iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062192

Ensembl Protein ID

ENSMODP00000021795.3

UniProt Accession

F6Z574; F6Z574_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017464.3	ENSMODT00000022174.3	ENSMODP00000021795.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.50e-19	68.0	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++y++++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHSYKPSHDGDLGFEKGEQLKIL---EQNGEWWKAQSLTTGQEGFIPFNFVAKVN 120
           6899**************************...***************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGCCCSSSLD EDWMENIDVC ERCHYPIVPL DAKDMLPMRN GSEVRDPLVD YNGLDPPVSP 60
LQDNLVIALH SYKPSHDGDL GFEKGEQLKI LEQNGEWWKA QSLTTGQEGF IPFNFVAKVN 120

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Nucleotide Sequence
(Fasta)

AAGGAGGCAG GAAGTTGGGG TTGGACGTGG GCTGGTTGCT GAGAAGTCAA ATTGAGGCAG 60
TGACAAGGAG TTGGAACCCT CATCCATCCT CCGGGGGGTG ATGGGGCTGA TGGACCCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0005102--F:receptor binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0006882--P:cellular zinc ion homeostasis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mdo:100025680

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	88.13	0.00e+00	985.00
IUUC-Apl-004134	Anas platyrhynchos	80.09	0.00e+00	731.00
IUUC-Bta-013264	Bos taurus	92.93	0.00e+00	998.00
IUUC-Cfa-021161	Canis familiaris	87.76	0.00e+00	981.00
IUUC-Cpo-022492	Cavia porcellus	91.55	0.00e+00	979.00
IUUC-Csa-023270	Chlorocebus sabaeus	74.32	0.00e+00	759.00
IUUC-Dre-028005	Danio rerio	75.00	0.00e+00	715.00
IUUC-Dno-029365	Dasypus novemcinctus	89.39	0.00e+00	947.00
IUUC-Dor-030892	Dipodomys ordii	88.45	0.00e+00	921.00
IUUC-Eca-033325	Equus caballus	91.37	0.00e+00	970.00
IUUC-Eeu-035004	Erinaceus europaeus	86.39	0.00e+00	786.00
IUUC-Fca-035908	Felis catus	93.32	0.00e+00	1001.00
IUUC-Fal-036804	Ficedula albicollis	71.70	0.00e+00	739.00
IUUC-Gmo-038984	Gadus morhua	65.18	0.00e+00	704.00
IUUC-Gga-040997	Gallus gallus	82.51	0.00e+00	904.00
IUUC-Gac-041854	Gasterosteus aculeatus	69.22	0.00e+00	734.00
IUUC-Ggo-045238	Gorilla gorilla	87.76	0.00e+00	980.00
IUUC-Hsa-047039	Homo sapiens	92.93	0.00e+00	996.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	93.12	0.00e+00	999.00
IUUC-Lch-049568	Latimeria chalumnae	77.54	0.00e+00	847.00
IUUC-Loc-052222	Lepisosteus oculatus	67.96	0.00e+00	678.00
IUUC-Laf-054499	Loxodonta africana	87.38	0.00e+00	980.00
IUUC-Mcc-054872	Macaca mulatta	73.90	0.00e+00	825.00
IUUC-Meu-056879	Macropus eugenii	94.74	0.00e+00	1012.00
IUUC-Mga-059971	Meleagris gallopavo	81.53	0.00e+00	890.00
IUUC-Mmr-060740	Microcebus murinus	92.34	0.00e+00	989.00
IUUC-Mmu-064241	Mus musculus	91.94	0.00e+00	990.00
IUUC-Mpu-066595	Mustela putorius furo	93.12	0.00e+00	998.00
IUUC-Mlu-067069	Myotis lucifugus	91.57	0.00e+00	979.00
IUUC-Opr-070472	Ochotona princeps	88.39	0.00e+00	980.00
IUUC-Ont-071711	Oreochromis niloticus	69.02	0.00e+00	709.00
IUUC-Ocu-074221	Oryctolagus cuniculus	92.16	0.00e+00	986.00
IUUC-Ola-087000	Oryzias latipes	68.50	0.00e+00	729.00
IUUC-Oga-088225	Otolemur garnettii	91.94	0.00e+00	986.00
IUUC-Oar-090244	Ovis aries	82.11	0.00e+00	937.00
IUUC-Ptr-090751	Pan troglodytes	95.71	0.00e+00	706.00
IUUC-Pan-091804	Papio anubis	92.73	0.00e+00	994.00
IUUC-Psi-093252	Pelodiscus sinensis	74.51	0.00e+00	796.00
IUUC-Pfo-096542	Poecilia formosa	68.09	0.00e+00	734.00
IUUC-Pab-098168	Pongo abelii	93.43	0.00e+00	956.00
IUUC-Pca-100547	Procavia capensis	91.59	2.00e-179	622.00
IUUC-Rno-105542	Rattus norvegicus	91.75	0.00e+00	990.00
IUUC-Sha-107524	Sarcophilus harrisii	96.27	0.00e+00	1031.00
IUUC-Sar-113235	Sorex araneus	85.77	0.00e+00	831.00
IUUC-Ssc-115624	Sus scrofa	93.32	0.00e+00	1000.00
IUUC-Tru-118559	Takifugu rubripes	68.60	0.00e+00	731.00
IUUC-Ttr-129002	Tursiops truncatus	84.23	0.00e+00	927.00
IUUC-Xtr-132224	Xenopus tropicalis	76.23	0.00e+00	835.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence