iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062518

UUCD1 version

UUC-MoD-00806

Ensembl Protein ID

ENSMODP00000037638.1

UniProt Accession

F7EP78; F7EP78_MONDO

Protein Name

Uncharacterized protein

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000000682.3	ENSMODT00000039239.2	ENSMODP00000037638.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-86	290.0	4450	4779

Active Site

Position(s)	Description	Evidence
4748	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4450 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakssLHTNMFRFLGVLLGIAIRTGSPL 4536
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4537 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEYVR 4618
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4619 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWEVMESFSNTERS 4703
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4704 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4779
           *************.8*************999988888***********************************99875 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSSEPFCLAA QARFDSKWLK TDLQLAFTRD GLCGLWNEMV KDGEILYPGT ELIQNGELPP 60
RKDDTAECQS GTKKEDQSEK EKKDEEETPV PMYRAKSIVE SWVWGKQPDV NELKECLYVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTCTG AACCCTTCTG TTTGGCTGCC CAGGCTAGGT TTGACTCCAA GTGGTTGAAA 60
ACAGATTTAC AGGTAAGATT CTAATATGAA TTTGGTTTCT TTTTTTTTTC CTAGTATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	89.26	0.00e+00	6642.00
IUUC-Atr-003065	Amborella trichopoda	35.29	3.00e-51	197.00
IUUC-Apl-003983	Anas platyrhynchos	92.39	0.00e+00	8452.00
IUUC-Aca-004300	Anolis carolinensis	91.46	0.00e+00	8299.00
IUUC-Aly-006441	Arabidopsis lyrata	34.15	8.00e-45	176.00
IUUC-Ame-010621	Astyanax mexicanus	84.39	0.00e+00	6843.00
IUUC-Bta-013067	Bos taurus	88.98	0.00e+00	8042.00
IUUC-Bdi-014093	Brachypodium distachyon	33.76	1.00e-49	192.00
IUUC-Bol-015203	Brassica oleracea	34.27	2.00e-52	201.00
IUUC-Bra-016737	Brassica rapa	34.27	7.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	87.93	0.00e+00	7869.00
IUUC-Cfa-020672	Canis familiaris	89.71	0.00e+00	8130.00
IUUC-Cpo-021819	Cavia porcellus	86.88	0.00e+00	7823.00
IUUC-Csa-023817	Chlorocebus sabaeus	89.56	0.00e+00	8081.00
IUUC-Cho-024387	Choloepus hoffmanni	92.28	0.00e+00	1858.00
IUUC-Cin-025709	Ciona intestinalis	52.51	0.00e+00	1240.00
IUUC-Csv-026336	Ciona savignyi	36.76	0.00e+00	1592.00
IUUC-Dre-027717	Danio rerio	79.08	0.00e+00	6903.00
IUUC-Dno-029296	Dasypus novemcinctus	89.58	0.00e+00	8090.00
IUUC-Dor-030979	Dipodomys ordii	86.23	0.00e+00	2773.00
IUUC-Dme-032171	Drosophila melanogaster	62.47	0.00e+00	1076.00
IUUC-Ete-032687	Echinops telfairi	86.07	0.00e+00	2684.00
IUUC-Eca-034046	Equus caballus	89.11	0.00e+00	8059.00
IUUC-Eeu-034859	Erinaceus europaeus	78.20	0.00e+00	1836.00
IUUC-Fca-036262	Felis catus	89.46	0.00e+00	8128.00
IUUC-Fal-037562	Ficedula albicollis	92.18	0.00e+00	8377.00
IUUC-Gmo-039054	Gadus morhua	88.24	0.00e+00	1111.00
IUUC-Gga-040359	Gallus gallus	92.49	0.00e+00	8410.00
IUUC-Gac-041879	Gasterosteus aculeatus	92.70	0.00e+00	1060.00
IUUC-Ggo-044692	Gorilla gorilla	89.98	0.00e+00	4005.00
IUUC-Hsa-045995	Homo sapiens	89.64	0.00e+00	8133.00
IUUC-Hvu-047529	Hordeum vulgare	35.65	2.00e-49	191.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	87.85	0.00e+00	2239.00
IUUC-Lch-049808	Latimeria chalumnae	83.34	0.00e+00	3171.00
IUUC-Lpe-051482	Leersia perrieri	34.46	1.00e-46	182.00
IUUC-Loc-052685	Lepisosteus oculatus	81.39	0.00e+00	7245.00
IUUC-Laf-053372	Loxodonta africana	89.01	0.00e+00	8048.00
IUUC-Mcc-054693	Macaca mulatta	89.62	0.00e+00	8117.00
IUUC-Meu-056660	Macropus eugenii	87.72	0.00e+00	1720.00
IUUC-Mga-059371	Meleagris gallopavo	92.01	0.00e+00	7194.00
IUUC-Mmr-060787	Microcebus murinus	89.77	0.00e+00	8163.00
IUUC-Mmu-063690	Mus musculus	88.63	0.00e+00	8012.00
IUUC-Mpu-066478	Mustela putorius furo	89.40	0.00e+00	8067.00
IUUC-Mlu-067596	Myotis lucifugus	81.56	0.00e+00	4004.00
IUUC-Nle-069445	Nomascus leucogenys	88.31	0.00e+00	2000.00
IUUC-Opr-070990	Ochotona princeps	80.58	0.00e+00	2707.00
IUUC-Ont-072285	Oreochromis niloticus	82.89	0.00e+00	7292.00
IUUC-Oan-072721	Ornithorhynchus anatinus	86.43	0.00e+00	3273.00
IUUC-Ocu-074273	Oryctolagus cuniculus	89.07	0.00e+00	8034.00
IUUC-Oba-075573	Oryza barthii	33.68	1.00e-45	178.00
IUUC-Obr-076107	Oryza brachyantha	33.77	4.00e-50	193.00
IUUC-Ogl-077193	Oryza glaberrima	33.68	1.00e-45	178.00
IUUC-Ogu-078817	Oryza glumaepatula	33.68	1.00e-45	178.00
IUUC-Oin-079609	Oryza indica	33.00	1.00e-49	192.00
IUUC-Olo-080629	Oryza longistaminata	33.68	2.00e-45	178.00
IUUC-Ome-081686	Oryza meridionalis	33.68	5.00e-46	179.00
IUUC-Opu-084137	Oryza punctata	33.94	3.00e-46	180.00
IUUC-Oru-085013	Oryza rufipogon	33.68	1.00e-45	178.00
IUUC-Osa-085597	Oryza sativa	33.68	1.00e-45	178.00
IUUC-Ola-087346	Oryzias latipes	94.28	0.00e+00	1211.00
IUUC-Oga-088742	Otolemur garnettii	88.81	0.00e+00	7979.00
IUUC-Oar-090093	Ovis aries	88.91	0.00e+00	8027.00
IUUC-Ptr-091034	Pan troglodytes	86.73	0.00e+00	5424.00
IUUC-Pan-092783	Papio anubis	87.45	0.00e+00	7889.00
IUUC-Psi-094027	Pelodiscus sinensis	92.44	0.00e+00	8036.00
IUUC-Pfo-096208	Poecilia formosa	82.19	0.00e+00	6031.00
IUUC-Pab-097681	Pongo abelii	86.64	0.00e+00	2411.00
IUUC-Pca-100705	Procavia capensis	93.35	0.00e+00	1150.00
IUUC-Pva-103147	Pteropus vampyrus	81.03	0.00e+00	2348.00
IUUC-Rno-105458	Rattus norvegicus	88.61	0.00e+00	7997.00
IUUC-Sha-106959	Sarcophilus harrisii	80.98	0.00e+00	6857.00
IUUC-Sit-109917	Setaria italica	36.39	5.00e-48	186.00
IUUC-Sly-110961	Solanum lycopersicum	35.33	2.00e-53	204.00
IUUC-Sar-113532	Sorex araneus	84.05	0.00e+00	1617.00
IUUC-Sbi-114352	Sorghum bicolor	32.65	6.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	85.17	0.00e+00	2796.00
IUUC-Tgu-116789	Taeniopygia guttata	92.28	0.00e+00	8400.00
IUUC-Tru-118129	Takifugu rubripes	82.14	0.00e+00	7314.00
IUUC-Tsy-119302	Tarsius syrichta	82.88	0.00e+00	1246.00
IUUC-Tni-120374	Tetraodon nigroviridis	80.84	0.00e+00	7151.00
IUUC-Tca-121094	Theobroma cacao	35.59	2.00e-54	207.00
IUUC-Tae-124157	Triticum aestivum	33.51	2.00e-49	191.00
IUUC-Tur-126300	Triticum urartu	35.29	9.00e-50	192.00
IUUC-Tbe-128137	Tupaia belangeri	82.62	0.00e+00	2186.00
IUUC-Ttr-128273	Tursiops truncatus	86.58	0.00e+00	2689.00
IUUC-Vpa-130471	Vicugna pacos	84.90	0.00e+00	1156.00
IUUC-Xtr-132185	Xenopus tropicalis	82.58	0.00e+00	7428.00
IUUC-Xma-133233	Xiphophorus maculatus	82.64	0.00e+00	7260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence