iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.60e-45	153.2	6	145

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.. 87
           Rlkkel+ l+ +pp+g+++ ++++ ++++++++ilG ++tpYe+g+F le+ +pe+YPf+PP+++flt+i+hPn++++G++Cl+ilk  
   Q: 6    RLKKELHMLAIEPPPGVTCWQEKD-KMDNLRAQILGGANTPYEKGIFTLEVIVPERYPFEPPQIRFLTPIYHPNIDSSGRICLDILKlp 93
           9***********************.7************************************************************998 PP
   S: 88   eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++ +W+p l++++vl+siq l+aepnp++pl +++++++k n+ ++ kk+r+
   Q: 94   PKGAWRPSLNIATVLTSIQLLMAEPNPDDPLMADISSEFKYNKIAFVKKARQ 145
           99*********************************************99985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MQRASRLKKE LHMLAIEPPP GVTCWQEKDK MDNLRAQILG GANTPYEKGI FTLEVIVPER 60
YPFEPPQIRF LTPIYHPNID SSGRICLDIL KLPPKGAWRP SLNIATVLTS IQLLMAEPNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGAGAG CTTCACGCCT GAAGAAAGAA CTGCACATGC TAGCCATCGA ACCTCCCCCA 60
GGCGTCACGT GCTGGCAGGA AAAGGACAAA ATGGATAATT TGCGAGCTCG TAGGTATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

rno:360847

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000366	Aegilops tauschii	54.61	8.00e-46	178.00
IUUC-Aml-001392	Ailuropoda melanoleuca	77.66	4.00e-91	326.00
IUUC-Atr-003069	Amborella trichopoda	45.69	2.00e-49	189.00
IUUC-Apl-003914	Anas platyrhynchos	76.92	5.00e-74	269.00
IUUC-Aca-004381	Anolis carolinensis	66.16	9.00e-78	282.00
IUUC-Aly-006059	Arabidopsis lyrata	53.80	6.00e-46	177.00
IUUC-Ath-007669	Arabidopsis thaliana	54.42	1.00e-43	171.00
IUUC-Ame-011372	Astyanax mexicanus	60.50	1.00e-68	252.00
IUUC-Bta-012479	Bos taurus	76.02	2.00e-84	304.00
IUUC-Bdi-014043	Brachypodium distachyon	56.95	3.00e-50	193.00
IUUC-Bol-016011	Brassica oleracea	48.39	5.00e-46	178.00
IUUC-Bra-017419	Brassica rapa	52.47	5.00e-45	175.00
IUUC-Cja-019773	Callithrix jacchus	77.27	1.00e-89	322.00
IUUC-Cfa-020043	Canis familiaris	77.66	5.00e-91	326.00
IUUC-Cpo-021481	Cavia porcellus	81.95	2.00e-99	354.00
IUUC-Csa-024083	Chlorocebus sabaeus	80.71	7.00e-94	335.00
IUUC-Cho-024386	Choloepus hoffmanni	79.89	2.00e-85	307.00
IUUC-Cin-025419	Ciona intestinalis	64.29	1.00e-60	225.00
IUUC-Csv-026224	Ciona savignyi	66.23	2.00e-63	234.00
IUUC-Cme-027179	Cyanidioschyzon merolae	50.32	5.00e-41	159.00
IUUC-Dre-028800	Danio rerio	67.76	1.00e-73	268.00
IUUC-Dno-029833	Dasypus novemcinctus	80.71	5.00e-93	333.00
IUUC-Ete-032625	Echinops telfairi	79.49	5.00e-70	256.00
IUUC-Eca-033821	Equus caballus	85.35	3.00e-80	290.00
IUUC-Eeu-034578	Erinaceus europaeus	78.10	2.00e-59	220.00
IUUC-Fca-036398	Felis catus	79.70	8.00e-93	332.00
IUUC-Fal-037564	Ficedula albicollis	68.88	2.00e-75	274.00
IUUC-Gmo-039142	Gadus morhua	77.85	7.00e-73	265.00
IUUC-Gga-041054	Gallus gallus	66.49	2.00e-73	267.00
IUUC-Gac-041370	Gasterosteus aculeatus	78.06	1.00e-72	265.00
IUUC-Ggo-045370	Gorilla gorilla	81.73	2.00e-94	338.00
IUUC-Hsa-046513	Homo sapiens	82.23	6.00e-95	339.00
IUUC-Hvu-047694	Hordeum vulgare	53.95	2.00e-47	183.00
IUUC-Itr-049076	Ictidomys tridecemlineatus	81.46	1.00e-98	351.00
IUUC-Lch-050484	Latimeria chalumnae	69.01	6.00e-68	249.00
IUUC-Loc-051967	Lepisosteus oculatus	64.29	1.00e-70	259.00
IUUC-Laf-053377	Loxodonta africana	78.17	3.00e-91	327.00
IUUC-Mcc-055453	Macaca mulatta	80.71	5.00e-94	336.00
IUUC-Meu-056745	Macropus eugenii	72.45	3.00e-83	300.00
IUUC-Mga-059729	Meleagris gallopavo	77.07	1.00e-73	268.00
IUUC-Mmr-060581	Microcebus murinus	81.22	5.00e-94	336.00
IUUC-Mdo-062434	Monodelphis domestica	73.10	1.00e-80	293.00
IUUC-Mmu-064379	Mus musculus	91.67	2.00e-112	397.00
IUUC-Mac-064647	Musa acuminata	53.75	6.00e-47	179.00
IUUC-Mpu-066713	Mustela putorius furo	77.66	4.00e-90	323.00
IUUC-Mlu-067525	Myotis lucifugus	83.12	1.00e-77	281.00
IUUC-Nle-069757	Nomascus leucogenys	82.23	9.00e-95	338.00
IUUC-Opr-070756	Ochotona princeps	79.19	7.00e-91	326.00
IUUC-Ont-071956	Oreochromis niloticus	65.50	6.00e-75	273.00
IUUC-Oan-072745	Ornithorhynchus anatinus	81.48	2.00e-78	284.00
IUUC-Ocu-074423	Oryctolagus cuniculus	76.65	3.00e-88	317.00
IUUC-Oba-075569	Oryza barthii	56.58	4.00e-48	185.00
IUUC-Obr-076131	Oryza brachyantha	57.24	3.00e-48	186.00
IUUC-Ogl-077132	Oryza glaberrima	56.58	4.00e-48	185.00
IUUC-Ogu-078880	Oryza glumaepatula	56.58	2.00e-48	186.00
IUUC-Oin-079748	Oryza indica	56.58	2.00e-48	186.00
IUUC-Olo-080501	Oryza longistaminata	56.58	1.00e-48	187.00
IUUC-Ome-081248	Oryza meridionalis	56.58	5.00e-48	185.00
IUUC-Oni-083033	Oryza nivara	56.58	2.00e-48	186.00
IUUC-Opu-083664	Oryza punctata	56.58	2.00e-48	186.00
IUUC-Oru-084580	Oryza rufipogon	56.58	2.00e-48	186.00
IUUC-Osa-085721	Oryza sativa	56.58	2.00e-48	186.00
IUUC-Ola-087559	Oryzias latipes	75.78	3.00e-72	264.00
IUUC-Oga-088420	Otolemur garnettii	79.13	2.00e-96	344.00
IUUC-Oar-090082	Ovis aries	75.38	8.00e-84	302.00
IUUC-Ptr-091134	Pan troglodytes	81.73	2.00e-94	338.00
IUUC-Pan-091735	Papio anubis	80.71	7.00e-94	335.00
IUUC-Psi-094064	Pelodiscus sinensis	71.35	3.00e-79	287.00
IUUC-Pma-094609	Petromyzon marinus	71.52	5.00e-65	239.00
IUUC-Ppa-095553	Physcomitrella patens	53.01	3.00e-49	189.00
IUUC-Pfo-096710	Poecilia formosa	68.65	1.00e-74	272.00
IUUC-Pab-098126	Pongo abelii	82.23	6.00e-95	339.00
IUUC-Pop-099108	Populus trichocarpa	53.29	6.00e-47	181.00
IUUC-Pca-100338	Procavia capensis	78.68	8.00e-92	328.00
IUUC-Ppe-101239	Prunus persica	57.66	4.00e-44	172.00
IUUC-Pva-102756	Pteropus vampyrus	74.66	3.00e-61	226.00
IUUC-Sha-106969	Sarcophilus harrisii	67.66	1.00e-71	261.00
IUUC-Smo-109052	Selaginella moellendorffii	54.84	8.00e-45	172.00
IUUC-Sit-110464	Setaria italica	57.82	7.00e-47	182.00
IUUC-Sly-110971	Solanum lycopersicum	57.43	3.00e-46	180.00
IUUC-Stu-112126	Solanum tuberosum	58.11	9.00e-47	181.00
IUUC-Sar-113633	Sorex araneus	73.37	2.00e-83	301.00
IUUC-Sbi-114875	Sorghum bicolor	56.29	5.00e-48	185.00
IUUC-Ssc-116375	Sus scrofa	73.10	6.00e-83	299.00
IUUC-Tgu-117292	Taeniopygia guttata	79.08	7.00e-72	262.00
IUUC-Tru-118157	Takifugu rubripes	67.95	5.00e-60	223.00
IUUC-Tsy-119260	Tarsius syrichta	79.19	5.00e-89	319.00
IUUC-Tni-120162	Tetraodon nigroviridis	66.67	3.00e-73	267.00
IUUC-Tca-121255	Theobroma cacao	51.67	3.00e-37	149.00
IUUC-Tae-123184	Triticum aestivum	54.61	8.00e-46	178.00
IUUC-Tbe-127296	Tupaia belangeri	83.76	1.00e-96	344.00
IUUC-Ttr-128443	Tursiops truncatus	75.00	6.00e-88	316.00
IUUC-Vpa-130689	Vicugna pacos	73.60	3.00e-86	310.00
IUUC-Vvi-130925	Vitis vinifera	56.49	3.00e-46	177.00
IUUC-Xma-133779	Xiphophorus maculatus	69.95	2.00e-73	267.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence