iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19345326; 12874135; 19802004

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.20e-05	26.6	632	673

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C +d+   + ++ lpC H fh +C+ +w       s + +CP+Cr
   Q: 632  CSVCISDYvtGNKLRQLPCMHEFHIHCIDRW------LSENCTCPICR 673
           9*******7744499****************......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

Protein Sequence
(Fasta)

MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL 60
LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTTAAGT GCTGGGACTT CCCAAGCCTG GAAAGCAGAC CGTGTCTCTG CAACTACGCG 60
GCTGCCACGA GCGCTGAGCG GCCGGGCATT TGGCCTCGAG GAGGAGGCAC TGTAAGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030517--P:negative regulation of axon extension
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044314--P:protein K27-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:6049

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000811	Aegilops tauschii	37.29	4.00e-08	50.80
IUUC-Aml-001415	Ailuropoda melanoleuca	88.18	0.00e+00	1070.00
IUUC-Atr-002558	Amborella trichopoda	32.73	1.00e-13	70.90
IUUC-Apl-003834	Anas platyrhynchos	59.59	0.00e+00	658.00
IUUC-Aca-004373	Anolis carolinensis	59.72	3.00e-86	312.00
IUUC-Ath-006611	Arabidopsis thaliana	40.40	1.00e-16	80.90
IUUC-Ame-011730	Astyanax mexicanus	65.05	3.00e-89	323.00
IUUC-Bta-012763	Bos taurus	74.05	0.00e+00	872.00
IUUC-Bol-016144	Brassica oleracea	38.27	5.00e-14	70.90
IUUC-Bra-017280	Brassica rapa	44.44	2.00e-15	76.30
IUUC-Cja-018980	Callithrix jacchus	92.85	0.00e+00	1177.00
IUUC-Cfa-020416	Canis familiaris	88.63	0.00e+00	1097.00
IUUC-Cpo-022086	Cavia porcellus	74.89	0.00e+00	835.00
IUUC-Csa-023246	Chlorocebus sabaeus	96.35	0.00e+00	1189.00
IUUC-Cho-024749	Choloepus hoffmanni	83.63	0.00e+00	888.00
IUUC-Dre-028428	Danio rerio	62.89	4.00e-87	316.00
IUUC-Dno-029617	Dasypus novemcinctus	86.34	0.00e+00	1033.00
IUUC-Dor-030800	Dipodomys ordii	83.08	7.00e-143	501.00
IUUC-Ete-032882	Echinops telfairi	74.25	2.00e-149	522.00
IUUC-Eca-033892	Equus caballus	89.05	0.00e+00	1130.00
IUUC-Eeu-034563	Erinaceus europaeus	85.88	1.00e-116	413.00
IUUC-Fca-035765	Felis catus	87.30	0.00e+00	1054.00
IUUC-Fal-036981	Ficedula albicollis	57.55	3.00e-175	608.00
IUUC-Gmo-039344	Gadus morhua	63.89	5.00e-97	348.00
IUUC-Gga-041114	Gallus gallus	71.62	1.00e-117	417.00
IUUC-Gac-042220	Gasterosteus aculeatus	62.63	2.00e-97	350.00
IUUC-Ggo-044902	Gorilla gorilla	99.27	0.00e+00	1283.00
IUUC-Itr-048447	Ictidomys tridecemlineatus	88.91	0.00e+00	1118.00
IUUC-Lch-050541	Latimeria chalumnae	63.45	1.00e-98	353.00
IUUC-Lpe-051237	Leersia perrieri	44.00	8.00e-14	70.50
IUUC-Laf-054296	Loxodonta africana	80.99	0.00e+00	971.00
IUUC-Mcc-054858	Macaca mulatta	96.20	0.00e+00	1214.00
IUUC-Meu-056296	Macropus eugenii	65.85	2.00e-133	469.00
IUUC-Mga-059307	Meleagris gallopavo	69.80	4.00e-111	395.00
IUUC-Mmr-060699	Microcebus murinus	91.24	0.00e+00	1146.00
IUUC-Mdo-062162	Monodelphis domestica	68.35	0.00e+00	749.00
IUUC-Mmu-064188	Mus musculus	71.58	0.00e+00	803.00
IUUC-Mac-065618	Musa acuminata	47.06	1.00e-13	69.30
IUUC-Mpu-065891	Mustela putorius furo	87.74	0.00e+00	1071.00
IUUC-Mlu-067177	Myotis lucifugus	86.80	0.00e+00	1013.00
IUUC-Nle-069127	Nomascus leucogenys	97.66	0.00e+00	1254.00
IUUC-Ont-072086	Oreochromis niloticus	62.80	2.00e-98	353.00
IUUC-Ocu-074281	Oryctolagus cuniculus	90.44	1.00e-68	251.00
IUUC-Ogl-077537	Oryza glaberrima	42.25	3.00e-13	68.20
IUUC-Ogu-078922	Oryza glumaepatula	37.50	7.00e-14	72.00
IUUC-Ome-081556	Oryza meridionalis	40.62	2.00e-15	75.50
IUUC-Oni-082313	Oryza nivara	37.50	7.00e-14	72.00
IUUC-Opu-083678	Oryza punctata	36.46	2.00e-13	70.90
IUUC-Ola-087452	Oryzias latipes	63.33	3.00e-98	353.00
IUUC-Oga-088750	Otolemur garnettii	89.33	0.00e+00	1103.00
IUUC-Oar-089523	Ovis aries	73.76	0.00e+00	845.00
IUUC-Ptr-091533	Pan troglodytes	99.85	0.00e+00	1292.00
IUUC-Pan-092675	Papio anubis	96.20	0.00e+00	1188.00
IUUC-Psi-093735	Pelodiscus sinensis	60.23	0.00e+00	688.00
IUUC-Pfo-096637	Poecilia formosa	61.28	1.00e-96	347.00
IUUC-Pab-098486	Pongo abelii	98.69	0.00e+00	1278.00
IUUC-Pop-099068	Populus trichocarpa	42.25	6.00e-14	70.10
IUUC-Pca-100143	Procavia capensis	80.28	3.00e-167	582.00
IUUC-Pva-103151	Pteropus vampyrus	81.31	0.00e+00	1002.00
IUUC-Rno-105745	Rattus norvegicus	71.13	0.00e+00	754.00
IUUC-Sha-106681	Sarcophilus harrisii	68.78	0.00e+00	754.00
IUUC-Sit-110544	Setaria italica	40.54	6.00e-14	72.00
IUUC-Sar-113229	Sorex araneus	87.21	6.00e-140	491.00
IUUC-Sbi-113902	Sorghum bicolor	39.24	1.00e-13	70.50
IUUC-Ssc-115345	Sus scrofa	60.94	1.00e-77	283.00
IUUC-Tgu-117477	Taeniopygia guttata	57.29	1.00e-166	580.00
IUUC-Tru-118302	Takifugu rubripes	62.00	3.00e-97	349.00
IUUC-Tsy-119338	Tarsius syrichta	74.20	0.00e+00	846.00
IUUC-Tni-119675	Tetraodon nigroviridis	58.82	9.00e-85	307.00
IUUC-Tca-120922	Theobroma cacao	50.00	1.00e-13	70.90
IUUC-Tae-122971	Triticum aestivum	39.44	1.00e-13	70.10
IUUC-Tbe-127505	Tupaia belangeri	71.10	6.00e-109	388.00
IUUC-Ttr-128367	Tursiops truncatus	79.36	0.00e+00	851.00
IUUC-Vpa-130480	Vicugna pacos	83.49	3.00e-144	505.00
IUUC-Vvi-130869	Vitis vinifera	33.01	7.00e-14	70.10
IUUC-Xma-133863	Xiphophorus maculatus	61.41	8.00e-97	348.00
IUUC-Yli-134656	Yarrowia lipolytica	48.94	3.00e-10	60.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence