC-Oba-075098	Oryza barthii	36.26	3.00e-44	171.00
IUUC-Obr-076041	Oryza brachyantha	38.72	2.00e-48	185.00
IUUC-Ogl-076980	Oryza glaberrima	38.72	1.00e-47	182.00
IUUC-Ogu-078978	Oryza glumaepatula	33.56	9.00e-41	160.00
IUUC-Oin-079285	Oryza indica	35.88	2.00e-43	168.00
IUUC-Olo-080671	Oryza longistaminata	36.64	4.00e-44	171.00
IUUC-Ome-081428	Oryza meridionalis	35.88	8.00e-43	166.00
IUUC-Oni-082406	Oryza nivara	36.26	3.00e-44	171.00
IUUC-Opu-083305	Oryza punctata	36.64	3.00e-43	168.00
IUUC-Oru-084969	Oryza rufipogon	36.26	3.00e-44	171.00
IUUC-Osa-085830	Oryza sativa	38.72	1.00e-47	182.00
IUUC-Ola-086893	Oryzias latipes	60.15	2.00e-81	294.00
IUUC-Olu-087858	Ostreococcus lucimarinus	37.88	2.00e-43	168.00
IUUC-Oga-088055	Otolemur garnettii	79.55	2.00e-116	410.00
IUUC-Oar-090319	Ovis aries	79.48	7.00e-117	412.00
IUUC-Pan-092714	Papio anubis	78.81	4.00e-115	406.00
IUUC-Psi-094036	Pelodiscus sinensis	74.80	4.00e-99	353.00
IUUC-Pma-094412	Petromyzon marinus	64.94	6.00e-55	206.00
IUUC-Pno-094997	Phaeosphaeria nodorum	32.07	2.00e-25	109.00
IUUC-Ppa-095519	Physcomitrella patens	43.89	3.00e-56	211.00
IUUC-Pfo-096182	Poecilia formosa	59.70	5.00e-82	296.00
IUUC-Pab-098216	Pongo abelii	73.63	2.00e-72	263.00
IUUC-Pop-099282	Populus trichocarpa	40.00	2.00e-45	175.00
IUUC-Ppe-101332	Prunus persica	40.00	1.00e-49	189.00
IUUC-Pgr-103430	Puccinia graminis	39.86	8.00e-42	163.00
IUUC-Ptt-103955	Puccinia triticina	41.48	3.00e-43	168.00
IUUC-Pte-104414	Pyrenophora teres	33.21	8.00e-32	130.00
IUUC-Pyt-104753	Pyrenophora triticirepentis	30.43	7.00e-29	120.00
IUUC-Rno-105096	Rattus norvegicus	79.40	1.00e-116	412.00
IUUC-Sce-106412	Saccharomyces cerevisiae	29.82	1.00e-23	102.00
IUUC-Sha-106677	Sarcophilus harrisii	84.25	3.00e-114	404.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	28.23	1.00e-20	92.80
IUUC-Smo-109283	Selaginella moellendorffii	41.70	3.00e-46	178.00
IUUC-Sit-110163	Setaria italica	39.02	3.00e-47	182.00
IUUC-Sly-111613	Solanum lycopersicum	41.13	1.00e-52	199.00
IUUC-Stu-112526	Solanum tuberosum	41.83	2.00e-49	188.00
IUUC-Sbi-114545	Sorghum bicolor	38.87	2.00e-45	175.00
IUUC-Sre-114961	Sporisorium reilianum	36.19	7.00e-33	133.00
IUUC-Ssc-115255	Sus scrofa	78.40	7.00e-106	375.00
IUUC-Tgu-117003	Taeniopygia guttata	75.75	6.00e-106	376.00
IUUC-Tru-118330	Takifugu rubripes	52.49	3.00e-59	223.00
IUUC-Tsy-119488	Tarsius syrichta	90.35	3.00e-53	201.00
IUUC-Tni-120042	Tetraodon nigroviridis	53.60	4.00e-61	229.00
IUUC-Tca-120976	Theobroma cacao	42.26	5.00e-52	197.00
IUUC-Tae-122693	Triticum aestivum	39.10	5.00e-47	181.00
IUUC-Tur-126250	Triticum urartu	37.13	7.00e-45	173.00
IUUC-Uma-129382	Ustilago maydis	35.56	7.00e-36	143.00
IUUC-Vda-129678	Verticillium dahliae	27.64	1.00e-24	106.00
IUUC-Vpa-130783	Vicugna pacos	71.31	3.00e-90	324.00
IUUC-Vvi-131661	Vitis vinifera	39.25	4.00e-49	187.00
IUUC-Xtr-132428	Xenopus tropicalis	62.78	3.00e-94	337.00
IUUC-Xma-134245	Xiphophorus maculatus	59.02	8.00e-82	296.00
IUUC-Yli-134570	Yarrowia lipolytica	32.23	2.00e-31	129.00
IUUC-Zma-134740	Zea mays	38.11	3.00e-47	181.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence