iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000148225.15	ENST00000341761.8	ENSP00000345027.3
ENSG00000148225.15	ENST00000374193.8	ENSP00000363308.3
ENSG00000148225.15	ENST00000465205.2	ENSP00000420074.1
ENSG00000148225.15	ENST00000465979.2	ENSP00000419246.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-26	91.9	144	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+  vt+la  +d   l++Gs+D+t+ +WD+ tg +
   Q: 144  GHAMVVTGLAVsPDsSQLCTGSRDNTLLLWDVVTGQS 180
           78889*******99999***************99976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGR PDEIIEERIQ TKAFQEYSPA 60
HMDTVSVVAA LNSDLCVSGG KDKTVVAYNW KTGNVVKRFK GHEHEITKVA CIPKSSQFFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGCGGGA GGGCTCGGAG GCTGTTCCCA CCCCCAGGCT CCGCGTTCCC GCCGGCCCCA 60
GCTCCAGCCC CGCAGCCCAC CGGTGGGTAC TGAGCCTGAG GTGGGAGAAA GGGGCATAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

KEGG

hsa:114987

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001303	Ailuropoda melanoleuca	83.38	2.00e-175	608.00
IUUC-Apl-003536	Anas platyrhynchos	62.79	5.00e-129	454.00
IUUC-Ame-010794	Astyanax mexicanus	50.84	3.00e-89	321.00
IUUC-Bta-013442	Bos taurus	86.38	0.00e+00	668.00
IUUC-Cel-018695	Caenorhabditis elegans	33.98	7.00e-32	131.00
IUUC-Cja-019562	Callithrix jacchus	95.10	0.00e+00	729.00
IUUC-Cfa-021028	Canis familiaris	85.45	7.00e-104	369.00
IUUC-Cpo-022343	Cavia porcellus	85.29	2.00e-179	621.00
IUUC-Csa-023542	Chlorocebus sabaeus	96.19	0.00e+00	735.00
IUUC-Cho-024760	Choloepus hoffmanni	67.80	1.00e-63	237.00
IUUC-Dre-027522	Danio rerio	53.49	7.00e-109	387.00
IUUC-Dno-029896	Dasypus novemcinctus	88.93	1.00e-124	439.00
IUUC-Dor-030765	Dipodomys ordii	81.20	3.00e-175	607.00
IUUC-Ete-033063	Echinops telfairi	69.11	3.00e-135	474.00
IUUC-Eca-033609	Equus caballus	84.47	2.00e-179	621.00
IUUC-Eeu-034966	Erinaceus europaeus	84.15	0.00e+00	640.00
IUUC-Fca-036069	Felis catus	86.67	0.00e+00	654.00
IUUC-Fal-036667	Ficedula albicollis	62.21	6.00e-124	437.00
IUUC-Gmo-039012	Gadus morhua	50.00	2.00e-102	365.00
IUUC-Gga-040523	Gallus gallus	62.79	2.00e-125	441.00
IUUC-Gac-041287	Gasterosteus aculeatus	49.47	3.00e-106	378.00
IUUC-Ggo-045296	Gorilla gorilla	99.18	0.00e+00	761.00
IUUC-Itr-049046	Ictidomys tridecemlineatus	85.32	0.00e+00	648.00
IUUC-Lch-049661	Latimeria chalumnae	63.14	7.00e-129	453.00
IUUC-Loc-051770	Lepisosteus oculatus	57.49	9.00e-80	290.00
IUUC-Laf-053619	Loxodonta africana	88.20	0.00e+00	653.00
IUUC-Mcc-054764	Macaca mulatta	96.46	0.00e+00	739.00
IUUC-Meu-056252	Macropus eugenii	72.20	9.00e-107	379.00
IUUC-Mga-059846	Meleagris gallopavo	61.34	2.00e-112	399.00
IUUC-Mmr-060750	Microcebus murinus	91.28	0.00e+00	670.00
IUUC-Mdo-062994	Monodelphis domestica	70.11	4.00e-149	520.00
IUUC-Mmu-063635	Mus musculus	83.11	4.00e-176	610.00
IUUC-Mpu-066603	Mustela putorius furo	86.92	0.00e+00	632.00
IUUC-Mlu-067615	Myotis lucifugus	88.01	0.00e+00	651.00
IUUC-Nle-070126	Nomascus leucogenys	98.64	0.00e+00	754.00
IUUC-Opr-071069	Ochotona princeps	80.11	8.00e-175	606.00
IUUC-Ont-072042	Oreochromis niloticus	52.05	3.00e-104	372.00
IUUC-Oan-073655	Ornithorhynchus anatinus	75.71	2.00e-79	287.00
IUUC-Ocu-074554	Oryctolagus cuniculus	84.20	3.00e-169	587.00
IUUC-Ola-087524	Oryzias latipes	52.26	9.00e-108	383.00
IUUC-Oga-088877	Otolemur garnettii	79.08	2.00e-169	588.00
IUUC-Oar-090049	Ovis aries	86.10	0.00e+00	664.00
IUUC-Ptr-091038	Pan troglodytes	99.73	0.00e+00	766.00
IUUC-Pan-092272	Papio anubis	96.73	0.00e+00	743.00
IUUC-Psi-093373	Pelodiscus sinensis	59.89	8.00e-122	430.00
IUUC-Pfo-096647	Poecilia formosa	53.61	2.00e-106	378.00
IUUC-Pab-097879	Pongo abelii	92.37	0.00e+00	692.00
IUUC-Pca-100192	Procavia capensis	86.10	0.00e+00	632.00
IUUC-Pva-102832	Pteropus vampyrus	89.37	0.00e+00	658.00
IUUC-Rno-105940	Rattus norvegicus	83.11	3.00e-176	610.00
IUUC-Sha-106913	Sarcophilus harrisii	71.22	2.00e-142	498.00
IUUC-Sar-113560	Sorex araneus	56.87	1.00e-93	336.00
IUUC-Ssc-115648	Sus scrofa	86.38	0.00e+00	640.00
IUUC-Tgu-117359	Taeniopygia guttata	64.44	1.00e-121	429.00
IUUC-Tru-117707	Takifugu rubripes	48.50	1.00e-100	360.00
IUUC-Tsy-119614	Tarsius syrichta	66.21	2.00e-135	475.00
IUUC-Tni-120445	Tetraodon nigroviridis	51.00	3.00e-105	375.00
IUUC-Tbe-128051	Tupaia belangeri	62.28	2.00e-91	328.00
IUUC-Ttr-129199	Tursiops truncatus	87.16	0.00e+00	641.00
IUUC-Vpa-130211	Vicugna pacos	88.03	3.00e-143	500.00
IUUC-Xtr-132403	Xenopus tropicalis	54.31	6.00e-109	387.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence