iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000619.4	ENSCAFT00000000972.4	ENSCAFP00000000890.3
ENSCAFG00000000619.4	ENSCAFT00000047363.1	ENSCAFP00000040958.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-80	269.5	2475	2797

Active Site

Position(s)	Description	Evidence
2767	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2475 ENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2557
           556778**************9999778888334444777777777775....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+  
   Q: 2558 LGRKVNWHDFAFFDPVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLV 2644
           ********************5556666655556888999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2645 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2731
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2732 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2797
           *********999******..799999.99**********************************9.99875 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF 60
LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR TSRPGRTNDS PWFLSGSETL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTAGCGC CCGTTTCCCG GAGCCCCGCC CCCTCGCAGC CGAGCCCCCG CCCGCCGGTC 60
TCCTCCCTCC TTCTCCTCCT CCCGTTCGCC CCTCCCCCGC CGCTCGGGAG CGGAGCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	99.07	0.00e+00	4597.00
IUUC-Apl-004165	Anas platyrhynchos	97.38	0.00e+00	4500.00
IUUC-Aca-004577	Anolis carolinensis	96.19	0.00e+00	3924.00
IUUC-Ame-010702	Astyanax mexicanus	84.73	0.00e+00	2486.00
IUUC-Bta-012313	Bos taurus	99.64	0.00e+00	4667.00
IUUC-Cel-018165	Caenorhabditis elegans	35.31	2.00e-69	259.00
IUUC-Cja-019858	Callithrix jacchus	99.35	0.00e+00	4634.00
IUUC-Cpo-022108	Cavia porcellus	97.88	0.00e+00	1944.00
IUUC-Csa-023985	Chlorocebus sabaeus	99.32	0.00e+00	4685.00
IUUC-Cho-025034	Choloepus hoffmanni	89.54	0.00e+00	989.00
IUUC-Cin-025715	Ciona intestinalis	40.30	0.00e+00	944.00
IUUC-Csv-026088	Ciona savignyi	39.93	6.00e-160	558.00
IUUC-Dre-027730	Danio rerio	88.20	0.00e+00	4051.00
IUUC-Dno-029123	Dasypus novemcinctus	96.47	0.00e+00	4456.00
IUUC-Dor-030757	Dipodomys ordii	94.57	0.00e+00	2906.00
IUUC-Dme-032192	Drosophila melanogaster	51.83	5.00e-174	606.00
IUUC-Ete-032292	Echinops telfairi	96.35	0.00e+00	2201.00
IUUC-Eca-034347	Equus caballus	99.39	0.00e+00	4563.00
IUUC-Eeu-034873	Erinaceus europaeus	94.74	0.00e+00	4381.00
IUUC-Fca-036485	Felis catus	98.24	0.00e+00	4502.00
IUUC-Fal-037071	Ficedula albicollis	98.06	0.00e+00	4516.00
IUUC-Gmo-039589	Gadus morhua	88.86	0.00e+00	3987.00
IUUC-Gga-041195	Gallus gallus	96.78	0.00e+00	4451.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.84	0.00e+00	4017.00
IUUC-Ggo-045351	Gorilla gorilla	98.49	0.00e+00	4663.00
IUUC-Hsa-045941	Homo sapiens	99.36	0.00e+00	4701.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	99.28	0.00e+00	4610.00
IUUC-Lch-050480	Latimeria chalumnae	94.15	0.00e+00	4338.00
IUUC-Loc-052664	Lepisosteus oculatus	89.94	0.00e+00	4145.00
IUUC-Laf-053935	Loxodonta africana	99.10	0.00e+00	1603.00
IUUC-Mcc-054703	Macaca mulatta	99.32	0.00e+00	4688.00
IUUC-Meu-056431	Macropus eugenii	87.78	0.00e+00	802.00
IUUC-Mga-059289	Meleagris gallopavo	97.61	0.00e+00	3613.00
IUUC-Mmr-061737	Microcebus murinus	99.06	0.00e+00	4547.00
IUUC-Mdo-062499	Monodelphis domestica	98.20	0.00e+00	4528.00
IUUC-Mmu-063273	Mus musculus	98.21	0.00e+00	4557.00
IUUC-Mpu-066907	Mustela putorius furo	99.53	0.00e+00	4249.00
IUUC-Mlu-067942	Myotis lucifugus	99.17	0.00e+00	4608.00
IUUC-Nle-069527	Nomascus leucogenys	99.39	0.00e+00	4665.00
IUUC-Opr-070626	Ochotona princeps	87.09	0.00e+00	1459.00
IUUC-Ont-071951	Oreochromis niloticus	87.53	0.00e+00	3992.00
IUUC-Oan-072958	Ornithorhynchus anatinus	98.43	0.00e+00	4188.00
IUUC-Ocu-074503	Oryctolagus cuniculus	96.65	0.00e+00	4533.00
IUUC-Ola-086757	Oryzias latipes	89.04	0.00e+00	4089.00
IUUC-Oga-088781	Otolemur garnettii	99.32	0.00e+00	4648.00
IUUC-Oar-089274	Ovis aries	99.35	0.00e+00	4585.00
IUUC-Ptr-090669	Pan troglodytes	99.12	0.00e+00	4052.00
IUUC-Pan-092226	Papio anubis	99.25	0.00e+00	4658.00
IUUC-Psi-093502	Pelodiscus sinensis	98.24	0.00e+00	4517.00
IUUC-Pma-094454	Petromyzon marinus	77.51	0.00e+00	736.00
IUUC-Pfo-096173	Poecilia formosa	88.58	0.00e+00	3754.00
IUUC-Pab-098355	Pongo abelii	97.38	0.00e+00	3355.00
IUUC-Pca-100570	Procavia capensis	99.25	0.00e+00	1180.00
IUUC-Pva-102572	Pteropus vampyrus	95.19	0.00e+00	1368.00
IUUC-Rno-104916	Rattus norvegicus	96.51	0.00e+00	3994.00
IUUC-Sha-106653	Sarcophilus harrisii	98.32	0.00e+00	4574.00
IUUC-Sar-113517	Sorex araneus	91.30	0.00e+00	1290.00
IUUC-Ssc-115470	Sus scrofa	99.75	0.00e+00	2550.00
IUUC-Tgu-116932	Taeniopygia guttata	97.81	0.00e+00	4501.00
IUUC-Tru-117682	Takifugu rubripes	88.08	0.00e+00	2588.00
IUUC-Tsy-119417	Tarsius syrichta	94.90	0.00e+00	2488.00
IUUC-Tni-120442	Tetraodon nigroviridis	84.50	0.00e+00	3646.00
IUUC-Tbe-127456	Tupaia belangeri	86.56	0.00e+00	2135.00
IUUC-Ttr-128606	Tursiops truncatus	95.76	0.00e+00	1611.00
IUUC-Vpa-130112	Vicugna pacos	96.99	0.00e+00	3763.00
IUUC-Xtr-131929	Xenopus tropicalis	94.47	0.00e+00	4457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence