iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120808

UUCD1 version

UUC-TeN-01123

Ensembl Protein ID

ENSTNIP00000017723.1

UniProt Accession

H3DB31; H3DB31_TETNG

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000014693.1	ENSTNIT00000017946.1	ENSTNIP00000017723.1
ENSTNIG00000014693.1	ENSTNIT00000000049.1	ENSTNIP00000000383.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.70e-160	533.6	3	730

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q pv+g+++lFk++e+r+s+rk+++++++++v+de+i++ +ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QSPVYGFIFLFKWIEERRSRRKVNTLVDETSVIDEEIVNDMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+ +  +lGttlsr+k +tk++spe+k++a+gn+++l+ +hns+ar+e+r++pe+q++ ++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSGV--ELGTTLSRIKAFTKGFSPESKGYAIGNAPELARAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSY 173
           ******************99..9****************************************************************** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i++rl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l++lk +         
   Q: 174  VPIKDRLFELDGLKAYPIDHGPWGEEEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYESKLEILKKNrqiilqglq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  kmirltqtelvhekkekdssspddstpavkkeaecepvppqstdqalpdsvdepgaqskeptspsenikvmgkppvpkgggppqvtsps 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  pivqrlpafldnhnyakspmqeeedlaagvgrtrmsappqppysddeddyedeeeevtgssvtsnrfrrkgslrsragrvvtgtesqia 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  ltvlaeklkkeaqrkdamntplsvrtegrtggicitsasqpsptpsnestdtaseigsafnsplrsparsqaatrpsspvashlsrvlf 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  gedemlrldsrhnravrelgpsvstallhlqedgvifavppsdkgkaslvskekegvnegdegpsvevkeeeskeraevdssketpssl 616
           ***************************************************************************************** PP
   S: 260  ..............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
                         keLl+Llk++e+ ++++e +l++e+ekrkk+kidd+rRt+nydefic+fi++la+eg+l+ lve++is++r++gv
   Q: 617  elvdskppgdkyspKELLALLKCVEADIANYEVSLKEEVEKRKKYKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGV 705
           ***************************************************************************************** PP
   S: 335  negrlakqrkqgrekkirplkrkrk 359
           ++grl+kqrk++r+k++rp+k+kr+
   Q: 706  SIGRLHKQRKPDRRKRSRPYKAKRQ 730
           ***********************97 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ SPVYGFIFLF KWIEERRSRR 60
KVNTLVDETS VIDEEIVNDM FFAHQLIPNS CATHALLSVL LNCSGVELGT TLSRIKAFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACAAAG GCTGGCTGGA GCTTGAGAGT GATCCAGGTA AGCATTATCG AAAGAAAACA 60
TAGCTAAACA ACGTTAGCTT ACACATAAAG CCAGATCGAC ACTTGGGCCA CCTTAAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	65.26	0.00e+00	880.00
IUUC-Apl-003405	Anas platyrhynchos	53.60	8.00e-127	446.00
IUUC-Aca-004836	Anolis carolinensis	67.12	0.00e+00	917.00
IUUC-Ame-011946	Astyanax mexicanus	71.01	0.00e+00	987.00
IUUC-Bta-013131	Bos taurus	62.11	0.00e+00	737.00
IUUC-Cja-019599	Callithrix jacchus	67.34	0.00e+00	919.00
IUUC-Cfa-021003	Canis familiaris	66.53	0.00e+00	874.00
IUUC-Cpo-022143	Cavia porcellus	66.13	0.00e+00	899.00
IUUC-Csa-023477	Chlorocebus sabaeus	67.20	0.00e+00	905.00
IUUC-Cho-024734	Choloepus hoffmanni	51.22	2.00e-125	442.00
IUUC-Csv-025842	Ciona savignyi	60.73	4.00e-94	337.00
IUUC-Dre-027793	Danio rerio	75.46	0.00e+00	1060.00
IUUC-Dno-029253	Dasypus novemcinctus	66.22	0.00e+00	887.00
IUUC-Dor-030891	Dipodomys ordii	62.28	0.00e+00	822.00
IUUC-Dme-031796	Drosophila melanogaster	59.18	3.00e-95	342.00
IUUC-Ete-032646	Echinops telfairi	82.64	4.00e-117	415.00
IUUC-Eca-033805	Equus caballus	67.52	0.00e+00	893.00
IUUC-Eeu-035216	Erinaceus europaeus	65.44	4.00e-95	342.00
IUUC-Fca-035611	Felis catus	66.07	0.00e+00	844.00
IUUC-Fal-037186	Ficedula albicollis	64.14	0.00e+00	786.00
IUUC-Gmo-038824	Gadus morhua	79.92	0.00e+00	742.00
IUUC-Gga-040875	Gallus gallus	67.98	0.00e+00	919.00
IUUC-Gac-042226	Gasterosteus aculeatus	86.85	0.00e+00	1189.00
IUUC-Ggo-045122	Gorilla gorilla	66.93	0.00e+00	912.00
IUUC-Hsa-045882	Homo sapiens	66.93	0.00e+00	911.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	67.15	0.00e+00	903.00
IUUC-Lch-049960	Latimeria chalumnae	63.78	0.00e+00	845.00
IUUC-Loc-052408	Lepisosteus oculatus	74.52	0.00e+00	638.00
IUUC-Laf-054187	Loxodonta africana	66.27	0.00e+00	907.00
IUUC-Mcc-055273	Macaca mulatta	66.13	0.00e+00	884.00
IUUC-Meu-056267	Macropus eugenii	64.79	0.00e+00	873.00
IUUC-Mga-059958	Meleagris gallopavo	81.37	5.00e-145	506.00
IUUC-Mmr-061280	Microcebus murinus	67.11	0.00e+00	893.00
IUUC-Mdo-062625	Monodelphis domestica	68.76	0.00e+00	948.00
IUUC-Mmu-063853	Mus musculus	67.34	0.00e+00	889.00
IUUC-Mlu-067771	Myotis lucifugus	67.79	0.00e+00	892.00
IUUC-Opr-070741	Ochotona princeps	67.43	0.00e+00	892.00
IUUC-Ont-072172	Oreochromis niloticus	84.70	0.00e+00	1212.00
IUUC-Oan-073167	Ornithorhynchus anatinus	66.40	0.00e+00	905.00
IUUC-Ocu-074176	Oryctolagus cuniculus	65.50	0.00e+00	876.00
IUUC-Ola-087203	Oryzias latipes	91.67	6.00e-145	506.00
IUUC-Oga-089153	Otolemur garnettii	67.03	0.00e+00	895.00
IUUC-Oar-090008	Ovis aries	66.40	0.00e+00	893.00
IUUC-Ptr-091234	Pan troglodytes	66.93	0.00e+00	911.00
IUUC-Pan-092005	Papio anubis	67.20	0.00e+00	912.00
IUUC-Psi-093995	Pelodiscus sinensis	74.13	4.00e-164	571.00
IUUC-Pma-094110	Petromyzon marinus	77.78	3.00e-62	232.00
IUUC-Pfo-097418	Poecilia formosa	83.18	0.00e+00	1146.00
IUUC-Pab-098267	Pongo abelii	66.13	0.00e+00	888.00
IUUC-Pca-101084	Procavia capensis	65.86	0.00e+00	851.00
IUUC-Pva-102292	Pteropus vampyrus	67.75	0.00e+00	632.00
IUUC-Rno-105251	Rattus norvegicus	66.23	0.00e+00	880.00
IUUC-Sha-107100	Sarcophilus harrisii	68.38	0.00e+00	924.00
IUUC-Sar-113559	Sorex araneus	63.48	7.00e-117	414.00
IUUC-Ssc-115688	Sus scrofa	67.39	0.00e+00	893.00
IUUC-Tgu-117424	Taeniopygia guttata	67.57	0.00e+00	915.00
IUUC-Tru-118585	Takifugu rubripes	91.31	0.00e+00	1288.00
IUUC-Tsy-119299	Tarsius syrichta	56.16	4.00e-180	624.00
IUUC-Tbe-127705	Tupaia belangeri	73.12	1.00e-143	502.00
IUUC-Ttr-128225	Tursiops truncatus	66.04	0.00e+00	873.00
IUUC-Vpa-130193	Vicugna pacos	67.90	6.00e-89	321.00
IUUC-Xtr-132449	Xenopus tropicalis	65.01	0.00e+00	845.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence