iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072243

Ensembl Protein ID

ENSONIP00000008120.1

UniProt Accession

I3JGX9; I3JGX9_ORENI

Genbank Protein ID

ENSONIP00000008120

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01050209

Gene Name

SMURF2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000006441.1	ENSONIT00000008125.1	ENSONIP00000008120.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.80e-128	427.7	443	775

Active Site

Position(s)	Description	Evidence
744	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 443  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 530
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+  +eLkp+G++i+Vt++ k+eYv+l+v+
   Q: 531  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIPHELKPNGKSISVTEDTKKEYVRLYVN 615
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id+ d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 616  WRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIADWKSNTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 703
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da++++lP+++TCfn++++P+Y+s+++l++kLl+Aieet gF +
   Q: 704  TGSSRVPLQGFKALQgaagPRLFTIHQiDANTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAV 775
           ***************************99999**************************************76 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSNQGVRRNG PVKLRLTVLC AKNLAKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLNKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCACTGAA CCCAGTGAAG TGATCCTGTT GGATTCGATT TTTTTCTTCT TTTTTTTTAA 60
ATAGCAAAAT CTGATCTATA ATATTCATAA TAAGGAAGTA GTTGGTACTG GAAAACTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005358	Anolis carolinensis	90.08	0.00e+00	1431.00
IUUC-Ame-011320	Astyanax mexicanus	89.88	0.00e+00	1441.00
IUUC-Dre-027650	Danio rerio	93.56	0.00e+00	1498.00
IUUC-Gga-041060	Gallus gallus	86.60	0.00e+00	1359.00
IUUC-Gac-041983	Gasterosteus aculeatus	93.53	0.00e+00	1502.00
IUUC-Lch-050026	Latimeria chalumnae	89.30	0.00e+00	1419.00
IUUC-Loc-051760	Lepisosteus oculatus	90.17	0.00e+00	1431.00
IUUC-Mcc-054815	Macaca mulatta	88.14	0.00e+00	1406.00
IUUC-Mdo-062805	Monodelphis domestica	88.66	0.00e+00	1405.00
IUUC-Mmu-064034	Mus musculus	88.92	0.00e+00	1409.00
IUUC-Oan-072699	Ornithorhynchus anatinus	89.56	0.00e+00	1426.00
IUUC-Ola-087161	Oryzias latipes	88.07	0.00e+00	1307.00
IUUC-Pma-094354	Petromyzon marinus	71.27	0.00e+00	1119.00
IUUC-Pfo-096142	Poecilia formosa	96.46	0.00e+00	1508.00
IUUC-Spo-108171	Schizosaccharomyces pombe	39.12	3.00e-161	562.00
IUUC-Tgu-117112	Taeniopygia guttata	89.30	0.00e+00	1422.00
IUUC-Tru-118497	Takifugu rubripes	93.69	0.00e+00	1479.00
IUUC-Tni-120781	Tetraodon nigroviridis	93.52	0.00e+00	1264.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence