iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044520

Ensembl Protein ID

ENSGGOP00000024648.1

UniProt Accession

G3S983; G3S983_GORGO

Protein Name

Protein kinase C

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000010639.2	ENSGGOT00000010686.2	ENSGGOP00000010381.2
ENSGGOG00000010639.2	ENSGGOT00000027392.1	ENSGGOP00000024648.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	1.30e-21	77.0	16	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 16   QVRVKAYYRGDI--MITHFEPSISFEGLCNEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 97
           69**********..88******************************************************************98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSHTVAGGGS GDHSHQVRVK AYYRGDIMIT HFEPSISFEG LCNEVRDMCS FDNEQLFTMK 60
WIDEEGDPCT VSSQLELEEA FRLYELNKDS ELLIHVFPCV PERPGMPCPG EDKSIYRRGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGACCC AGAGGGACAG CAGCACCATG TCCCACACGG TCGCAGGCGG CGGCAGCGGG 60
GACCATTCCC ACCAGGTCCG GGTGAAAGCC TACTACCGCG GGTGAGTGTC CTGGGGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	92.18	0.00e+00	970.00
IUUC-Apl-003711	Anas platyrhynchos	88.87	0.00e+00	997.00
IUUC-Aca-005142	Anolis carolinensis	88.19	0.00e+00	1012.00
IUUC-Ame-010977	Astyanax mexicanus	83.74	0.00e+00	937.00
IUUC-Bta-013414	Bos taurus	92.36	0.00e+00	1090.00
IUUC-Bol-015169	Brassica oleracea	33.72	2.00e-49	191.00
IUUC-Cel-018340	Caenorhabditis elegans	56.71	0.00e+00	671.00
IUUC-Cja-019802	Callithrix jacchus	92.73	0.00e+00	1048.00
IUUC-Cfa-021236	Canis familiaris	91.85	0.00e+00	1050.00
IUUC-Cpo-022127	Cavia porcellus	90.67	0.00e+00	997.00
IUUC-Csa-023332	Chlorocebus sabaeus	91.53	0.00e+00	876.00
IUUC-Cho-025054	Choloepus hoffmanni	67.01	5.00e-126	444.00
IUUC-Cin-025740	Ciona intestinalis	56.97	0.00e+00	655.00
IUUC-Csv-026145	Ciona savignyi	58.71	0.00e+00	658.00
IUUC-Dre-028444	Danio rerio	84.31	0.00e+00	947.00
IUUC-Dno-029228	Dasypus novemcinctus	91.03	1.00e-167	582.00
IUUC-Dme-031630	Drosophila melanogaster	63.85	0.00e+00	752.00
IUUC-Ete-032633	Echinops telfairi	67.95	2.00e-167	582.00
IUUC-Eca-033572	Equus caballus	92.38	0.00e+00	1039.00
IUUC-Eeu-035110	Erinaceus europaeus	91.51	0.00e+00	1075.00
IUUC-Fca-035559	Felis catus	92.02	0.00e+00	1089.00
IUUC-Fal-036953	Ficedula albicollis	89.54	0.00e+00	1007.00
IUUC-Gmo-039334	Gadus morhua	83.94	0.00e+00	966.00
IUUC-Gga-040223	Gallus gallus	88.93	0.00e+00	1029.00
IUUC-Gac-042113	Gasterosteus aculeatus	84.51	0.00e+00	973.00
IUUC-Hsa-046991	Homo sapiens	93.21	0.00e+00	1099.00
IUUC-Lch-050263	Latimeria chalumnae	83.77	0.00e+00	977.00
IUUC-Loc-052221	Lepisosteus oculatus	84.46	0.00e+00	945.00
IUUC-Laf-053591	Loxodonta africana	92.02	0.00e+00	1087.00
IUUC-Mcc-055118	Macaca mulatta	90.31	0.00e+00	1049.00
IUUC-Mga-059886	Meleagris gallopavo	88.69	0.00e+00	996.00
IUUC-Mmr-060926	Microcebus murinus	92.87	0.00e+00	1096.00
IUUC-Mdo-062698	Monodelphis domestica	88.75	0.00e+00	1017.00
IUUC-Mmu-063689	Mus musculus	91.51	0.00e+00	1074.00
IUUC-Mpu-066630	Mustela putorius furo	92.29	0.00e+00	1079.00
IUUC-Mlu-067416	Myotis lucifugus	88.96	0.00e+00	1013.00
IUUC-Nle-069811	Nomascus leucogenys	92.87	0.00e+00	1095.00
IUUC-Opr-070466	Ochotona princeps	83.71	0.00e+00	714.00
IUUC-Ont-072278	Oreochromis niloticus	82.16	0.00e+00	915.00
IUUC-Oan-073651	Ornithorhynchus anatinus	90.93	0.00e+00	677.00
IUUC-Ocu-074383	Oryctolagus cuniculus	92.36	0.00e+00	1090.00
IUUC-Ola-087283	Oryzias latipes	83.08	0.00e+00	790.00
IUUC-Oga-088337	Otolemur garnettii	83.98	0.00e+00	964.00
IUUC-Oar-089954	Ovis aries	92.57	0.00e+00	1047.00
IUUC-Ptr-091673	Pan troglodytes	93.21	0.00e+00	1099.00
IUUC-Pan-092494	Papio anubis	93.04	0.00e+00	1096.00
IUUC-Psi-094044	Pelodiscus sinensis	89.62	0.00e+00	1035.00
IUUC-Pfo-096661	Poecilia formosa	83.13	0.00e+00	935.00
IUUC-Pab-097659	Pongo abelii	92.53	0.00e+00	1090.00
IUUC-Pca-101107	Procavia capensis	88.78	0.00e+00	710.00
IUUC-Rno-105790	Rattus norvegicus	91.85	0.00e+00	1082.00
IUUC-Sha-106895	Sarcophilus harrisii	90.32	0.00e+00	1001.00
IUUC-Sar-113513	Sorex araneus	95.33	3.00e-174	604.00
IUUC-Ssc-115835	Sus scrofa	91.41	0.00e+00	950.00
IUUC-Tgu-116874	Taeniopygia guttata	89.24	0.00e+00	1030.00
IUUC-Tru-117823	Takifugu rubripes	83.30	0.00e+00	946.00
IUUC-Tsy-119154	Tarsius syrichta	92.02	0.00e+00	1036.00
IUUC-Tni-119968	Tetraodon nigroviridis	82.03	0.00e+00	929.00
IUUC-Tbe-127238	Tupaia belangeri	77.87	0.00e+00	729.00
IUUC-Ttr-129208	Tursiops truncatus	92.20	0.00e+00	1085.00
IUUC-Vpa-130363	Vicugna pacos	83.19	0.00e+00	951.00
IUUC-Xtr-132652	Xenopus tropicalis	83.42	0.00e+00	969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence