iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033961

Ensembl Protein ID

ENSECAP00000009477.1

UniProt Accession

F7BA56; F7BA56_HORSE

Protein Name

Uncharacterized protein

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011099.1	ENSECAT00000012045.1	ENSECAP00000009477.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.20e-15	54.5	707	758

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 707  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 758
           688*********************9.999999*****..9*************86 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MRKSELFEAF DLFDVRDFGK VIETLSRLSR TPIALATGIR PFPTEESVDD EDIYKGLPDL 60
IDETRVEDEE GLYDCVYGED EGGEVYEDLM KAEEAHQPKC PENDIRSCCL AEIKQTEEKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATACAACC TCCCGGCGCG CTCTCATTCA ACTGAGAGGA GACTCAACTG AGGCCGCAGA 60
TGTTCCACGG TTAAGGAGGC CGGCGCGGGC GCTCGCCTCT CAGACGGCAT CTCTCCATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	97.89	0.00e+00	1449.00
IUUC-Apl-003734	Anas platyrhynchos	87.37	0.00e+00	1325.00
IUUC-Aca-004477	Anolis carolinensis	81.60	0.00e+00	1231.00
IUUC-Ame-011279	Astyanax mexicanus	64.17	0.00e+00	954.00
IUUC-Bta-012722	Bos taurus	96.18	0.00e+00	1433.00
IUUC-Cja-018941	Callithrix jacchus	96.84	0.00e+00	1439.00
IUUC-Cfa-020266	Canis familiaris	97.63	0.00e+00	1449.00
IUUC-Cpo-021966	Cavia porcellus	95.59	0.00e+00	1392.00
IUUC-Csa-023892	Chlorocebus sabaeus	96.32	0.00e+00	1434.00
IUUC-Dre-028199	Danio rerio	64.46	0.00e+00	961.00
IUUC-Dno-029474	Dasypus novemcinctus	96.05	0.00e+00	1427.00
IUUC-Eeu-034719	Erinaceus europaeus	75.93	0.00e+00	793.00
IUUC-Fca-036572	Felis catus	97.11	0.00e+00	1433.00
IUUC-Fal-036802	Ficedula albicollis	85.03	0.00e+00	1320.00
IUUC-Gmo-039409	Gadus morhua	67.67	0.00e+00	1004.00
IUUC-Gga-040884	Gallus gallus	86.05	0.00e+00	1308.00
IUUC-Gac-041395	Gasterosteus aculeatus	69.63	0.00e+00	1078.00
IUUC-Ggo-044460	Gorilla gorilla	94.86	0.00e+00	1402.00
IUUC-Hsa-046099	Homo sapiens	93.53	0.00e+00	1424.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	93.00	0.00e+00	1408.00
IUUC-Lch-049650	Latimeria chalumnae	82.16	3.00e-109	387.00
IUUC-Loc-052487	Lepisosteus oculatus	71.93	0.00e+00	1081.00
IUUC-Laf-054564	Loxodonta africana	95.13	0.00e+00	1418.00
IUUC-Mcc-054622	Macaca mulatta	92.89	0.00e+00	1415.00
IUUC-Meu-056680	Macropus eugenii	84.87	0.00e+00	1247.00
IUUC-Mga-060013	Meleagris gallopavo	82.28	0.00e+00	1239.00
IUUC-Mmr-061251	Microcebus murinus	91.33	0.00e+00	1434.00
IUUC-Mdo-061875	Monodelphis domestica	93.16	0.00e+00	1395.00
IUUC-Mmu-063735	Mus musculus	95.13	0.00e+00	1439.00
IUUC-Mpu-065856	Mustela putorius furo	97.24	0.00e+00	1439.00
IUUC-Mlu-068108	Myotis lucifugus	91.24	0.00e+00	1353.00
IUUC-Nle-069863	Nomascus leucogenys	92.77	0.00e+00	1411.00
IUUC-Opr-070372	Ochotona princeps	82.58	0.00e+00	873.00
IUUC-Ont-072286	Oreochromis niloticus	70.49	0.00e+00	1072.00
IUUC-Ocu-074194	Oryctolagus cuniculus	96.97	0.00e+00	1434.00
IUUC-Ola-086336	Oryzias latipes	69.16	0.00e+00	1063.00
IUUC-Oar-089272	Ovis aries	95.92	0.00e+00	1471.00
IUUC-Ptr-090652	Pan troglodytes	94.23	0.00e+00	1420.00
IUUC-Pan-092550	Papio anubis	92.89	0.00e+00	1415.00
IUUC-Psi-093784	Pelodiscus sinensis	81.12	0.00e+00	1232.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	2.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	67.72	0.00e+00	1060.00
IUUC-Pab-098698	Pongo abelii	94.21	0.00e+00	1421.00
IUUC-Pva-102262	Pteropus vampyrus	96.92	0.00e+00	1373.00
IUUC-Rno-105421	Rattus norvegicus	94.61	0.00e+00	1440.00
IUUC-Sha-107325	Sarcophilus harrisii	93.29	0.00e+00	1414.00
IUUC-Sar-113456	Sorex araneus	90.26	0.00e+00	1357.00
IUUC-Tgu-116595	Taeniopygia guttata	83.49	0.00e+00	1243.00
IUUC-Tru-118577	Takifugu rubripes	65.72	0.00e+00	1034.00
IUUC-Tsy-119429	Tarsius syrichta	87.63	0.00e+00	1287.00
IUUC-Tni-119951	Tetraodon nigroviridis	68.19	0.00e+00	1009.00
IUUC-Tbe-127995	Tupaia belangeri	69.65	9.00e-140	491.00
IUUC-Ttr-128281	Tursiops truncatus	96.71	0.00e+00	1434.00
IUUC-Xtr-132427	Xenopus tropicalis	72.21	0.00e+00	1141.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence