iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-063036

Ensembl Protein ID

ENSMODP00000014600.3

UniProt Accession

F6YES1; F6YES1_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000011651.3	ENSMODT00000014868.3	ENSMODP00000014600.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-12	48.0	216	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +lydy++ n ++L l+kG+  +++  ee    W+k+ ++ +g++G +P+n+v+++e
   Q: 216  LKRVVALYDYMPMNANDLRLQKGEEYFIL--EESTLPWWKA-RDKNGQEGYIPNNYVTEAE 273
           6899*************************..888999****.5***************987 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSVDVEK 60
ITCVETVVPE KNPPPERQIP RKGEEASEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATGTCTC CAGTGCCAGT CTCTATGCGG ATCGAGTCCC ACCTTCCAAG TCTGGGCAGC 60
TTAATGCATC TGGGAATCTG CCAGCATTAA GTCAAGACTG AGGTAGGTGG TTAATGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005102--F:receptor binding
GO:0002344--P:B cell affinity maturation
GO:0030154--P:cell differentiation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	94.68	0.00e+00	1228.00
IUUC-Apl-003907	Anas platyrhynchos	86.90	0.00e+00	1129.00
IUUC-Aca-004978	Anolis carolinensis	76.72	0.00e+00	1028.00
IUUC-Bta-012467	Bos taurus	95.15	0.00e+00	1236.00
IUUC-Cja-018841	Callithrix jacchus	94.37	0.00e+00	1223.00
IUUC-Cfa-020983	Canis familiaris	94.99	0.00e+00	1197.00
IUUC-Cpo-021307	Cavia porcellus	95.15	0.00e+00	1233.00
IUUC-Csa-023508	Chlorocebus sabaeus	94.13	0.00e+00	906.00
IUUC-Dno-029828	Dasypus novemcinctus	93.74	0.00e+00	1206.00
IUUC-Dor-030102	Dipodomys ordii	87.16	0.00e+00	1013.00
IUUC-Ete-032981	Echinops telfairi	86.38	0.00e+00	1099.00
IUUC-Eca-033594	Equus caballus	95.46	0.00e+00	1237.00
IUUC-Eeu-035281	Erinaceus europaeus	90.42	0.00e+00	1002.00
IUUC-Fca-035495	Felis catus	94.52	0.00e+00	1192.00
IUUC-Fal-036719	Ficedula albicollis	86.99	0.00e+00	1150.00
IUUC-Gga-041193	Gallus gallus	86.56	0.00e+00	1122.00
IUUC-Hsa-045931	Homo sapiens	94.99	0.00e+00	1207.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	94.99	0.00e+00	1229.00
IUUC-Lch-049868	Latimeria chalumnae	75.91	0.00e+00	958.00
IUUC-Laf-053516	Loxodonta africana	94.38	0.00e+00	1253.00
IUUC-Mcc-054795	Macaca mulatta	94.99	0.00e+00	1207.00
IUUC-Meu-056157	Macropus eugenii	93.11	0.00e+00	1087.00
IUUC-Mga-059529	Meleagris gallopavo	86.25	0.00e+00	953.00
IUUC-Mmr-060824	Microcebus murinus	90.30	0.00e+00	1129.00
IUUC-Mmu-064047	Mus musculus	95.15	0.00e+00	1236.00
IUUC-Mpu-066810	Mustela putorius furo	94.99	0.00e+00	1229.00
IUUC-Mlu-067671	Myotis lucifugus	94.09	0.00e+00	1223.00
IUUC-Nle-069108	Nomascus leucogenys	94.99	0.00e+00	1207.00
IUUC-Opr-070505	Ochotona princeps	74.77	0.00e+00	662.00
IUUC-Oan-073495	Ornithorhynchus anatinus	92.64	0.00e+00	1225.00
IUUC-Ocu-074416	Oryctolagus cuniculus	95.15	0.00e+00	1234.00
IUUC-Oga-088995	Otolemur garnettii	93.77	0.00e+00	1194.00
IUUC-Oar-089632	Ovis aries	94.05	0.00e+00	1211.00
IUUC-Ptr-090941	Pan troglodytes	94.84	0.00e+00	1206.00
IUUC-Pan-091900	Papio anubis	91.86	0.00e+00	1158.00
IUUC-Psi-093048	Pelodiscus sinensis	85.05	0.00e+00	1084.00
IUUC-Pab-097587	Pongo abelii	94.99	0.00e+00	1207.00
IUUC-Pca-100374	Procavia capensis	85.57	2.00e-144	506.00
IUUC-Pva-102583	Pteropus vampyrus	94.84	0.00e+00	1205.00
IUUC-Rno-104868	Rattus norvegicus	90.19	0.00e+00	1150.00
IUUC-Sha-106744	Sarcophilus harrisii	96.87	0.00e+00	1266.00
IUUC-Sar-113041	Sorex araneus	94.40	0.00e+00	1095.00
IUUC-Ssc-115294	Sus scrofa	94.99	0.00e+00	1233.00
IUUC-Tsy-118945	Tarsius syrichta	93.65	0.00e+00	839.00
IUUC-Ttr-128769	Tursiops truncatus	90.37	0.00e+00	1109.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence