iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034157

Ensembl Protein ID

ENSECAP00000019686.1

UniProt Accession

F6YPC4; F6YPC4_HORSE

Protein Name

Tyrosine-protein kinase

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021666.1	ENSECAT00000023742.1	ENSECAP00000019686.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.30e-15	54.5	94	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 94   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 149
           789***********************..8999**********************9875 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEHTAVA PSSSAKGTSV NFSNLSVTPF 60
GGSSGVTPFG GASSSFSVVP SSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGTAGAT TTGATAATGG GCTGCATTAA AAGTAAAGAG AACAAAAGTC CAGCCATTAA 60
ATACCGACCG GAAAACACTC CAGAACCTGT CAGTACAAGT GTCAGCCATT ATGGAGCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	97.97	0.00e+00	1064.00
IUUC-Apl-004032	Anas platyrhynchos	91.87	0.00e+00	1011.00
IUUC-Aca-004255	Anolis carolinensis	90.57	0.00e+00	1021.00
IUUC-Ame-010954	Astyanax mexicanus	85.74	0.00e+00	969.00
IUUC-Bta-013503	Bos taurus	97.23	0.00e+00	1036.00
IUUC-Cel-018682	Caenorhabditis elegans	57.94	1.00e-148	520.00
IUUC-Cja-019694	Callithrix jacchus	97.24	0.00e+00	1042.00
IUUC-Cfa-020402	Canis familiaris	98.15	0.00e+00	1068.00
IUUC-Cpo-022506	Cavia porcellus	96.86	0.00e+00	1055.00
IUUC-Csa-023713	Chlorocebus sabaeus	97.42	0.00e+00	1052.00
IUUC-Dre-027978	Danio rerio	84.43	0.00e+00	935.00
IUUC-Dno-029897	Dasypus novemcinctus	97.69	0.00e+00	944.00
IUUC-Dor-030202	Dipodomys ordii	98.01	0.00e+00	930.00
IUUC-Eeu-034950	Erinaceus europaeus	92.90	3.00e-179	620.00
IUUC-Fca-036233	Felis catus	97.78	0.00e+00	1087.00
IUUC-Fal-037461	Ficedula albicollis	91.87	0.00e+00	1031.00
IUUC-Gmo-038929	Gadus morhua	82.51	0.00e+00	904.00
IUUC-Gga-041107	Gallus gallus	91.50	0.00e+00	1011.00
IUUC-Gac-042321	Gasterosteus aculeatus	83.61	0.00e+00	933.00
IUUC-Ggo-044597	Gorilla gorilla	77.11	0.00e+00	806.00
IUUC-Hsa-047010	Homo sapiens	97.97	0.00e+00	1065.00
IUUC-Lch-050239	Latimeria chalumnae	88.91	0.00e+00	1006.00
IUUC-Loc-052314	Lepisosteus oculatus	86.97	0.00e+00	936.00
IUUC-Laf-053517	Loxodonta africana	97.41	0.00e+00	1040.00
IUUC-Mcc-055626	Macaca mulatta	97.42	0.00e+00	1051.00
IUUC-Mga-059310	Meleagris gallopavo	91.50	0.00e+00	1011.00
IUUC-Mmr-061652	Microcebus murinus	97.41	0.00e+00	1056.00
IUUC-Mdo-062963	Monodelphis domestica	91.50	0.00e+00	1025.00
IUUC-Mmu-064128	Mus musculus	96.12	0.00e+00	1069.00
IUUC-Mpu-065906	Mustela putorius furo	98.34	0.00e+00	1071.00
IUUC-Mlu-067035	Myotis lucifugus	97.61	0.00e+00	1062.00
IUUC-Nle-069041	Nomascus leucogenys	93.92	0.00e+00	1005.00
IUUC-Opr-070299	Ochotona princeps	87.62	0.00e+00	924.00
IUUC-Ont-072337	Oreochromis niloticus	85.01	0.00e+00	952.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.14	0.00e+00	930.00
IUUC-Ocu-074171	Oryctolagus cuniculus	97.60	0.00e+00	1068.00
IUUC-Ola-086619	Oryzias latipes	84.21	0.00e+00	952.00
IUUC-Oga-087957	Otolemur garnettii	96.67	0.00e+00	1041.00
IUUC-Oar-089670	Ovis aries	96.30	0.00e+00	1031.00
IUUC-Ptr-091352	Pan troglodytes	97.97	0.00e+00	1065.00
IUUC-Pan-092202	Papio anubis	97.42	0.00e+00	1051.00
IUUC-Psi-093310	Pelodiscus sinensis	91.13	0.00e+00	1022.00
IUUC-Pma-094232	Petromyzon marinus	87.47	0.00e+00	859.00
IUUC-Pfo-096137	Poecilia formosa	83.36	0.00e+00	935.00
IUUC-Pab-098301	Pongo abelii	99.38	0.00e+00	966.00
IUUC-Pca-100245	Procavia capensis	81.50	0.00e+00	780.00
IUUC-Pva-102592	Pteropus vampyrus	93.16	0.00e+00	1002.00
IUUC-Rno-105544	Rattus norvegicus	96.12	0.00e+00	1036.00
IUUC-Sar-113364	Sorex araneus	93.72	0.00e+00	993.00
IUUC-Tgu-117380	Taeniopygia guttata	91.87	0.00e+00	1031.00
IUUC-Tru-117594	Takifugu rubripes	84.21	0.00e+00	944.00
IUUC-Tni-120433	Tetraodon nigroviridis	84.27	0.00e+00	936.00
IUUC-Tbe-127707	Tupaia belangeri	81.19	0.00e+00	767.00
IUUC-Ttr-128893	Tursiops truncatus	98.34	0.00e+00	1074.00
IUUC-Vpa-130060	Vicugna pacos	98.34	0.00e+00	1055.00
IUUC-Xtr-132322	Xenopus tropicalis	89.46	0.00e+00	999.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence